Kris De Boeck

Summary

Affiliation: University Hospitals Leuven
Country: Belgium

Publications

  1. doi request reprint Airway clearance techniques to treat acute respiratory disorders in previously healthy children: where is the evidence?
    Kris De Boeck
    Department of Paediatrics, University Hospital of Leuven, Herestraat 49, 3000 Leuven, Belgium
    Eur J Pediatr 167:607-12. 2008
  2. doi request reprint Medical consensus, guidelines, and position papers: a policy for the ECFS
    K De Boeck
    Pediatric Pulmonology, Department of Pediatrics, University of Leuven, Leuven, Belgium Electronic address
    J Cyst Fibros 13:495-8. 2014
  3. doi request reprint Efficacy and safety of ivacaftor in patients with cystic fibrosis and a non-G551D gating mutation
    Kris De Boeck
    University Hospital Gasthuisberg, Leuven, Belgium Electronic address
    J Cyst Fibros 13:674-80. 2014
  4. doi request reprint The relative frequency of CFTR mutation classes in European patients with cystic fibrosis
    K De Boeck
    Department of Pediatrics, University Hospitals of Leuven, Belgium Electronic address
    J Cyst Fibros 13:403-9. 2014
  5. doi request reprint CFTR biomarkers: time for promotion to surrogate end-point
    K De Boeck
    University Hospital of Leuven, Leuven, Belgium
    Eur Respir J 41:203-16. 2013
  6. doi request reprint 'Difficult asthma': can symptoms be controlled in a structured environment?
    K De Boeck
    University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    Pediatr Pulmonol 44:743-8. 2009
  7. doi request reprint Guideline on the design and conduct of cystic fibrosis clinical trials: the European Cystic Fibrosis Society-Clinical Trials Network (ECFS-CTN)
    K De Boeck
    Department of Pediatrics, University Hospital of Leuven, Leuven, Belgium
    J Cyst Fibros 10:S67-74. 2011
  8. ncbi request reprint Coexistence of (partial) immune defects and risk of recurrent respiratory infections
    Xavier Bossuyt
    Department of Laboratory Medicine, University Hospital Leuven, Leuven, Belgium
    Clin Chem 53:124-30. 2007
  9. doi request reprint Laboratory diagnosis of specific antibody deficiency to pneumococcal capsular polysaccharide antigens by multiplexed bead assay
    Heleen Borgers
    Experimental Laboratory Medicine, Department of Medical Diagnostic Sciences, Biomedical Sciences Group, Catholic University Leuven, Leuven, Belgium
    Clin Immunol 134:198-205. 2010
  10. ncbi request reprint Human memory B lymphocyte subsets fulfill distinct roles in the anti-polysaccharide and anti-protein immune response
    Leen Moens
    Experimental Laboratory Medicine, Department of Medical Diagnostic Sciences, Group Biomedical Sciences, Catholic University, Leuven, Belgium
    J Immunol 181:5306-12. 2008

Detail Information

Publications51

  1. doi request reprint Airway clearance techniques to treat acute respiratory disorders in previously healthy children: where is the evidence?
    Kris De Boeck
    Department of Paediatrics, University Hospital of Leuven, Herestraat 49, 3000 Leuven, Belgium
    Eur J Pediatr 167:607-12. 2008
    ..Physicians routinely prescribing airway clearance techniques in previously healthy children should question their practice...
  2. doi request reprint Medical consensus, guidelines, and position papers: a policy for the ECFS
    K De Boeck
    Pediatric Pulmonology, Department of Pediatrics, University of Leuven, Leuven, Belgium Electronic address
    J Cyst Fibros 13:495-8. 2014
    ..The Board of the European Cystic Fibrosis Society deemed it to be helpful to provide a short commentary on the definition of these terms, on their interconnections and on how ECFS considers them in documents endorsed by the society. ..
  3. doi request reprint Efficacy and safety of ivacaftor in patients with cystic fibrosis and a non-G551D gating mutation
    Kris De Boeck
    University Hospital Gasthuisberg, Leuven, Belgium Electronic address
    J Cyst Fibros 13:674-80. 2014
    ..Ivacaftor is used to treat patients with CF and a G551D gating mutation; the KONNECTION study assessed the efficacy and safety of ivacaftor in patients with CF and a non-G551D gating mutation...
  4. doi request reprint The relative frequency of CFTR mutation classes in European patients with cystic fibrosis
    K De Boeck
    Department of Pediatrics, University Hospitals of Leuven, Belgium Electronic address
    J Cyst Fibros 13:403-9. 2014
    ....
  5. doi request reprint CFTR biomarkers: time for promotion to surrogate end-point
    K De Boeck
    University Hospital of Leuven, Leuven, Belgium
    Eur Respir J 41:203-16. 2013
    ..This body of work adds useful information to support the promotion of CFTR biomarkers to surrogate end-points and to guide further research in the area...
  6. doi request reprint 'Difficult asthma': can symptoms be controlled in a structured environment?
    K De Boeck
    University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    Pediatr Pulmonol 44:743-8. 2009
    ..The objective was to evaluate children with difficult asthma in a setting that excludes aggravating factors such as poor treatment adherence and adverse environmental influences...
  7. doi request reprint Guideline on the design and conduct of cystic fibrosis clinical trials: the European Cystic Fibrosis Society-Clinical Trials Network (ECFS-CTN)
    K De Boeck
    Department of Pediatrics, University Hospital of Leuven, Leuven, Belgium
    J Cyst Fibros 10:S67-74. 2011
    ..A strong partnership with European CF patient parent organizations aims to increase awareness of the need for efficient clinical research and the participation of patients in clinical trials...
  8. ncbi request reprint Coexistence of (partial) immune defects and risk of recurrent respiratory infections
    Xavier Bossuyt
    Department of Laboratory Medicine, University Hospital Leuven, Leuven, Belgium
    Clin Chem 53:124-30. 2007
    ..We studied whether and to what extent immunologic and genetic factors are associated with increased susceptibility to respiratory infections...
  9. doi request reprint Laboratory diagnosis of specific antibody deficiency to pneumococcal capsular polysaccharide antigens by multiplexed bead assay
    Heleen Borgers
    Experimental Laboratory Medicine, Department of Medical Diagnostic Sciences, Biomedical Sciences Group, Catholic University Leuven, Leuven, Belgium
    Clin Immunol 134:198-205. 2010
    ..The XMAP pneumococcal immunity panel appears useful for identifying individuals with a low response to the unconjugated pneumococcal vaccine...
  10. ncbi request reprint Human memory B lymphocyte subsets fulfill distinct roles in the anti-polysaccharide and anti-protein immune response
    Leen Moens
    Experimental Laboratory Medicine, Department of Medical Diagnostic Sciences, Group Biomedical Sciences, Catholic University, Leuven, Belgium
    J Immunol 181:5306-12. 2008
    ..pneumoniae or soluble pneumococcal capsular polysaccharides. In conclusion, our findings provide evidence for a versatile role of IgM memory B cells in T-independent and T-dependent immune responses...
  11. doi request reprint Lung clearance index predicts pulmonary exacerbations in young patients with cystic fibrosis
    Francois Vermeulen
    Department of Pediatrics, Cystic Fibrosis Centre, University Hospital Leuven, Leuven, Belgium
    Thorax 69:39-45. 2014
    ..The lung clearance index (LCI) is a promising endpoint for use in cystic fibrosis (CF) clinical trials, but correlations with validated clinical endpoints have not yet been established...
  12. doi request reprint Complicated parapneumonic effusion in Belgian children: increased occurrence before routine pneumococcal vaccine implementation
    Tine Van Ackere
    Department of Pediatrics, University Hospital of Leuven, Herestraat 49, 3000, Leuven, Belgium
    Eur J Pediatr 168:51-8. 2009
    ..This increase is pronounced from 2003 onwards (late cohort) and, thus, occurred later than that reported in the UK and USA; several parameters point towards the occurrence of more serious disease in the late cohort patients...
  13. ncbi request reprint Toll-like receptor 2 and Toll-like receptor 4 polymorphisms in invasive pneumococcal disease
    Leen Moens
    Department of Laboratory Medicine, University Hospital Leuven, Centraal Dienstengebouw, Herestraat 49, B 3000 Leuven, Belgium
    Microbes Infect 9:15-20. 2007
    ..Studies have revealed associations between polymorphisms in TLRs and human diseases. The effect of polymorphisms in TLR2 and TLR4 in the human defense to S. pneumoniae has not been studied...
  14. doi request reprint What's new in cystic fibrosis? From treating symptoms to correction of the basic defect
    Marijke Proesmans
    Department of Pediatrics, University Hospital of Leuven, Herestraat 49, 3000, Leuven, Belgium
    Eur J Pediatr 167:839-49. 2008
    ....
  15. doi request reprint Lung transplantation in cystic fibrosis normalizes essential fatty acid profiles
    Peter Witters
    Department of Paediatrics, University Hospitals Leuven, Kathollieke Universiteit Leuven, Leuven, Belgium
    J Cyst Fibros 12:222-8. 2013
    ..However, the mechanisms leading to these disturbances remain elusive. We wanted to investigate the role of the diseased CF lung on fatty acid profiles...
  16. doi request reprint New clinical diagnostic procedures for cystic fibrosis in Europe
    K De Boeck
    Department of Pediatrics, University Hospital of Leuven, Leuven, Belgium
    J Cyst Fibros 10:S53-66. 2011
    ..New approaches to evaluate the sweat gland, future of genetic testing and methods on the horizon like CFTR expression in human leucocytes and erythrocytes are discussed briefly...
  17. doi request reprint Non-invasive liver elastography (Fibroscan) for detection of cystic fibrosis-associated liver disease
    Peter Witters
    Department of Paediatrics, Katholieke Universiteit Leuven, Belgium
    J Cyst Fibros 8:392-9. 2009
    ..The prevalence is estimated to be 26-45%, but sensitive diagnostic tools are lacking. We investigated whether non-invasive liver elastography (Fibroscan) could serve as a screening tool...
  18. doi request reprint Comparison of lung clearance index measured during helium washin and washout in children with cystic fibrosis
    Francois Vermeulen
    University Hospital Leuven, Cystic Fibrosis Centre, Leuven, Belgium
    Pediatr Pulmonol 48:962-9. 2013
    ..This preliminary study compares results obtained from the washin and the washout phase of the multiple breath washout in CF children and healthy controls using an early commercially available device...
  19. doi request reprint Diagnostic accuracy of nitric oxide measurements to detect primary ciliary dyskinesia
    Mieke Boon
    Department of Pediatrics, Pediatric Pulmonology, University Hospital Gasthuisberg, Leuven, Belgium
    Eur J Clin Invest 44:477-85. 2014
    ..The test sensitivity is good, but specificity has not been studied widely. Therefore, we evaluated the diagnostic accuracy of low nNO to diagnose PCD in a large cohort, including healthy patients and different disease controls...
  20. doi request reprint Lung structure-function correlation in patients with primary ciliary dyskinesia
    Mieke Boon
    Department of Pediatrics, Pediatric Pulmonology, University Hospital Gasthuisberg, Leuven, Belgium
    Thorax 70:339-45. 2015
    ..In PCD, the relationship between functional and structural abnormalities has been less studied. We aimed to re-examine this in a cohort of children and adults with mild to moderate PCD...
  21. ncbi request reprint Pancreatitis among patients with cystic fibrosis: correlation with pancreatic status and genotype
    Kris De Boeck
    University Hospital, Leuven, Belgium
    Pediatrics 115:e463-9. 2005
    ....
  22. ncbi request reprint Impact of air pollution on cystic fibrosis pulmonary exacerbations: a case-crossover analysis
    Pieter C Goeminne
    Department of Lung Disease, UZ Leuven, Leuven, Belgium
    Chest 143:946-54. 2013
    ..Our aim was to evaluate whether exacerbations, defi ned by antibiotic use, were triggered by daily fl uctuations in air pollution...
  23. doi request reprint Serum procalcitonin is not an early marker of pulmonary exacerbation in children with cystic fibrosis
    Jacoba Johanna Louw
    Catholic University of Leuven, Leuven, Belgium
    Eur J Pediatr 171:139-42. 2012
    ..PCT values were markedly higher in two CF patients with an acute nonrespiratory infection (central venous catheter-associated bloodstream infection, acute gastroenteritis), demonstrating that they can mount a PCT response...
  24. doi request reprint Coprescription of antibiotics and asthma drugs in children
    Kris De Boeck
    Department of Pediatric Pulmonology and Infectious Diseases, University Hospital of Leuven, Leuven, Belgium
    Pediatrics 127:1022-6. 2011
    ..In children, antibiotics as well as asthma drugs are frequently prescribed. We investigated the effects of the codispensing of antibiotics and asthma drugs to children...
  25. doi request reprint Nasal potential measurements on the nasal floor and under the inferior turbinate: does it matter?
    Francois Vermeulen
    Cystic Fibrosis Reference Centre, University Hospital Gasthuisberg, Catholic University of Leuven, Leuven, Belgium
    Pediatr Pulmonol 46:145-52. 2011
    ..Several methods are used to measure NPD. This study explores the influence of the site of measurement and compares NPD results obtained on the nasal floor and under the inferior turbinate...
  26. pmc Primary ciliary dyskinesia: critical evaluation of clinical symptoms and diagnosis in patients with normal and abnormal ultrastructure
    Mieke Boon
    Department of Pediatrics, Pediatric Pulmonology, University Hospital Leuven, Leuven, Belgium
    Orphanet J Rare Dis 9:11. 2014
    ..Additionally, we aimed to demonstrate the need for biopsy and cell culture to reliably diagnose PCD, especially the NU subtype...
  27. pmc Gain-of-function mutations in signal transducer and activator of transcription 1 (STAT1): chronic mucocutaneous candidiasis accompanied by enamel defects and delayed dental shedding
    Glynis Frans
    Department of Microbiology and Immunology, Experimental Laboratory Immunology, Katholieke Universiteit Leuven, Leuven, Belgium
    J Allergy Clin Immunol 134:1209-13.e6. 2014
  28. doi request reprint Proximity to blue spaces and risk of infection with Pseudomonas aeruginosa in cystic fibrosis: A case-control analysis
    Pieter C Goeminne
    Department of Respiratory Disease, University Hospital of Leuven, Belgium Electronic address
    J Cyst Fibros 14:741-7. 2015
    ..Open water is a known reservoir and a potential source of exposure to P. aeruginosa...
  29. doi request reprint Treatment burden in patients with at least one class IV or V CFTR mutation
    Jonas Dewulf
    Department of Pediatrics, University Hospitals of Leuven, Belgium
    Pediatr Pulmonol 50:1230-6. 2015
    ..Pediatr Pulmonol. 2015; 50:1230-1236. © 2015 Wiley Periodicals, Inc. ..
  30. doi request reprint Improved repeatability of nasal potential difference with a larger surface catheter
    Francois Vermeulen
    CF Center, Department of Pediatrics, University Hospital of Leuven, Leuven, Belgium Electronic address
    J Cyst Fibros 14:317-23. 2015
    ..We evaluated the improvement in repeatability resulting from measuring NPD (1) over a larger surface area and (2) at a fixed location...
  31. doi request reprint Clinical outcome of parapneumonic empyema in children treated according to a standardized medical treatment
    Marijke Proesmans
    Department of Pediatrics, Pediatric Pulmonology, University Hospital of Leuven, Herestraat 49, 3000, Leuven, Belgium
    Eur J Pediatr 173:1339-45. 2014
    ..002) and pleural glucose (r = -0.248; p = 0.021) and was inversely correlated with pleural pH (r = -0.249; p = 0.046). Based on pleural PCR data, 85 % of PE were caused by Streptococcus pneumoniae (40 % serotype 1)...
  32. doi request reprint Primary ciliary dyskinesia and humoral immunodeficiency--is there a missing link?
    Mieke Boon
    Department of Pediatrics, Pediatric Pulmonology, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium Electronic address
    Respir Med 108:931-4. 2014
    ..Primary ciliary dyskinesia (PCD) and humoral mmunodeficiency (HID) are both rare disorders which cause recurrent upper and lower respiratory tract infections...
  33. ncbi request reprint Exhaled nitric oxide corresponds with office evaluation of asthma control
    Isabelle Meyts
    Pediatric Pulmonology Department, University Hospital Gasthuisberg Leuven, Herestraat 49, 3000 Leuven, Belgium
    Pediatr Pulmonol 36:283-9. 2003
    ..These results suggest that ENO measurements may be useful for monitoring asthma patients...
  34. ncbi request reprint Omeprazole, a proton pump inhibitor, improves residual steatorrhoea in cystic fibrosis patients treated with high dose pancreatic enzymes
    Marijke Proesmans
    Department of Paediatrics, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    Eur J Pediatr 162:760-3. 2003
    ..5-16.5 g/day) to 5.5 g (quartiles 4.9-8.1 g/day) (P<0.01). The same improvement was noted when fat absorption was calculated: 87% (quartiles 81-89%) without versus 94% (quartiles 90-96%) with omeprazole (P<0.001)...
  35. doi request reprint Mutations in the amiloride-sensitive epithelial sodium channel in patients with cystic fibrosis-like disease
    Abul Kalam Azad
    Center for Human Genetics, Katholieke Universiteit Leuven, Leuven, Belgium
    Hum Mutat 30:1093-103. 2009
    ..W493R-SCNN1A mutation and a cystic fibrosis transmembrane conductance regulator (CFTR) gene that results in very low amounts (0-10%) functional CFTR. These ENaC/CFTR genotypes may play a hitherto unrecognized role in lung diseases...
  36. doi request reprint Real life evaluation of intravenous antibiotic treatment in a paediatric cystic fibrosis centre: outcome of home therapy is not inferior
    M Proesmans
    Department of Pediatrics, Pediatric Pulmonology, Cystic Fibrosis Centre, University Hospital of Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Respir Med 103:244-50. 2009
    ..Limited data exist on the efficacy and safety of home intravenous antibiotic (IV-AB) therapy for pulmonary infection specifically in children with cystic fibrosis (CF)...
  37. doi request reprint Phenotypic characterisation of patients with intermediate sweat chloride values: towards validation of the European diagnostic algorithm for cystic fibrosis
    C Goubau
    Department of Paediatrics, Paediatric Pulmonology, University Hospital of Leuven, Herestraat 49, 3000 Leuven, Belgium
    Thorax 64:683-91. 2009
    ....
  38. doi request reprint Breaking bad news, the diagnosis of cystic fibrosis in childhood
    Trudy Havermans
    Cystic Fibrosis Centre, Pediatric Pulmonology, University Hospital Gasthuisberg Leuven, Belgium Electronic address
    J Cyst Fibros 14:540-6. 2015
    ..The day parents are told their child has cystic fibrosis (CF) is imprinted in their memory. Parents often show strong emotions (e.g. shock, anxiety); they need to cope with bad news and restructure their lives taking into account CF...
  39. ncbi request reprint A 1-year old girl with fever and a unilateral swelling of the jaw
    Brita de Jong
    Department of Paediatrics, University Hospital Leuven, Herestraat 49, 3000, Leuven, Belgium
    Eur J Pediatr 163:179-80. 2004
  40. ncbi request reprint Fcgamma-receptor IIA genotype and invasive pneumococcal infection
    Leen Moens
    Department of Laboratory Medicine, University Hospital Leuven, Centraal Dienstengebouw, Herestraat 49, B 3000 Leuven, Belgium
    Clin Immunol 118:20-3. 2006
    ..In contrast to previous reports, we found no association between Fcgamma-RIIA genotype and invasive pneumococcal disease...
  41. ncbi request reprint Do inhaled corticosteroids impair long-term growth in prepubertal cystic fibrosis patients?
    Kris De Boeck
    Department of Pediatric Pulmonology and Cystic Fibrosis Clinic, University Hospital of Leuven, Herestraat 49, 3000 Leuven, Belgium
    Eur J Pediatr 166:23-8. 2007
    ..01 (0.07) in the placebo group (p<0.003, ANOVA). No catch-up growth was noted 1-2 years after discontinuation of inhaled steroids. The use of high-dose ICS in CF patients with mild lung disease may lead to persistent growth impairment...
  42. doi request reprint Introduction to Section I: the relevance of CF diagnostic tools for measuring restoration of CFTR function after therapeutic interventions in human clinical trials
    Kris De Boeck
    Department of Pediatrics, University of Leuven, Leuven, Belgium
    Methods Mol Biol 741:3-11. 2011
    ..It is hoped that lessons learned through the use of these measures will inform the future development of other robust methods to assess novel therapeutic strategies uncovered by basic scientists...
  43. pmc Elevated expression of both mRNA and protein levels of IL-17A in sputum of stable Cystic Fibrosis patients
    Ann Decraene
    Laboratory of Pneumology, KULeuven, Herestraat, Leuven, Belgium
    Respir Res 11:177. 2010
    ....
  44. doi request reprint Misdiagnosis as asphyxiating thoracic dystrophy and CMV-associated haemophagocytic lymphohistiocytosis in Shwachman-Diamond syndrome
    Heidi Schaballie
    Department of Microbiology and Immunology, University Hospitals Leuven, Leuven, Belgium
    Eur J Pediatr 172:613-22. 2013
    ..One patient developed hepatopulmonary syndrome. The findings in this national cohort of SDS patients could contribute to the prevention of misdiagnosis in the future and enable more rapid recognition of certain severe complications...
  45. doi request reprint Primary ciliary dyskinesia, an orphan disease
    Mieke Boon
    Department of Pediatric Pulmonology, University Hospital Leuven, Herestraat 49, 3000, Leuven, Belgium
    Eur J Pediatr 172:151-62. 2013
    ..Given the heterogeneity and the rarity of the disorder, therapy is not evidence-based. Many treatment schedules are proposed in analogy with the treatment for cystic fibrosis...
  46. ncbi request reprint Unusual and severe disease course in a child with ataxia-telangiectasia
    Isabelle Meyts
    University Hospital Gasthuisberg Leuven, Pediatric Department, Herestraat 49, 3000 Leuven, Belgium
    Pediatr Allergy Immunol 14:330-3. 2003
    ..At the age of 26 months she developed persistent fever, progressive lymphadenopathy and pulmonary nodular infiltrates, which were responsive to steroid therapy...
  47. doi request reprint MCIDAS mutations result in a mucociliary clearance disorder with reduced generation of multiple motile cilia
    Mieke Boon
    1 Department of Pediatrics, Pediatric Pulmonology, University Hospital of Leuven, Leuven 3000, Belgium 2
    Nat Commun 5:4418. 2014
    ..Thus, our findings identify Multicilin as a key regulator of CCNO/FOXJ1 for human multiciliated cell differentiation, and highlight the 5q11 region containing CCNO and MCIDAS as a locus underlying RGMC. ..
  48. doi request reprint Clinical practice: treatment of childhood empyema
    Marijke Proesmans
    Department of Pediatric Pulmonology, UZ Leuven, Leuven, Belgium
    Eur J Pediatr 168:639-45. 2009
    ..As to the surgical interventions, there is at present insufficient evidence that early surgery is superior to noninvasive medical treatment. Therefore, video-assisted thoracoscopy cannot be advised as general first-line therapy...
  49. pmc Massive lung collapse with partial resolution after several years: a case report
    Elke Govaere
    Dept of Pediatrics, University Hospital of Leuven, Herestraat 49, 3000 Leuven, Belgium
    BMC Pediatr 5:39. 2005
    ..Of the rare cases reported in the literature all surviving children underwent surgical resection of the collapsed lung...
  50. ncbi request reprint Distribution of human beta-defensin polymorphisms in various control and cystic fibrosis populations
    Anne Vankeerberghen
    Department of Human Genetics, KULeuven, Herestraat 49, O and N6, 3000 Louvain, Belgium
    Genomics 85:574-81. 2005
    ..No association with the age of first infection by Pseudomonas aeruginosa or with the FEV1 percentage at the age of 11-13 years could be found...
  51. ncbi request reprint IL-12 contributes to allergen-induced airway inflammation in experimental asthma
    Isabelle Meyts
    Laboratory of Experimental Immunology, University Hospitals, Faculty of Medicine, Catholic University of Leuven, Herestraat 49, B 3000 Leuven, Belgium
    J Immunol 177:6460-70. 2006
    ..IFN-gamma-producing cells or cells dependent on IFN-gamma activity, play a major role in this unexpected proinflammatory effect of IL-12 in allergic airway disease...