Mustapha Najimi

Summary

Country: Belgium

Publications

  1. ncbi request reprint Distinct regions of C-terminus of the high affinity neurotensin receptor mediate the functional coupling with pertussis toxin sensitive and insensitive G-proteins
    Mustapha Najimi
    Laboratoire de Pharmacologie Exprimentale FARL, Département de Physiologie et de Pharmacologie, Université catholique de Louvain 54 10, Avenue Hippocrate 54, B 1200, Brussels, Belgium
    FEBS Lett 512:329-33. 2002
  2. ncbi request reprint Human skin fibroblasts: From mesodermal to hepatocyte-like differentiation
    Philippe A Lysy
    Université Catholique de Louvain et Cliniques Universitaires Saint Luc, HPED Department, PEDI Unit, Laboratory of Pediatric Hepatology and Cell Therapy, 1200 Brussels, Belgium
    Hepatology 46:1574-85. 2007
  3. ncbi request reprint Adult-derived human liver mesenchymal-like cells as a potential progenitor reservoir of hepatocytes?
    Mustapha Najimi
    Universite Catholique de Louvain, Laboratory of Pediatric Hepatology and Cell Therapy, B 1200 Brussels, Belgium
    Cell Transplant 16:717-28. 2007
  4. pmc Hepato-biliary profile of potential candidate liver progenitor cells from healthy rat liver
    Cédric Maerckx
    Laboratory of Pediatric Hepatology and Cell Therapy, Universite Catholique de Louvain, 1200 Brussels, Belgium
    World J Gastroenterol 18:3511-9. 2012
  5. doi request reprint Native umbilical cord matrix stem cells express hepatic markers and differentiate into hepatocyte-like cells
    David Campard
    HPED Department, PEDI Unit, Laboratory of Pediatric Hepatology and Cell Therapy, Universite Catholique de Louvain, Brussels, Belgium
    Gastroenterology 134:833-48. 2008
  6. pmc Human umbilical cord matrix stem cells maintain multilineage differentiation abilities and do not transform during long-term culture
    Isabelle Scheers
    Universite Catholique de Louvain, Institut de Recherche Expérimentale et Clinique IREC, Laboratory of Pediatric Hepatology and Cell Therapy, Brussels, Belgium
    PLoS ONE 8:e71374. 2013
  7. doi request reprint Adult human liver mesenchymal stem/progenitor cells participate in mouse liver regeneration after hepatectomy
    Dung Ngoc Khuu
    Universite Catholique de Louvain, Institut de Recherche Clinique et Expérimentale IREC, Laboratory of Pediatric Hepatology and Cell Therapy, Brussels, Belgium
    Cell Transplant 22:1369-80. 2013
  8. pmc Stem cells for liver tissue repair: current knowledge and perspectives
    Philippe A Lysy
    Université catholique de Louvain and Cliniques Universitaires Saint Luc, HPED Department, Unit PEDI, Laboratory of Pediatric Hepatology and Cell Therapy, Bussels 1200, Belgium
    World J Gastroenterol 14:864-75. 2008
  9. doi request reprint Adult-derived human liver progenitor cells in long-term culture maintain appropriate gatekeeper mechanisms against transformation
    Isabelle Scheers
    Universite Catholique de Louvain, Institut de Recherche Clinique et Expérimentale, Laboratory of Pediatric Hepatology and Cell Therapy, Brussels, Belgium
    Cell Transplant 21:2241-55. 2012
  10. doi request reprint MRI of iron-oxide labelled transplanted hepatocytes in mice: effect of treatment with cyclophosphamide
    Isabelle Leconte
    Radiodiagnostic Unit, Universite Catholique de Louvain, St Luc University Hospital, Brussels, Belgium
    J Magn Reson Imaging 32:367-75. 2010

Collaborators

  • Efienne M Sokal
  • David Campard
  • Isabelle A Leclercq
  • Tatiana Tondreau
  • Pau Sancho-Bru
  • Harry Heimberg
  • Cedric Hermans
  • Peter Starkel
  • Andreas Nussler
  • Louis Hue
  • Bruno Guigas
  • Juan Jose Lozano
  • Isabelle Leconte
  • F Smets
  • M Goldman
  • C Sempoux
  • Sabrina Ehnert
  • R Reding
  • Frank Peeters
  • Xavier Stephenne
  • Dung Ngoc Khuu
  • Philippe A Lysy
  • Cédric Maerckx
  • Isabelle Scheers
  • Silvia Berardis
  • Omar Nyabi
  • Ange Clarisse Dusabineza
  • Catherine Lombard
  • Brice Sid
  • Massimiliano Paganelli
  • Céline Vermeiren
  • Leo van Grunsven
  • Pedro Buc Calderon
  • Jonathan Evraerts
  • Gwenaëlle Sana
  • Emmanuel Hermans
  • Anabelle Decottignies
  • Nawal Jazouli
  • Olivier Vosters
  • Barbara Bosier
  • Catherine Sibille
  • Sébastien Tilleux
  • Jean Marie Maloteaux
  • Ahmed A Darwish
  • Noémi Van Hul
  • Vanessa Legry
  • Leo A van Grunsven
  • Prenali Dwisthi Sattwika
  • Carley Benton
  • Christophe Glorieux
  • Jos van Pelt
  • Julien Verrax
  • Floriane Andre
  • Laurent Dollé
  • Yves Heremans
  • Imane El Malmi
  • Guillaume Rommelaere
  • Nicolas Dejeans
  • Manuel Valenzuela
  • Valérie Rosseels
  • Patricia Renard
  • Adil El Taghdouini
  • Jean Luc Gala
  • Noémi K Van Hul
  • Stephane Eeckhoudt
  • Sabrina Marcelle
  • Emanuele Nicastro
  • Jorge Abarca-Quinones
  • Pedro Buc-Calderon
  • Ann Meulemans
  • Annick Bourgois
  • Didier M Lambert
  • Khuu Ngoc Dung
  • Claire Beuneu
  • Walter Wijns
  • Dung Khuu Ngoc
  • Marie Cecile Nassogne
  • Nicolas Vanhoutte
  • Isabelle de Hemptinne
  • Jean de Ville de Goyet

Detail Information

Publications35

  1. ncbi request reprint Distinct regions of C-terminus of the high affinity neurotensin receptor mediate the functional coupling with pertussis toxin sensitive and insensitive G-proteins
    Mustapha Najimi
    Laboratoire de Pharmacologie Exprimentale FARL, Département de Physiologie et de Pharmacologie, Université catholique de Louvain 54 10, Avenue Hippocrate 54, B 1200, Brussels, Belgium
    FEBS Lett 512:329-33. 2002
    ..This region was also found to be involved in the control of receptor internalization. However, PTx failed to impair internalization, indicating that these two properties are not directly related...
  2. ncbi request reprint Human skin fibroblasts: From mesodermal to hepatocyte-like differentiation
    Philippe A Lysy
    Université Catholique de Louvain et Cliniques Universitaires Saint Luc, HPED Department, PEDI Unit, Laboratory of Pediatric Hepatology and Cell Therapy, 1200 Brussels, Belgium
    Hepatology 46:1574-85. 2007
    ....
  3. ncbi request reprint Adult-derived human liver mesenchymal-like cells as a potential progenitor reservoir of hepatocytes?
    Mustapha Najimi
    Universite Catholique de Louvain, Laboratory of Pediatric Hepatology and Cell Therapy, B 1200 Brussels, Belgium
    Cell Transplant 16:717-28. 2007
    ....
  4. pmc Hepato-biliary profile of potential candidate liver progenitor cells from healthy rat liver
    Cédric Maerckx
    Laboratory of Pediatric Hepatology and Cell Therapy, Universite Catholique de Louvain, 1200 Brussels, Belgium
    World J Gastroenterol 18:3511-9. 2012
    ..To evaluate the presence of progenitor cells in healthy adult rat liver displaying the equivalent advanced hepatogenic profile as that obtained in human...
  5. doi request reprint Native umbilical cord matrix stem cells express hepatic markers and differentiate into hepatocyte-like cells
    David Campard
    HPED Department, PEDI Unit, Laboratory of Pediatric Hepatology and Cell Therapy, Universite Catholique de Louvain, Brussels, Belgium
    Gastroenterology 134:833-48. 2008
    ..Umbilical cord matrix stem cells (UCMSCs) are able to differentiate into mesodermal and ectodermal lineages. The present study investigates the differentiation potential of human UCMSCs into hepatic lineage...
  6. pmc Human umbilical cord matrix stem cells maintain multilineage differentiation abilities and do not transform during long-term culture
    Isabelle Scheers
    Universite Catholique de Louvain, Institut de Recherche Expérimentale et Clinique IREC, Laboratory of Pediatric Hepatology and Cell Therapy, Brussels, Belgium
    PLoS ONE 8:e71374. 2013
    ..UCMSC could be expanded in long-term cultures while maintaining stable genetic features and endodermal differentiation potential. UCMSC therefore represent safe candidates for liver regenerative medicine...
  7. doi request reprint Adult human liver mesenchymal stem/progenitor cells participate in mouse liver regeneration after hepatectomy
    Dung Ngoc Khuu
    Universite Catholique de Louvain, Institut de Recherche Clinique et Expérimentale IREC, Laboratory of Pediatric Hepatology and Cell Therapy, Brussels, Belgium
    Cell Transplant 22:1369-80. 2013
    ..In response to partial hepatectomy, integrated ADHLSCs proliferate and participate to recipient mouse liver regeneration...
  8. pmc Stem cells for liver tissue repair: current knowledge and perspectives
    Philippe A Lysy
    Université catholique de Louvain and Cliniques Universitaires Saint Luc, HPED Department, Unit PEDI, Laboratory of Pediatric Hepatology and Cell Therapy, Bussels 1200, Belgium
    World J Gastroenterol 14:864-75. 2008
    ..We finally address the question of the future clinical applications of stem cells for liver tissue repair and the technical aspects that remain to be investigated...
  9. doi request reprint Adult-derived human liver progenitor cells in long-term culture maintain appropriate gatekeeper mechanisms against transformation
    Isabelle Scheers
    Universite Catholique de Louvain, Institut de Recherche Clinique et Expérimentale, Laboratory of Pediatric Hepatology and Cell Therapy, Brussels, Belgium
    Cell Transplant 21:2241-55. 2012
    ..All ADHLPCs reached senescence and growth arrest. Presenescent ADHLPCs might therefore be considered as a suitable source for liver-based cell therapy...
  10. doi request reprint MRI of iron-oxide labelled transplanted hepatocytes in mice: effect of treatment with cyclophosphamide
    Isabelle Leconte
    Radiodiagnostic Unit, Universite Catholique de Louvain, St Luc University Hospital, Brussels, Belgium
    J Magn Reson Imaging 32:367-75. 2010
    ..To assess if 1.5T MRI can be used to study the transport to the liver, the intrahepatic distribution and engraftment of iron-oxide labelled hepatocytes in cyclophosphamide-treated and untreated mice...
  11. doi request reprint Leukemia inhibitory factor contributes to hepatocyte-like differentiation of human bone marrow mesenchymal stem cells
    Philippe A Lysy
    HPED Department, PEDI Unit, Universite Catholique de Louvain, Cliniques Universitaires Saint Luc, Brussels, Belgium
    Differentiation 76:1057-67. 2008
    ..In conclusion, we demonstrated that LIF can play a similar role as OSM in the hepatocyte differentiation process of human MSCs...
  12. doi request reprint In vitro differentiated adult human liver progenitor cells display mature hepatic metabolic functions: a potential tool for in vitro pharmacotoxicological testing
    Dung Ngoc Khuu
    Institut de Recherche Clinique et Expérimentale IREC, Laboratory of Pediatric Hepatology and Cell Therapy, Universite Catholique de Louvain, Brussels, Belgium
    Cell Transplant 20:287-302. 2011
    ....
  13. doi request reprint Adult human hepatocytes promote CD4(+) T-cell hyporesponsiveness via interleukin-10-producing allogeneic dendritic cells
    Gwenaëlle Sana
    Université catholique de Louvain and Cliniques Universitaires Saint Luc, Laboratory of Pediatric Hepatology and Cell Therapy, Brussels, Belgium
    Cell Transplant 23:1127-42. 2014
    ..Allogeneic hHeps, but not ADHLPCs, promote a cell contact-dependent production of IL-10 by myeloid DCs, which induces naive CD4(+) T-cells antigen-independent hyporesponsiveness. ..
  14. doi request reprint Participation of liver progenitor cells in liver regeneration: lack of evidence in the AAF/PH rat model
    Ange Clarisse Dusabineza
    Laboratory of Hepato Gastroenterology, Institut de Recherche Expérimentale et Clinique, Universite Catholique de Louvain, Brussels, Belgium
    Lab Invest 92:72-81. 2012
    ..These observations suggest that, in this model, the efficient recovery of the liver function was ensured rather by the proliferation of mature hepatocytes than by the LPC expansion and differentiation into hepatocytes...
  15. pmc Liver cell transplantation for Crigler-Najjar syndrome type I: update and perspectives
    Philippe A Lysy
    Pediatric Hepatology and Cell Therapy, Universite Catholique de Louvain, Cliniques Saint Luc, 10 av Hippocrate, Brussels B 1200, Belgium
    World J Gastroenterol 14:3464-70. 2008
    ..We discuss the future developments of the technique and new emerging perspectives...
  16. doi request reprint Hepatic Stellate Cells Improve Engraftment of Human Primary Hepatocytes: A Preclinical Transplantation Study in an Animal Model
    Ange Clarisse Dusabineza
    Laboratory of Hepato Gastroenterology, Institut de Recherche Expérimentale et Clinique IREC, Universite Catholique de Louvain, UCL, Brussels, Belgium
    Cell Transplant 24:2557-71. 2015
    ..In vivo, cotransplantation of hepatocytes with HSCs into a healthy liver recipient does not generate fibrosis, but significantly improves the engraftment of hepatocytes, probably by ameliorating cell homing. ..
  17. pmc Human liver stem/progenitor cells decrease serum bilirubin in hyperbilirubinemic Gunn rat
    Cédric Maerckx
    Cédric Maerckx, Tatiana Tondreau, Silvia Berardis, Mustapha Najimi, Etienne Sokal, Laboratory of Pediatric Hepatology and Cell Therapy, Université Catholique de Louvain Institut de Recherche Expérimentale et Clinique IRCE, 1200 Brussels, Belgium
    World J Gastroenterol 20:10553-63. 2014
    ..To test the ability of adult-derived human liver stem/progenitor cells (ADHLSC) from large scale cultures to conjugate bilirubin in vitro and in bilirubin conjugation deficient rat...
  18. ncbi request reprint Pertussis toxin-sensitive modulation of glutamate transport by endothelin-1 type A receptors in glioma cells
    Mustapha Najimi
    Laboratoire de Pharmacologie Expérimentale, Universite Catholique de Louvain, 54 10, Avenue Hippocrate 54, 1200 Bruxelles, Belgium
    Biochim Biophys Acta 1668:195-202. 2005
    ....
  19. ncbi request reprint Cytoskeleton-related trafficking of the EAAC1 glutamate transporter after activation of the G(q/11)-coupled neurotensin receptor NTS1
    Mustapha Najimi
    Laboratoire de Pharmacologie Expérimentale, Universite Catholique de Louvain, Avenue Hippocrate 54, 1200, Brussels, Belgium
    FEBS Lett 523:224-8. 2002
    ..Together, these results provide evidence for an acute regulation of EAAC1 trafficking after activation of a G protein-coupled receptor...
  20. pmc Regulation of hepatic EAAT-2 glutamate transporter expression in human liver cholestasis
    Mustapha Najimi
    Mustapha Najimi, Xavier Stéphenne, Etienne Sokal, Universite Catholique de Louvain, Institut de Recherche Expérimentale et Clinique IREC, Laboratory of Pediatric Hepatology and Cell Therapy, Brussels 1200, Belgium
    World J Gastroenterol 20:1554-64. 2014
    ..To investigate the activity and expression of EAAT2 glutamate transporter in both in vitro and in vivo models of cholestasis...
  21. doi request reprint Downregulation of Sox9 expression associates with hepatogenic differentiation of human liver mesenchymal stem/progenitor cells
    Massimiliano Paganelli
    1 Laboratory of Pediatric Hepatology and Cell Therapy, Institut de Recherche Expérimentale et Clinique IREC, Universite Catholique de Louvain, Brussels, Belgium
    Stem Cells Dev 23:1377-91. 2014
    ..Further studies on the identification of pathways regulated by or regulating Sox9 will certainly gain insight into the molecular networks controlling hepatogenic differentiation. ..
  22. pmc Bivalirudin in combination with heparin to control mesenchymal cell procoagulant activity
    Xavier Stephenne
    Universite Catholique de Louvain, Institut de Recherche Expérimentale et Clinique, Unité de Recherche PEDI, Brussels, Belgium
    PLoS ONE 7:e42819. 2012
    ..The results suggest that this dual antithrombotic therapy should also improve the efficacy of cell transplantation in humans...
  23. doi request reprint Hepatocyte apoptosis
    Mustapha Najimi
    Universite Catholique de Louvain, Laboratory of Pediatric Hepatology and Cell Therapy, Brussels, Belgium
    Methods Mol Biol 481:59-74. 2009
    ..This chapter presents a brief overview of these techniques and provides methodology for the evaluation of hepatocyte apoptosis at the structural and biochemical levels...
  24. pmc Epithelial cells with hepatobiliary phenotype: is it another stem cell candidate for healthy adult human liver?
    Dung Ngoc Khuu
    Universite Catholique de Louvain, Laboratory of Pediatric Hepatology and Cell Therapy, Brussels, Belgium
    World J Gastroenterol 13:1554-60. 2007
    ..To investigate the presence and role of liver epithelial cells in the healthy human adult liver...
  25. doi request reprint AICAR induces Nrf2 activation by an AMPK-independent mechanism in hepatocarcinoma cells
    Brice Sid
    Toxicology and Cancer Biology Research Group GTOX, Louvain Drug Research Institute, Universite Catholique de Louvain, Brussels, Belgium
    Biochem Pharmacol 91:168-80. 2014
    ..In conclusion, we identified AICAR as a potent modulator of the redox state of human hepatocarcinoma cells, via the Nrf2 signaling pathway and in an AMPK-independent mechanism. ..
  26. pmc Use of mesenchymal stem cells to treat liver fibrosis: current situation and future prospects
    Silvia Berardis
    Silvia Berardis, Prenali Dwisthi Sattwika, Mustapha Najimi, Etienne Marc Sokal, Laboratory of Pediatric Hepatology and Cell Therapy, Institut de Recherche Expérimentale et Clinique, Cliniques Universitaires St Luc, Universite Catholique de Louvain, 1200 Brussels, Belgium
    World J Gastroenterol 21:742-58. 2015
    ..However, despite these promising results, some limitations need to be considered. Future prospects will also be discussed in this review. ..
  27. pmc Gene expression profiling and secretome analysis differentiate adult-derived human liver stem/progenitor cells and human hepatic stellate cells
    Silvia Berardis
    Universite Catholique de Louvain, Institut de Recherche Expérimentale et Clinique IREC, Laboratory of Pediatric Hepatology and Cell Therapy, Brussels, Belgium
    PLoS ONE 9:e86137. 2014
    ..Our study demonstrates that ADHLSC and HSC are distinct liver fibroblastic cell populations exhibiting significant different expression and secretion profiles. ..
  28. ncbi request reprint Cryopreservation of human hepatocytes alters the mitochondrial respiratory chain complex 1
    Xavier Stephenne
    Laboratory of Paediatric Hepatology and Cell Therapy, Universite Catholique de Louvain, Cliniques St Luc, Brussels, Belgium
    Cell Transplant 16:409-19. 2007
    ..They also suggest that, in addition to technical progress in the cryopreservation procedure, protection of the respiratory chain complex 1 should be considered to improve the quality of cryopreserved hepatocytes...
  29. ncbi request reprint Agonist selective modulation of tyrosine hydroxylase expression by cannabinoid ligands in a murine neuroblastoma cell line
    Barbara Bosier
    Unité de Chimie Pharmaceutique et de Radiopharmacie UCL 7340, Universite Catholique de Louvain, Brussels, Belgium
    J Neurochem 102:1996-2007. 2007
    ....
  30. ncbi request reprint Tissue factor-dependent procoagulant activity of isolated human hepatocytes: relevance to liver cell transplantation
    Xavier Stephenne
    Laboratory of Paediatric Hepatology and Cell Therapy, Unité Pé diatrie PEDI, Universite Catholique de Louvain, Brussels, Belgium
    Liver Transpl 13:599-606. 2007
    ..In conclusion, hepatocytes exert TF-dependent PCA, which may contribute to early loss of infused cells. Addition of N-acetyl-L-cysteine to the suspensions of hepatocytes might be beneficial in LCT by inhibiting activation of coagulation...
  31. ncbi request reprint Acute up-regulation of glutamate uptake mediated by mGluR5a in reactive astrocytes
    Céline Vermeiren
    Laboratoire de Pharmacologie Expérimentale, Universite Catholique de Louvain, Brussels, Belgium
    J Neurochem 94:405-16. 2005
    ..We conclude that mGluR5a contributes to a dynamic control of GLT-1 function in activated astrocytes, acting as a glial sensor of the extracellular glutamate concentration in order to acutely regulate the excitatory transmission...
  32. ncbi request reprint Neurotensin induces tyrosine hydroxylase gene activation through nitric oxide and protein kinase C signaling pathways
    Mustapha Najimi
    Centre National de la Recherche Scientifique Unité Mixte Recherche 9223, Hopital de la Pitie Salpetriere, Paris, France
    Mol Pharmacol 62:647-53. 2002
    ..The requirement for two distinct and concomitant pathways by NT demonstrates a very fine level of control of specificity on TH gene activation...
  33. ncbi request reprint Molecular and functional characterisation of glutamate transporters in rat cortical astrocytes exposed to a defined combination of growth factors during in vitro differentiation
    Céline Vermeiren
    Laboratoire de Pharmacologie Expérimentale, Universite Catholique de Louvain, av Hippocrate 54, 1200 Brussels, Belgium
    Neurochem Int 46:137-47. 2005
    ....
  34. ncbi request reprint Sustained engraftment and tissue enzyme activity after liver cell transplantation for argininosuccinate lyase deficiency
    Xavier Stephenne
    Laboratoire d hépatologie Pédiatrique et Transplantation Cellulaire, Département GYPE, Service de Pediatrie, Université Catholique de Louvain and Cliniques St Luc, Brussels, Belgium
    Gastroenterology 130:1317-23. 2006
    ..Donor cell engraftment with expression of enzyme activity is the goal of liver cell transplantation for inborn errors of liver metabolism with a view to achieving sustained metabolic control...
  35. ncbi request reprint Permanent access to the portal system for cellular transplantation using an implantable port device
    Ahmed A Darwish
    Pediatric Liver Transplant Program, Universite Catholique de Louvain, Saint Luc University Clinics, Brussels, Belgium
    Liver Transpl 10:1213-5. 2004
    ..We suggest that this technique might also be valuable in pancreatic islet cell transplantation...