P Holvoet

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. ncbi request reprint Endothelial dysfunction, oxidation of low-density lipoprotein, and cardiovascular disease
    P Holvoet
    Center for Molecular and Vascular Biology, University of Leuven, Belgium
    Ther Apher 3:287-93. 1999
  2. ncbi request reprint Adenovirus-mediated gene transfer of human platelet-activating factor-acetylhydrolase prevents injury-induced neointima formation and reduces spontaneous atherosclerosis in apolipoprotein E-deficient mice
    R Quarck
    Center for Molecular and Vascular Biology, Department of Experimental Surgery and Anesthesiology, Katholieke Universiteit Leuven, Leuven, Belgium
    Circulation 103:2495-500. 2001
  3. ncbi request reprint Oxidized LDL and malondialdehyde-modified LDL in patients with acute coronary syndromes and stable coronary artery disease
    P Holvoet
    Center for Molecular and Vascular Biology, University of Leuven, Belgium
    Circulation 98:1487-94. 1998
  4. ncbi request reprint Oxidized low density lipoproteins in patients with transplant-associated coronary artery disease
    P Holvoet
    Center for Molecular and Vascular Biology, University of Leuven, Belgium
    Arterioscler Thromb Vasc Biol 18:100-7. 1998
  5. ncbi request reprint LDL hypercholesterolemia is associated with accumulation of oxidized LDL, atherosclerotic plaque growth, and compensatory vessel enlargement in coronary arteries of miniature pigs
    P Holvoet
    Center for Molecular and Vascular Biology, University of Leuven, Belgium
    Arterioscler Thromb Vasc Biol 18:415-22. 1998
  6. ncbi request reprint The Arg123-Tyr166 central domain of human ApoAI is critical for lecithin:cholesterol acyltransferase-induced hyperalphalipoproteinemia and HDL remodeling in transgenic mice
    P Holvoet
    Center for Molecular and Vascular Biology, University of Leuven, Leuven, Belgium
    Arterioscler Thromb Vasc Biol 20:459-66. 2000
  7. ncbi request reprint Characterization of a chimeric plasminogen activator consisting of a single-chain Fv fragment derived from a fibrin fragment D-dimer-specific antibody and a truncated single-chain urokinase
    P Holvoet
    Center for Thrombosis and Vascular Research, University of Leuven, Belgium
    J Biol Chem 266:19717-24. 1991
  8. ncbi request reprint Oxidation of low density lipoproteins in the pathogenesis of atherosclerosis
    P Holvoet
    Center for Molecular and Vascular Biology, University of Leuven, Belgium
    Atherosclerosis 137:S33-8. 1998
  9. ncbi request reprint beta-VLDL hypercholesterolemia relative to LDL hypercholesterolemia is associated with higher levels of oxidized lipoproteins and a more rapid progression of coronary atherosclerosis in rabbits
    P Holvoet
    Center for Molecular and Vascular Biology, University of Leuven, Belgium
    Arterioscler Thromb Vasc Biol 17:2376-82. 1997
  10. ncbi request reprint Circulating oxidized LDL is a useful marker for identifying patients with coronary artery disease
    P Holvoet
    Center for Molecular and Vascular Biology, Catholic University of Leuven, Leuven, Belgium
    Arterioscler Thromb Vasc Biol 21:844-8. 2001

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Endothelial dysfunction, oxidation of low-density lipoprotein, and cardiovascular disease
    P Holvoet
    Center for Molecular and Vascular Biology, University of Leuven, Belgium
    Ther Apher 3:287-93. 1999
    ..Oxidized LDL may contribute to the progression of atherosclerosis by enhancing endothelial injury by inducing foam cell generation and smooth muscle proliferation...
  2. ncbi request reprint Adenovirus-mediated gene transfer of human platelet-activating factor-acetylhydrolase prevents injury-induced neointima formation and reduces spontaneous atherosclerosis in apolipoprotein E-deficient mice
    R Quarck
    Center for Molecular and Vascular Biology, Department of Experimental Surgery and Anesthesiology, Katholieke Universiteit Leuven, Leuven, Belgium
    Circulation 103:2495-500. 2001
    ..The effect of adenovirus-mediated expression of PAF-AH on injury-induced neointima formation and spontaneous atherosclerosis was studied in apolipoprotein E-deficient mice...
  3. ncbi request reprint Oxidized LDL and malondialdehyde-modified LDL in patients with acute coronary syndromes and stable coronary artery disease
    P Holvoet
    Center for Molecular and Vascular Biology, University of Leuven, Belgium
    Circulation 98:1487-94. 1998
    ..Therefore, the association between plasma levels of oxidized LDL and malondialdehyde (MDA)-modified LDL and acute coronary syndromes and stable CAD was investigated...
  4. ncbi request reprint Oxidized low density lipoproteins in patients with transplant-associated coronary artery disease
    P Holvoet
    Center for Molecular and Vascular Biology, University of Leuven, Belgium
    Arterioscler Thromb Vasc Biol 18:100-7. 1998
    ..047). Thus, the present study demonstrates that plasma levels of oxidized LDL correlate with the extent of CAD in heart transplant patients and suggests that elevated levels of oxidized LDL may be a marker for CAD...
  5. ncbi request reprint LDL hypercholesterolemia is associated with accumulation of oxidized LDL, atherosclerotic plaque growth, and compensatory vessel enlargement in coronary arteries of miniature pigs
    P Holvoet
    Center for Molecular and Vascular Biology, University of Leuven, Belgium
    Arterioscler Thromb Vasc Biol 18:415-22. 1998
    ....
  6. ncbi request reprint The Arg123-Tyr166 central domain of human ApoAI is critical for lecithin:cholesterol acyltransferase-induced hyperalphalipoproteinemia and HDL remodeling in transgenic mice
    P Holvoet
    Center for Molecular and Vascular Biology, University of Leuven, Leuven, Belgium
    Arterioscler Thromb Vasc Biol 20:459-66. 2000
    ..It is, however, critical for LCAT-induced hyperalphalipoproteinemia and HDL remodeling independent of the lipid-binding properties of apoAI...
  7. ncbi request reprint Characterization of a chimeric plasminogen activator consisting of a single-chain Fv fragment derived from a fibrin fragment D-dimer-specific antibody and a truncated single-chain urokinase
    P Holvoet
    Center for Thrombosis and Vascular Research, University of Leuven, Belgium
    J Biol Chem 266:19717-24. 1991
    ..5-fold increase of the potency of the two-chain form...
  8. ncbi request reprint Oxidation of low density lipoproteins in the pathogenesis of atherosclerosis
    P Holvoet
    Center for Molecular and Vascular Biology, University of Leuven, Belgium
    Atherosclerosis 137:S33-8. 1998
    ..g. vitamin E), estrogen supplementation and increased levels of high density lipoproteins (HDL) may, at least partially, be due to the inhibition of oxidation of LDL or to the reversal of the atherothrombotic effects of oxidized LDL...
  9. ncbi request reprint beta-VLDL hypercholesterolemia relative to LDL hypercholesterolemia is associated with higher levels of oxidized lipoproteins and a more rapid progression of coronary atherosclerosis in rabbits
    P Holvoet
    Center for Molecular and Vascular Biology, University of Leuven, Belgium
    Arterioscler Thromb Vasc Biol 17:2376-82. 1997
    ....
  10. ncbi request reprint Circulating oxidized LDL is a useful marker for identifying patients with coronary artery disease
    P Holvoet
    Center for Molecular and Vascular Biology, Catholic University of Leuven, Leuven, Belgium
    Arterioscler Thromb Vasc Biol 21:844-8. 2001
    ..Thus, circulating oxidized LDL is a sensitive marker of CAD. Addition of oxidized LDL to the established risk factors may improve cardiovascular risk prediction...
  11. ncbi request reprint Malondialdehyde-modified LDL as a marker of acute coronary syndromes
    P Holvoet
    Center for Molecular and Vascular Biology, University of Leuven, Belgium
    JAMA 281:1718-21. 1999
    ..Release of circulating malondialdehyde (MDA)-modified low-density lipoprotein (LDL) may reflect endothelial injury or plaque instability...
  12. ncbi request reprint Oxidized low density lipoprotein is a prognostic marker of transplant-associated coronary artery disease
    P Holvoet
    Center for Molecular and Vascular Biology, University of Leuven, Leuven, Belgium
    Arterioscler Thromb Vasc Biol 20:698-702. 2000
    ..The development of transplant CAD was associated with a further increase of plasma levels of oxidized LDL (chi(2)=14, P=0.0002). Oxidized LDL is a prognostic marker of transplant CAD...
  13. ncbi request reprint Thrombosis and atherosclerosis
    P Holvoet
    Center for Molecular and Vascular Biology, University of Leuven, Belgium
    Curr Opin Lipidol 8:320-8. 1997
    ..Plasminogen activator inhibitor-1 inhibits smooth muscle cell migration and, in the presence of vitronectin, promotes the clearance of thrombin by LDL receptor-related protein at sites of endothelial injury...
  14. ncbi request reprint Oxidative modification of low-density lipoproteins in atherothrombosis
    P Holvoet
    Center for Molecular and Vascular Biology, University of Leuven, Belgium
    Acta Cardiol 53:253-60. 1998
    ..At present, in the absence of prospective studies, the causative role of oxidatively modified LDL in atherothrombosis is, however, not established...
  15. ncbi request reprint Restenosis and gene therapy
    R Quarck
    Department of Experimental Surgery and Anaesthesiology, University of Leuven, Campus Gasthuisberg O and N, Herestraat 49, B-3000 Leuven, Belgium
    Expert Opin Biol Ther 1:79-91. 2001
    ..The potential of different vector systems and devices for local gene transfer in the arterial wall is discussed...
  16. ncbi request reprint HDL-associated PAF-AH reduces endothelial adhesiveness in apoE-/- mice
    G Theilmeier
    Center for Molecular and Vascular Biology, KU Leuven, Leuven, Belgium
    FASEB J 14:2032-9. 2000
    ..This protective mechanism is independent of the function of HDL as cholesterol acceptor. Modulation of lipoprotein oxidation by PAF-AH may prevent leukocyte recruitment to the vessel wall, a key feature in atherogenesis...
  17. ncbi request reprint Adipose tissue expression of gelatinases in mouse models of obesity
    H R Lijnen
    Center for Molecular and Vascular Biology, University of Leuven, Belgium
    Thromb Haemost 85:1111-6. 2001
    ..The presence of MMP-2 in the adipose tissue was confirmed immunologically and its localization in adipocytes revealed by immunogold electron microscopy. The potential functional role of MMP-2 in adipose tissue remains to be determined...
  18. pmc Substitution of the carboxyl-terminal domain of apo AI with apo AII sequences restores the potential of HDL to reduce the progression of atherosclerosis in apo E knockout mice
    P Holvoet
    Center for Molecular and Vascular Biology, University of Leuven, Leuven, Belgium
    J Clin Invest 102:379-85. 1998
    ..Amino acid sequences of apo AII, which is considered to be less antiatherogenic, can be used to restore the structure of apo AI and thereby its antiatherogenicity...
  19. ncbi request reprint Effects of adenovirus-mediated human apo A-I gene transfer on neointima formation after endothelial denudation in apo E-deficient mice
    B De Geest
    Center for Molecular and Vascular Biology, University of Leuven, Belgium
    Circulation 96:4349-56. 1997
    ....
  20. pmc Paraoxonase 1 gene transfer lowers vascular oxidative stress and improves vasomotor function in apolipoprotein E-deficient mice with pre-existing atherosclerosis
    P J Guns
    Division of Pharmacology, University of Antwerp, Wilrijk, Belgium
    Br J Pharmacol 153:508-16. 2008
    ..The present study explored the therapeutic potential of human PON1 gene transfer in old apolipoprotein E-deficient (apoE(-/-)) mice with advanced atherosclerosis...
  21. ncbi request reprint Antineutrophil cytoplasmatic antibodies in patients with premature atherosclerosis: prevalence and association with risk factors
    P L van Haelst
    Department of Cardiology, University Hospital Groningen, The Netherlands
    J Intern Med 251:29-34. 2002
    ..In this study the hypothesis is tested that ANCA play a role in premature atherosclerosis...
  22. pmc Rosuvastatin restores superoxide dismutase expression and inhibits accumulation of oxidized LDL in the aortic arch of obese dyslipidemic mice
    W Verreth
    Atherosclerosis and Metabolism Unit, Department of Cardiovascular Diseases, Katholieke Universiteit, Leuven, Belgium
    Br J Pharmacol 151:347-55. 2007
    ....
  23. ncbi request reprint Oxidized low-density lipoprotein-induced expression of ABCA1 in blood monocytes precedes coronary atherosclerosis and is associated with plaque complexity in hypercholesterolemic pigs
    B Geeraert
    Atherosclerosis and Metabolism Unit, Department of Cardiovascular Diseases, Katholieke Universiteit Leuven, Herestraat 49, Leuven, Belgium
    J Thromb Haemost 5:2529-36. 2007
    ..Previously, we identified 18 genes in coronary plaque macrophages of hypercholesterolemic pigs that correlated with plaque oxLDL...