Rik Vandenberghe

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. ncbi request reprint Brain activity underlying stereotyped and non-stereotyped retrieval of learned stimulus-response associations
    R Vandenberghe
    Laboratorium voor Neuro en Psychofysiologie, Katholieke Universiteit Leuven, Belgium
    Eur J Neurosci 11:4037-50. 1999
  2. pmc Classification of the primary progressive aphasias: principles and review of progress since 2011
    Rik Vandenberghe
    Department of Neurosciences, Laboratory for Cognitive Neurology, KU Leuven, Leuven, Belgium
    Alzheimers Res Ther 8:16. 2016
  3. doi request reprint The relationship between amyloid deposition, neurodegeneration, and cognitive decline in dementia
    Rik Vandenberghe
    Laboratory for Cognitive Neurology, Department of Neurosciences, University of Leuven, Leuven, Belgium
    Curr Neurol Neurosci Rep 14:498. 2014
  4. doi request reprint The associative-semantic network for words and pictures: effective connectivity and graph analysis
    Rik Vandenberghe
    Laboratory for Cognitive Neurology, University of Leuven, Belgium Neurology Department, University Hospitals Leuven, Belgium Electronic address
    Brain Lang 127:264-72. 2013
  5. doi request reprint Binary classification of ¹⁸F-flutemetamol PET using machine learning: comparison with visual reads and structural MRI
    Rik Vandenberghe
    Laboratory for Cognitive Neurology, Experimental Neurology Section, Katholieke Universiteit Leuven, Belgium
    Neuroimage 64:517-25. 2013
  6. doi request reprint Spatial attention deficits in humans: the critical role of superior compared to inferior parietal lesions
    Rik Vandenberghe
    Laboratory for Cognitive Neurology, Neurology Department, University Hospitals Leuven, Leuven, Belgium
    Neuropsychologia 50:1092-103. 2012
  7. doi request reprint 18F-flutemetamol amyloid imaging in Alzheimer disease and mild cognitive impairment: a phase 2 trial
    Rik Vandenberghe
    Laboratory for Cognitive Neurology, Catholic University Leuven, Leuven, Belgium
    Ann Neurol 68:319-29. 2010
  8. doi request reprint Parcellation of parietal cortex: convergence between lesion-symptom mapping and mapping of the intact functioning brain
    Rik Vandenberghe
    Cognitive Neurology Laboratory, Experimental Neurology Section, K U Leuven, Belgium
    Behav Brain Res 199:171-82. 2009
  9. ncbi request reprint Astronomia nova to human brain mapping
    Rik Vandenberghe
    Neurology Department, University Hospital Gasthuisberg, Leuven, Belgium
    Neural Netw 19:1453-4. 2006
  10. pmc Cognitive aging and Alzheimer's disease
    R Vandenberghe
    Neurology Department, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    Postgrad Med J 81:343-52. 2005

Detail Information

Publications64

  1. ncbi request reprint Brain activity underlying stereotyped and non-stereotyped retrieval of learned stimulus-response associations
    R Vandenberghe
    Laboratorium voor Neuro en Psychofysiologie, Katholieke Universiteit Leuven, Belgium
    Eur J Neurosci 11:4037-50. 1999
    ....
  2. pmc Classification of the primary progressive aphasias: principles and review of progress since 2011
    Rik Vandenberghe
    Department of Neurosciences, Laboratory for Cognitive Neurology, KU Leuven, Leuven, Belgium
    Alzheimers Res Ther 8:16. 2016
    ..Finally, given the limited predictive value of the clinical phenotype for the underlying neuropathology, biomarkers of the underlying pathology are likely of clinical utility in PPA...
  3. doi request reprint The relationship between amyloid deposition, neurodegeneration, and cognitive decline in dementia
    Rik Vandenberghe
    Laboratory for Cognitive Neurology, Department of Neurosciences, University of Leuven, Leuven, Belgium
    Curr Neurol Neurosci Rep 14:498. 2014
    ..More tools will become available in the future that allow one to carve out a causal-mechanistic space for explaing cognitive decline in a personalized manner, enhancing progress towards more efficacious interventions. ..
  4. doi request reprint The associative-semantic network for words and pictures: effective connectivity and graph analysis
    Rik Vandenberghe
    Laboratory for Cognitive Neurology, University of Leuven, Belgium Neurology Department, University Hospitals Leuven, Belgium Electronic address
    Brain Lang 127:264-72. 2013
    ..Graph analysis reveals novel insights into the structure of the network for associative-semantic processing...
  5. doi request reprint Binary classification of ¹⁸F-flutemetamol PET using machine learning: comparison with visual reads and structural MRI
    Rik Vandenberghe
    Laboratory for Cognitive Neurology, Experimental Neurology Section, Katholieke Universiteit Leuven, Belgium
    Neuroimage 64:517-25. 2013
    ..In this sample the specificity of (18)F-flutemetamol based SVM for distinguishing AD from controls is higher than that of gray matter volume-based SVM...
  6. doi request reprint Spatial attention deficits in humans: the critical role of superior compared to inferior parietal lesions
    Rik Vandenberghe
    Laboratory for Cognitive Neurology, Neurology Department, University Hospitals Leuven, Leuven, Belgium
    Neuropsychologia 50:1092-103. 2012
    ..Functional imaging has also provided hints about the differences in functional contribution between inferior and superior parietal cortex. These hypotheses await further confirmation based on lesion evidence...
  7. doi request reprint 18F-flutemetamol amyloid imaging in Alzheimer disease and mild cognitive impairment: a phase 2 trial
    Rik Vandenberghe
    Laboratory for Cognitive Neurology, Catholic University Leuven, Leuven, Belgium
    Ann Neurol 68:319-29. 2010
    ..Its availability, however, is limited by the need for an on-site cyclotron. Validation of the (18)F-labeled PIB derivative (18)F-flutemetamol could significantly enhance access to this novel technology...
  8. doi request reprint Parcellation of parietal cortex: convergence between lesion-symptom mapping and mapping of the intact functioning brain
    Rik Vandenberghe
    Cognitive Neurology Laboratory, Experimental Neurology Section, K U Leuven, Belgium
    Behav Brain Res 199:171-82. 2009
    ....
  9. ncbi request reprint Astronomia nova to human brain mapping
    Rik Vandenberghe
    Neurology Department, University Hospital Gasthuisberg, Leuven, Belgium
    Neural Netw 19:1453-4. 2006
  10. pmc Cognitive aging and Alzheimer's disease
    R Vandenberghe
    Neurology Department, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    Postgrad Med J 81:343-52. 2005
    ..The advances at the clinical and at the basic research levels are necessary if we wish to meet the formidable challenge that the increasing prevalence of Alzheimer's disease poses to the medical community...
  11. ncbi request reprint Attentional responses to unattended stimuli in human parietal cortex
    R Vandenberghe
    Neurology Department, KU LeuvenLeuven, Belgium
    Brain 128:2843-57. 2005
    ..Functional imaging in neglect patients will be necessary to assess IPS function in those cases where the structural lesion spares the middle IPS segment...
  12. ncbi request reprint Paradoxical features of word finding difficulty in primary progressive aphasia
    Rik R Vandenberghe
    Cognitive Neurology and Alzheimer s Disease Center, Northwestern University Medical School, Chicago, IL, USA
    Ann Neurol 57:204-9. 2005
    ..Selection among competing word forms sharing a same semantic field is abnormal in PPA. The semantic interference effect constitutes a positive distinguishing feature between PPA and PRAD...
  13. ncbi request reprint The response of left temporal cortex to sentences
    R Vandenberghe
    University Hospital Gasthuisberg, Leuven, Belgium
    J Cogn Neurosci 14:550-60. 2002
    ....
  14. ncbi request reprint Abeta amyloid deposition in the language system and how the brain responds
    Natalie Nelissen
    Cognitive Neurology Laboratory, KU Leuven, Belgium
    Brain 130:2055-69. 2007
    ..Functional reorganization of the language system in response to Abeta amyloid-related brain injury exists in early-stage AD and determines the degree of anomia more than Abeta amyloid load per se does...
  15. doi request reprint Similarity of fMRI activity patterns in left perirhinal cortex reflects semantic similarity between words
    Rose Bruffaerts
    Laboratory for Cognitive Neurology, Department of Neurosciences, Neurology Department, and Radiology Department, University Hospitals Leuven, 3000 Leuven, Belgium, and Laboratory of Experimental Psychology, Humanities and Social Sciences Group, University of Leuven, 3000 Leuven, Belgium
    J Neurosci 33:18597-607. 2013
    ..Semantic similarity is reflected by similarity of functional topography at a fine-grained level in left perirhinal cortex. The word specificity excludes perceptually driven confounds as an explanation and is likely to be task dependent. ..
  16. doi request reprint Lesion neuroanatomy of the Sustained Attention to Response task
    Pascal Molenberghs
    Cognitive Neurology Laboratory, Experimental Neurology Section, K U Leuven, Belgium
    Neuropsychologia 47:2866-75. 2009
    ..Omissions and reaction time variability had less localising value in our sample. To conclude, commission errors and post-error slowing in the SART mainly probe right inferior frontal integrity...
  17. doi request reprint Gesture discrimination in primary progressive aphasia: the intersection between gesture and language processing pathways
    Natalie Nelissen
    Laboratory for Cognitive Neurology, Experimental Neurology Section, Katholieke Universiteit Leuven, 3000 Leuven, Belgium
    J Neurosci 30:6334-41. 2010
    ..Thus, the left perisylvian temporoparietal area may underpin verbal imitative behavior, gesture imitation, and gesture discrimination indicative of a partly shared neural substrate for language and gesture resonance...
  18. doi request reprint Cytoarchitectonic mapping of attentional selection and reorienting in parietal cortex
    Celine R Gillebert
    Laboratory for Cognitive Neurology, KU Leuven, Belgium
    Neuroimage 67:257-72. 2013
    ..Furthermore, the study demonstrated within a same experiment a functional dissociation between reorienting and selection in parietal cortex...
  19. doi request reprint Convergence between lesion-symptom mapping and functional magnetic resonance imaging of spatially selective attention in the intact brain
    Pascal Molenberghs
    Cognitive Neurology Laboratory, Experimental Neurology Section, Katholieke Universiteit Leuven, Belgium
    J Neurosci 28:3359-73. 2008
    ....
  20. doi request reprint Lesion evidence for the critical role of the intraparietal sulcus in spatial attention
    Celine R Gillebert
    Laboratory for Cognitive Neurology, Department of Neurosciences, K U Leuven, and Department of Neurology, University Hospitals, Herestraat 49 Box 7003, B 3000 Leuven, Belgium
    Brain 134:1694-709. 2011
    ..Our findings demonstrate that the human superior parietal cortex critically contributes to spatially selective attention...
  21. ncbi request reprint Cognitive deficits during status epilepticus and time course of recovery: a case report
    Wim Van Paesschen
    Department of Neurology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Belgium
    Epilepsia 48:1979-83. 2007
    ....
  22. doi request reprint Whole-body biodistribution and radiation dosimetry of 18F-GE067: a radioligand for in vivo brain amyloid imaging
    Michel Koole
    Nuclear Medicine, University Hospital and K U Leuven, Leuven, Belgium
    J Nucl Med 50:818-22. 2009
    ..We have characterized the biodistribution and dosimetry of (18)F-3'-F-6-OH-BTA1 ((18)F-GE067), a newly developed radioligand to visualize and quantify amyloid burden, in healthy elderly human subjects...
  23. doi request reprint Amygdala atrophy affects emotion-related activity in face-responsive regions in frontotemporal degeneration
    François Laurent De Winter
    Laboratory for Translational Neuropsychiatry, Research Group Psychiatry, Department of Neurosciences, KU Leuven, Leuven, Belgium Department of Old Age Psychiatry, University Hospitals Leuven, Leuven, Belgium
    Cortex 82:179-91. 2016
    ..The data suggests that anterior medio-temporal atrophy in bvFTD affects emotion processing in distant posterior areas. ..
  24. pmc Cholinergic depletion and basal forebrain volume in primary progressive aphasia
    Jolien Schaeverbeke
    Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Herestraat 49, Box 1027, Leuven 3000, Belgium Alzheimer Research Centre, KU Leuven, Herestraat 49, Leuven 3000, Belgium Leuven Institute of Neuroscience and Disease, Herestraat 49, Leuven 3000, Belgium
    Neuroimage Clin 13:271-279. 2017
    ..BF volume did not correlate with AChE activity levels in PPA. To conclude, in our sample of PPA patients, LV but not SV was associated with cholinergic depletion. BF atrophy in PPA does not imply cholinergic depletion...
  25. ncbi request reprint Knowledge of visual attributes in the right hemisphere
    Mathieu Vandenbulcke
    Cognitive Neurology Laboratory, KU Leuven, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    Nat Neurosci 9:964-70. 2006
    ..Therefore, right fusiform gyrus critically contributes to the conscious recollection of visual attributes of familiar entities...
  26. ncbi request reprint Word reading and posterior temporal dysfunction in amnestic mild cognitive impairment
    Mathieu Vandenbulcke
    Cognitive Neurology Laboratory, Experimental Neurology Division, Katholieke Universiteit Leuven, Belgium
    Cereb Cortex 17:542-51. 2007
    ..Our data provide converging evidence for a critical contribution of the lower bank of the left posterior STS to mapping word form onto word meaning (lexical-semantic retrieval)...
  27. doi request reprint Phase 1 study of the Pittsburgh compound B derivative 18F-flutemetamol in healthy volunteers and patients with probable Alzheimer disease
    Natalie Nelissen
    Laboratory for Cognitive Neurology, K U Leuven, Leuven, Belgium
    J Nucl Med 50:1251-9. 2009
    ....
  28. ncbi request reprint Anterior temporal laterality in primary progressive aphasia shifts to the right
    Mathieu Vandenbulcke
    Cognitive Neurology Laboratory, Section Experimental Neurology, K U Leuven, Belgium
    Ann Neurol 58:362-70. 2005
    ..34; SE, 0.19), with an intermediate pattern in PPA without comprehension deficit (LI, +0.23; SE, 0.14). The rightward laterality shift previously reported in aphasic stroke extends to PPA, in particular, when comprehension is deficient...
  29. pmc Diagnostic value of cerebrospinal fluid Aβ ratios in preclinical Alzheimer's disease
    Katarzyna Adamczuk
    Laboratory for Cognitive Neurology, KU Leuven, Herestraat 49, 3000, Leuven, Belgium
    Alzheimers Res Ther 7:75. 2015
    ....
  30. doi request reprint Amyloid imaging in cognitively normal older adults: comparison between (18)F-flutemetamol and (11)C-Pittsburgh compound B
    Katarzyna Adamczuk
    Laboratory for Cognitive Neurology, KU Leuven, Herestraat 49, 3000, Leuven, Belgium
    Eur J Nucl Med Mol Imaging 43:142-51. 2016
    ..In a prospective community-recruited cohort of cognitively intact older adults, we compared two amyloid imaging markers within subjects: (18)F-flutemetamol and (11)C-Pittsburgh compound B (PIB)...
  31. pmc Reproducibility and robustness of graph measures of the associative-semantic network
    Yu Wang
    Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Leuven, Belgium
    PLoS ONE 9:e115215. 2014
    ..4) when using subject specific networks and this will allow us to relate network properties to individual subject information. ..
  32. doi request reprint Right hemisphere recruitment during language processing in frontotemporal lobar degeneration and Alzheimer's disease
    Natalie Nelissen
    Laboratory for Cognitive Neurology, Leuven Research Institute for Neurodegenerative Disorders, K U Leuven, Leuven, Belgium
    J Mol Neurosci 45:637-47. 2011
    ..Right-hemispheric recruitment and disconnections within the right temporal lobe may affect the degree of aphasia in cortical neurodegenerative disease...
  33. doi request reprint Functional Changes in the Language Network in Response to Increased Amyloid β Deposition in Cognitively Intact Older Adults
    Katarzyna Adamczuk
    Laboratory for Cognitive Neurology, KU Leuven, Belgium Alzheimer Research Centre KU Leuven, Leuven Institute of Neurodegenerative Disorders, KU Leuven, Belgium
    Cereb Cortex 26:358-73. 2016
    ..A binary classification into amyloid-positive and amyloid-negative cases confirmed our findings. The left posterior temporal activity increase may reflect higher demands for semantic control in the presence of a higher amyloid burden...
  34. doi request reprint Left perirhinal cortex codes for similarity in meaning between written words: Comparison with auditory word input
    Antonietta Gabriella Liuzzi
    Laboratory for Cognitive Neurology, Department of Neurosciences, University of Leuven, Belgium
    Neuropsychologia 76:4-16. 2015
    ..Our findings situate the contribution of left perirhinal cortex to word processing at the top of the visual processing pathway, rather than at an amodal stage where visual and auditory word processing pathways have already converged. ..
  35. doi request reprint Noun and knowledge retrieval for biological and non-biological entities following right occipitotemporal lesions
    Rose Bruffaerts
    Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Belgium Neurology Department, University Hospitals Leuven, Leuven, Belgium
    Neuropsychologia 62:163-74. 2014
    ..Second, dissociations along the dimension of attribute type during feature generation do not co-occur with category-specificity during naming in the current patient sample. ..
  36. doi request reprint Chronometry of word and picture identification: common and modality-specific effects
    Leen Van Doren
    Laboratory for Cognitive Neurology, Katholieke Universiteit Leuven, Belgium
    Neuroimage 59:3701-12. 2012
    ..Our findings are in line with a model where the initial stages of perceptual identification and visual short-term memory access rely on long-distance connections that are shared between written words and pictures...
  37. pmc 3D Shape Perception in Posterior Cortical Atrophy: A Visual Neuroscience Perspective
    Celine R Gillebert
    Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, 3000 Leuven, Belgium, Department of Experimental Psychology, University of Oxford, Oxford OX1 3UD, United Kingdom
    J Neurosci 35:12673-92. 2015
    ..However, in DLBD, 3D shape deficits rely on mechanisms distinct from inferior temporal structural integrity...
  38. doi request reprint Attentional priorities and access to short-term memory: parietal interactions
    Celine R Gillebert
    Laboratory for Cognitive Neurology, KU Leuven, Herestraat 49 Box 1022, 3000 Leuven, Belgium
    Neuroimage 62:1551-62. 2012
    ..Our study reconciles the role of middle IPS in attentional selection and biased competition with its role in VSTM access...
  39. doi request reprint The amodal system for conscious word and picture identification in the absence of a semantic task
    Leen Van Doren
    Cognitive Neurology Laboratory, Experimental Neurology Section, K U Leuven, Belgium
    Neuroimage 49:3295-307. 2010
    ..The amodal nature of left OTS and IFS involvement in word and picture processing extends to tasks with minimal semantic executive demands...
  40. ncbi request reprint Maintaining and shifting attention within left or right hemifield
    R Vandenberghe
    Laboratorium voor Neuroen Psychofysiologie, Katholieke Universiteit Leuven, Belgium
    Cereb Cortex 10:706-13. 2000
    ..The current experiment confirms that left frontal convexity is sensitive to manipulations of the direction of visuospatial attention. The results do not indicate a specific role of parietal cortex in attentional shifting...
  41. doi request reprint The interest of amyloid PET imaging in the diagnosis of Alzheimer's disease
    Rik Vandenberghe
    aLaboratory for Cognitive Neurology, Department of Neurosciences, University of Leuven bNeurology Department, University Hospitals Leuven cAlzheimer Research Centre KU Leuven, Leuven Institute for Neuroscience and Disease, University of Leuven, dNuclear Medicine and Molecular Imaging, University Hospitals and University of Leuven, Leuven, Belgium
    Curr Opin Neurol 26:646-55. 2013
    ..This review evaluates the potential clinical utility of amyloid imaging...
  42. ncbi request reprint Symptomatic internal carotid artery dissecting pseudoaneurysm: endovascular treatment by stent-graft
    Sam Heye
    Department of Radiology, University Hospitals Gasthuisberg, Herestraat 49, B 3000 Leuven, Belgium
    Cardiovasc Intervent Radiol 28:499-501. 2005
    ..Placement of a coronary stent-graft resulted in immediate complete resolution of clinical symptoms and radiologic restoration of normal flow...
  43. ncbi request reprint Human brain activity related to speed discrimination tasks
    G A Orban
    Laboratorium voor Neuro en Psychofysiologie, KULeuven, Medical School, Campus Gasthuisberg, Belgium
    Exp Brain Res 122:9-22. 1998
    ..These results confirm that processing in the human visual cortex is task dependent and underscore the role of the middle fusiform gyrus in temporal comparison of simple attributes...
  44. doi request reprint Functional dissociation between anterior temporal lobe and inferior frontal gyrus in the processing of dynamic body expressions: Insights from behavioral variant frontotemporal dementia
    Jan Jastorff
    Laboratory for Translational Neuropsychiatry, Division of Psychiatry, Department of Neurosciences, KU Leuven, Belgium
    Hum Brain Mapp 37:4472-4486. 2016
    ..In bvFTD, communication between the networks is reduced, indicating one possible cause underlying the behavioral symptoms. Hum Brain Mapp 37:4472-4486, 2016. © 2016 Wiley Periodicals, Inc...
  45. pmc Face shape and face identity processing in behavioral variant fronto-temporal dementia: A specific deficit for familiarity and name recognition of famous faces
    François Laurent De Winter
    Laboratory for Translational Neuropsychiatry, Research Group Psychiatry, Department of Neurosciences, KU Leuven, Leuven, Belgium Department of Old Age Psychiatry, University Hospitals Leuven, Leuven, Belgium
    Neuroimage Clin 11:368-77. 2016
    ..These findings extent previous results by documenting the involvement of the left anterior temporal lobe (ATL) in familiarity detection and the right ATL in name recognition deficits in fronto-temporal lobar degeneration. ..
  46. doi request reprint Right fusiform response patterns reflect visual object identity rather than semantic similarity
    Rose Bruffaerts
    Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Belgium Neurology Department, University Hospitals Leuven, Leuven, Belgium
    Neuroimage 83:87-97. 2013
    ....
  47. ncbi request reprint Location- or feature-based targeting of peripheral attention
    R Vandenberghe
    Cognitive Neurology and Alzheimer's Disease Center, Northwestern University Medical School, Chicago, Illinois, USA
    Neuroimage 14:37-47. 2001
    ..Its relatively equal activation for leftward and rightward attentional shifts is also consistent with models of right hemispheric dominance of spatial attention...
  48. ncbi request reprint Comparison of Different Generalizations of Clustering Coefficient and Local Efficiency for Weighted Undirected Graphs
    Yu Wang
    Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Leuven 3000, Belgium
    Neural Comput . 2016
    ..Depending on the application and the relative importance of sensitivity and robustness to noise, other generalizations may be selected on the basis of the properties investigated in this letter...
  49. doi request reprint Reduced expression of hsa-miR-27a-3p in CSF of patients with Alzheimer disease
    Carlo Sala Frigerio
    From the VIB Center for the Biology of Disease C S F, P L, E S, B D S, Leuven Center for Human Genetics and LIND C S F, P L, E S, B D S, and Alzheimer Research Centre KU Leuven, Leuven Institute for Neuroscience and Disease R V, University of Leuven Geriatric Medicine J T, and Neurology Department R V, University Hospitals Leuven Department of Clinical and Experimental Medicine and LIND J T, Laboratory for Cognitive Neurology, Department of Neurosciences R V, KU Leuven, Belgium Netherlands Institute for Neuroscience K B, Amsterdam, the Netherlands Clinical Neurochemistry Laboratory A W, M B, H Z, K B, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Molndal, Sweden and UCL Institute of Neurology H Z, Queen Square, London, UK
    Neurology 81:2103-6. 2013
    ..We evaluated microRNAs (miRNAs) as potential biomarkers for Alzheimer disease (AD) by analyzing the expression level of miRNAs in CSF of patients with AD dementia and nonaffected control subjects...
  50. doi request reprint Impaired recognition of body expressions in the behavioral variant of frontotemporal dementia
    Jan van den Stock
    Laboratory for Translational Neuropsychiatry, Research Group Psychiatry, Department of Neurosciences, KU Leuven and Old Age Psychiatry, University Hospitals Leuven, Leuven, Belgium Electronic address
    Neuropsychologia 75:496-504. 2015
    ..The results are in line with a supramodal emotion recognition deficit in bvFTD. ..
  51. ncbi request reprint BACE1 levels correlate with phospho-tau levels in human cerebrospinal fluid
    Soraia Barão
    VIB Center for the Biology of Disease and Center for Human Genetics, KULeuven, Herestraat 49, 3000 Leuven, Belgium
    Curr Alzheimer Res 10:671-8. 2013
    ..BACE1 levels in CSF were well correlated with total-tau and hyperphosphorylated tau levels in the CSF, suggesting that the recorded alterations in BACE1 levels correlate with cell death and neurodegeneration. ..
  52. doi request reprint Autoimmune-mediated encephalitis
    Philippe Demaerel
    Department of Radiology, University Hospitals K U Leuven, Herestraat 49, 3000 Leuven, Belgium
    Neuroradiology 53:837-51. 2011
    ..This report is based on a review of the literature (except the literature in Japanese) and own findings in patients with autoimmune-mediated encephalitis...
  53. ncbi request reprint Functional specificity of superior parietal mediation of spatial shifting
    R Vandenberghe
    Cognitive Neurology and Alzheimer's Disease Center, Northwestern University Medical School, Chicago, Illinois, USA
    Neuroimage 14:661-73. 2001
    ..The response to spatial shifts and the correlation with the distance between the original and the new location points to a specific role of the superior parietal gyrus in shifting the locus of spatial attention...
  54. ncbi request reprint No Association of Lower Hippocampal Volume With Alzheimer's Disease Pathology in Late-Life Depression
    François Laurent De Winter
    From the Department of Old Age Psychiatry, University Psychiatric Center, KU Leuven, Belgium Translational MRI, Department of Imaging and Pathology, KU Leuven, and Radiology, University Hospitals Leuven Research and Development, icoMetrix, Leuven GE Healthcare, London University Psychiatric Center, KU Leuven, and Academic Center for ECT and Neuromodulation, Kortenberg, Belgium Laboratory for Cognitive Neurology, KU Leuven the Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston the Department of Neurology, University Hospitals Leuven Nuclear Medicine and Molecular Imaging, Department of Imaging and Pathology, KU Leuven and University Hospitals Leuven
    Am J Psychiatry . 2016
    ..The purpose of this prospective study was to examine whether lower hippocampal volume in late-life depression is associated with Alzheimer's disease pathology...
  55. doi request reprint The spectrum of epilepsy caused by POLG mutations
    Wouter Janssen
    Department of Neurology, University Hospitals Leuven, Herestraat 49, 3000, Louvain, Belgium
    Acta Neurol Belg 116:17-25. 2016
    ..Refractory OLE and SE in a patient with polyneuropathy, ataxia, PEO or migraine warrant screening for POLG mutations. In this clinical setting, valproate should not be given in view of the risk of fatal hepatotoxicity...
  56. pmc Covert shifts of spatial attention in the macaque monkey
    Natalie Caspari
    Laboratory for Neuro and Psychophysiology, KU Leuven Medical School, 3000 Leuven, Belgium, Laboratory for Cognitive Neurology, Neurosciences Department, KU Leuven, 3000 Leuven, Belgium
    J Neurosci 35:7695-714. 2015
    ....
  57. ncbi request reprint Language, ageing and neurodegenerative disease
    R Vandenberghe
    Memory Clinic, Department of Neurology, University Hospital Gasthuisberg, Leuven, Belgium
    Bull Mem Acad R Med Belg 159:161-6. 2004
    ....
  58. ncbi request reprint Mutations other than null mutations producing a pathogenic loss of progranulin in frontotemporal dementia
    Julie van der Zee
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerpen, Belgium
    Hum Mutat 28:416. 2007
    ..Our findings extend the mutation spectrum in PGRN leading to loss of functional PGRN as the basis for FTD...
  59. ncbi request reprint Alzheimer and Parkinson diagnoses in progranulin null mutation carriers in an extended founder family
    Nathalie Brouwers
    VIB Department of Molecular Genetics, Neurodegenerative Brain Diseases Group, University of Antwerp CDE, Universiteitsplein 1, BE 2610 Antwerpen, Belgium
    Arch Neurol 64:1436-46. 2007
    ..Progranulin gene (PGRN) haploinsufficiency was recently associated with ubiquitin-positive frontotemporal lobar degeneration linked to chromosome 17q21 (FTLDU-17)...
  60. ncbi request reprint Reversible posterior leucoencephalopathy during oral treatment with methotrexate
    Dimitri Renard
    J Neurol 251:226-8. 2004
  61. ncbi request reprint Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21
    Marc Cruts
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, Universiteitsplein 1, BE 2610 Antwerpen, Belgium
    Nature 442:920-4. 2006
    ..Furthermore, in a Belgian series of familial FTD patients, PGRN mutations were 3.5 times more frequent than mutations in MAPT, underscoring a principal involvement of PGRN in FTD pathogenesis...