Lode Godderis

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. pmc Epidemiological and performance indicators for occupational health services: a feasibility study in Belgium
    Lode Godderis
    Groep IDEWE, External Service for Prevention and Protection at Work, Interleuvenlaan 58, Heverlee 3001, Belgium
    BMC Health Serv Res 14:410. 2014
  2. pmc What factors determine Belgian general practitioners' approaches to detecting and managing substance abuse? A qualitative study based on the I-Change Model
    Frédéric Ketterer
    Department of General Practice Family Medicine, University of Liege, Avenue de l hôpital 3, CHU B23, Liege 4000, Belgium
    BMC Fam Pract 15:119. 2014
  3. pmc Effect of chemical mutagens and carcinogens on gene expression profiles in human TK6 cells
    Lode Godderis
    Occupational, Environmental and Insurance Medicine, Katholieke Universiteit Leuven, Leuven, Belgium
    PLoS ONE 7:e39205. 2012
  4. doi request reprint Epigenetic changes in lymphocytes of solvent-exposed individuals
    Lode Godderis
    Katholieke Universiteit Leuven, Occupational, Environmental and Insurance Medicine, Kapucijnenvoer 35 5, Leuven, Belgium
    Epigenomics 4:269-77. 2012
  5. doi request reprint Genetic susceptibility in solvent induced neurobehavioral effects
    L Godderis
    Department of Occupational, Environmental and Insurance Medicine, Katholieke Universiteit Leuven, Kapucijnenvoer 35 5, Leuven, 3000, Belgium
    Neurotox Res 17:268-78. 2010
  6. doi request reprint Sleep apnoeas and neurobehavioral effects in solvent exposed workers
    L Godderis
    Katholieke Universiteit Leuven, Department of Occupational, Environmental and Insurance Medicine, Leuven 3000, Belgium
    Int J Hyg Environ Health 214:66-70. 2011
  7. ncbi request reprint Dose-dependent influence of genetic polymorphisms on DNA damage induced by styrene oxide, ethylene oxide and gamma-radiation
    Lode Godderis
    Katholieke Universiteit Leuven K U L, Laboratorium Voor Arbeidshygiëne en Toxicologie, Kapucijnenvoer 35 6, 3000 Leuven, Belgium
    Toxicology 219:220-9. 2006
  8. ncbi request reprint Influence of genetic polymorphisms on biomarkers of exposure and genotoxic effects in styrene-exposed workers
    Lode Godderis
    Katholieke Universiteit Leuven, Laboratorium Voor Arbeidshygiëne en Toxicologie, 3000 Leuven, Belgium
    Environ Mol Mutagen 44:293-303. 2004
  9. pmc Epigenetic factors in cancer risk: effect of chemical carcinogens on global DNA methylation pattern in human TK6 cells
    Ali M Tabish
    Department of Occupational, Environmental and Insurance Medicine, Katholieke Universiteit Leuven, Leuven, Belgium
    PLoS ONE 7:e34674. 2012
  10. pmc Changes in DNA Methylation in Mouse Lungs after a Single Intra-Tracheal Administration of Nanomaterials
    Ali M Tabish
    Centre for Environment and Health, KU Leuven, Leuven, Belgium
    PLoS ONE 12:e0169886. 2017

Collaborators

Detail Information

Publications23

  1. pmc Epidemiological and performance indicators for occupational health services: a feasibility study in Belgium
    Lode Godderis
    Groep IDEWE, External Service for Prevention and Protection at Work, Interleuvenlaan 58, Heverlee 3001, Belgium
    BMC Health Serv Res 14:410. 2014
    ..Consequently, the selected data can serve as indicators for exposure to and prevention of occupational risks (epidemiology), and contribute to the evaluation of the functioning (performance) of OHS providers...
  2. pmc What factors determine Belgian general practitioners' approaches to detecting and managing substance abuse? A qualitative study based on the I-Change Model
    Frédéric Ketterer
    Department of General Practice Family Medicine, University of Liege, Avenue de l hôpital 3, CHU B23, Liege 4000, Belgium
    BMC Fam Pract 15:119. 2014
    ..However, little is known about how or why they decide to manage it. This study investigated the factors that influence GP behaviours with regard to the abuse of alcohol, illegal drugs, hypnotics, and tranquilisers among working Belgians...
  3. pmc Effect of chemical mutagens and carcinogens on gene expression profiles in human TK6 cells
    Lode Godderis
    Occupational, Environmental and Insurance Medicine, Katholieke Universiteit Leuven, Leuven, Belgium
    PLoS ONE 7:e39205. 2012
    ..Our findings expand our understanding of the transcriptomic response to genotoxic carcinogens, revealing the alteration of diverse sets of genes and pathways involved in cellular homeostasis and cell cycle control...
  4. doi request reprint Epigenetic changes in lymphocytes of solvent-exposed individuals
    Lode Godderis
    Katholieke Universiteit Leuven, Occupational, Environmental and Insurance Medicine, Kapucijnenvoer 35 5, Leuven, Belgium
    Epigenomics 4:269-77. 2012
    ..POPULATION & METHODS: A cross-sectional study was set up in 41 referents, 128 solvent workers and 23 CTE patients...
  5. doi request reprint Genetic susceptibility in solvent induced neurobehavioral effects
    L Godderis
    Department of Occupational, Environmental and Insurance Medicine, Katholieke Universiteit Leuven, Kapucijnenvoer 35 5, Leuven, 3000, Belgium
    Neurotox Res 17:268-78. 2010
    ..Individuals possessing DRD2-141Cdel variant experienced more visuomotor problems...
  6. doi request reprint Sleep apnoeas and neurobehavioral effects in solvent exposed workers
    L Godderis
    Katholieke Universiteit Leuven, Department of Occupational, Environmental and Insurance Medicine, Leuven 3000, Belgium
    Int J Hyg Environ Health 214:66-70. 2011
    ..Exposure to organic solvents may cause an increase of sleep apnoeas, which may explain the excess of fatigue, concentration and memory problems reported in exposed workers...
  7. ncbi request reprint Dose-dependent influence of genetic polymorphisms on DNA damage induced by styrene oxide, ethylene oxide and gamma-radiation
    Lode Godderis
    Katholieke Universiteit Leuven K U L, Laboratorium Voor Arbeidshygiëne en Toxicologie, Kapucijnenvoer 35 6, 3000 Leuven, Belgium
    Toxicology 219:220-9. 2006
    ..The influence of hOGG1326 on TL was borderline dose-dependent. We conclude that the influence of genetic polymorphisms of enzymes involved in DNA repair on induced genotoxicity depends on exposure dose...
  8. ncbi request reprint Influence of genetic polymorphisms on biomarkers of exposure and genotoxic effects in styrene-exposed workers
    Lode Godderis
    Katholieke Universiteit Leuven, Laboratorium Voor Arbeidshygiëne en Toxicologie, 3000 Leuven, Belgium
    Environ Mol Mutagen 44:293-303. 2004
    ..The in vitro DNA repair phenotype assay might be a valuable method to estimate the susceptibility of workers...
  9. pmc Epigenetic factors in cancer risk: effect of chemical carcinogens on global DNA methylation pattern in human TK6 cells
    Ali M Tabish
    Department of Occupational, Environmental and Insurance Medicine, Katholieke Universiteit Leuven, Leuven, Belgium
    PLoS ONE 7:e34674. 2012
    ..Furthermore, we showed that dose did not have an effect on global DNA methylation in TK6 cells. In conclusion we report changes in global DNA methylation as an early event in response to agents traditionally considered as genotoxic...
  10. pmc Changes in DNA Methylation in Mouse Lungs after a Single Intra-Tracheal Administration of Nanomaterials
    Ali M Tabish
    Centre for Environment and Health, KU Leuven, Leuven, Belgium
    PLoS ONE 12:e0169886. 2017
    ..This study aimed to investigate the effects of nanomaterial (NM) exposure on DNA methylation...
  11. ncbi request reprint Comparison of genotoxic potency of styrene 7,8-oxide with gamma radiation and human cancer risk estimation of styrene using the rad-equivalence approach
    Lode Godderis
    IDEWE, External Service for Prevention at Work, Interleuvenlaan 58, 3001 Heverlee, Belgium
    Mutagenesis 22:209-15. 2007
    ..17 in 10(3) workers (between 0.037 x 10(-)(3) and 5.0 x 10(-)(3)) exposed to 20 ppm styrene during 40 years...
  12. ncbi request reprint Neurobehavioral and clinical effects in workers exposed to CS(2)
    Lode Godderis
    Department of Occupational, Insurance and Environmental Medicine, Catholic University of Leuven, Belgium
    Int J Hyg Environ Health 209:139-50. 2006
    ..The current study aimed to evaluate whether the decrease of exposure below the threshold limit value (TLV) of 31 mg/m(3) results in an absence of neurological health effects using the same health outcomes as in the first study...
  13. doi request reprint Assessment of Changes in Global DNA Methylation Levels by Pyrosequencing® of Repetitive Elements
    Ali M Tabish
    Department of Public Health and Primary Care, Katholieke Universiteit Leuven, Kapucijnenvoer 35 blok d, Leuven, B 3000, Belgium
    Methods Mol Biol 1315:201-7. 2015
    ..In this chapter, we provide an overview of the analysis of repetitive element DNA methylation by bisulfite Pyrosequencing, and we describe a protocol that can be used for such purposes. ..
  14. doi request reprint Effects of environmental stressors on histone modifications and their relevance to carcinogenesis: a systematic review
    Sander Dik
    Department of Occupational, Environmental and Insurance Medicine, Katholieke Universiteit Leuven, Leuven, Belgium
    Crit Rev Toxicol 42:491-500. 2012
    ..This review contributes to the understanding of environmental exposure and its possible effects on cancer risk by inducing changes in histone modifications and hence gene expression...
  15. doi request reprint Sleep disturbances and occupational exposure to solvents
    Mineke Viaene
    Department of Occupational, Environmental and Insurance Medicine, Catholic University of Leuven, UZ St Rafael, Leuven, Belgium
    Sleep Med Rev 13:235-43. 2009
    ....
  16. doi request reprint Epigenetic effects of carbon nanotubes in human monocytic cells
    Deniz Öner
    Laboratory of Toxicology, Unit of Environment and Health, Department of Public Health and Primary Care, O and N I Herestraat 49 bus 706, 3000 Leuven, Belgium
    Mutagenesis 32:181-191. 2017
    ..Moreover, possible contribution of the epigenetic alterations to monocyte differentiation and mixed M1/M2 macrophage polarisation were discussed...
  17. doi request reprint Cytotoxic effects of composite dust on human bronchial epithelial cells
    Stevan M Cokic
    KU Leuven BIOMAT, Department of Oral Health Sciences, University of Leuven and Dentistry University Hospitals Leuven, Kapucijnenvoer 7, 3000 Leuven, Belgium
    Dent Mater 32:1482-1491. 2016
    ..Previous research revealed that during routine abrasive procedures like polishing, shaping or removing of composites, high amounts of respirable dust particles (<5μm) including nano-sized particles (<100nm) may be released...
  18. pmc Global Methylation and Hydroxymethylation in DNA from Blood and Saliva in Healthy Volunteers
    Lode Godderis
    Centre Environment and Health, Department of Public Health and Primary Care, KU Leuven, Kapucijnenvoer 35 5, 3000 Leuven, Belgium Idewe, External Service for Prevention and Protection at Work, 3001 Heverlee, Belgium
    Biomed Res Int 2015:845041. 2015
    ..Conclusion. Global DNA methylation and hydroxymethylation of cytosine can be quantified simultaneously by LC-MS/MS. Saliva DNA cannot be considered as a surrogate for blood DNA to study epigenetic endpoints. ..
  19. doi request reprint Increased Risk of Burnout for Physicians and Nurses Involved in a Patient Safety Incident
    Eva Van Gerven
    Leuven Institute for Healthcare Policy, KU Leuven, Leuven Knowledge, Information and Research Center KIR, IDEWE, Brussels Occupational and Organisational Psychology and Professional Learning Environment and Health, KU Leuven, Leuven Department of Family Medicine and Chronic Care, Vrije Universiteit Brussel, Ixelles Department of Sociology, Ghent University, Ghent Optentia Research Focus Area, Vanderbijlpark, North West University, Potchefstroom, South Africa General Management, University Hospitals Leuven and Flemish Hospital Network Department of Public Health and Primary Care, KU Leuven, Leuven, Belgium
    Med Care 54:937-43. 2016
    ..Human errors occur everywhere, including in health care. Not only the patient, but also the involved health professional is affected (ie, the "second victim")...
  20. doi request reprint Job demands-resources predicting burnout and work engagement among Belgian home health care nurses: A cross-sectional study
    Tinne Vander Elst
    Knowledge, Information and Research Center KIR, IDEWE, An External Service for Prevention and Protection at Work, Leuven, Vlaams Brabant, Belgium Occupational and Organisational Psychology and Professional Learning, KU Leuven, Leuven, Vlaams Brabant, Belgium Electronic address
    Nurs Outlook 64:542-556. 2016
    ..The Job Demands-Resources model predicts that job demands and resources relate to burnout and work engagement but has not previously been tested in the specific context of home health care nursing...
  21. doi request reprint Fentanyl transdermal absorption linked to pharmacokinetic characteristics in patients undergoing palliative care
    Nadine F J Van Nimmen
    Katholieke Universiteit Leuven, Department of Occupational, Environmental and Insurance Medicine, B 3000 Leuven, Belgium
    J Clin Pharmacol 50:667-78. 2010
    ..03) exerted significant effects on the linear model, explaining 40% and 64% of the variability, respectively. Delivery efficiency of fentanyl patches can vary substantially, possibly leading to either underdosing or overdosing...
  22. ncbi request reprint The effects of GSTM1 and GSTT1 polymorphisms on micronucleus frequencies in human lymphocytes in vivo
    Micheline Kirsch-Volders
    Laboratory of Cell Genetics, Vrije Universiteit Brussel, Pleinlaan 2, B 1050 Brussels, Belgium
    Cancer Epidemiol Biomarkers Prev 15:1038-42. 2006
    ..79). This study confirms that pooled analyses, by increasing the statistical power, are adequate for assessing the involvement of genetic variants on genome stability and for resolving discrepancies among individual studies...
  23. ncbi request reprint hOGG1(326), XRCC1(399) and XRCC3(241) polymorphisms influence micronucleus frequencies in human lymphocytes in vivo
    Raluca A Mateuca
    Laboratorium voor Cellulaire Genetica, Vrije Universiteit Brussel, Pleinlaan 2, B 1050 Brussel, Belgium
    Mutagenesis 23:35-41. 2008
    ..Understanding the complexity of the relationships between exposure, DNA repair and MN frequencies require larger scale studies and complementary biomarkers...