Pierre R Smeesters
- You'll be a clinician-scientist, my sonPierre R Smeesters
Group A Streptococcus Research Group, Murdoch Childrens Research Institute, Melbourne, Australia
J Transl Med 13:345. 2015..The essay uses the beautiful, but old, poem "If" from Rudyard Kipling to draw a parallel with the ambitions, dreams and limits of being a clinical-scientist today...
- Pharyngitis in low-resources settings: a pragmatic clinical approach to reduce unnecessary antibiotic usePierre Robert Smeesters
Servico de Pediatria, Hospital Universitario de Brasilia, Universidade de Brasilia, Brasilia, Brazil
Pediatrics 118:e1607-11. 2006....
- Science that "knows" and science that "asks"Pierre R Smeesters
Laboratory of Bacterial Genetics and Physiology, IBMM, Faculte des Sciences, Universite Libre de Bruxelles, Belgium
J Transl Med 9:128. 2011..A stereotypic representation of both these worlds is presented as a starting point to encourage debate on this issue...
- Polyclonal dissemination of tetracycline resistance among Streptococcus pyogenes paediatric isolates from BrazilPierre Robert Smeesters
Institut de Biologie et de Médecine Moléculaires, Faculte des Sciences, Universite Libre de Bruxelles, Belgium
J Infect Dev Ctries 4:704-11. 2010..Scarce data are available on Group A Streptococcus (GAS) antibiotic resistance in South America...
- The streptococcal M protein: a highly versatile moleculePierre R Smeesters
Bacterial Pathogenesis Laboratory, Queensland Institute of Medical Research, Brisbane 4029, Queensland, Australia
Trends Microbiol 18:275-82. 2010..This review focuses on the known interactions between M proteins and host ligand proteins, emphasizing that our understanding of this well-studied molecule is fragmented...
- Differences among group A streptococcus epidemiological landscapes: consequences for M protein-based vaccines?Pierre R Smeesters
Bacterial Pathogenesis Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia
Expert Rev Vaccines 8:1705-20. 2009..In this review, we have compiled GAS epidemiological studies from several countries around the world to highlight the consequences on the theoretical efficacy of two different M protein-based vaccine strategies...
- Group A Streptococcus virulence and host factors in two toddlers with rheumatic fever following toxic shock syndromePierre Robert Smeesters
Laboratoire de Génétique et Physiologie Bactérienne, Institut de Biologie et de Médecine Moléculaires, Faculte des Sciences, Universite Libre de Bruxelles, 12 rue des Professeurs Jeener et Brachet, B6041 Gosselies, Belgium
Int J Infect Dis 14:e403-9. 2010..The present report describes the bacterial and host determinants in non-related toddlers who developed RF diagnostic criteria after toxic shock syndrome (TSS)...
- Differences between Belgian and Brazilian group A Streptococcus epidemiologic landscapePierre Robert Smeesters
Infectious Diseases Department, Hopital Universitaire des Enfants Reine Fabiola, Universite Libre de Bruxelles, Brussels, Belgium
PLoS ONE 1:e10. 2006..Group A Streptococcus (GAS) clinical and molecular epidemiology varies with location and time. These differences are not or are poorly understood...
- Emerging fluoroquinolone-non-susceptible group A streptococci in two different paediatric populationsPierre Robert Smeesters
Laboratoire de Génétique et Physiologie Bactérienne, Institut de Biologie et de Médecine Moléculaires IBMM, Faculte des Sciences, Universite Libre de Bruxelles, 12 rue des Professeurs Jeener et Brachet, 6041 Gosselies, Belgium
Int J Antimicrob Agents 34:44-9. 2009..All the Brazilian and Belgian emm type 6 strains displayed a S79A/F mutation in parC that convincingly explains the non-susceptible phenotype...
- Genetic diversity of Group A Streptococcus M protein: implications for typing and vaccine developmentPierre R Smeesters
Laboratoire de Génétique et Physiologie Bactérienne, Institut de Biologie et de Médecine Moléculaires, Faculte des Sciences, Universite Libre de Bruxelles, 12 rue des Professeurs Jeener et Brachet, 6041 Gosselies, Belgium
Vaccine 26:5835-42. 2008....
- Carriage-associated Streptocccus pneumoniae serotype 1 in Brussels, BelgiumSarah Jourdain
Laboratoire de Génétique et Physiologie Bactérienne, Institut de Biologie et de Médecine Moléculaires, Faculte des Sciences, Bruxelles, Belgium
Pediatr Infect Dis J 32:86-7. 2013..Invasive and colonizing isolates were characterized by both antibiotic resistance profile and multilocus sequence typing and were shown to share the same backbone (ST306 and ST350)...
- Characterization of novel phages isolated in coagulase-negative staphylococci reveals evolutionary relationships with Staphylococcus aureus phagesMarie Deghorain
Laboratoire de Génétique et Physiologie Bactérienne, Faculte de Sciences, IBMM, Universite Libre de Bruxelles, Gosselies, Belgium
J Bacteriol 194:5829-39. 2012..Our findings support the notion of a possible reciprocal exchange of genes between phages originating from S. aureus and CoNS, which may be of crucial importance for pathogenesis in staphylococci...
- Group A streptococcus colonies from a single throat swab can have heterogeneous antimicrobial susceptibility patternsAurélie Vandevoorde
Bacterial Genetics and Physiology Laboratory, Institut de Biologie et de Médecine Moléculaires, Faculte des Sciences, Belgium
Pediatr Infect Dis J 32:296-8. 2013....
- Detection of group a streptococcal pharyngitis by quantitative PCREileen M Dunne
Pneumococcal Research, Murdoch Childrens Research Institute, Parkville, Vic, Australia
BMC Infect Dis 13:312. 2013..The aim of this study was to develop a quantitative polymerase chain reaction (qPCR) assay for detecting GAS pharyngitis and assess its suitability for clinical diagnosis...
- Recombination drives genetic diversification of Streptococcus dysgalactiae subspecies equisimilis in a region of streptococcal endemicityDavid J McMillan
Bacterial Pathogenesis Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
PLoS ONE 6:e21346. 2011..Our data demonstrate that genetic recombination in endemic regions is more frequent than non-endemic regions, and gives rise to novel local SDSE variants, some of which may have increased fitness or pathogenic potential...
- Sequential multiplex PCR assay for determining capsular serotypes of colonizing S. pneumoniaeSarah Jourdain
Laboratoire de Génétique et Physiologie Bactérienne, Institut de Biologie et de Médecine Moléculaires, Universite Libre de Bruxelles, Bruxelles, Belgium
BMC Infect Dis 11:100. 2011..Serotype determination by conventional method (Quellung reaction) is technically and financially challenging. On the contrary, PCR-based serotyping represents a simple, economic and promising alternative method...
- Characterization of a novel temperate phage originating from a cereulide-producing Bacillus cereus strainPierre R Smeesters
Laboratoire de Génétique et Physiologie Bactérienne, IBMM, Faculte des Sciences, Universite Libre de Bruxelles, 12 Rue des Professeurs, Jeener et Brachet, 6041 Gosselies, Belgium
Res Microbiol 162:446-59. 2011..Genome analysis further illustrates the diversity of mobile genetic elements and their plasticity within the B. cereus group...
- Pneumococcal aetiology and serotype distribution in paediatric community-acquired pneumoniaIris De Schutter
Department of Pediatric Pulmonology, Cystic Fibrosis Clinic and Pediatric Infectious Diseases, Universitair Ziekenhuis Brussel UZ Brussel, Brussels, Belgium
PLoS ONE 9:e89013. 2014..The use of recently developed methods improves diagnosis of pneumococcal aetiology. ..
- Status of research and development of vaccines for Streptococcus pyogenesAndrew C Steer
Centre for International Child Health, University of Melbourne, Melbourne, Australia Group A Streptococcal Research Group, Murdoch Children s Research Institute, Melbourne, Australia Electronic address
Vaccine 34:2953-8. 2016..Considerable effort is needed by key players to bring current vaccine candidates through phase III clinical trials and there is a clear need to develop a roadmap for future development of current and new candidates. ..
- Predicted Coverage and Immuno-Safety of a Recombinant C-Repeat Region Based Streptococcus pyogenes Vaccine CandidateCelia McNeilly
Bacterial Pathogenesis Laboratory, QIMR Berghofer Medical Research Institute, 300 Herston Rd, Herston, QLD, 4006, Australia
PLoS ONE 11:e0156639. 2016..These results suggest that SV1 is a safe vaccine candidate that will elicit antibodies that recognise the vast majority of circulating GAS M-types. ..
- Correlates of Protection for M Protein-Based Vaccines against Group A StreptococcusShu Ki Tsoi
Group A Streptococcus Research Group, Murdoch Childrens Research Institute, Melbourne, VIC 3052, Australia
J Immunol Res 2015:167089. 2015....
- Streptococcal skin infection and rheumatic heart diseaseTom Parks
Wellcome Trust Centre for Human Genetics, Oxford, UK
Curr Opin Infect Dis 25:145-53. 2012..In this review, we summarize recent advances in the epidemiology of group A streptococcal skin disease and examine evidence for the relationship between group A streptococcal skin disease and rheumatic fever...
- Pragmatic scoring system for pharyngitis in low-resource settingsLaure Joachim
Department of Pediatrics, Queen Fabiola Unversity Children s Hospital, Institute for Molecular Biology and Medicine, Free University of Brussels, Brussels, Belgium
Pediatrics 126:e608-14. 2010..Our objective was to develop an easy, safe, pragmatic, clinical scoring system that would allow decreases in unnecessary treatment with antimicrobial agents in low-resource settings...