Maarten Albersen

Summary

Affiliation: University Hospitals Leuven
Country: Belgium

Publications

  1. doi request reprint Stem Cell Therapy for Erectile Dysfunction: Progress and Future Directions
    Maarten Albersen
    Laboratory for Experimental Urology, Gene and Stem Cells Applications, Department of Development and Regeneration, University of Leuven, Leuven, Belgium Electronic address
    Sex Med Rev 1:50-64. 2013
  2. ncbi request reprint Molecular pathophysiology of cavernous nerve injury and identification of strategies for nerve function recovery after radical prostatectomy
    Emmanuel Weyne
    Laboratory for Experimental Urology, Department of Development and Regeneration, University of Leuven, Orgaansystemen, UZ Herestraat 49 bus 802, 3000 Leuven, Belgium
    Curr Drug Targets 16:459-73. 2015
  3. doi request reprint Evaluation and treatment of erectile dysfunction in the aging male: a mini-review
    Maarten Albersen
    Department of Urology, University of California at San Francisco, San Francisco, CA, USA
    Gerontology 58:3-14. 2012
  4. pmc Functional, metabolic, and morphologic characteristics of a novel rat model of type 2 diabetes-associated erectile dysfunction
    Maarten Albersen
    Knuppe Molecular Urology Laboratory, Department of Urology, University of California, San Francisco, CA, USA
    Urology 78:476.e1-8. 2011
  5. pmc Both immediate and delayed intracavernous injection of autologous adipose-derived stromal vascular fraction enhances recovery of erectile function in a rat model of cavernous nerve injury
    Xuefeng Qiu
    Knuppe Molecular Urology Laboratory, Department of Urology, University of California, San Francisco, CA 94143 0738, USA
    Eur Urol 62:720-7. 2012
  6. pmc Recruitment of intracavernously injected adipose-derived stem cells to the major pelvic ganglion improves erectile function in a rat model of cavernous nerve injury
    Thomas M Fandel
    Knuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, CA, USA
    Eur Urol 61:201-10. 2012
  7. pmc Effects of prolonged vaginal distension and β-aminopropionitrile on urinary continence and urethral structure
    Guifang Wang
    Department of Urology, University of California, School of Medicine, San Francisco, CA, USA
    Urology 78:968.e13-9. 2011
  8. pmc Effects of intravenous injection of adipose-derived stem cells in a rat model of radiation therapy-induced erectile dysfunction
    Xuefeng Qiu
    Knuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, CA 94143 0738, USA
    J Sex Med 9:1834-41. 2012
  9. pmc The N-shaped orthotopic ileal neobladder: functional outcomes and complication rates in 119 patients
    Thomas De Sutter
    Department of Urology, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium
    Springerplus 5:646. 2016
  10. pmc Cavernous nerve repair with allogenic adipose matrix and autologous adipose-derived stem cells
    Guiting Lin
    Knuppe Molecular Urology Laboratory, Department of Urology, University of California, San Francisco, CA 94143 0738, USA
    Urology 77:1509.e1-8. 2011

Collaborators

Detail Information

Publications34

  1. doi request reprint Stem Cell Therapy for Erectile Dysfunction: Progress and Future Directions
    Maarten Albersen
    Laboratory for Experimental Urology, Gene and Stem Cells Applications, Department of Development and Regeneration, University of Leuven, Leuven, Belgium Electronic address
    Sex Med Rev 1:50-64. 2013
    ..Preclinical studies have shown that these cells may reverse pathophysiological changes leading to ED rather than treating the symptom ED...
  2. ncbi request reprint Molecular pathophysiology of cavernous nerve injury and identification of strategies for nerve function recovery after radical prostatectomy
    Emmanuel Weyne
    Laboratory for Experimental Urology, Department of Development and Regeneration, University of Leuven, Orgaansystemen, UZ Herestraat 49 bus 802, 3000 Leuven, Belgium
    Curr Drug Targets 16:459-73. 2015
    ..Many of these strategies reviewed have the potential to optimize erectile function recovery after radical prostatectomy when translated from pre-clinical models to clinical practice. ..
  3. doi request reprint Evaluation and treatment of erectile dysfunction in the aging male: a mini-review
    Maarten Albersen
    Department of Urology, University of California at San Francisco, San Francisco, CA, USA
    Gerontology 58:3-14. 2012
    ..This mini-review provides an overview of contemporary literature concerning epidemiology, pathophysiology, assessment and treatment of erectile dysfunction in the aging male...
  4. pmc Functional, metabolic, and morphologic characteristics of a novel rat model of type 2 diabetes-associated erectile dysfunction
    Maarten Albersen
    Knuppe Molecular Urology Laboratory, Department of Urology, University of California, San Francisco, CA, USA
    Urology 78:476.e1-8. 2011
    ..To conduct a pilot study to investigate functional, metabolic, and penile morphologic changes in a novel model of lean DM2. Erectile dysfunction (ED) is a frequent sequela in patients with type 2 diabetes mellitus (DM2)...
  5. pmc Both immediate and delayed intracavernous injection of autologous adipose-derived stromal vascular fraction enhances recovery of erectile function in a rat model of cavernous nerve injury
    Xuefeng Qiu
    Knuppe Molecular Urology Laboratory, Department of Urology, University of California, San Francisco, CA 94143 0738, USA
    Eur Urol 62:720-7. 2012
    ..However, culturing exposes ADSCs to the risk of contamination and dedifferentiation...
  6. pmc Recruitment of intracavernously injected adipose-derived stem cells to the major pelvic ganglion improves erectile function in a rat model of cavernous nerve injury
    Thomas M Fandel
    Knuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, CA, USA
    Eur Urol 61:201-10. 2012
    ..Intracavernous (IC) injection of stem cells has been shown to ameliorate cavernous-nerve (CN) injury-induced erectile dysfunction (ED). However, the mechanisms of action of adipose-derived stem cells (ADSC) remain unclear...
  7. pmc Effects of prolonged vaginal distension and β-aminopropionitrile on urinary continence and urethral structure
    Guifang Wang
    Department of Urology, University of California, School of Medicine, San Francisco, CA, USA
    Urology 78:968.e13-9. 2011
    ..To investigate the effects of prolonged vaginal distension and β-aminopropionitrile (BAPN) on the urinary patterns and urethral structure in female virgin rats...
  8. pmc Effects of intravenous injection of adipose-derived stem cells in a rat model of radiation therapy-induced erectile dysfunction
    Xuefeng Qiu
    Knuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, CA 94143 0738, USA
    J Sex Med 9:1834-41. 2012
    ..Radiation therapy (RT) for prostate cancer is frequently associated with posttreatment erectile dysfunction (ED)...
  9. pmc The N-shaped orthotopic ileal neobladder: functional outcomes and complication rates in 119 patients
    Thomas De Sutter
    Department of Urology, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium
    Springerplus 5:646. 2016
    ..We report our long-term experience with 119 cases of N-shaped orthotopic ileal neobladder...
  10. pmc Cavernous nerve repair with allogenic adipose matrix and autologous adipose-derived stem cells
    Guiting Lin
    Knuppe Molecular Urology Laboratory, Department of Urology, University of California, San Francisco, CA 94143 0738, USA
    Urology 77:1509.e1-8. 2011
    ..To investigate whether adipose-derived matrix seeded with adipose-derived stem cells (ADSC) can facilitate the repair of injured cavernous nerves (CNs)...
  11. pmc Pentoxifylline promotes recovery of erectile function in a rat model of postprostatectomy erectile dysfunction
    Maarten Albersen
    Knuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, CA 94143 0738, USA
    Eur Urol 59:286-96. 2011
    ..Pentoxifylline (PTX) is a phosphodiesterase inhibitor that further inhibits multiple cytokine pathways involved in nerve degeneration, apoptosis, and fibrosis...
  12. doi request reprint Increased expression of the neuroregenerative peptide galanin in the major pelvic ganglion following cavernous nerve injury
    Emmanuel Weyne
    Laboratory for Experimental Urology, Department of Development and Regeneration, University of Leuven, Leuven, Belgium
    J Sex Med 11:1685-93. 2014
    ..A recent microarray showed the neuropeptide galanin to be one of the most strikingly upregulated genes in the rat major pelvic ganglion (MPG) after bilateral CN crush injury (BCNI)...
  13. pmc Improved penile histology by phalloidin stain: circular and longitudinal cavernous smooth muscles, dual-endothelium arteries, and erectile dysfunction-associated changes
    Guiting Lin
    Department of Urology, University of California, San Francisco, CA, USA
    Urology 78:970.e1-8. 2011
    ..To investigate whether fluorochrome-conjugated phalloidin can delineate cavernous smooth muscle (CSM) cells and whether it can be combined with immunofluorescence (IF) staining to quantify erectile dysfunction (ED)-associated changes...
  14. doi request reprint Additive effects of the Rho kinase inhibitor Y-27632 and vardenafil on relaxation of the corpus cavernosum tissue of patients with erectile dysfunction and clinical phosphodiesterase type 5 inhibitor failure
    Pieter Uvin
    Department of Urology, University Hospitals Leuven, Leuven, Belgium
    BJU Int . 2016
    ....
  15. doi request reprint Adipose-derived Stem Cells Counteract Urethral Stricture Formation in Rats
    Fabio Castiglione
    Laboratory for Experimental Urology, Organ Systems, Department of Development and Regeneration, University of Leuven, Leuven, Belgium Division of Oncology Unit of Urology, Urological Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy
    Eur Urol 70:1032-1041. 2016
    ..A medical treatment for urethral stricture (US) is not yet available...
  16. pmc Effects of EdU labeling on mesenchymal stem cells
    Hongxiu Ning
    Knuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, CA 94143, USA
    Cytotherapy 15:57-63. 2013
    ..In the present study, we tested whether EdU was cytotoxic and whether it interfered with differentiation, cytokine secretion and migration of MSCs...
  17. doi request reprint Multipotent stromal cell therapy for cavernous nerve injury-induced erectile dysfunction
    Maarten Albersen
    Laboratory of Experimental Urology, University Hospitals Leuven, Leuven, Belgium
    J Sex Med 9:385-403. 2012
    ..Multipotent stromal cells (MSCs) are an attractive cell source for this application based on their regenerative potential and their clinical applicability...
  18. doi request reprint Tumor Volume and Clinical Failure in High-Risk Prostate Cancer Patients Treated With Radical Prostatectomy
    Fabio Castiglione
    Department of Urology, University Hospitals Leuven, Leuven, Belgium
    Prostate 77:3-9. 2017
    ..To identify the most significant cut-off of tumor volume (TV) for prediction of clinical failure (CF) among high-risk prostate cancer (hPCa) patients...
  19. pmc Impact of Lymph Node Burden on Survival of High-risk Prostate Cancer Patients Following Radical Prostatectomy and Pelvic Lymph Node Dissection
    Lisa Moris
    Department of Development and Regeneration, Urology, University Hospitals Leuven, Leuven, Belgium Laboratory of Molecular Endocrinology, KULeuven, Leuven, Belgium
    Front Surg 3:65. 2016
    ..To determine the impact of the extent of lymph node invasion (LNI) on long-term oncological outcomes after radical prostatectomy (RP)...
  20. pmc Injections of adipose tissue-derived stem cells and stem cell lysate improve recovery of erectile function in a rat model of cavernous nerve injury
    Maarten Albersen
    Knuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, CA 94143 0738, USA
    J Sex Med 7:3331-40. 2010
    ..However, the mechanisms of action for stem cell therapy remain controversial, with increasing evidence pointing to paracrine pathways...
  21. doi request reprint Landmarks in erectile function recovery after radical prostatectomy
    Emmanuel Weyne
    Laboratory for Experimental Urology, Department of Development and Regeneration, University of Leuven, Herestraat 49, Box 802, 3000 Leuven, Belgium
    Nat Rev Urol 12:289-97. 2015
    ..Penile rehabilitation with PDE5Is is currently the most commonly used clinical strategy, in spite of the absence of solid clinical evidence to support its use. ..
  22. pmc The future is today: emerging drugs for the treatment of erectile dysfunction
    Maarten Albersen
    Basic Research Fellow Male Sexual Dysfunction, University of California at San Francisco, Department of Urology, Knuppe Molecular Urology Laboratory, Campus Box 0738, San Francisco, CA 94143 0738, USA
    Expert Opin Emerg Drugs 15:467-80. 2010
    ..PDE type 5 inhibitors (PDE5I) now account for the largest segment of the ED market. While these drugs are highly efficacious for many men, a relatively large subset of ED patients who do not respond to PDE5I is increasingly recognized...
  23. pmc Inhibition of Rho-kinase improves erectile function, increases nitric oxide signaling and decreases penile apoptosis in a rat model of cavernous nerve injury
    Johanna L Hannan
    James Buchanan Brady Urological Institute, Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
    J Urol 189:1155-61. 2013
    ..We evaluated whether daily treatment with the ROCK inhibitor Y-27632 (Tocris Bioscience, Ellisville, Missouri) would prevent erectile dysfunction in a rat model of bilateral cavernous nerve injury...
  24. doi request reprint High-frequency micro-ultrasound: a novel method to assess external urethral sphincter function in rats following simulated birth injury
    Lukman Hakim
    Laboratory of Experimental Urology, Department of Development and Regeneration, KU Leuven, Leuven, Belgium Department of Urology, Airlangga University School of Medicine Dr Soetomo General Hospital, Surabaya, Indonesia
    Neurourol Urodyn 34:264-9. 2015
    ....
  25. doi request reprint Current Pharmacological Management of Premature Ejaculation: A Systematic Review and Meta-analysis
    Fabio Castiglione
    Division of Oncology Unit of Urology, IRCCS Ospedale San Raffaele, Milan, Italy Università Vita Salute San Raffaele, Milan, Italy Laboratory for Experimental Urology, Gene and Stem Cells Applications, Department of Development and Regeneration, University of Leuven, Leuven, Belgium Electronic address
    Eur Urol 69:904-16. 2016
    ..Premature ejaculation (PE) is the most prevalent male sexual dysfunction. In the last few years, several pharmacologic approaches for oral or topical treatment of PE have been studied...
  26. doi request reprint Emerging tools for erectile dysfunction: a role for regenerative medicine
    Lukman Hakim
    Laboratory of Experimental Urology, Department of Urology, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium
    Nat Rev Urol 9:520-36. 2012
    ..However, the search for novel treatment targets and a wealth of preclinical studies represent a dynamic and continuing field of enquiry...
  27. pmc Phosphodiesterase-5 expression and function in the lower urinary tract: a critical review
    Ching Shwun Lin
    Knuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, CA 94143 0738, USA
    Urology 81:480-7. 2013
    ..For PDE-5 expression, the data have ranged from extremely low to highly abundant. PDE-5 has been found in the glandular epithelium, vascular smooth muscle, endothelium, and fibromuscular stroma...
  28. doi request reprint Advances in stem cell research for the treatment of male sexual dysfunctions
    M Ayodhia Soebadi
    aLaboratory of Experimental Urology, Department of Development and Regeneration, KU Leuven, Leuven, Belgium bDepartment of Urology, Faculty of Medicine Airlangga University, Surabaya, Indonesia
    Curr Opin Urol 26:129-39. 2016
    ..To summarize recent literature on basic stem cell research in erectile dysfunction in cavernous nerve injury, aging, diabetes, and Peyronie's disease and to provide a perspective on clinical translation of these cellular therapies...
  29. doi request reprint Stem Cells in Male Sexual Dysfunction: Are We Getting Somewhere?
    Mohammad Ayodhia Soebadi
    Laboratory of Experimental Urology, Department of Development and Regeneration, KU Leuven, Leuven, Belgium Department of Urology, Airlangga University School of Medicine, Dr Soetomo General Hospital, Surabaya, Indonesia
    Sex Med Rev . 2016
    ..Cellular therapy offers a treatment modality that might reverse disease progression. It would be used in a curative setting, in contrast to other pharmaceutical agents that are currently available...
  30. doi request reprint Synergistic effects of BAY 60-4552 and vardenafil on relaxation of corpus cavernosum tissue of patients with erectile dysfunction and clinical phosphodiesterase type 5 inhibitor failure
    Maarten Albersen
    Laboratory for Experimental Urology, University Hospitals Leuven, Leuven, Belgium
    J Sex Med 10:1268-77. 2013
    ..To evaluate the effects of BAY 60-4552, a stimulator of soluble guanylate cyclase (sGC), and vardenafil on relaxation of HCC strips from PDE5-i nonresponders...
  31. pmc Stem cells: novel players in the treatment of erectile dysfunction
    Haiyang Zhang
    Minimally Invasive Urology Center, Provincial Hospital affiliated to Shandong University, Jinan, China
    Asian J Androl 14:145-55. 2012
    ..In addition, several subtypes of ASCs are localized in the penis, and circulating endogenous stem cells can be employed to predict the outcome of ED and ED-related cardiovascular diseases...
  32. ncbi request reprint Evaluation of conservative approach in the management of ureteroenteric strictures following radical cystectomy with Bricker ileal conduit: a single-center experience
    Evert Baten
    a Department of Urology, School of Medicine, Katholieke Universiteit Leuven, Leuven, Belgium
    Scand J Urol 50:439-444. 2016
    ....
  33. doi request reprint Idiopathic Partial Thrombosis (IPT) of the Corpus Cavernosum: A Hypothesis-Generating Case Series and Review of the Literature
    Emmanuel Weyne
    Department of Urology, University Hospitals Leuven, Leuven, Belgium
    J Sex Med 12:2118-25. 2015
    ..Idiopathic partial thrombosis (IPT) of the corpus cavernosum is a rare condition. The etiology is not fully understood; however, the presence of an either or not congenital web in these patients may contribute to the development of IPT...
  34. doi request reprint Evaluation and treatment of erectile dysfunction
    Maarten Albersen
    Laboratory of Experimental Urology, Department of Urology, University Hospitals Leuven, Herestraat 49, Leuven 3000, Belgium
    Med Clin North Am 95:201-12. 2011
    ..This article discusses the physiology and pathophysiology of erectile function in men, how the primary care physician may address the clinical problem of ED in practice, and when specialty referral is indicated...