Frederic P Lemaigre

Summary

Country: Belgium

Publications

  1. doi request reprint [Lineage fate decisions in normal and regenerating liver]
    Frederic Lemaigre
    Institut de Duve, Universite Catholique de Louvain, Bruxelles, Belgique
    Med Sci (Paris) 28:958-62. 2012
  2. doi request reprint Mechanisms of liver development: concepts for understanding liver disorders and design of novel therapies
    Frederic P Lemaigre
    de Duve Institute, Universite Catholique de Louvain, Brussels, Belgium
    Gastroenterology 137:62-79. 2009
  3. pmc Intrahepatic bile ducts develop according to a new mode of tubulogenesis regulated by the transcription factor SOX9
    Aline Antoniou
    Universite Catholique de Louvain, de Duve Institute, Brussels, Belgium
    Gastroenterology 136:2325-33. 2009
  4. ncbi request reprint The Onecut transcription factors HNF-6/OC-1 and OC-2 regulate early liver expansion by controlling hepatoblast migration
    Sabrina Margagliotti
    Universite Catholique de Louvain, Christian de Duve Institute of Cellular Pathology, Avenue Hippocrate 75 7529, B 1200 Brussels, Belgium
    Dev Biol 311:579-89. 2007
  5. pmc Control of liver cell fate decision by a gradient of TGF beta signaling modulated by Onecut transcription factors
    Frederic Clotman
    Hormone and Metabolic Research Unit, Cell Biology Unit, Institute of Cellular Pathology and Université catholique de Louvain, Brussels, Belgium
    Genes Dev 19:1849-54. 2005
  6. pmc Embryonic ductal plate cells give rise to cholangiocytes, periportal hepatocytes, and adult liver progenitor cells
    Rodolphe Carpentier
    de Duve Institute, Universite Catholique de Louvain, Brussels, Belgium
    Gastroenterology 141:1432-8, 1438.e1-4. 2011
  7. doi request reprint Transcription factors SOX4 and SOX9 cooperatively control development of bile ducts
    Alexis Poncy
    Universite Catholique de Louvain, de Duve Institute, Avenue Hippocrate 75 B1 7503, Brussels 1200, Belgium Electronic address
    Dev Biol 404:136-48. 2015
  8. pmc Mechanism of primitive duct formation in the pancreas and submandibular glands: a role for SDF-1
    Anne Christine Hick
    Universite Catholique de Louvain, de Duve Institute, Brussels, Belgium
    BMC Dev Biol 9:66. 2009
  9. pmc Role of β-catenin in development of bile ducts
    Sabine Cordi
    Universite Catholique de Louvain, de Duve Institute, Avenue Hippocrate 75 B1 7503, 1200 Brussels, Belgium
    Differentiation 91:42-9. 2016
  10. ncbi request reprint Cloning and embryonic expression pattern of the mouse Onecut transcription factor OC-2
    Patrick Jacquemin
    Hormone and Metabolic Research Unit, Institute of Cellular Pathology and Université catholique de Louvain, 75 Avenue Hippocrate, B 1200, Brussels, Belgium
    Gene Expr Patterns 3:639-44. 2003

Collaborators

Detail Information

Publications32

  1. doi request reprint [Lineage fate decisions in normal and regenerating liver]
    Frederic Lemaigre
    Institut de Duve, Universite Catholique de Louvain, Bruxelles, Belgique
    Med Sci (Paris) 28:958-62. 2012
    ..The mesodermal origin of stellate and sinusoidal cells is also established...
  2. doi request reprint Mechanisms of liver development: concepts for understanding liver disorders and design of novel therapies
    Frederic P Lemaigre
    de Duve Institute, Universite Catholique de Louvain, Brussels, Belgium
    Gastroenterology 137:62-79. 2009
    ....
  3. pmc Intrahepatic bile ducts develop according to a new mode of tubulogenesis regulated by the transcription factor SOX9
    Aline Antoniou
    Universite Catholique de Louvain, de Duve Institute, Brussels, Belgium
    Gastroenterology 136:2325-33. 2009
    ..In the embryo, hepatoblasts differentiate to cholangiocytes, which give rise to the bile ducts. Here, we investigated duct development in mouse liver and characterized the role of the SRY-related HMG box transcription factor 9 (SOX9)...
  4. ncbi request reprint The Onecut transcription factors HNF-6/OC-1 and OC-2 regulate early liver expansion by controlling hepatoblast migration
    Sabrina Margagliotti
    Universite Catholique de Louvain, Christian de Duve Institute of Cellular Pathology, Avenue Hippocrate 75 7529, B 1200 Brussels, Belgium
    Dev Biol 311:579-89. 2007
    ..This network operating at the onset of liver development contains candidate genes for investigation of liver carcinogenesis...
  5. pmc Control of liver cell fate decision by a gradient of TGF beta signaling modulated by Onecut transcription factors
    Frederic Clotman
    Hormone and Metabolic Research Unit, Cell Biology Unit, Institute of Cellular Pathology and Université catholique de Louvain, Brussels, Belgium
    Genes Dev 19:1849-54. 2005
    ..Thus, a gradient of activin/TGFbeta signaling modulated by Onecut factors is required to segregate the hepatocytic and the biliary lineages...
  6. pmc Embryonic ductal plate cells give rise to cholangiocytes, periportal hepatocytes, and adult liver progenitor cells
    Rodolphe Carpentier
    de Duve Institute, Universite Catholique de Louvain, Brussels, Belgium
    Gastroenterology 141:1432-8, 1438.e1-4. 2011
    ..We investigated the role of the ductal plate in hepatic morphogenesis...
  7. doi request reprint Transcription factors SOX4 and SOX9 cooperatively control development of bile ducts
    Alexis Poncy
    Universite Catholique de Louvain, de Duve Institute, Avenue Hippocrate 75 B1 7503, Brussels 1200, Belgium Electronic address
    Dev Biol 404:136-48. 2015
    ..We conclude that SOX4 is a new regulator of liver development and that it exerts a pleiotropic control on bile duct development in cooperation with SOX9. ..
  8. pmc Mechanism of primitive duct formation in the pancreas and submandibular glands: a role for SDF-1
    Anne Christine Hick
    Universite Catholique de Louvain, de Duve Institute, Brussels, Belgium
    BMC Dev Biol 9:66. 2009
    ..The morphogenic mechanisms by which the ductal network is established as well as the signaling pathways involved in this process are poorly understood...
  9. pmc Role of β-catenin in development of bile ducts
    Sabine Cordi
    Universite Catholique de Louvain, de Duve Institute, Avenue Hippocrate 75 B1 7503, 1200 Brussels, Belgium
    Differentiation 91:42-9. 2016
    ..Our work is expected to significantly impact on in vitro differentiation of stem cells to cholangiocytes for toxicology studies and disease modeling. ..
  10. ncbi request reprint Cloning and embryonic expression pattern of the mouse Onecut transcription factor OC-2
    Patrick Jacquemin
    Hormone and Metabolic Research Unit, Institute of Cellular Pathology and Université catholique de Louvain, 75 Avenue Hippocrate, B 1200, Brussels, Belgium
    Gene Expr Patterns 3:639-44. 2003
    ..Like Hnf6, Oc2 was expressed in developing liver and pancreas. As many genes that are targeted by Onecut factors are recognized by both OC-2 and HNF-6, this overlap of expression patterns may have functional implications...
  11. doi request reprint Epithelial: Endothelial cross-talk regulates exocrine differentiation in developing pancreas
    Christophe E Pierreux
    Universite Catholique de Louvain, de Duve Institute, Brussels 1200, Belgium
    Dev Biol 347:216-27. 2010
    ..In conclusion, our data suggest that, in developing pancreas, epithelial production of VEGF-A determines the spatial organization of endothelial cells which, in turn, limit acinar differentiation of the epithelium...
  12. ncbi request reprint Transcription factor HNF-6/OC-1 inhibits the stimulation of the HNF-3alpha/Foxa1 gene by TGF-beta in mouse liver
    Nicolas Plumb-Rudewiez
    Hormone and Metabolic Research Unit, Institute of Cellular Pathology and Université catholique de Louvain, Brussels, Belgium
    Hepatology 40:1266-74. 2004
    ..This identifies a new mechanism of interaction between liver-enriched transcription factors whereby one factor indirectly controls another by modulating the activity of a signaling pathway...
  13. doi request reprint Let-7b and miR-495 stimulate differentiation and prevent metaplasia of pancreatic acinar cells by repressing HNF6
    Pierre Paul Prevot
    Universite Catholique de Louvain, de Duve Institute, Brussels, Belgium
    Gastroenterology 145:668-78.e3. 2013
    ..MicroRNAs (miRNAs) regulate pancreas development, yet little is known about their contribution to acinar cell differentiation. We aimed to identify miRNAs that promote and control the maintenance of acinar differentiation...
  14. doi request reprint Biliary differentiation and bile duct morphogenesis in development and disease
    Peggy Raynaud
    Universite Catholique de Louvain, de Duve Institute, Brussels, Belgium
    Int J Biochem Cell Biol 43:245-56. 2011
    ..We also present an overview of the mechanisms of biliary dysgenesis in humans...
  15. ncbi request reprint The transcription factor hepatocyte nuclear factor-6 controls the development of pancreatic ducts in the mouse
    Christophe E Pierreux
    Hormone and Metabolic Research Unit, Université catholique de Louvain and Institute of Cellular Pathology, Brussels, Belgium
    Gastroenterology 130:532-41. 2006
    ..Here, we investigate the transcriptional mechanisms that control pancreatic duct development by addressing the role of the transcription factor hepatocyte nuclear factor (HNF)-6...
  16. doi request reprint MiR-495 and miR-218 regulate the expression of the Onecut transcription factors HNF-6 and OC-2
    Alexandru Simion
    Universite Catholique de Louvain, de Duve Institute, 75 Avenue Hippocrate 7529, B 1200 Brussels, Belgium
    Biochem Biophys Res Commun 391:293-8. 2010
    ..These results indicate that the expression of regulators of liver and pancreas development is modulated by microRNAs. They also suggest a developmental role for miR-495 and miR-218...
  17. doi request reprint A feedback loop between the liver-enriched transcription factor network and miR-122 controls hepatocyte differentiation
    Ilaria Laudadio
    de Duve Institute, Universite Catholique de Louvain, Brussels, Belgium
    Gastroenterology 142:119-29. 2012
    ..Hepatocyte differentiation is controlled by liver-enriched transcription factors (LETFs). We investigated whether LETFs control microRNA expression during development and whether this control is required for hepatocyte differentiation...
  18. doi request reprint Role of metalloproteinases at the onset of liver development
    Sabrina Margagliotti
    Hormone and Metabolic Research Unit, Universite Catholique de Louvain, de Duve Institute, 1200 Brussels, Belgium
    Dev Growth Differ 50:331-8. 2008
    ..We conclude that MMPs are required to initiate expansion of the liver during development and that our culture system provides a new model to study hepatoblast migration...
  19. pmc Role of the ductal transcription factors HNF6 and Sox9 in pancreatic acinar-to-ductal metaplasia
    Pierre Paul Prevot
    Universite Catholique de Louvain, de Duve Institute, Avenue Hippocrate 75 B1 7503, B 1200 Brussels, Belgium
    Gut 61:1723-32. 2012
    ..In this study, the role of the ductal transcription factors hepatocyte nuclear factor 6 (HNF6, also known as Onecut1) and SRY-related HMG box factor 9 (Sox9) in ADM was investigated...
  20. ncbi request reprint Eph receptors and their ephrin ligands are expressed in developing mouse pancreas
    Jonathan M van Eyll
    Hormone and Metabolic Research Unit, Institute of Cellular Pathology, Universite Catholique de Louvain, 75 Avenue Hippocrate, B 1200 Brussels, Belgium
    Gene Expr Patterns 6:353-9. 2006
    ..We conclude that specific members of the Eph/ephrin family are expressed in embryonic pancreas according to a dynamic temporal and regional pattern...
  21. pmc Proliferation-Independent Initiation of Biliary Cysts in Polycystic Liver Diseases
    Jean Bernard Beaudry
    Universite Catholique de Louvain, de Duve Institute, Brussels, Belgium
    PLoS ONE 10:e0132295. 2015
    ..Combining our prenatal data with available data from adult livers, we propose that polycystic liver can be initiated by proliferation-independent mechanisms at a fetal stage, followed by postnatal proliferation-dependent cyst expansion. ..
  22. ncbi request reprint Control of hepatic differentiation by activin/TGFbeta signaling
    Frederic Clotman
    Hormone and Metabolic Research Unit, Institute of Cellular Pathology and Université catholique de Louvain, Brussels, Belgium
    Cell Cycle 5:168-71. 2006
    ....
  23. pmc A classification of ductal plate malformations based on distinct pathogenic mechanisms of biliary dysmorphogenesis
    Peggy Raynaud
    de Duve Institute, Universite Catholique de Louvain, Brussels, Belgium
    Hepatology 53:1959-66. 2011
    ..In HNF1β-deficient liver, maturation of the primitive ductal structures was impaired. Normal differentiation and maturation but abnormal duct expansion was apparent in cpk mouse livers and in human fetal ARPKD...
  24. ncbi request reprint Development of the biliary tract
    Frederic P Lemaigre
    Hormone and Metabolic Research Unit, Université catholique de Louvain and Institute of Cellular Pathology, Brussels, Belgium
    Mech Dev 120:81-7. 2003
  25. ncbi request reprint The onecut transcription factor hepatocyte nuclear factor-6 controls B lymphopoiesis in fetal liver
    Caroline Bouzin
    Hormone and Metabolic Research Unit, Université catholique de Louvain and Institute of Cellular Pathology, Brussels, Belgium
    J Immunol 171:1297-303. 2003
    ..This work identifies HNF-6 as the first noncell-intrinsic transcription factor known to control B lymphopoiesis specifically in fetal liver...
  26. ncbi request reprint Lack of cilia and differentiation defects in the liver of human foetuses with the Meckel syndrome
    Frederic Clotman
    Universite Catholique de Louvain, de Duve Institute, Brussels, Belgium
    Liver Int 28:377-84. 2008
    ..The aim of the present work was to investigate the formation of the primary cilia and the differentiation of the hepatic cells in foetuses with Meckel syndrome...
  27. doi request reprint SOX9 regulates ERBB signalling in pancreatic cancer development
    Adrien Grimont
    Universite Catholique de Louvain, de Duve Institute, Brussels, Belgium
    Gut 64:1790-9. 2015
    ..Here, we investigate how SOX9 operates in pancreatic tumourigenesis...
  28. doi request reprint Extraction of high-quality RNA from pancreatic tissues for gene expression studies
    Cécile Augereau
    de Duve Institute, Universite Catholique de Louvain, B 1200 Brussels, Belgium
    Anal Biochem 500:60-2. 2016
    ..Our method uses an RNase inhibitor and combines different protocols using guanidium thiocyanate-phenol extraction. It enables reproducible isolation of RNA with an RNA integrity number around 9. ..
  29. pmc Expression of Molecular Differentiation Markers Does Not Correlate with Histological Differentiation Grade in Intrahepatic Cholangiocarcinoma
    Céline Demarez
    de Duve Institute, Universite Catholique de Louvain, Avenue Hippocrate 75, B 1200 Brussels, Belgium
    PLoS ONE 11:e0157140. 2016
    ..Therefore, our data point toward necessary caution when investigating the evolution and prognosis of ICC on the basis of cell differentiation criteria. ..
  30. ncbi request reprint Chronic pancreatitis and lipomatosis are associated with defective function of ciliary genes in pancreatic ductal cells
    Cécile Augereau
    Universite Catholique de Louvain, de Duve Institute, Brussels, Belgium
    Hum Mol Genet . 2016
    ..Such injuries can account for the increased risk to develop pancreatic cancer in Peutz-Jeghers patients who carry LKB1 loss-of-function mutations...
  31. doi request reprint Molecular mechanisms of biliary development
    Frederic P Lemaigre
    de Duve Institute, Universite Catholique de Louvain, Brussels, Belgium
    Prog Mol Biol Transl Sci 97:103-26. 2010
    ..In this chapter, we describe how bile ducts are formed and cholangiocytes differentiate, and focus on the regulation of these processes by intercellular signaling pathways and by transcriptional and posttranscriptional mechanisms...
  32. ncbi request reprint OC-3, a novel mammalian member of the ONECUT class of transcription factors
    Vinciane Vanhorenbeeck
    Hormone and Metabolic Research Unit, Université catholique de Louvain and Institute of Cellular Pathology, 75 Avenue Hippocrate, Brussels, B 1200, Belgium
    Biochem Biophys Res Commun 292:848-54. 2002
    ..Our earlier work on HNF-6 and the expression patterns of the three mammalian ONECUT genes suggest that they all participate to the control of organ development from the foregut and midgut endoderm...