Lieven Lagae

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. ncbi request reprint Refractory photosensitive epilepsy associated with a complex rearrangement of chromosome 2
    H Van Esch
    University Hospitals Gasthuisberg, Department of Pediatric Neurology, Leuven, Belgium
    Neuropediatrics 33:320-3. 2002
  2. ncbi request reprint Effect of levetiracetam in refractory childhood epilepsy syndromes
    L Lagae
    Department Paediatric Neurology, University Hospitals Gasthuisberg, Leuven, Belgium
    Eur J Paediatr Neurol 7:123-8. 2003
  3. doi request reprint Rational treatment options with AEDs and ketogenic diet in Landau-Kleffner syndrome: still waiting after all these years
    Lieven Lagae
    Department of Pediatric Neurology, University Hospitals KULeuven, Herestraat 49, Leuven, Belgium
    Epilepsia 50:59-62. 2009
  4. ncbi request reprint Cognitive side effects of anti-epileptic drugs. The relevance in childhood epilepsy
    Lieven Lagae
    University Hospitals KULeuven, Department Paediatric Neurology, Herestraat 49, 3000 Leuven, Belgium
    Seizure 15:235-41. 2006
  5. doi request reprint Learning disabilities: definitions, epidemiology, diagnosis, and intervention strategies
    Lieven Lagae
    Department of Pediatric Neurology, University of Leuven Medical School, University Hospitals KULeuven, Herestraat 49, 3000 Leuven, Belgium
    Pediatr Clin North Am 55:1259-68, vii. 2008
  6. ncbi request reprint Clinical experience with levetiracetam in childhood epilepsy: an add-on and mono-therapy trial
    L Lagae
    University Hospitals KULeuven, Department of Paediatric Neurology, Herestraat 49, B3000 Leuven, Belgium
    Seizure 14:66-71. 2005
  7. ncbi request reprint Anti-epileptogenesis research: the clinical relevance
    L Lagae
    University Hospitals Gasthuisberg, Department Paediatric Neurology, Herestraat 49, B 3000 Leuven, Belgium
    Acta Neurol Belg 103:78-82. 2003
  8. ncbi request reprint Frontal absences in children
    L Lagae
    KU Leuven, University Hospital Gasthuisberg, Department of Paediatric Neurology, Leuven, Belgium
    Eur J Paediatr Neurol 5:243-51. 2001
  9. ncbi request reprint Cortical malformations: a frequent cause of epilepsy in children
    L Lagae
    Department of Paediatric Neurology, University Hospital, Gasthuisberg, Belgium
    Eur J Pediatr 159:555-62. 2000
  10. doi request reprint Hippocampal malrotation in pediatric patients with epilepsy associated with complex prefrontal dysfunction
    Peter Stiers
    Department of Paediatric Neurology, University Hospitals K U Leuven, Herestraat 49, Leuven, Belgium
    Epilepsia 51:546-55. 2010

Detail Information

Publications76

  1. ncbi request reprint Refractory photosensitive epilepsy associated with a complex rearrangement of chromosome 2
    H Van Esch
    University Hospitals Gasthuisberg, Department of Pediatric Neurology, Leuven, Belgium
    Neuropediatrics 33:320-3. 2002
    ..Our data can be used in further genetic studies on the exact location and identification of photosensitivity genes...
  2. ncbi request reprint Effect of levetiracetam in refractory childhood epilepsy syndromes
    L Lagae
    Department Paediatric Neurology, University Hospitals Gasthuisberg, Leuven, Belgium
    Eur J Paediatr Neurol 7:123-8. 2003
    ..Levetiracetam was effective both in partial and generalized seizures, with a significant effect on myoclonic seizures. Only mild side-effects were observed in four of 21 children, at a dosage of more than 40 mg/kg/day...
  3. doi request reprint Rational treatment options with AEDs and ketogenic diet in Landau-Kleffner syndrome: still waiting after all these years
    Lieven Lagae
    Department of Pediatric Neurology, University Hospitals KULeuven, Herestraat 49, Leuven, Belgium
    Epilepsia 50:59-62. 2009
    ..More recent case series show that sulthiame and especially levetiracetam can be considered as effective drugs. Smaller studies also point to the ketogenic diet as a valuable treatment option in LKS...
  4. ncbi request reprint Cognitive side effects of anti-epileptic drugs. The relevance in childhood epilepsy
    Lieven Lagae
    University Hospitals KULeuven, Department Paediatric Neurology, Herestraat 49, 3000 Leuven, Belgium
    Seizure 15:235-41. 2006
    ..As these processes are important instruments in every day learning and cognition, it is necessary to test these newer anti-epileptic drugs in well designed studies and in specific childhood epilepsy syndromes...
  5. doi request reprint Learning disabilities: definitions, epidemiology, diagnosis, and intervention strategies
    Lieven Lagae
    Department of Pediatric Neurology, University of Leuven Medical School, University Hospitals KULeuven, Herestraat 49, 3000 Leuven, Belgium
    Pediatr Clin North Am 55:1259-68, vii. 2008
    ..The role of the medical professional is important to guide parents in the diagnostic and therapeutic process...
  6. ncbi request reprint Clinical experience with levetiracetam in childhood epilepsy: an add-on and mono-therapy trial
    L Lagae
    University Hospitals KULeuven, Department of Paediatric Neurology, Herestraat 49, B3000 Leuven, Belgium
    Seizure 14:66-71. 2005
    ..Overall, these two clinical trials confirm that levetiracetam is a broad spectrum anti-epileptic drug with a favourable safety profile. The positive effect on behaviour needs further quantitative study...
  7. ncbi request reprint Anti-epileptogenesis research: the clinical relevance
    L Lagae
    University Hospitals Gasthuisberg, Department Paediatric Neurology, Herestraat 49, B 3000 Leuven, Belgium
    Acta Neurol Belg 103:78-82. 2003
    ..In clinical practice, a structured diagnostic work-up in all patients with recurrent seizures is a first and necessary step in the recognition of patients at risk for developing chronic and refractory epilepsy...
  8. ncbi request reprint Frontal absences in children
    L Lagae
    KU Leuven, University Hospital Gasthuisberg, Department of Paediatric Neurology, Leuven, Belgium
    Eur J Paediatr Neurol 5:243-51. 2001
    ..We believe that frontal onset absences should be considered as a secondarily generalized epilepsy syndrome, originating in the frontal regions...
  9. ncbi request reprint Cortical malformations: a frequent cause of epilepsy in children
    L Lagae
    Department of Paediatric Neurology, University Hospital, Gasthuisberg, Belgium
    Eur J Pediatr 159:555-62. 2000
    ..In this respect, the paediatrician can play a pivotal role in referring candidate patients for further specialised assessment...
  10. doi request reprint Hippocampal malrotation in pediatric patients with epilepsy associated with complex prefrontal dysfunction
    Peter Stiers
    Department of Paediatric Neurology, University Hospitals K U Leuven, Herestraat 49, Leuven, Belgium
    Epilepsia 51:546-55. 2010
    ..The cognitive consequences of hippocampal malrotation (HIMAL) were investigated in a matched control study of children with epilepsy...
  11. doi request reprint Single trial ERP reading based on parallel factor analysis
    Katrien Vanderperren
    Department of Electrical Engineering, ESAT SCD, Katholieke Universiteit Leuven, Leuven, Belgium
    Psychophysiology 50:97-110. 2013
    ..Despite the need for parameter tuning and careful preprocessing, the approach is shown to be successful, especially when prior knowledge about the expected ERPs is incorporated...
  12. doi request reprint Working memory in children with epilepsy: an event-related potentials study
    Ivan Myatchin
    Department of Woman and Child, Section Paediatric Neurology, K U Leuven, Leuven, Belgium
    Epilepsy Res 86:183-90. 2009
    ..A quantitative analysis technique to analyze the ERP data, without any 'a priori' decisions on 'peak' presence, amplitudes or latencies, is used...
  13. doi request reprint Developmental brain alterations in 17 year old boys are related to antenatal maternal anxiety
    Maarten Mennes
    Department of Woman and Child, Section Paediatric Neurology, K U Leuven, Leuven, Belgium
    Clin Neurophysiol 120:1116-22. 2009
    ..To assess the association between maternal anxiety during pregnancy and the brain activity of 17 year old adolescents performing two cognitive control tasks...
  14. doi request reprint The "why" and "how" of JointICA: results from a visual detection task
    Bogdan Mijovic
    Katholieke Universiteit Leuven, Department of Electrical Engineering, ESAT SCD, Leuven, Belgium
    Neuroimage 60:1171-85. 2012
    ..The performance of the algorithm in all the experiments is validated based on results from previous studies...
  15. doi request reprint Integrity of the inferior longitudinal fasciculus and impaired object recognition in children: a diffusion tensor imaging study
    Els Ortibus
    Paediatric Neurology Department, University Hospitals of the Catholic University of Leuven, Leuven, Belgium
    Dev Med Child Neurol 54:38-43. 2012
    ....
  16. doi request reprint Removal of BCG artifacts from EEG recordings inside the MR scanner: a comparison of methodological and validation-related aspects
    Katrien Vanderperren
    Katholieke Universiteit Leuven, Department of Electrical Engineering, ESAT SCD, Leuven, Belgium
    Neuroimage 50:920-34. 2010
    ..Moreover, applying OBS prior to ICA can optimize the data quality even more, but caution is recommended since the effect of the additional ICA step may be strongly subject-dependent...
  17. doi request reprint Validation of ICA as a tool to remove eye movement artifacts from EEG/ERP
    Maarten Mennes
    Department of Woman and Child, KU Leuven, Leuven, Belgium
    Psychophysiology 47:1142-50. 2010
    ..ICA performed as well as the Gratton and Coles method. By selecting only eye movement epochs for ICA compilation, we were able to facilitate the identification of components representing eye movement artifacts...
  18. pmc Long-term accelerometry-triggered video monitoring and detection of tonic-clonic and clonic seizures in a home environment: Pilot study
    Anouk Van de Vel
    Department of Neurology Paediatric Neurology, University Hospital, University of Antwerpen, Wilrijkstraat 10, 1650 Edegem, Belgium
    Epilepsy Behav Case Rep 5:66-71. 2016
    ....
  19. pmc Altered functional connectivity of the language network in ASD: role of classical language areas and cerebellum
    Marjolein Verly
    Department of Neurosciences, Exp ORL, Catholic University of Leuven, Leuven, Belgium Department of Radiology, University Hospitals of the Catholic University of Leuven, Leuven, Belgium
    Neuroimage Clin 4:374-82. 2014
    ..This disruption of normal modulatory control and automation function by the cerebellum may underlie the abnormal language function in children with ASD-LI. ..
  20. doi request reprint Ictal and interictal respiratory changes in temporal lobe and absence epilepsy in childhood
    Katrien Jansen
    Pediatric Neurology, University Hospitals, Leuven, Belgium
    Epilepsy Res 106:410-6. 2013
    ..We hypothesize that the interictal autonomic changes are due to changes in the neuronal network, by studying epilepsy patients with normal interictal background EEG...
  21. ncbi request reprint Neurocognitive development of children 4 years after critical illness and treatment with tight glucose control: a randomized controlled trial
    Dieter Mesotten
    Department of Intensive Care Medicine, Catholic University of Leuven, Leuven, Belgium
    JAMA 308:1641-50. 2012
    ....
  22. doi request reprint Ring chromosome 20 syndrome: electroclinical description of six patients and review of the literature
    Iris Elens
    Department of Paediatric Neurology, University Hospital Leuven, Belgium
    Epilepsy Behav 23:409-14. 2012
    ..Ring chromosome 20 syndrome is a rare chromosomal disorder...
  23. ncbi request reprint Intravenous immunoglobulins in refractory childhood-onset epilepsy: effects on seizure frequency, EEG activity, and cerebrospinal fluid cytokine profile
    An D Billiau
    Laboratory of Experimental Transplantation, University of Leuven, Leuven, Belgium
    Epilepsia 48:1739-49. 2007
    ..In an open-label study, we prospectively investigated the effect of IVIG on clinical, EEG and serum/CSF immunological parameters in patients with refractory childhood-onset epilepsy...
  24. doi request reprint Autonomic effects of refractory epilepsy on heart rate variability in children: influence of intermittent vagus nerve stimulation
    Katrien Jansen
    Department of Pediatric Neurology, University Hospitals Leuven, Leuven, Belgium
    Dev Med Child Neurol 53:1143-9. 2011
    ..Reduced heart rate variability is a marker of dysfunction of the autonomic nervous system. Our goal was to study heart rate variability in children with refractory epilepsy and the influence of VNS on this parameter...
  25. doi request reprint Are children with ADHD predominantly inattentive and combined subtypes different in terms of aspects of everyday attention?
    Jurgen Lemiere
    Child and Adolescent Psychiatry, UPC KULeuven, Herestraat 49, Leuven, Belgium
    Eur Child Adolesc Psychiatry 19:679-85. 2010
    ..ADHD-C and ADHD-I showed very few differences across tasks. In conclusion, our results provided not much support for the value of the ADHD-C and ADHD-I distinction in predicting difficulties in everyday attention...
  26. doi request reprint ERP correlates of complex human decision making in a gambling paradigm: detection and resolution of conflict
    Maarten Mennes
    Department of Woman and Child, Section Paediatric Neurology, K U Leuven, Leuven, Belgium
    Psychophysiology 45:714-20. 2008
    ..The P3 showed a fronto-central increase in amplitude in trials including two forms of response conflict compared to trials including only one conflict. These findings suggest that P3 reflects part of the conflict resolution processes...
  27. ncbi request reprint Feature selection methods for accelerometry-based seizure detection in children
    Milica Milosevic
    Department of Electrical Engineering ESAT, STADIUS Center for Dynamical Systems, Signal Processing and Data Analytics iMinds Medical IT, KU Leuven, 3001, Leuven, Belgium
    Med Biol Eng Comput . 2016
    ..The attained results could facilitate further development of accelerometry-based seizure detection and alarm systems...
  28. doi request reprint Structural and functional underconnectivity as a negative predictor for language in autism
    Marjolein Verly
    Department of Neurosciences, ExpORL, KU Leuven, Leuven, Belgium
    Hum Brain Mapp 35:3602-15. 2014
    ..Both structural and functional underconnectivity patterns coincide and are related to an abnormal language function in children with ASD...
  29. doi request reprint Is there a common neuroanatomical substrate of language deficit between autism spectrum disorder and specific language impairment?
    Judith S Verhoeven
    Department of Pediatrics, University Hospitals of the Catholic University of Leuven, Leuven, Belgium
    Cereb Cortex 22:2263-71. 2012
    ..The observation of structural SLF disturbances in SLI but not in ASD-LI suggests the existence of a different neuroanatomical substrate for the language deficits in both disorders...
  30. doi request reprint Treatment and long term outcome in West syndrome: the clinical reality. A multicentre follow up study
    Lieven Lagae
    University Hospitals KULeuven, Department of Pediatric Neurology, Herestraat 49, 3000 Leuven, Belgium
    Seizure 19:159-64. 2010
    ....
  31. ncbi request reprint Specific memory impairment in a multiple disabled male with fragile X syndrome and temporal lobe epilepsy
    Heidi Wouters
    Laboratory for Neuropsychology, KU Leuven, Medical School, Leuven, Belgium
    Dev Med Child Neurol 48:378-82. 2006
    ..This made it possible to accurately evaluate neuropsychological abilities before and 6 months after anterior temporal lobe resection even in this male with a complex neurological pathology...
  32. ncbi request reprint Atypical neuropsychological profile in a boy with 22q11.2 Deletion Syndrome
    Peter Stiers
    Department of Pediatrics, K U Leuven, Medical School, Herestraat 49, B 3000 Leuven, Belgium
    Child Neuropsychol 11:87-108. 2005
    ..At least in this boy the microdeletion seems to have interfered with the development and functioning of particular neural subsystems, while the structure and functioning of other subsystems was left intact...
  33. ncbi request reprint Long-term cognitive sequelae of antenatal maternal anxiety: involvement of the orbitofrontal cortex
    Maarten Mennes
    Department of Psychology, K U Leuven, Tiensestraat 102, 3000 Leuven, Belgium
    Neurosci Biobehav Rev 30:1078-86. 2006
    ..Based on the established cortical map, these results were related to subtle developmental aberrations in a part of, or in cortical and sub-cortical regions linked to, the orbitofrontal cortex...
  34. doi request reprint Gynecologic cancers in pregnancy: guidelines of an international consensus meeting
    Frederic Amant
    Division of Gynaecologic Oncology, Department of Obstetrics and Gynaecology, Leuven Cancer Institute LKI, UZ Gasthuisberg, Katholieke Universiteit Leuven, Belgium
    Int J Gynecol Cancer 19:S1-12. 2009
    ..Currently, there are no guidelines on how to deal with this special coincidence...
  35. doi request reprint Assessment of cerebral visual impairment with the L94 visual perceptual battery: clinical value and correlation with MRI findings
    E Ortibus
    University Hospitals, Paediatric Neurology Department, Leuven, Belgium
    Dev Med Child Neurol 51:209-17. 2009
    ..Normal magnetic resonance imaging did not exclude the presence of PVI. In these children, however, we found another impairment profile, more in favour of dorsal stream impairment...
  36. ncbi request reprint Results after surgery for lumbosacral lipoma: the significance of early and late worsening
    F van Calenbergh
    Department of Neurosurgery, University Hospital Gasthuisberg, Catholic University, Herestraat 49, B 3000 Leuven, Belgium
    Childs Nerv Syst 15:439-42; discussion 443. 1999
    ..This can be interpreted as an argument against prophylactic surgery in asymptomatic patients...
  37. ncbi request reprint Long-term external drainage for subdural collections in infants
    F van Calenbergh
    Department of Neurosurgery, University Hospital Gasthuisberg, Catholic University, Leuven, Belgium
    Childs Nerv Syst 16:429-32. 2000
    ..However, the long period of external drainage, and therefore of hospitalization, might make if general application of these guidelines problematic...
  38. ncbi request reprint Treatment of a symptomatic posterior fossa subdural effusion in a child
    P Van Schaeybroeck
    Department of Neurosurgery, University Hospital Leuven, Belgium
    Childs Nerv Syst 15:90-3. 1999
    ..We review the physiopathology and treatment of subdural effusions in general, and propose some guidelines for the management of symptomatic effusions occurring in the posterior fossa in particular...
  39. doi request reprint Can ECG monitoring identify seizures?
    Carolina Varon
    KU Leuven, Department of Electrical Engineering ESAT STADIUS, Kasteelpark Arenberg 10, Leuven, Belgium iMinds Medical IT Department, Kasteelpark Arenberg 10, Leuven, Belgium Electronic address
    J Electrocardiol 48:1069-74. 2015
    ..Seizures affect the autonomic control of the heart rate and respiration, and changes in these two variables are known to occur during, and even before the EEG onset of the seizure...
  40. doi request reprint Longitudinal changes in mathematical abilities and white matter following paediatric mild traumatic brain injury
    Leen Van Beek
    a Parenting and Special Education, Faculty of Psychology and Educational Sciences, University of Leuven, Leuven, Belgium
    Brain Inj 29:1701-10. 2015
    ..Little is known about the recovery of these impairments in children with mild TBI (mTBI) and their underlying pathophysiology, such as white matter abnormalities...
  41. doi request reprint Interictal cardiorespiratory variability in temporal lobe and absence epilepsy in childhood
    Carolina Varon
    Department of Electrical Engineering ESAT, STADIUS Center for Dynamical Systems, Signal Processing and Data Analytics, KU Leuven, Belgium iMinds Medical IT, Oude Markt 13 bus 5005, 3000 Leuven, Belgium
    Physiol Meas 36:845-56. 2015
    ..And a more remarkable finding indicates that this type of epilepsy seems to have a long term effect on the cardiac and respiratory control mechanisms of the autonomic nervous system. ..
  42. doi request reprint First line management of prolonged convulsive seizures in children and adults: good practice points
    Liesbeth de Waele
    Department of Paediatric Neurology, University Hospitals Leuven, 49 Herestraat, 3000, Leuven, Belgium
    Acta Neurol Belg 113:375-80. 2013
    ..In this paper, we propose "good practice points" for first line management of prolonged convulsive seizures in children and adults in a 'pre-medical' setting. ..
  43. doi request reprint Apnea as the sole manifestation of a seizure attributable to meningioangiomatosis of the temporal lobe in an infant
    Katrien Jansen
    Department of Pediatric Neurology, University Hospitals Leuven, Leuven, Belgium
    Pediatr Neurol 47:144-6. 2012
    ..This case demonstrates that a focal lesion in the temporal lobe can present during infancy with apnea as sole seizure manifestation, without other clear clinical evidence...
  44. doi request reprint Neuromyelitis optica-IgG+ optic neuritis associated with celiac disease and dysgammaglobulinemia: a role for tacrolimus?
    Isabelle Meyts
    Pediatric Immune Deficiencies, University Hospitals Leuven, Leuven, Belgium
    Eur J Paediatr Neurol 15:265-7. 2011
    ..Treatment with tacrolimus was successful in preventing disease relapses. This case stresses the relevance of central nervous system anti-aquaporin-4 auto-immunity in a broader context of immune dysregulation and neuro-immunology...
  45. doi request reprint Bathing epilepsy: a video case of an autonomic seizure
    Katrien Jansen
    Department of Pediatrics, Katholieke Universiteit Leuven, Leuven, Belgium
    Epileptic Disord 12:236-8. 2010
    ..Bathing epilepsy or water immersion epilepsy is a rare form of reflex epilepsy often presenting with autonomic seizures. The onset is usually in the first year of life and the evolution is benign. [Published with video sequences]...
  46. ncbi request reprint Levetiracetam pharmacokinetics in neonates at birth
    Karel Allegaert
    Neonatal Intensive Care Unit, Division of Women and Child, University Hospital Gasthuisberg, Leuven, Belgium
    Epilepsia 47:1068-9. 2006
    ..Based on blood sampling in a formula-fed pair of twins, the estimated serum half-life of levetiracetam (LEV) at birth is 16-18 h...
  47. doi request reprint Clinical practice: the treatment of acute convulsive seizures in children
    Lieven Lagae
    Department of Paediatric Neurology, University Hospitals KULeuven, Leuven, Belgium
    Eur J Pediatr 170:413-8. 2011
    ..Such a plan should include instruction and education of the parents and the caregivers surrounding the child...
  48. doi request reprint Transient hypothyroidism associated with viral Human Parechovirus encephalitis in a newborn
    Anneleen Dereymaeker
    Neonatal Intensive Care Unit, University Hospitals Leuven, Herestraat 49, B 3000 Leuven, Belgium Department of Pediatrics, Children s Clinical Neurophysiology, University Hospitals Leuven, Herestraat 49, B 3000 Leuven, Belgium Electronic address
    Eur J Paediatr Neurol 19:706-10. 2015
    ....
  49. doi request reprint Overlap between linear scleroderma, progressive facial hemiatrophy and immune-inflammatory encephalitis in a paediatric cohort
    Lien De Somer
    Department of Pediatric Rheumatology, University Hospital Leuven, Herestraat 49, 3000, Leuven, Belgium
    Eur J Pediatr 174:1247-54. 2015
    ..Brain biopsy in one patient was consistent with Rasmussen encephalitis. In two other children, associated autoimmune manifestations were present...
  50. doi request reprint Successful use of fenfluramine as an add-on treatment for Dravet syndrome
    Berten Ceulemans
    Department of Neurology Pediatric Neurology, Antwerp University Hospital, University of Antwerp, Edegem, Belgium
    Epilepsia 53:1131-9. 2012
    ..In Belgium, a Royal Decree permitted examination of the potential anticonvulsive effects of fenfluramine in a clinical trial consisting of a small group of patients diagnosed with Dravet syndrome...
  51. doi request reprint Neuroimaging of autism
    Judith S Verhoeven
    Department of Pediatrics, University Hospitals of the Catholic University of Leuven, Leuven, Belgium
    Neuroradiology 52:3-14. 2010
    ..Finally, we also discuss white matter alterations in important communication pathways in the brain of autistic patients...
  52. ncbi request reprint Antenatal maternal anxiety is related to HPA-axis dysregulation and self-reported depressive symptoms in adolescence: a prospective study on the fetal origins of depressed mood
    Bea R H Van den Bergh
    Department of Psychology, Katholieke Universiteit Leuven, Tiensestraat, Leuven, Belgium
    Neuropsychopharmacology 33:536-45. 2008
    ..Our prospective study demonstrates, for the first time, the involvement of the HPA-axis in the link between antenatal maternal anxiety/prenatal ELS and depressive symptoms for post-pubertal female adolescents...
  53. ncbi request reprint The need for broad spectrum and safe anti-epileptic drugs in childhood epilepsy
    Lieven Lagae
    University Hospitals Leuven, Paediatric Neurology Department, Leuven, Belgium
    Acta Neurol Belg 109:167-70. 2009
    ..At this moment, valproate, lamotrigine, topiramate, levetiracetam and possibly zonisamide can be considered as safe broad spectrum anti-epileptic drugs...
  54. ncbi request reprint Mapping multiple visual areas in the human brain with a short fMRI sequence
    Peter Stiers
    Laboratorium voor Neuropsychologie, K U Leuven, Faculteit Geneeskunde, Herestraat 49, O and N bus 504, B 3000 Leuven, Belgium
    Neuroimage 29:74-89. 2006
    ..Thus, the short stimulus sequence robustly invoked multiple visual areas and can be used to map the organization of the visual system in normal and brain-damaged individuals...
  55. doi request reprint The use of generic medication in epilepsy: a review of potential issues and challenges
    Wim Van Paesschen
    Department of Neurology, University Hospital Leuven, Leuven, Belgium
    Eur J Paediatr Neurol 13:87-92. 2009
    ..Closer follow-up during the transitional period is necessary, and dosage adjustment may be required. The patient should be given full and correct advice about risks involved in switching AED formulations...
  56. ncbi request reprint Sleep spindle abnormalities in children with generalized spike-wave discharges
    Ivan Myatchin
    University Hospitals KULeuven, Division Pediatric Neurology, Leuven, Belgium
    Pediatr Neurol 36:106-11. 2007
    ..The data indicate sleep architecture dysfunctions in children with generalized spike-and-wave discharges. These dysfunctions could account for the frequently encountered sleep problems in children with primary generalized epilepsy...
  57. doi request reprint Serotonergic Modulation as Effective Treatment for Dravet Syndrome in a Zebrafish Mutant Model
    Jo Sourbron
    Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, Belgium
    ACS Chem Neurosci 7:588-98. 2016
    ..Modulating certain serotonergic receptors was shown to effectively reduce seizures. Our findings therefore open new avenues for the development of future novel DS therapeutics. ..
  58. doi request reprint Tuberous sclerosis complex: the past and the future
    Liesbeth de Waele
    Department of Pediatric Neurology, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium
    Pediatr Nephrol 30:1771-80. 2015
    ..This review focuses on these novel recommendations and highlights the need for multidisciplinary follow-up of this multi-systemic disease. ..
  59. doi request reprint Arithmetic difficulties in children with mild traumatic brain injury at the subacute stage of recovery
    Leen Van Beek
    Parenting and Special Education, Faculty of Psychology and Educational Sciences, University of Leuven, Leuven, Belgium
    Dev Med Child Neurol 57:1042-8. 2015
    ..We therefore used event-related potentials (ERPs) to investigate brain functioning during arithmetic in children in the subacute phase after mTBI...
  60. pmc Pharmacological characterization of an antisense knockdown zebrafish model of Dravet syndrome: inhibition of epileptic seizures by the serotonin agonist fenfluramine
    Yifan Zhang
    Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven, Leuven, Belgium
    PLoS ONE 10:e0125898. 2015
    ..Moreover, these results provide a basis for identifying novel analogs with improved activity and significantly milder or no side effects. ..
  61. doi request reprint Developmental changes in visuo-spatial working memory in normally developing children: event-related potentials study
    Ivan Myatchin
    Department of Development and Regeneration, Section Paediatric Neurology, University Hospitals KU Leuven, Belgium
    Brain Dev 35:853-64. 2013
    ..Less is known about the cortical activity changes during development of WM. We evaluated the maturation of visual WM network at the electrophysiological level in a group of normally developing children...
  62. ncbi request reprint High antenatal maternal anxiety is related to impulsivity during performance on cognitive tasks in 14- and 15-year-olds
    Bea R H Van den Bergh
    Department of Psychology, Catholic University Leuven, Tiensestraat 102, 3000 Leuven, Belgium
    Neurosci Biobehav Rev 29:259-69. 2005
    ..We suspect that high maternal anxiety in the first half of pregnancy may negatively affect brain development of the fetus, reflected by impulsivity and lower WISC-R scores at 14-15 years...
  63. ncbi request reprint Linear normalization of MR brain images in pediatric patients with periventricular leukomalacia
    Bart Machilsen
    Laboratorium voor Neuropsychologie, K U Leuven Medical School, Leuven, Belgium
    Neuroimage 35:686-97. 2007
    ..The overall performance of the normalization algorithm was only improved when background noise was removed from the images. The results show that linear normalization of PVL affected brain images is feasible...
  64. doi request reprint What's new in: "genetics in childhood epilepsy"
    Lieven Lagae
    Department of Paediatric Neurology, University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium
    Eur J Pediatr 167:715-22. 2008
    ..Genetic studies are nowadays becoming a necessary diagnostic step in the evaluation of idiopathic childhood epilepsies, not only in familial cases, but also in sporadic cases...
  65. doi request reprint Congenital anterolateral bowing of the tibia with ipsilateral polydactyly of the great toe associated with cerebral cyst: a new entity?
    Jeroen Breckpot
    Center for Human Genetics, Department of Pediatric Neurology, University Hospital Leuven, Belgium
    Clin Dysmorphol 18:195-200. 2009
    ..We discuss phenotypic overlap with the acrocallosal syndrome...
  66. doi request reprint The pregnancy and long-term neurodevelopmental outcome of monochorionic diamniotic twin gestations: a multicenter prospective cohort study from the first trimester onward
    Els Ortibus
    Department of Pediatrics, University Hospitals, Leuven, Belgium
    Am J Obstet Gynecol 200:494.e1-8. 2009
    ..We sought to document the pregnancy and neurodevelopmental outcome in monochorionic diamniotic twin pregnancies and to identify risk factors for death and impairment...
  67. ncbi request reprint Event related potentials during attention tasks in VLBW children with and without attention deficit disorder
    S Potgieter
    Department of Paediatric Neurology, University Hospitals Gasthuisberg, 49 Herestreet, 3000, Leuven, Belgium
    Clin Neurophysiol 114:1841-9. 2003
    ..Children born prematurely have a higher incidence of attention deficit disorder with or without hyperactivity. We have used visual event related potentials to study possible brain dysfunctions that could explain this higher incidence...
  68. ncbi request reprint Duplication of the VHL and IRAK2 genes in a patient with mental retardation/multiple congenital anomalies, epilepsy and ectomorphic habitus
    E Chabchoub
    Centre for Human Genetics, Hospitals of Leuven, Leuven, Belgium
    Genet Couns 21:35-40. 2010
    ..To our knowledge, this is the smallest 3p duplication encompassing the VHL region. Its prognosis is unknown and a long-term follow-up is essential for an early diagnosis of malignancy...
  69. ncbi request reprint Supracondylar femur fracture complicating epileptic insult: a specific and under diagnosed complication?
    Petra Vanheer
    Rehabilitation and Epilepsy Centre for Children and Youth, Pulderbos, Belgium
    Acta Neurol Belg 108:17-20. 2008
    ..In epileptic patients fractures are six times more frequent than in the general population. Known predisposing factors are anticonvulsant drugs, malnutrition, lack of physical activity and sunlight exposure...
  70. pmc Clinical and molecular phenotype of Aicardi-Goutieres syndrome
    Gillian Rice
    Leeds Institute of Molecular Medicine, St James s University Hospital, Leeds, LS9 7TF, UK
    Am J Hum Genet 81:713-25. 2007
    ..Our analysis defines the phenotypic spectrum of AGS and suggests a coherent mutation-screening strategy in this heterogeneous disorder. Additionally, our data indicate that at least one further AGS-causing gene remains to be identified...
  71. ncbi request reprint Vagus nerve stimulation for refractory epilepsy: a Belgian multicenter study
    Veerle De Herdt
    Reference Center for Refractory Epilepsy, Ghent University Hospital, Belgium
    Eur J Paediatr Neurol 11:261-9. 2007
    ..It consists of continuous electrical stimulation of the left vagus nerve by means of a helical electrode and an implantable, programmable pulse generator. Currently, over 50,000 patients are treated with VNS worldwide...
  72. ncbi request reprint Microdeletions involving the SCN1A gene may be common in SCN1A-mutation-negative SMEI patients
    Arvid Suls
    Neurogenetics Group, Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology VIB, University of Antwerp, Antwerp, Belgium
    Hum Mutat 27:914-20. 2006
    ....
  73. ncbi request reprint In utero exposure to chemotherapy: effect on cardiac and neurologic outcome
    Kristel Van Calsteren
    J Clin Oncol 24:e16-7. 2006
  74. ncbi request reprint Steroids in intractable childhood epilepsy: clinical experience and review of the literature
    Helene Verhelst
    Department of Pediatrics, Division of Pediatric Neurology, Ghent University Hospital, De Pintelaan 185, 9000 Gent, Belgium
    Seizure 14:412-21. 2005
    ..The possible side effects, however, especially during prolonged therapy remain an important concern...
  75. ncbi request reprint Severe myoclonic epilepsy in infancy: toward an optimal treatment
    Berten Ceulemans
    Epilepsy Center for Children and Youth, Pulderbos, Belgium
    J Child Neurol 19:516-21. 2004
    ..To prevent long-lasting periods of status epilepticus, this acute seizure treatment must be taught to parents and caregivers...
  76. ncbi request reprint New syndrome characterized by hypomyelination with atrophy of the basal ganglia and cerebellum
    Marjo S van der Knaap
    Department of Child Neurology, Free University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    AJNR Am J Neuroradiol 23:1466-74. 2002
    ..Leukoencephalopathies of unknown origin constitute a considerable problem in child neurology. The purpose of our ongoing study of the subject was to define new disease entities among them by using primarily MR imaging pattern recognition...