Affiliation: Laboratory for Thrombosis Research
- Increased Na+ concentration and altered Na/K pump activity in hypertrophied canine ventricular cellsFons Verdonck
Interdisciplinary Research Center, University of Leuven Campus Kortrijk, E Sabbelaan 53, B 8500, Kortrijk, Belgium
Cardiovasc Res 57:1035-43. 2003..To investigate whether hypertrophy in the dog with chronic atrioventricular block (CAVB) alters [Na+]i and Na/K-pump function of ventricular myocytes...
- Intracellular Na+ and altered Na+ transport mechanisms in cardiac hypertrophy and failureFons Verdonck
Interdisciplinary Research Centre, University of Leuven Campus Kortrijk, E Sabbelaan 53, B 8500, Kortrijk, Belgium
J Mol Cell Cardiol 35:5-25. 2003....
- Parabutoporin--an antibiotic peptide from scorpion venom--can both induce activation and inhibition of granulocyte cell functionsJean Willems
Interdisciplinary Research Center, KULAK, University Campus, B 8500 Kortrijk, Belgium
Peptides 25:1079-84. 2004..The unexpected inhibitory effect of PP, despite Rac activation, on superoxide production in granulocytes is explained by the direct interaction of membrane localized PP which prevents the formation of a functional NADPH oxidase complex...
- Cationic peptides from scorpion venom can stimulate and inhibit polymorphonuclear granulocytesJean Willems
Interdisciplinary Research Centre, KULAK, B 8500 Kortrijk, Belgium
Toxicon 40:1679-83. 2002..They also strongly inhibit the production of superoxide anions. At higher concentrations they act as pore formers and induce leakage of the cells. These different effects may be related to their amphipathic structure...
- Antimicrobial peptides from scorpion venom induce Ca(2+) signaling in HL-60 cellsLeentje Moerman
Interdisciplinary Research Center, Catholic University Leuven Campus Kortrijk, Belgium
Biochem Biophys Res Commun 311:90-7. 2003..Ca(2+) release by OP1 was found not to be mediated via interaction with the formyl peptide receptor-like 1. Although some of the results might favor a receptor-like interaction, the receptor involved could not be identified...
- [Na(+)] in the subsarcolemmal 'fuzzy' space and modulation of [Ca(2+)](i) and contraction in cardiac myocytesFons Verdonck
Interdisciplinary Research Center, Katholieke University of Leuven, Campus Kortrijk, Kortrijk, Belgium
Cell Calcium 35:603-12. 2004..This has implications for modulation of [Ca(2+)](i) during a single beat as well as during alterations in Na(+) fluxes seen in pathological conditions...
- Antibacterial and antifungal properties of alpha-helical, cationic peptides in the venom of scorpions from southern AfricaLeentje Moerman
Interdisciplinary Research Center, Katholieke Universiteit Leuven Campus Kortrijk, Kortrijk, Belgium
Eur J Biochem 269:4799-810. 2002..Furthermore, all peptides inhibited growth of fungi. Experiments with SYTOX green suggested that this effect is related to membrane permeabilization...
- The amiodarone derivative KB130015 [2-methyl-3-(3,5-diiodo-4-carboxymethoxybenzyl)benzofuran] induces an Na+-dependent increase of [Ca2+] in ventricular myocytesVirginie Bito
Laboratory of Experimental Cardiology, Catholic University Leuven, Campus Gasthuisberg O N 7th Floor, Herestraat 49, B 3000 Leuven, Belgium
J Pharmacol Exp Ther 316:162-8. 2006..This effect is partially offset by a decrease in I(CaL) resulting in a mild inotropic effect without the signs of Ca(2+) overload and related arrhythmias usually associated with Na(+) channel openers...
- Determination of species-specific components in the venom of Parabuthus scorpions from southern Africa using matrix-assisted laser desorption time-of-flight mass spectrometryKarin Dyason
Department of Physiology, Potchefstroom University for Christian Higher Education, Private Bag X6001, Potchefstroom 2520, South Africa
Rapid Commun Mass Spectrom 16:768-73. 2002..MALDI-TOFMS is therefore proposed as a complementary method to morphological and behavioural characteristics for species and ultimately subspecies discrimination...
- The antimicrobial peptide parabutoporin competes with p47(phox) as a PKC-substrate and inhibits NADPH oxidase in human neutrophilsQuinten F M Remijsen
Laboratory of Biochemistry, IRC, KULAK, B8500 Kortrijk, Belgium
FEBS Lett 580:6206-10. 2006..In contrast, PP affects the PKC-independent activation to a much lesser degree. This indicates that PP inhibits the activation of NADPH oxidase at submicromolar concentrations in a strongly PKC-dependent manner...
- Evolutionary origin of inhibitor cystine knot peptidesShunyi Zhu
Laboratory of Toxicology, University of Leuven, Belgium
FASEB J 17:1765-7. 2003..In contrast, ICK peptides from plant and fungus might be independently evolved from another ancestor...
- Intracellular Na in animal models of hypertrophy and heart failure: contractile function and arrhythmogenesisSteven M Pogwizd
Department of Medicine, University of Illinois at Chicago, 840 South Wood Street, M C 787, Chicago, IL 60612, USA
Cardiovasc Res 57:887-96. 2003
- Evolutionary trace analysis of scorpion toxins specific for K-channelsShunyi Zhu
Laboratory of Toxicology, University of Leuven, Leuven, Belgium
Proteins 54:361-70. 2004....
- Role of the Na/Ca exchanger in arrhythmias in compensated hypertrophyKarin R Sipido
Laboratory of Experimental Cardiology, University of Leuven, Leuven, Belgium
Ann N Y Acad Sci 976:438-45. 2002..However, more than one ionic remodeling process is likely to be present, and different cellular mechanisms of arrhythmias can coexist...
- Purification, characterization and biosynthesis of parabutoxin 3, a component of Parabuthus transvaalicus venomIsabelle Huys
Laboratory of Toxicology, University of Leuven, Leuven, Belgium
Eur J Biochem 269:1854-65. 2002..The scaffold of PBTx3 is homologous to most other alpha-KTx scorpion toxins...
- The poison Dart frog's batrachotoxin modulates Nav1.8Frank Bosmans
Laboratory of Toxicology, University of Leuven, E Van Evenstraat 4, B 3000 Leuven, Belgium
FEBS Lett 577:245-8. 2004..8 at more negative membrane potentials and the ion selectivity is modified...
- Altered Na/Ca exchange activity in cardiac hypertrophy and heart failure: a new target for therapy?Karin R Sipido
Laboratory of Experimental Cardiology, University of Leuven, KUL, Campus Gasthuisberg O N, 7th Floor, Herestraat 49, B 3000 Leuven, Belgium
Cardiovasc Res 53:782-805. 2002..Development of drugs that target only a specific mode of the exchanger may offer a further advantage...