P Verhamme

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. ncbi request reprint The pivotal role of the endothelium in haemostasis and thrombosis
    P Verhamme
    Bloedings en Vaatziekten Centrum voor Moleculaire en Vasculaire Biologie, Leuven
    Acta Clin Belg 61:213-9. 2006
  2. ncbi request reprint A new era for oral anticoagulation? Old and new anticoagulant drugs
    Peter Verhamme
    Vascular Medicine and Coagulation Disorders, Centre for Molecular and Vascular Biology, Gasthuisberg University Hospital, Leuven, Belgium
    Acta Cardiol 62:189-98. 2007
  3. ncbi request reprint Impending paradoxical embolism
    Peter Verhamme
    Department of Cardiovascular Diseases, University Hospital Gasthuisberg, Catholic University of Leuven, Herestraat 49, 3000 Leuven, Belgium
    Eur Heart J 28:2660. 2007
  4. ncbi request reprint Carotid intima-media thickness: more than a research tool?
    Peter Verhamme
    Dept of Vascular Medicine and Haemostasis, UZ Leuven Hospitals, Leuven, Belgium
    Acta Cardiol 65:59-66. 2010
  5. doi request reprint A pilot trial of microplasmin in patients with long-term venous access catheter thrombosis
    Peter Verhamme
    Department of Vascular Medicine and Haemostasis, University Hospitals Leuven, Catholic University Leuven, Herestraat 49, 3000, Leuven, Belgium
    J Thromb Thrombolysis 28:477-81. 2009
  6. ncbi request reprint Current primary care practice in the diagnosis and management of patients with suspected venous thromboembolism and prescription of initiation dose of enoxaparin
    P Verhamme
    Department of Vascular Medicine and Haemostasis, University Hospital Gasthuisberg, Leuven, Belgium
    Int Angiol 29:58-63. 2010
  7. doi request reprint Fibrin formation by staphylothrombin facilitates Staphylococcus aureus-induced platelet aggregation
    Thomas Vanassche
    Center for Molecular and Vascular Biology, University of Leuven, University Hospitals Leuven, B 3000 Leuven, Belgium
    Thromb Haemost 107:1107-21. 2012
  8. doi request reprint Antidote strategies to reverse anticoagulation with TB-402, a long-acting partial inhibitor of factor VIII
    M Tangelder
    Research and Development, ThromboGenics NV, Heverlee, Belgium
    J Thromb Haemost 10:1371-8. 2012
  9. ncbi request reprint Catheter-directed thrombolysis with microplasmin for acute peripheral arterial occlusion (PAO): an exploratory study
    P Verhamme
    Department of Vascular Medicine and Hemostasis, University Hospitals Leuven, Leuven, Belgium
    Int Angiol 31:289-96. 2012
  10. doi request reprint Partial versus complete factor VIII inhibition in a mouse model of venous thrombosis
    J Emmerechts
    Center for Molecular and Vascular Biology, KULeuven, Leuven, Belgium
    Thromb Res 129:514-9. 2012

Collaborators

Detail Information

Publications27

  1. ncbi request reprint The pivotal role of the endothelium in haemostasis and thrombosis
    P Verhamme
    Bloedings en Vaatziekten Centrum voor Moleculaire en Vasculaire Biologie, Leuven
    Acta Clin Belg 61:213-9. 2006
    ..In diffuse intravascular coagulation, the endothelium is the interface between inflammation and inappropriate activation of the coagulation system...
  2. ncbi request reprint A new era for oral anticoagulation? Old and new anticoagulant drugs
    Peter Verhamme
    Vascular Medicine and Coagulation Disorders, Centre for Molecular and Vascular Biology, Gasthuisberg University Hospital, Leuven, Belgium
    Acta Cardiol 62:189-98. 2007
    ..Large clinical trials evaluate several compounds both in the primary and secondary prevention of venous thromboembolism and in the prevention of cardioembolism in patients with atrial fibrillation...
  3. ncbi request reprint Impending paradoxical embolism
    Peter Verhamme
    Department of Cardiovascular Diseases, University Hospital Gasthuisberg, Catholic University of Leuven, Herestraat 49, 3000 Leuven, Belgium
    Eur Heart J 28:2660. 2007
  4. ncbi request reprint Carotid intima-media thickness: more than a research tool?
    Peter Verhamme
    Dept of Vascular Medicine and Haemostasis, UZ Leuven Hospitals, Leuven, Belgium
    Acta Cardiol 65:59-66. 2010
    ..At present, CIMT is increasingly being used as a surrogate aimed at reducing CVD risk at an individual level. In this paper we discuss the potential usefulness of CIMT as a risk marker in clinical programmes of CVD prevention...
  5. doi request reprint A pilot trial of microplasmin in patients with long-term venous access catheter thrombosis
    Peter Verhamme
    Department of Vascular Medicine and Haemostasis, University Hospitals Leuven, Catholic University Leuven, Herestraat 49, 3000, Leuven, Belgium
    J Thromb Thrombolysis 28:477-81. 2009
    ..We investigated the safety and efficacy of intra-catheter microplasmin bolus administration for the restoration of catheter function in long-term venous access catheter thrombosis...
  6. ncbi request reprint Current primary care practice in the diagnosis and management of patients with suspected venous thromboembolism and prescription of initiation dose of enoxaparin
    P Verhamme
    Department of Vascular Medicine and Haemostasis, University Hospital Gasthuisberg, Leuven, Belgium
    Int Angiol 29:58-63. 2010
    ..Ambulatory care of patients with deep vein thrombosis (DVT) has been well validated but limited data exist on the diagnostic and therapeutic management of venous thromboembolism (VTE) in primary care...
  7. doi request reprint Fibrin formation by staphylothrombin facilitates Staphylococcus aureus-induced platelet aggregation
    Thomas Vanassche
    Center for Molecular and Vascular Biology, University of Leuven, University Hospitals Leuven, B 3000 Leuven, Belgium
    Thromb Haemost 107:1107-21. 2012
    ..aureus...
  8. doi request reprint Antidote strategies to reverse anticoagulation with TB-402, a long-acting partial inhibitor of factor VIII
    M Tangelder
    Research and Development, ThromboGenics NV, Heverlee, Belgium
    J Thromb Haemost 10:1371-8. 2012
    ..TB-402 is a partially inhibiting antibody of factor VIII that is under development as a long-acting anticoagulant...
  9. ncbi request reprint Catheter-directed thrombolysis with microplasmin for acute peripheral arterial occlusion (PAO): an exploratory study
    P Verhamme
    Department of Vascular Medicine and Hemostasis, University Hospitals Leuven, Leuven, Belgium
    Int Angiol 31:289-96. 2012
    ..We performed an open-label, dose-ascending, single-centre, Phase IIa study to explore the safety and efficacy of catheter-directed thrombolysis (CDT) with microplasmin for infrainguinal arterial or bypass occlusions...
  10. doi request reprint Partial versus complete factor VIII inhibition in a mouse model of venous thrombosis
    J Emmerechts
    Center for Molecular and Vascular Biology, KULeuven, Leuven, Belgium
    Thromb Res 129:514-9. 2012
    ..Partial inhibition of Factor VIII (FVIII) may provide antithrombotic efficacy whilst avoiding excessive anticoagulation...
  11. ncbi request reprint Circulating oxidized LDL is a useful marker for identifying patients with coronary artery disease
    P Holvoet
    Center for Molecular and Vascular Biology, Catholic University of Leuven, Leuven, Belgium
    Arterioscler Thromb Vasc Biol 21:844-8. 2001
    ..Thus, circulating oxidized LDL is a sensitive marker of CAD. Addition of oxidized LDL to the established risk factors may improve cardiovascular risk prediction...
  12. doi request reprint The addition of idarucizumab to plasma samples containing dabigatran allows the use of routine coagulation assays for the diagnosis of hemostasis disorders
    M Jacquemin
    Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, University of Leuven, Leuven, Belgium
    J Thromb Haemost 13:2087-92. 2015
    ..Consequently, dabigatran also interferes with thrombophilia screening or with diagnosing hemostasis disorders that have developed after the initiation of anticoagulant treatment, such as vitamin K deficiency or acquired hemophilia A...
  13. doi request reprint The effect of anastomosis time on outcome in recipients of kidneys donated after brain death: a cohort study
    L Heylen
    Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium
    Am J Transplant 15:2900-7. 2015
    ..In conclusion, prolonged anastomosis time is not only detrimental for renal allograft outcome immediately after transplantation, also longer-term allograft function and histology are affected by the duration of this warm ischemia. ..
  14. doi request reprint A human monoclonal antibody inhibiting partially factor VIII activity reduces thrombus growth in baboons
    M Jacquemin
    Center for Molecular and Vascular Biology, University of Leuven, Leuven, Belgium
    J Thromb Haemost 7:429-37. 2009
    ..This offers the opportunity to develop an optimized anticoagulant agent targeting partial FVIII inhibition...
  15. doi request reprint Penetration of a fractured Bird's Nest filter strut into the liver parenchyma: report of two cases
    Geert Maleux
    Department of Radiology, University Hospitals Leuven, Belgium
    Acta Radiol 52:643-5. 2011
    ..Follow-up over 4 and 6 years, respectively, could not reveal any changes in the position of the fragmented strut in the liver parenchyma or any evidence of clinical symptoms owing to the migrated strut fragment...
  16. ncbi request reprint Periprocedural bridging of anticoagulation
    E Vandermeulen
    Department of Anaesthesiology, University Hospitals Leuven, Belgium
    Acta Anaesthesiol Belg 61:133-8. 2010
    ..The decision will primarily be based upon the initial indication to antithrombotic treatment and the nature of the planned procedure...
  17. ncbi request reprint Outcome of carotid artery stenting at 2 years follow-up: comparison of nitinol open cell versus stainless steel closed cell stent design
    G Maleux
    Department of Radiology, University Hospitals Leuven, Leuven, Belgium
    J Cardiovasc Surg (Torino) 50:669-75. 2009
    ..The aim of this study was to compare the clinical and ultrasound outcome of carotid artery stenting at 2-year follow-up in patients treated with open-cell nitinol stents versus patients treated with closed cell stainless steel stents...
  18. ncbi request reprint Major coagulation disturbances during fractionated plasma separation and adsorption
    B K I Meijers
    Department of Medicine, Division of Nephrology, University Hospital Leuven, Leuven, Belgium
    Am J Transplant 7:2195-9. 2007
    ..Direct contact between fractionated plasma and the Prometh02 anion exchanger causes significant adsorption of procoagulant and anti-coagulant factors, associated with clinically relevant adverse events...
  19. doi request reprint Inhibition of staphylothrombin by dabigatran reduces Staphylococcus aureus virulence
    T Vanassche
    Center for Molecular and Vascular Biology, University of Leuven, Leuven, Belgium
    J Thromb Haemost 9:2436-46. 2011
    ..Staphylocoagulase and von Willebrand binding protein (VWbp) bind to prothrombin to form the staphylothrombin complex that converts fibrinogen into fibrin...
  20. ncbi request reprint Arg123-Tyr166 domain of human ApoA-I is critical for HDL-mediated inhibition of macrophage homing and early atherosclerosis in mice
    P Holvoet
    Center for Experimental Surgery and Anesthesiology, Katholieke Universiteit Leuven, Leuven, Belgium
    Arterioscler Thromb Vasc Biol 21:1977-83. 2001
    ..Thus, the Arg123-Tyr166 central domain of apoA-I is critical for reducing oxidative stress, macrophage homing, and early atherosclerosis in apoE knockout mice independent of its role in HDL production and cholesterol efflux...
  21. doi request reprint Keeping your vascular integrity: What can we learn from fish?
    Aernout Luttun
    Center for Molecular and Vascular Biology, KULeuven, Leuven, Belgium
    Bioessays 30:418-22. 2008
    ..Here, we summarize the factors determining vascular integrity and elaborate on the suitability of the zebrafish to study this phenomenon...
  22. ncbi request reprint Improving the quality of anticoagulant therapy in patients with mechanical heart valves: what are we waiting for?
    Paul Herijgers
    Eur Heart J 28:2424-6. 2007
  23. ncbi request reprint Heparin-coated polyacrylonitrile membrane versus regional citrate anticoagulation: a prospective randomized study of 2 anticoagulation strategies in patients at risk of bleeding
    Pieter Evenepoel
    Department of Medicine, Division of Nephrology, University Hospital Leuven, Leuven, Belgium
    Am J Kidney Dis 49:642-9. 2007
    ..0), and heparin-coated membranes (1.3 m(2); AN69ST; Nephral 300ST, Gambro-Hospal, Meyzieu, France) may represent valid alternatives...
  24. ncbi request reprint A dose-finding clinical trial of staphylokinase SY162 in patients with long-term venous access catheter thrombotic occlusion
    Peter Verhamme
    Center of Molecular and Vascular Biology, University Hospitals Gasthuisberg, Catholic University Leuven, Herestraat 49, 3000, Leuven, Belgium
    J Thromb Thrombolysis 24:1-5. 2007
    ..We investigated the safety and efficacy of several dosing regimens of catheter-directed staphylokinase (SY162) bolus administration for the treatment of long-term venous access catheter occlusion...
  25. ncbi request reprint Weight-loss-associated induction of peroxisome proliferator-activated receptor-alpha and peroxisome proliferator-activated receptor-gamma correlate with reduced atherosclerosis and improved cardiovascular function in obese insulin-resistant mice
    Wim Verreth
    Cardiovascular Research Unit of the Center for Experimental Surgery and Anesthesiology, Katholieke Universiteit Leuven, Belgium
    Circulation 110:3259-69. 2004
    ..Weight loss in obese insulin-resistant but not in insulin-sensitive persons reduces coronary heart disease risk. To what extent changes in gene expression are related to atherosclerosis and cardiovascular function is unknown...
  26. ncbi request reprint Dietary cholesterol withdrawal reduces vascular inflammation and induces coronary plaque stabilization in miniature pigs
    Peter Verhamme
    Cardiovascular Research Unit, Center for Experimental Surgery and Anesthesiology, KU Leuven, Campus Gasthuisberg, O and N, Herestraat 49, Leuven, Belgium
    Cardiovasc Res 56:135-44. 2002
    ..To study the effect of dietary cholesterol withdrawal on size and composition of LDL-hypercholesterolemia-induced coronary plaques in miniature pigs...
  27. ncbi request reprint Hypercholesterolemia in minipigs impairs left ventricular response to stress: association with decreased coronary flow reserve and reduced capillary density
    Gregor Theilmeier
    Center for Molecular and Vascular Biology, Katholieke Universiteit Leuven, Leuven, Belgium
    Circulation 106:1140-6. 2002
    ..Our objective was therefore to assess the effect of hypercholesterolemia and cholesterol withdrawal on LV function in the presence of advanced coronary plaques that do not cause stenosis...