Nicole Morel

Summary

Country: Belgium

Publications

  1. doi request reprint Vascular effects of Tanacetum vulgare L. leaf extract: in vitro pharmacological study
    Sanaa Lahlou
    UFR Physiology Pharmacology, Faculty of Sciences, Dhar Elmahraz, Fes, Morocco
    J Ethnopharmacol 120:98-102. 2008
  2. doi request reprint PKD1 haploinsufficiency is associated with altered vascular reactivity and abnormal calcium signaling in the mouse aorta
    Nicole Morel
    Laboratoire de Physiologie Cellulaire, Universite Catholique de Louvain, Avenue Hippocrate 55, UCL 5540, Brussels, Belgium
    Pflugers Arch 457:845-56. 2009
  3. doi request reprint Effect of organ culture on noradrenaline- evoked contraction, calcium signalling and TRPC expression in rat mesenteric artery
    Khalid Tai
    Laboratories of Cellular Physiology, Universite Catholique de Louvain, Brussels, Belgium
    J Vasc Res 46:353-64. 2009
  4. doi request reprint Different effect of Rho kinase inhibition on calcium signaling in rat isolated large and small arteries
    Anneloes Martinsen
    Department of Cellular Physiology, Institute of Neuroscience, Universite Catholique de Louvain, Brussels, Belgium
    J Vasc Res 49:522-33. 2012
  5. ncbi request reprint Marrubenol interacts with the phenylalkylamine binding site of the L-type calcium channel
    Sanae El Bardai
    Laboratoire de Pharmacologie, Universite Catholique de Louvain, UCL 5410, Avenue Hippocrate, 54, B 1200 Brussels, Belgium
    Eur J Pharmacol 492:269-72. 2004
  6. doi request reprint Vascular activity of a natural diterpene isolated from Croton zambesicus and of a structurally similar synthetic trachylobane
    Anneloes Martinsen
    Universite Catholique de Louvain, Laboratoire de Physiologie Cellulaire, Avenue Hippocrate 55, FYCL 5540, B 1200 Brussels, Belgium
    Vascul Pharmacol 52:63-9. 2010
  7. ncbi request reprint Vasorelaxant activity of diterpenes from Croton zambesicus and synthetic trachylobanes and their structure-activity relationships
    Chiara Baccelli
    Laboratoire de Pharmacognosie, Unité d Analyse Chimique et Physico Chimique des Médicaments et Pharmacognosie, Universite Catholique de Louvain, UCL 72 30 CHAM, Avenue E Mounier 72, 1200 Bruxelles, Belgium
    J Nat Prod 70:910-7. 2007
  8. doi request reprint Rho kinase regulation of vasopressin-induced calcium entry in vascular smooth muscle cell: comparison between rat isolated aorta and cultured aortic cells
    Anneloes Martinsen
    Cellular Physiology, Ions, UCLouvain, Brussels, Belgium
    Cell Calcium 52:413-21. 2012
  9. doi request reprint Identification and functional implication of a Rho kinase-dependent moesin-EBP50 interaction in noradrenaline-stimulated artery
    Nicolas Baeyens
    Laboratory of Cell Physiology, Institute of Neuroscience, Universite Catholique de Louvain, Brussels, Belgium
    Am J Physiol Cell Physiol 299:C1530-40. 2010
  10. doi request reprint Agonist-evoked calcium entry in vascular smooth muscle cells requires IP3 receptor-mediated activation of TRPC1
    Khalid Tai
    Unit of Cellular Physiology, Universite Catholique de Louvain, Bruxelles, Belgium
    Eur J Pharmacol 583:135-47. 2008

Collaborators

Detail Information

Publications21

  1. doi request reprint Vascular effects of Tanacetum vulgare L. leaf extract: in vitro pharmacological study
    Sanaa Lahlou
    UFR Physiology Pharmacology, Faculty of Sciences, Dhar Elmahraz, Fes, Morocco
    J Ethnopharmacol 120:98-102. 2008
    ..Asteraceae/Compositae) is principally used in traditional Moroccan medicine as antihypertensive remedy. The aim of the present study was to investigate the in vitro vascular activity of the aqueous extract of Tanacetum vulgare L...
  2. doi request reprint PKD1 haploinsufficiency is associated with altered vascular reactivity and abnormal calcium signaling in the mouse aorta
    Nicole Morel
    Laboratoire de Physiologie Cellulaire, Universite Catholique de Louvain, Avenue Hippocrate 55, UCL 5540, Brussels, Belgium
    Pflugers Arch 457:845-56. 2009
    ....
  3. doi request reprint Effect of organ culture on noradrenaline- evoked contraction, calcium signalling and TRPC expression in rat mesenteric artery
    Khalid Tai
    Laboratories of Cellular Physiology, Universite Catholique de Louvain, Brussels, Belgium
    J Vasc Res 46:353-64. 2009
    ..These results indicate that mesenteric artery culture results in src kinase-dependent increase in the responses to noradrenaline and in a change in cation channel activity, which could contribute to the increased contraction...
  4. doi request reprint Different effect of Rho kinase inhibition on calcium signaling in rat isolated large and small arteries
    Anneloes Martinsen
    Department of Cellular Physiology, Institute of Neuroscience, Universite Catholique de Louvain, Brussels, Belgium
    J Vasc Res 49:522-33. 2012
    ..In pressurized RMA, Y-27632 and H-1152 depressed pressure-induced calcium responses and abolished myogenic contraction. These results stress the important differences in calcium signaling between conductance and resistance arteries...
  5. ncbi request reprint Marrubenol interacts with the phenylalkylamine binding site of the L-type calcium channel
    Sanae El Bardai
    Laboratoire de Pharmacologie, Universite Catholique de Louvain, UCL 5410, Avenue Hippocrate, 54, B 1200 Brussels, Belgium
    Eur J Pharmacol 492:269-72. 2004
    ....
  6. doi request reprint Vascular activity of a natural diterpene isolated from Croton zambesicus and of a structurally similar synthetic trachylobane
    Anneloes Martinsen
    Universite Catholique de Louvain, Laboratoire de Physiologie Cellulaire, Avenue Hippocrate 55, FYCL 5540, B 1200 Brussels, Belgium
    Vascul Pharmacol 52:63-9. 2010
    ..Inhibition of NO-dependent relaxation by DT could be related to a decrease in NO availability...
  7. ncbi request reprint Vasorelaxant activity of diterpenes from Croton zambesicus and synthetic trachylobanes and their structure-activity relationships
    Chiara Baccelli
    Laboratoire de Pharmacognosie, Unité d Analyse Chimique et Physico Chimique des Médicaments et Pharmacognosie, Universite Catholique de Louvain, UCL 72 30 CHAM, Avenue E Mounier 72, 1200 Bruxelles, Belgium
    J Nat Prod 70:910-7. 2007
    ..The cytotoxicity of all of these compounds has also been evaluated on HeLa cells in order to verify that the vasorelaxant activity was not correlated with general cytotoxicity...
  8. doi request reprint Rho kinase regulation of vasopressin-induced calcium entry in vascular smooth muscle cell: comparison between rat isolated aorta and cultured aortic cells
    Anneloes Martinsen
    Cellular Physiology, Ions, UCLouvain, Brussels, Belgium
    Cell Calcium 52:413-21. 2012
    ..These results underline the important differences in Ca(2+) regulation between whole tissue and cultured cells...
  9. doi request reprint Identification and functional implication of a Rho kinase-dependent moesin-EBP50 interaction in noradrenaline-stimulated artery
    Nicolas Baeyens
    Laboratory of Cell Physiology, Institute of Neuroscience, Universite Catholique de Louvain, Brussels, Belgium
    Am J Physiol Cell Physiol 299:C1530-40. 2010
    ....
  10. doi request reprint Agonist-evoked calcium entry in vascular smooth muscle cells requires IP3 receptor-mediated activation of TRPC1
    Khalid Tai
    Unit of Cellular Physiology, Universite Catholique de Louvain, Bruxelles, Belgium
    Eur J Pharmacol 583:135-47. 2008
    ..These results indicate that in aortic smooth muscle cells, TRPC1 is not only involved in Ca2+ entry activated by store depletion but also in receptor-operated Ca2+ entry, which requires inositol (1,4,5) triphosphate receptor activation...
  11. doi request reprint Vasorelaxant activity of essential oils from Croton zambesicus and some of their constituents
    Chiara Baccelli
    Louvain Drug Research Institute, Universite Catholique de Louvain, Brussels, Belgium
    Planta Med 76:1506-11. 2010
    ..4 µg/mL) and particularly to caryophyllene oxide (IC (50) 2.5 µg/mL)...
  12. doi request reprint Redundant control of migration and adhesion by ERM proteins in vascular smooth muscle cells
    Nicolas Baeyens
    Laboratory of Cell Physiology, Ions, Universite Catholique de Louvain, Belgium
    Biochem Biophys Res Commun 441:579-85. 2013
    ..These results indicate that ERM proteins exert a redundant control on PDGF-induced VSMC migration by regulating focal adhesion turn-over and cell adhesion to substrate. ..
  13. ncbi request reprint Diterpenes isolated from Croton zambesicus inhibit KCl-induced contraction
    Chiara Baccelli
    Laboratoire de Pharmacognosie, Unité d Analyse Chimique et Physico Chimique des Médicaments, Universite Catholique de Louvain, Bruxelles, Belgium
    Planta Med 71:1036-9. 2005
    ..The mixture of the two compounds inhibited the KCl-induced contraction of male Wistar rat aorta (IC (50) = 1 microg/mL), while the purified trachylobane (compound 1) and the hydroxylated pimarane showed a lower activity than the mixture...
  14. ncbi request reprint Vasoconstrictor and inotropic effects induced by the root bark extracts of Anthocleista schweinfurthii
    Nadège Kabamba Ngombe
    Laboratoire de Pharmacognosie, Louvain Drug Research Institute, Universite Catholique de Louvain, Av E Mounier 72, 1200 Bruxelles, Belgium
    Nat Prod Commun 5:369-72. 2010
    ....
  15. pmc Characterisation of marrubenol, a diterpene extracted from Marrubium vulgare, as an L-type calcium channel blocker
    Sanae El-Bardai
    Laboratoire de Pharmacologie, Universite Catholique de Louvain, UCL 5410, Avenue Hippocrate, 54, Bruxelles B 1200, Belgium
    Br J Pharmacol 140:1211-6. 2003
    ..4. These results showed that marrubenol inhibits smooth muscle contraction by blocking L-type calcium channels...
  16. doi request reprint Expression of human amyloid precursor protein in rat cortical neurons inhibits calcium oscillations
    Susana Ferrao Santos
    Experimental Pharmacology Unit, Institute of Neuroscience, Universite Catholique de Louvain, B 1200 Brussels, Belgium
    J Neurosci 29:4708-18. 2009
    ..Altogether, these data support a key role for APP in the control of neuronal excitability...
  17. doi request reprint EBP50 is involved in the regulation of vascular smooth muscle cell migration and cytokinesis
    Nicolas Baeyens
    Laboratory of Cell Physiology, Institute of Neuroscience, Universite Catholique de Louvain, Avenue Hippocrate 55, 1200 Brussels, Belgium
    J Cell Biochem 112:2574-84. 2011
    ..This signaling cascade leads to the formation of lamellipodia, trailing tails and decrease of focal adhesion formation, triggering cell migration...
  18. ncbi request reprint A simple method for rapid separation of endothelial and smooth muscle mRNA reveals Na/K+ -ATPase alpha-subunit distribution in rat arteries
    Peter Krenek
    Laboratoire de Pharmacologie, Universite Catholique de Louvain, Brussels, Belgium
    J Vasc Res 43:502-10. 2006
    ....
  19. ncbi request reprint Amlodipine at high dose increases preproendothelin-1 expression in the ventricles and aorta of normotensive rats
    Peter Krenek
    Laboratoire de Pharmacologie, Universite Catholique de Louvain, Avenue Hippocrate 54, B 1200 Brussels, Belgium
    J Hypertens 22:827-35. 2004
    ..Both noradrenaline and angiotensin II stimulate preproendothelin-1 gene expression, yet the effects of high doses of dihydropyridines on preproendothelin-1 expression in vivo remain unknown...
  20. pmc Rho-dependent kinase is involved in agonist-activated calcium entry in rat arteries
    Philippe Ghisdal
    Laboratoire de Pharmacologie, Universite Catholique de Louvain, UCL 5410, B 1200 Brussels, Belgium
    J Physiol 551:855-67. 2003
    ..These results indicate that Rho-kinase is involved in noradrenaline activation of a Ca2+ entry distinct from voltage- or store-operated channels in rat arteries...
  21. doi request reprint Extracellular calcium modulates the inhibitory effect of 4-aminopyridine on Kv current in vascular smooth muscle cells
    Nicolas Baeyens
    Cell Physiology, Institute of Neuroscience, Universite Catholique de Louvain, Bruxelles, Belgium
    Eur J Pharmacol 723:116-23. 2014
    ..The component of Kv current that was inhibited by 4-aminopyridine in a calcium-sensitive manner was distinct from Kv2 current. ..