Robin Lemmens

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. doi Network meta-analysis: simultaneous meta-analysis of common antiplatelet regimens after transient ischaemic attack or stroke
    Vincent Thijs
    Department of Neurology, University Hospitals Leuven, VIB Herestraat 49, 3000 Leuven, Belgium
    Eur Heart J 29:1086-92. 2008
  2. ncbi Overexpression of mutant superoxide dismutase 1 causes a motor axonopathy in the zebrafish
    Robin Lemmens
    Department of Neurology, University Hospital Gasthuisberg, K U Leuven, Belgium
    Hum Mol Genet 16:2359-65. 2007
  3. pmc Variant on 9p21 strongly associates with coronary heart disease, but lacks association with common stroke
    Robin Lemmens
    Department of Neurology, University Hospitals Leuven, Leuven, Belgium
    Eur J Hum Genet 17:1287-93. 2009
  4. doi Is there a decline in the vascular event rate after transient ischemic attack or stroke in antiplatelet trials?
    Robin Lemmens
    Department of Neurology, University Hospitals Leuven, Belgium
    Cerebrovasc Dis 28:439-47. 2009
  5. doi The association of the 4q25 susceptibility variant for atrial fibrillation with stroke is limited to stroke of cardioembolic etiology
    Robin Lemmens
    Department of Neurology and Laboratory for Neurobiology, Section of Experimental Neurology, School of Medicine, University of Leuven, Belgium
    Stroke 41:1850-7. 2010
  6. doi Microbleeds and the risk of recurrent stroke
    Vincent Thijs
    Department of Neurology, Vesalius Research Center, University Hospitals, Herestraat 49, B3000 Leuven, Belgium
    Stroke 41:2005-9. 2010
  7. ncbi EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans
    Annelies Van Hoecke
    Laboratory of Neurobiology, Vesalius Research Center, VIB, Leuven, Belgium
    Nat Med 18:1418-22. 2012
  8. pmc Association Between Time From Stroke Onset and Fluid-Attenuated Inversion Recovery Lesion Intensity Is Modified by Status of Collateral Circulation
    Anke Wouters
    From the Department of Neurosciences, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease LIND, KU Leuven University of Leuven, Leuven, Belgium A W, R L Laboratory of Neurobiology, VIB, Vesalius Research Center, Leuven, Belgium A W, R L Department of Neurology, University Hospitals Leuven, Leuven, Belgium A W, R L Laboratory for Cognitive Neurology, KU Leuven, Leuven, Belgium P D Department of Neurology, Stroke Center, Stanford University, Palo Alto, CA S C, G A Section of Neurology, Department of Clinical Sciences, Lund University, Lund, Sweden B N Guided Development GmbH, Heidelberg, Germany R L Uinversitätsklinikum Hamburg Eppendorf, Klinik und Poliklinik fur Neurologie, Kopf und Neurozentrum, Hamburg, Germany G T and Department of Neurology Austin Health, Melbourne Brain Center, Florey Institute of Neuroscience and Mental Health, Heidelberg, Australia V T
    Stroke 47:1018-22. 2016
  9. doi Modifying expression of EphA4 and its downstream targets improves functional recovery after stroke
    Robin Lemmens
    Laboratory of Neurobiology, Vesalius Research Center, VIB, Leuven, Belgium
    Hum Mol Genet 22:2214-20. 2013
  10. pmc Polymorphisms in the GluR2 gene are not associated with amyotrophic lateral sclerosis
    Elke Bogaert
    Laboratory for Neurobiology, Experimental Neurology, University of Leuven, Leuven, Belgium
    Neurobiol Aging 33:418-20. 2012

Collaborators

Detail Information

Publications24

  1. doi Network meta-analysis: simultaneous meta-analysis of common antiplatelet regimens after transient ischaemic attack or stroke
    Vincent Thijs
    Department of Neurology, University Hospitals Leuven, VIB Herestraat 49, 3000 Leuven, Belgium
    Eur Heart J 29:1086-92. 2008
    ..Network meta-analysis could be used to synthesize accumulating evidence from clinical trials in a broad range of vascular disorders...
  2. ncbi Overexpression of mutant superoxide dismutase 1 causes a motor axonopathy in the zebrafish
    Robin Lemmens
    Department of Neurology, University Hospital Gasthuisberg, K U Leuven, Belgium
    Hum Mol Genet 16:2359-65. 2007
    ....
  3. pmc Variant on 9p21 strongly associates with coronary heart disease, but lacks association with common stroke
    Robin Lemmens
    Department of Neurology, University Hospitals Leuven, Leuven, Belgium
    Eur J Hum Genet 17:1287-93. 2009
    ..The risk variant on chromosome 9, tagged by rs10757278, is associated with coronary heart disease in the Belgian population, but not with isolated CVD. These findings suggest different pathogenic mechanisms in CAD versus CVD...
  4. doi Is there a decline in the vascular event rate after transient ischemic attack or stroke in antiplatelet trials?
    Robin Lemmens
    Department of Neurology, University Hospitals Leuven, Belgium
    Cerebrovasc Dis 28:439-47. 2009
    ....
  5. doi The association of the 4q25 susceptibility variant for atrial fibrillation with stroke is limited to stroke of cardioembolic etiology
    Robin Lemmens
    Department of Neurology and Laboratory for Neurobiology, Section of Experimental Neurology, School of Medicine, University of Leuven, Belgium
    Stroke 41:1850-7. 2010
    ..However, it remains unclear whether 4q25 associates with all the stroke subtypes or with cardioembolic stroke in particular, which is often attributable to atrial fibrillation...
  6. doi Microbleeds and the risk of recurrent stroke
    Vincent Thijs
    Department of Neurology, Vesalius Research Center, University Hospitals, Herestraat 49, B3000 Leuven, Belgium
    Stroke 41:2005-9. 2010
    ..We studied the risk of recurrent cerebrovascular events in patients who had a transient ischemic attack or ischemic stroke and who had evidence of microbleeds on MRI...
  7. ncbi EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans
    Annelies Van Hoecke
    Laboratory of Neurobiology, Vesalius Research Center, VIB, Leuven, Belgium
    Nat Med 18:1418-22. 2012
    ..This suggests that Epha4 generically modulates the vulnerability of (motor) neurons to axonal degeneration and may represent a new target for therapeutic intervention...
  8. pmc Association Between Time From Stroke Onset and Fluid-Attenuated Inversion Recovery Lesion Intensity Is Modified by Status of Collateral Circulation
    Anke Wouters
    From the Department of Neurosciences, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease LIND, KU Leuven University of Leuven, Leuven, Belgium A W, R L Laboratory of Neurobiology, VIB, Vesalius Research Center, Leuven, Belgium A W, R L Department of Neurology, University Hospitals Leuven, Leuven, Belgium A W, R L Laboratory for Cognitive Neurology, KU Leuven, Leuven, Belgium P D Department of Neurology, Stroke Center, Stanford University, Palo Alto, CA S C, G A Section of Neurology, Department of Clinical Sciences, Lund University, Lund, Sweden B N Guided Development GmbH, Heidelberg, Germany R L Uinversitätsklinikum Hamburg Eppendorf, Klinik und Poliklinik fur Neurologie, Kopf und Neurozentrum, Hamburg, Germany G T and Department of Neurology Austin Health, Melbourne Brain Center, Florey Institute of Neuroscience and Mental Health, Heidelberg, Australia V T
    Stroke 47:1018-22. 2016
    ..We hypothesized that collateral status as assessed by the hypoperfusion intensity ratio could modify the association between time from stroke onset and FLAIR lesion intensity...
  9. doi Modifying expression of EphA4 and its downstream targets improves functional recovery after stroke
    Robin Lemmens
    Laboratory of Neurobiology, Vesalius Research Center, VIB, Leuven, Belgium
    Hum Mol Genet 22:2214-20. 2013
    ..Our findings show that reduction of EphA4 improves motor function after experimental stroke and demonstrate that ROCK inhibition is a promising therapeutic strategy to enhance recovery after ischemic stroke...
  10. pmc Polymorphisms in the GluR2 gene are not associated with amyotrophic lateral sclerosis
    Elke Bogaert
    Laboratory for Neurobiology, Experimental Neurology, University of Leuven, Leuven, Belgium
    Neurobiol Aging 33:418-20. 2012
    ..We conclude that polymorphisms in the GluR2 gene (GRIA2) are not a major contributory factor in the pathogenesis of ALS...
  11. ncbi is leukoaraiosis on CT an accurate surrogate marker for the presence of microbleeds in acute stroke patients?
    Astrid Görner
    Department of Neurology, University Hospitals Leuven, Herestraat 49, B 3000, Leuven, Belgium
    J Neurol 254:284-9. 2007
    ..We assessed whether the presence of MB could be predicted from the extent of white matter disease (WMD) on computed tomography (CT)...
  12. doi Magnetic resonance imaging-based endovascular versus medical stroke treatment for symptom onset up to 12 h
    Anke Wouters
    KU Leuven University of Leuven, Department of Neurosciences, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease LIND, Leuven, Belgium VIB, Vesalius Research Center, Laboratory of Neurobiology, Leuven, Belgium University Hospitals Leuven, Department of Neurology, Leuven, Belgium
    Int J Stroke 11:127-33. 2016
    ..Imaging-based selection may identify a cohort with a favorable response to endovascular therapy, in an even later time window...
  13. pmc Novel COL4A1 mutations cause cerebral small vessel disease by haploinsufficiency
    Robin Lemmens
    Laboratory of Neurobiology, Vesalius Research Center, VIB, Leuven, Belgium
    Hum Mol Genet 22:391-7. 2013
    ..These findings suggest haploinsufficiency, a different mechanism from the commonly assumed dominant-negative effect, for COL4A1 mutations as a cause of (antenatal) intracerebral hemorrhage and white matter disease...
  14. ncbi Lipoprotein (a) and stroke: a meta-analysis of observational studies
    Barbara Smolders
    Department of Clinical and Experimental Neurology, University Hospitals Leuven, Leuven, Belgium
    Stroke 38:1959-66. 2007
    ..The relationship between elevated lipoprotein (a) levels[Lp(a)] and stroke is controversial. We systematically reviewed the literature to determine whether Lp(a) is a risk factor for stroke...
  15. ncbi Association of apolipoprotein E epsilon2 with white matter disease but not with microbleeds
    Robin Lemmens
    Department of Neurology, University Hospitals Leuven, Leuven, Belgium
    Stroke 38:1185-8. 2007
    ..We studied apoE alleles in relation to white matter disease and microbleeds in patients with transient ischemic attack or ischemic stroke...
  16. pmc Detection of Atrial Fibrillation Among Patients With Stroke Due to Large or Small Vessel Disease: A Meta-Analysis
    Jelle Demeestere
    Department of Neurology, University Hospitals Leuven, Leuven, Belgium
    J Am Heart Assoc 5:. 2016
    ..The utility of extended cardiac monitoring is uncertain among patients with stroke caused by small and large vessel disease. We conducted a meta-analysis to estimate the yield of AF detection in this population...
  17. doi Postpartum RCVS and PRES with normal initial imaging findings
    Robin Lemmens
    Laboratory for Neurobiology, Experimental Neurology, KU Leuven, and Vesalius Research Center, VIB, Leuven, Belgium
    Acta Neurol Belg 112:189-92. 2012
    ..This case underscores the complex and variable presentation of postpartum angiopathy and illustrates the diagnosis to be (re)considered even if cerebral vasoconstriction is not documented at the onset of symptoms...
  18. doi RNA metabolism and the pathogenesis of motor neuron diseases
    Robin Lemmens
    Department of Neurology University Hospitals Leuven and Laboratory for Neurobiology, Section of Experimental Neurology, School of Medicine, University of Leuven, Leuven, Belgium
    Trends Neurosci 33:249-58. 2010
    ..Therefore, here we review some of the recent data linking RNA metabolism and motor neuron disorders, but also critically assess their relevance for our understanding of the mechanism of neurodegeneration...
  19. doi Mechanical endovascular thrombectomy for acute ischemic stroke: a retrospective multicenter study in Belgium
    Niels Fockaert
    Department of Neurology, University Hospitals Leuven, 3000, Leuven, Belgium
    Acta Neurol Belg 116:7-14. 2016
    ..Rates of symptomatic intracranial hemorrhage are low and comparable to other cohort studies and clinical trials...
  20. pmc Deletion or Inhibition of the Oxygen Sensor PHD1 Protects against Ischemic Stroke via Reprogramming of Neuronal Metabolism
    Annelies Quaegebeur
    Laboratory of Angiogenesis and Neurovascular Link, Department of Oncology, University of Leuven, Leuven, Belgium Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, VIB, Leuven, Belgium
    Cell Metab 23:280-91. 2016
    ..These data identify PHD1 as a regulator of neuronal metabolism and a potential therapeutic target in ischemic stroke...
  21. pmc Effect of endovascular reperfusion in relation to site of arterial occlusion
    Robin Lemmens
    From KU Leuven, University of Leuven, Belgium, Department of Neurosciences, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease R L University Hospitals Leuven, Department of Neurology R L VIB, Vesalius Research Center, Laboratory of Neurobiology R L Stanford Stroke Center S A H, M P M, G W A, M G L, Stanford University of Medicine, CA Neurovascular Imaging Research Core and Department of Neurology and Comprehensive Stroke Center D S L, J L S, and Division of Interventional Neuroradiology, Department of Radiology, David Geffen School of Medicine R J, University of California, Los Angeles Departments of Radiology T A T and Neurology J P B, University of Cincinnati Medical Center, OH Departments of Clinical Neurosciences and Radiology A M D, Hotchkiss Brain Institute, Faculty of Medicine, University of Calgary, Canada Departments of Neurology, Neurosurgery, and Radiology R G N, Emory University School of Medicine, Marcus Stroke and Neuroscience Center, Grady Memorial Hospital, Atlanta, GA Department of Diagnostic and Interventional Neuroradiology J G, University Hospital Bern, Switzerland Division of Diagnostic and Interventional Neuroradiology A J Y, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston Department of Public Health Sciences S D Y, Y Y P, Medical University of South Carolina
    Neurology 86:762-70. 2016
    ..To assess whether the association between reperfusion and improved clinical outcomes after stroke differs depending on the site of the arterial occlusive lesion (AOL)...
  22. doi Transient hemiparesis caused by spontaneous cervical epidural hematoma
    Robin Lemmens
    Laboratory for Neurobiology, Experimental Neurology, KU Leuven, and Vesalius Research Center, VIB, Leuven, Belgium
    Acta Neurol Belg 112:291-3. 2012
    ..Therefore, in patients with transient focal neurological deficits this diagnosis should be included in the differential, particularly when cortical and cranial signs are lacking...
  23. pmc Genetics of atrial fibrillation and possible implications for ischemic stroke
    Robin Lemmens
    Department of Neurology and Laboratory for Neurobiology, Section of Experimental Neurology, School of Medicine, University of Leuven, Herestraat 49, 3000 Leuven, Belgium
    Stroke Res Treat 2011:208694. 2011
    ..Here we review the current knowledge on the genetic background of atrial fibrillation and the consequences for cerebrovascular disease...
  24. doi Reducing prehospital delay in acute stroke
    Miriam Bouckaert
    Department of Neurology, University Hospitals Leuven, Leuven, Belgium
    Nat Rev Neurol 5:477-83. 2009
    ..In this Review, we explore the extent of prehospital delay in stroke, identify the factors that affect the time taken for patients to reach hospital, and describe strategies designed to reduce the delay...