Christophe E Pierreux

Summary

Country: Belgium

Publications

  1. ncbi request reprint Eph receptors and their ephrin ligands are expressed in developing mouse pancreas
    Jonathan M van Eyll
    Hormone and Metabolic Research Unit, Institute of Cellular Pathology, Universite Catholique de Louvain, 75 Avenue Hippocrate, B 1200 Brussels, Belgium
    Gene Expr Patterns 6:353-9. 2006
  2. ncbi request reprint The transcription factor hepatocyte nuclear factor-6 controls the development of pancreatic ducts in the mouse
    Christophe E Pierreux
    Hormone and Metabolic Research Unit, Université catholique de Louvain and Institute of Cellular Pathology, Brussels, Belgium
    Gastroenterology 130:532-41. 2006
  3. pmc Threshold levels of hepatocyte nuclear factor 6 (HNF-6) acting in synergy with HNF-4 and PGC-1alpha are required for time-specific gene expression during liver development
    Jean Bernard Beaudry
    box 7529, 75 Avenue Hippocrate, B 1200 Brussels, Belgium
    Mol Cell Biol 26:6037-46. 2006
  4. ncbi request reprint The transcription factor hepatocyte nuclear factor-6/Onecut-1 controls the expression of its paralog Onecut-3 in developing mouse endoderm
    Christophe E Pierreux
    Hormone and Metabolic Research Unit, Institute of Cellular Pathology and Université catholique de Louvain, 75 Avenue Hippocrate, B 1200 Brussels, Belgium
    J Biol Chem 279:51298-304. 2004
  5. ncbi request reprint The Onecut transcription factors HNF-6/OC-1 and OC-2 regulate early liver expansion by controlling hepatoblast migration
    Sabrina Margagliotti
    Universite Catholique de Louvain, Christian de Duve Institute of Cellular Pathology, Avenue Hippocrate 75 7529, B 1200 Brussels, Belgium
    Dev Biol 311:579-89. 2007
  6. pmc Control of liver cell fate decision by a gradient of TGF beta signaling modulated by Onecut transcription factors
    Frederic Clotman
    Hormone and Metabolic Research Unit, Cell Biology Unit, Institute of Cellular Pathology and Université catholique de Louvain, Brussels, Belgium
    Genes Dev 19:1849-54. 2005
  7. ncbi request reprint Cloning and embryonic expression pattern of the mouse Onecut transcription factor OC-2
    Patrick Jacquemin
    Hormone and Metabolic Research Unit, Institute of Cellular Pathology and Université catholique de Louvain, 75 Avenue Hippocrate, B 1200, Brussels, Belgium
    Gene Expr Patterns 3:639-44. 2003
  8. ncbi request reprint Gene transfer into mouse prepancreatic endoderm by whole embryo electroporation
    Christophe E Pierreux
    Hormone and Metabolic Research Unit, Institute of Cellular Pathology and Université Catholique de Louvain Brussels, Belgium
    JOP 6:128-35. 2005
  9. ncbi request reprint A vHNF1/TCF2-HNF6 cascade regulates the transcription factor network that controls generation of pancreatic precursor cells
    Aurélie V Poll
    Hormone and Metabolic Research Unit, Université catholique de Louvain and Institute of Cellular Pathology, Avenue Hippocrate 75 7529, B 1200 Brussels, Belgium
    Diabetes 55:61-9. 2006
  10. ncbi request reprint Transcription factor HNF-6/OC-1 inhibits the stimulation of the HNF-3alpha/Foxa1 gene by TGF-beta in mouse liver
    Nicolas Plumb-Rudewiez
    Hormone and Metabolic Research Unit, Institute of Cellular Pathology and Université catholique de Louvain, Brussels, Belgium
    Hepatology 40:1266-74. 2004

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Eph receptors and their ephrin ligands are expressed in developing mouse pancreas
    Jonathan M van Eyll
    Hormone and Metabolic Research Unit, Institute of Cellular Pathology, Universite Catholique de Louvain, 75 Avenue Hippocrate, B 1200 Brussels, Belgium
    Gene Expr Patterns 6:353-9. 2006
    ..We conclude that specific members of the Eph/ephrin family are expressed in embryonic pancreas according to a dynamic temporal and regional pattern...
  2. ncbi request reprint The transcription factor hepatocyte nuclear factor-6 controls the development of pancreatic ducts in the mouse
    Christophe E Pierreux
    Hormone and Metabolic Research Unit, Université catholique de Louvain and Institute of Cellular Pathology, Brussels, Belgium
    Gastroenterology 130:532-41. 2006
    ..Here, we investigate the transcriptional mechanisms that control pancreatic duct development by addressing the role of the transcription factor hepatocyte nuclear factor (HNF)-6...
  3. pmc Threshold levels of hepatocyte nuclear factor 6 (HNF-6) acting in synergy with HNF-4 and PGC-1alpha are required for time-specific gene expression during liver development
    Jean Bernard Beaudry
    box 7529, 75 Avenue Hippocrate, B 1200 Brussels, Belgium
    Mol Cell Biol 26:6037-46. 2006
    ..Our observations on the regulation of g6pc by HNF-6 provide a model whereby synergism, interdependency, and threshold concentrations of LETFs and coactivators determine time-specific expression of genes during liver development...
  4. ncbi request reprint The transcription factor hepatocyte nuclear factor-6/Onecut-1 controls the expression of its paralog Onecut-3 in developing mouse endoderm
    Christophe E Pierreux
    Hormone and Metabolic Research Unit, Institute of Cellular Pathology and Université catholique de Louvain, 75 Avenue Hippocrate, B 1200 Brussels, Belgium
    J Biol Chem 279:51298-304. 2004
    ....
  5. ncbi request reprint The Onecut transcription factors HNF-6/OC-1 and OC-2 regulate early liver expansion by controlling hepatoblast migration
    Sabrina Margagliotti
    Universite Catholique de Louvain, Christian de Duve Institute of Cellular Pathology, Avenue Hippocrate 75 7529, B 1200 Brussels, Belgium
    Dev Biol 311:579-89. 2007
    ..This network operating at the onset of liver development contains candidate genes for investigation of liver carcinogenesis...
  6. pmc Control of liver cell fate decision by a gradient of TGF beta signaling modulated by Onecut transcription factors
    Frederic Clotman
    Hormone and Metabolic Research Unit, Cell Biology Unit, Institute of Cellular Pathology and Université catholique de Louvain, Brussels, Belgium
    Genes Dev 19:1849-54. 2005
    ..Thus, a gradient of activin/TGFbeta signaling modulated by Onecut factors is required to segregate the hepatocytic and the biliary lineages...
  7. ncbi request reprint Cloning and embryonic expression pattern of the mouse Onecut transcription factor OC-2
    Patrick Jacquemin
    Hormone and Metabolic Research Unit, Institute of Cellular Pathology and Université catholique de Louvain, 75 Avenue Hippocrate, B 1200, Brussels, Belgium
    Gene Expr Patterns 3:639-44. 2003
    ..Like Hnf6, Oc2 was expressed in developing liver and pancreas. As many genes that are targeted by Onecut factors are recognized by both OC-2 and HNF-6, this overlap of expression patterns may have functional implications...
  8. ncbi request reprint Gene transfer into mouse prepancreatic endoderm by whole embryo electroporation
    Christophe E Pierreux
    Hormone and Metabolic Research Unit, Institute of Cellular Pathology and Université Catholique de Louvain Brussels, Belgium
    JOP 6:128-35. 2005
    ..A faster and easier method is electroporation of mouse embryos. This technique, coupled with whole embryo culture, enables one to deliver genes and analyze their effects in a spatially and temporally regulated manner...
  9. ncbi request reprint A vHNF1/TCF2-HNF6 cascade regulates the transcription factor network that controls generation of pancreatic precursor cells
    Aurélie V Poll
    Hormone and Metabolic Research Unit, Université catholique de Louvain and Institute of Cellular Pathology, Avenue Hippocrate 75 7529, B 1200 Brussels, Belgium
    Diabetes 55:61-9. 2006
    ..This cascade may be used to benchmark in vitro differentiation of pancreatic precursor cells from embryonic stem cells, for cell therapy of diabetes...
  10. ncbi request reprint Transcription factor HNF-6/OC-1 inhibits the stimulation of the HNF-3alpha/Foxa1 gene by TGF-beta in mouse liver
    Nicolas Plumb-Rudewiez
    Hormone and Metabolic Research Unit, Institute of Cellular Pathology and Université catholique de Louvain, Brussels, Belgium
    Hepatology 40:1266-74. 2004
    ..This identifies a new mechanism of interaction between liver-enriched transcription factors whereby one factor indirectly controls another by modulating the activity of a signaling pathway...
  11. ncbi request reprint Shh-dependent differentiation of intestinal tissue from embryonic pancreas by activin A
    Jonathan M van Eyll
    Hormone and Metabolic Research Unit, Institute of Cellular Pathology and Université catholique de Louvain, 75 Avenue Hippocrate, B 1200 Brussels, Belgium
    J Cell Sci 117:2077-86. 2004
    ..These findings illustrate the plasticity of differentiation programs in response to extracellular signals in the pancreas and they shed new light on the regulation of pancreas and intestinal development...
  12. doi request reprint Role of metalloproteinases at the onset of liver development
    Sabrina Margagliotti
    Hormone and Metabolic Research Unit, Universite Catholique de Louvain, de Duve Institute, 1200 Brussels, Belgium
    Dev Growth Differ 50:331-8. 2008
    ..We conclude that MMPs are required to initiate expansion of the liver during development and that our culture system provides a new model to study hepatoblast migration...
  13. doi request reprint Reciprocal epithelial:endothelial paracrine interactions during thyroid development govern follicular organization and C-cells differentiation
    Anne Christine Hick
    de Duve Institute, Universite Catholique de Louvain UCL, B 1200 Brussels, Belgium
    Dev Biol 381:227-40. 2013
    ..In turn, endothelial cells control epithelial reorganization in follicles and C-cells differentiation...
  14. ncbi request reprint Hnf6 and Tcf2 (MODY5) are linked in a gene network operating in a precursor cell domain of the embryonic pancreas
    Miguel A Maestro
    Endocrinology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
    Hum Mol Genet 12:3307-14. 2003
    ..These findings define a precursor cellular stage of the embryonic pancreas and place Hnf1beta in a genetic hierarchy that regulates the generation of pancreatic endocrine cells...
  15. ncbi request reprint Plasticity of a transcriptional regulation network among alpha-proteobacteria is supported by the identification of CtrA targets in Brucella abortus
    Anne Flore Bellefontaine
    Unité de Recherche en Biologie Moléculaire URBM, Facultes Universitaires Notre Dame de la Paix, 61, rue de Bruxelles, B 5000 Namur, Belgium
    Mol Microbiol 43:945-60. 2002
    ..crescentus, similar cellular processes are regulated by CtrA through the control of distinct target genes. The plasticity of the regulation network involving CtrA in these two bacteria may be related to their distinct lifestyles...