Robert J Paridaens

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. pmc The Gene expression Grade Index: a potential predictor of relapse for endocrine-treated breast cancer patients in the BIG 1-98 trial
    Christine Desmedt
    Institut Jules Bordet, , Brussels, Belgium
    BMC Med Genomics 2:40. 2009
  2. ncbi request reprint Promising results with exemestane in the first-line treatment of metastatic breast cancer: a randomized phase II EORTC trial with a tamoxifen control
    R Paridaens
    Universitair Ziekenhuis Gasthuisberg, Leuven, Belgium
    Clin Breast Cancer 1:S19-21. 2000
  3. pmc Adjuvant! Online estimation of chemotherapy effectiveness when added to ovarian function suppression plus tamoxifen for premenopausal women with estrogen-receptor-positive breast cancer
    Robert J Paridaens
    Department of Medical Oncology, University Hospital Gasthuisberg, Catholic University of Leuven, Herestraat 49, 3000 Leuven, Belgium
    Breast Cancer Res Treat 123:303-10. 2010
  4. pmc Phase III study comparing exemestane with tamoxifen as first-line hormonal treatment of metastatic breast cancer in postmenopausal women: the European Organisation for Research and Treatment of Cancer Breast Cancer Cooperative Group
    Robert J Paridaens
    University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    J Clin Oncol 26:4883-90. 2008
  5. doi request reprint Phase I/II pharmacokinetic study of pemetrexed and epirubicin in patients with locally advanced or metastatic breast cancer
    Robert Paridaens
    Universitair Ziekenhuis Gasthuisberg, Katholieke Universiteit Leuven, Belgium
    Clin Breast Cancer 7:861-6. 2007
  6. ncbi request reprint A randomized phase II study of alternating and sequential regimens of docetaxel and doxorubicin as first-line chemotherapy for metastatic breast cancer
    R Paridaens
    University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    Ann Oncol 14:433-40. 2003
  7. doi request reprint Axillary lymph node status of operable breast cancers by combined steroid receptor and HER-2 status: triple positive tumours are more likely lymph node positive
    Ben Van Calster
    Multidisciplinary Breast Centre, UZ Leuven, Herestraat 49, 3000 Leuven, Belgium
    Breast Cancer Res Treat 113:181-7. 2009
  8. ncbi request reprint Taxanes in elderly breast cancer patients
    Hans Wildiers
    Department of Oncology, University Hospital Gasthuisberg, Catholic University of Leuven, Herestraat 49, Leuven B 3000, Belgium
    Cancer Treat Rev 30:333-42. 2004
  9. doi request reprint Relationship between age and axillary lymph node involvement in women with breast cancer
    Hans Wildiers
    Multidisciplinary Breast Centre and Department of General Medical Oncology, University Hospitals Leuven, Leuven, Belgium
    J Clin Oncol 27:2931-7. 2009
  10. doi request reprint Polysomy 17 in breast cancer: clinicopathologic significance and impact on HER-2 testing
    Isabelle Vanden Bempt
    Department of Pathology, Katholieke Universiteit Leuven, Leuven, Belgium
    J Clin Oncol 26:4869-74. 2008

Collaborators

Detail Information

Publications30

  1. pmc The Gene expression Grade Index: a potential predictor of relapse for endocrine-treated breast cancer patients in the BIG 1-98 trial
    Christine Desmedt
    Institut Jules Bordet, , Brussels, Belgium
    BMC Med Genomics 2:40. 2009
    ..Validation of these results, in a larger series from BIG 1-98, is planned using the simplified GGI represented by a smaller set of genes and tested by qRT-PCR on paraffin-embedded tissues...
  2. ncbi request reprint Promising results with exemestane in the first-line treatment of metastatic breast cancer: a randomized phase II EORTC trial with a tamoxifen control
    R Paridaens
    Universitair Ziekenhuis Gasthuisberg, Leuven, Belgium
    Clin Breast Cancer 1:S19-21. 2000
    ..Based on these encouraging results, a phase III trial will compare EXE and TAM...
  3. pmc Adjuvant! Online estimation of chemotherapy effectiveness when added to ovarian function suppression plus tamoxifen for premenopausal women with estrogen-receptor-positive breast cancer
    Robert J Paridaens
    Department of Medical Oncology, University Hospital Gasthuisberg, Catholic University of Leuven, Herestraat 49, 3000 Leuven, Belgium
    Breast Cancer Res Treat 123:303-10. 2010
    ....
  4. pmc Phase III study comparing exemestane with tamoxifen as first-line hormonal treatment of metastatic breast cancer in postmenopausal women: the European Organisation for Research and Treatment of Cancer Breast Cancer Cooperative Group
    Robert J Paridaens
    University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    J Clin Oncol 26:4883-90. 2008
    ....
  5. doi request reprint Phase I/II pharmacokinetic study of pemetrexed and epirubicin in patients with locally advanced or metastatic breast cancer
    Robert Paridaens
    Universitair Ziekenhuis Gasthuisberg, Katholieke Universiteit Leuven, Belgium
    Clin Breast Cancer 7:861-6. 2007
    ..Pemetrexed and epirubicin are each active in patients with advanced/metastatic breast cancer (MBC). This phase I/II study evaluated these drugs as a combination regimen...
  6. ncbi request reprint A randomized phase II study of alternating and sequential regimens of docetaxel and doxorubicin as first-line chemotherapy for metastatic breast cancer
    R Paridaens
    University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    Ann Oncol 14:433-40. 2003
    ..This phase II study evaluated the feasibility and efficacy of alternating and sequential regimens of docetaxel and doxorubicin as first-line chemotherapy for metastatic breast cancer (MBC)...
  7. doi request reprint Axillary lymph node status of operable breast cancers by combined steroid receptor and HER-2 status: triple positive tumours are more likely lymph node positive
    Ben Van Calster
    Multidisciplinary Breast Centre, UZ Leuven, Herestraat 49, 3000 Leuven, Belgium
    Breast Cancer Res Treat 113:181-7. 2009
    ..To examine the frequency of axillary lymph node (ALN) invasion of operable breast cancers by their combined oestrogen receptor (ER), progesterone receptor (PR) and HER-2 status...
  8. ncbi request reprint Taxanes in elderly breast cancer patients
    Hans Wildiers
    Department of Oncology, University Hospital Gasthuisberg, Catholic University of Leuven, Herestraat 49, Leuven B 3000, Belgium
    Cancer Treat Rev 30:333-42. 2004
    ..In general however, weekly taxanes are a reasonable option for older patients with metastatic breast cancer...
  9. doi request reprint Relationship between age and axillary lymph node involvement in women with breast cancer
    Hans Wildiers
    Multidisciplinary Breast Centre and Department of General Medical Oncology, University Hospitals Leuven, Leuven, Belgium
    J Clin Oncol 27:2931-7. 2009
    ..To study the relation between the presence of axillary lymph node (LN) involvement and age in breast cancer...
  10. doi request reprint Polysomy 17 in breast cancer: clinicopathologic significance and impact on HER-2 testing
    Isabelle Vanden Bempt
    Department of Pathology, Katholieke Universiteit Leuven, Leuven, Belgium
    J Clin Oncol 26:4869-74. 2008
    ..We investigated the impact of polysomy 17 on HER-2 testing and studied its clinicopathologic significance in relation to HER2 gene amplification...
  11. ncbi request reprint Fulvestrant (Faslodex) in advanced breast cancer: clinical experience from a Belgian cooperative study
    Patrick Neven
    Multidisciplinary Breast Centre and Gynaecological Oncology, UZ KULeuven, Leuven, Belgium
    Breast Cancer Res Treat 109:59-65. 2008
    ....
  12. ncbi request reprint Postoperative adjuvant chemotherapy followed by adjuvant tamoxifen versus nil for patients with operable breast cancer: a randomised phase III trial of the European Organisation for Research and Treatment of Cancer Breast Group
    Leilani Morales
    University Hospital Gasthuisberg, Leuven, Belgium
    Eur J Cancer 43:331-40. 2007
    ..We investigated the impact of tamoxifen, given sequentially after completion of adjuvant chemotherapy in patients with operable breast cancer...
  13. doi request reprint Weekly paclitaxel versus weekly docetaxel in elderly or frail patients with metastatic breast carcinoma: a randomized phase-II study of the Belgian Society of Medical Oncology
    Benoit Beuselinck
    Medical Oncology Department, Catholic University Leuven, University Hospitals Leuven, Herestraat 49, Leuven, Belgium
    Crit Rev Oncol Hematol 75:70-7. 2010
    ..They display different, but acceptable toxicity profiles, with levels of antitumoral efficacy comparable to those previously reported for 3-weekly regimens...
  14. ncbi request reprint Proteases and metastasis: clinical relevance nowadays?
    Julie Decock
    Laboratory for Experimental Oncology, Department of General Medical Oncology, University Hospital Gasthuisberg, Leuven, Belgium
    Curr Opin Oncol 17:545-50. 2005
    ..This article reviews the developments during the last year in this field...
  15. doi request reprint Qualitative assessment of the progesterone receptor and HER2 improves the Nottingham Prognostic Index up to 5 years after breast cancer diagnosis
    Vanya Van Belle
    Department of Electrical Engineering, Katholieke Universiteit Leuven, Kasteelpark Arenber, 10 2446, B 3001 Leuven, Belgium
    J Clin Oncol 28:4129-34. 2010
    ....
  16. ncbi request reprint Safety and efficacy of weekly docetaxel in frail and/or elderly patients with metastatic breast cancer: a phase II study
    Randal D'hondt
    Department of Oncology, University Hospital Gasthuisberg, Catholic University of Leuven, Leuven, Belgium
    Anticancer Drugs 15:341-6. 2004
    ....
  17. doi request reprint Triple-negative breast cancer
    Gert Stockmans
    Department of Internal Medicine, University Hospital Gasthuisberg, Herestraat, Leuven, Belgium
    Curr Opin Oncol 20:614-20. 2008
    ..We would like to describe recent pathological and genetic advancements and their possible implications on the development of new treatment strategies...
  18. pmc Plasma MMP1 and MMP8 expression in breast cancer: protective role of MMP8 against lymph node metastasis
    Julie Decock
    Laboratory for Experimental Oncology LEO, K, U, Leuven, Campus University Hospital Gasthuisberg, O and N1 bus 815, Herestraat 49, 3000 Leuven, Belgium
    BMC Cancer 8:77. 2008
    ..Elevated levels of matrix metalloproteinases have been found to associate with poor prognosis in various carcinomas. This study aimed at evaluating plasma levels of MMP1, MMP8 and MMP13 as diagnostic and prognostic markers of breast cancer...
  19. ncbi request reprint Detection of micrometastatic disease and monitoring of perioperative tumor cell dissemination in primary operable breast cancer patients using real-time quantitative reverse transcription-PCR
    Mohamed Saad Ismail
    Universitair Ziekenhuis Gasthuisberg, Leuven, Belgium and National Cancer Institute, Cairo, Egypt
    Clin Cancer Res 10:196-201. 2004
    ..We aimed to apply the technique on bone marrow (BM) of primary operable BC patients. Pre- and postoperative PB samples of these patients were further analyzed to investigate possible shedding of CK19+ cells during the operation...
  20. doi request reprint Prospective assessment of the endometrium in postmenopausal breast cancer patients treated with fulvestrant
    Leilani Morales
    Department of Medical Oncology, University Hospital Gasthuisberg, Leuven, Belgium
    Breast Cancer Res Treat 117:77-81. 2009
    ..Furthermore, no new uterine pathologies were detected, indicating that fulvestrant behaves as a pure antiestrogen at the uterine level...
  21. doi request reprint Strain rate imaging detects early cardiac effects of pegylated liposomal Doxorubicin as adjuvant therapy in elderly patients with breast cancer
    Ruxandra Jurcut
    Department of Cardiovascular Diseases, University Hospital Gasthuisberg, KU Leuven, Leuven, Belgium
    J Am Soc Echocardiogr 21:1283-9. 2008
    ..Doppler myocardial imaging-based velocity, strain, and strain rate measurements have been shown to sensitively quantify abnormalities in cardiac function in other settings...
  22. doi request reprint Prospective study to assess short-term intra-articular and tenosynovial changes in the aromatase inhibitor-associated arthralgia syndrome
    Leilani Morales
    Department of Obstetrics and Gynecology, Division of Gynecological Oncology, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    J Clin Oncol 26:3147-52. 2008
    ..To date, its exact mechanism remains unclear. The purpose of this study was to investigate the changes in clinical rheumatologic features and magnetic resonance imaging (MRI) of hands and wrists in AI and tamoxifen users...
  23. ncbi request reprint Acute effects of tamoxifen and third-generation aromatase inhibitors on menopausal symptoms of breast cancer patients
    Leilani Morales
    Department of Medical Oncology, University Hospitals, Leuven, Belgium
    Anticancer Drugs 15:753-60. 2004
    ..Our results underscore the need for safe and effective non-hormonal interventions to alleviate vasomotor and musculoskeletal symptoms which were the most prevalent and severe symptoms...
  24. doi request reprint A pilot study to investigate the feasibility and cardiac effects of pegylated liposomal doxorubicin (PL-DOX) as adjuvant therapy in medically fit elderly breast cancer patients
    Hans Wildiers
    Multidisciplinary Breast Centre, University Hospital Gasthuisberg, KU Leuven, Belgium
    Crit Rev Oncol Hematol 67:133-8. 2008
    ..SRI may be a useful tool in the follow-up of elderly patients treated with anthracyclines, allowing early initiation of preventive measures in order to prevent further irreversible cardiac damage...
  25. ncbi request reprint Association of matrix metalloproteinase-8 gene variation with breast cancer prognosis
    Julie Decock
    Laboratory for Experimental Oncology, Department of General Medical Oncology, University Hospital Gasthuisberg, Leuven, Belgium
    Cancer Res 67:10214-21. 2007
    ..The data suggest that MMP8 gene variation may influence breast cancer prognosis and support the notion that MMP8 has an inhibitory effect on cancer metastasis...
  26. ncbi request reprint Intra-hepatic Mitomycin C bolus infusion in the treatment of extensive liver metastases of breast cancer
    Toon Maes
    Department of General Medical Oncology, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    Breast Cancer Res Treat 110:135-42. 2008
    ..In the treatment of extensive liver metastasis of breast cancer (LMBC), locally administered Mitomycin C (MMC) to the liver might be an effective approach with limited toxicity...
  27. ncbi request reprint Choosing between an aromatase inhibitor and tamoxifen in the adjuvant setting
    Leilani Morales
    Department of Medical Oncology, University Hospital Gasthuisberg, Leuven, Belgium
    Curr Opin Oncol 17:559-65. 2005
    ..In making a choice between the use of an aromatase inhibitor or tamoxifen in the adjuvant setting, a careful analysis of both the efficacy data and toxicity profiles of each drug is essential...
  28. doi request reprint Detection and monitoring of cardiotoxicity-what does modern cardiology offer?
    Ruxandra Jurcut
    Department of Cardiology, University Hospital Gasthuisberg, Catholic University Leuven, Herestraat 49, 3000, Leuven, Belgium
    Support Care Cancer 16:437-45. 2008
    ..This parameter is, however, insensitive to subtle changes in myocardial function as they occur in early cardiotoxicity...
  29. ncbi request reprint Debilitating musculoskeletal pain and stiffness with letrozole and exemestane: associated tenosynovial changes on magnetic resonance imaging
    Leilani Morales
    Department of General Medical Oncology, University Hospital Gasthuisberg, Katholieke Universiteit Leuven, Leuven, Belgium
    Breast Cancer Res Treat 104:87-91. 2007
    ..However, the pathogenesis and anatomic correlate of musculoskeletal pains have not been thoroughly evaluated. Moreover, the impact of AI-induced musculoskeletal symptoms on normal daily functioning needs to be further explored...
  30. doi request reprint Letrozole compared with tamoxifen for elderly patients with endocrine-responsive early breast cancer: the BIG 1-98 trial
    Diana Crivellari
    IBCSG Coordinating Center, Effingerstrasse 40, CH 3008 Bern, Switzerland
    J Clin Oncol 26:1972-9. 2008
    ..To explore potential differences in efficacy, treatment completion, and adverse events (AEs) in elderly women receiving adjuvant tamoxifen or letrozole for five years in the Breast International Group (BIG) 1-98 trial...