Inge Depoortere

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. ncbi request reprint Desensitization of the human motilin receptor by motilides
    Leen Thielemans
    Gut Hormone Lab, Center for Gastroenterological Research, Department of Pathophysiology, Katholieke Universiteit Leuven, Belgium
    J Pharmacol Exp Ther 313:1397-405. 2005
  2. ncbi request reprint Delineation of the motilin domain involved in desensitization and internalization of the motilin receptor by using full and partial antagonists
    Anna Mitselos
    Centre for Gastroenterological Research, Catholic University of Leuven, B 3000 Leuven, Belgium
    Biochem Pharmacol 73:115-24. 2007
  3. pmc The therapeutic effect of the neuropeptide hormone somatostatin on Schistosoma mansoni caused liver fibrosis
    Shyama Chatterjee
    Laboratory of Pathology, Faculty of Medicine, University of Antwerp, Universiteitsplein 1, B 2610 Antwerp, Belgium
    BMC Infect Dis 5:45. 2005
  4. pmc Generalized loss of inhibitory innervation reverses serotonergic inhibition into excitation in a rabbit model of TNBS-colitis
    Inge Depoortere
    Centre for Gastroenterological Research, Department of Pathophysiology, University of Leuven, B 3000 Leuven, Belgium
    Br J Pharmacol 135:2011-9. 2002
  5. ncbi request reprint The contractile effect of the ghrelin receptor antagonist, D-Lys3-GHRP-6, in rat fundic strips is mediated through 5-HT receptors
    Inge Depoortere
    Centre for Gastroenterological Research, Catholic University of Leuven, Leuven, Belgium
    Eur J Pharmacol 537:160-5. 2006
  6. ncbi request reprint Treatment with interleukin-11 affects plasma leptin levels in inflamed and non-inflamed rabbits
    Inge Depoortere
    Centre for Gastroenterological Research, Department of Pathophysiology, University of Leuven, Gasthuisberg O and N, B 3000 Louvain, Belgium
    Regul Pept 122:149-56. 2004
  7. ncbi request reprint Comparison of the gastroprokinetic effects of ghrelin, GHRP-6 and motilin in rats in vivo and in vitro
    Inge Depoortere
    Centre for Gastroenterological Research, Department of Pathophysiology, University of Leuven, Gasthuisberg O and N, B 3000, Leuven, Belgium
    Eur J Pharmacol 515:160-8. 2005
  8. ncbi request reprint Mechanisms involved in the loss of excitatory post-stimulus responses by inflammation
    Inge Depoortere
    Department of Pathophysiology, Center for Gastroenterological Research, University of Leuven, Gasthuisberg O and N, 3000 Leuven, Belgium
    Naunyn Schmiedebergs Arch Pharmacol 367:245-52. 2003
  9. ncbi request reprint Interaction of the growth hormone-releasing peptides ghrelin and growth hormone-releasing peptide-6 with the motilin receptor in the rabbit gastric antrum
    Inge Depoortere
    Department of Pathophysiology, Centre for Gastroenterological Research, University of Leuven, Leuven, Belgium
    J Pharmacol Exp Ther 305:660-7. 2003
  10. doi request reprint Desensitization and internalization of the human motilin receptor is independent of the C-terminal tail
    Anna Mitselos
    Centre for Gastroenterological Research, Catholic University of Leuven, B 3000 Leuven, Belgium
    Peptides 29:1167-75. 2008

Collaborators

Detail Information

Publications41

  1. ncbi request reprint Desensitization of the human motilin receptor by motilides
    Leen Thielemans
    Gut Hormone Lab, Center for Gastroenterological Research, Department of Pathophysiology, Katholieke Universiteit Leuven, Belgium
    J Pharmacol Exp Ther 313:1397-405. 2005
    ..The ability to desensitize and internalize the MTLR is not only determined by potency. This may be an important criterion for the development of a clinically useful compound...
  2. ncbi request reprint Delineation of the motilin domain involved in desensitization and internalization of the motilin receptor by using full and partial antagonists
    Anna Mitselos
    Centre for Gastroenterological Research, Catholic University of Leuven, B 3000 Leuven, Belgium
    Biochem Pharmacol 73:115-24. 2007
    ..Studies with fragments of the gastrointestinal peptide, motilin, indicate that the C-terminal region of this peptide plays an important role in the desensitization of the motilin receptor (MTLR)...
  3. pmc The therapeutic effect of the neuropeptide hormone somatostatin on Schistosoma mansoni caused liver fibrosis
    Shyama Chatterjee
    Laboratory of Pathology, Faculty of Medicine, University of Antwerp, Universiteitsplein 1, B 2610 Antwerp, Belgium
    BMC Infect Dis 5:45. 2005
    ..Based on these results this paper explores the therapeutic potential of somatostatin in a mouse model of hepatic fibrosis associated with S. mansoni infections...
  4. pmc Generalized loss of inhibitory innervation reverses serotonergic inhibition into excitation in a rabbit model of TNBS-colitis
    Inge Depoortere
    Centre for Gastroenterological Research, Department of Pathophysiology, University of Leuven, B 3000 Leuven, Belgium
    Br J Pharmacol 135:2011-9. 2002
    ..Accordingly, in inflamed strips L-NAME or suramin did not affect the excitatory effects of 5-MeOT. 7. TNBS-colitis abolishes nitrergic, purinergic and adrenergic neurotransmission. This reverses serotonergic inhibition into excitation...
  5. ncbi request reprint The contractile effect of the ghrelin receptor antagonist, D-Lys3-GHRP-6, in rat fundic strips is mediated through 5-HT receptors
    Inge Depoortere
    Centre for Gastroenterological Research, Catholic University of Leuven, Leuven, Belgium
    Eur J Pharmacol 537:160-5. 2006
    ..This may question the role of endogenous ghrelin in the effects observed with D-Lys(3)-GHRP-6 on food intake and gastric emptying in vivo...
  6. ncbi request reprint Treatment with interleukin-11 affects plasma leptin levels in inflamed and non-inflamed rabbits
    Inge Depoortere
    Centre for Gastroenterological Research, Department of Pathophysiology, University of Leuven, Gasthuisberg O and N, B 3000 Louvain, Belgium
    Regul Pept 122:149-56. 2004
    ..Increase of motilin expression by leptin may be part of a feedback mechanism...
  7. ncbi request reprint Comparison of the gastroprokinetic effects of ghrelin, GHRP-6 and motilin in rats in vivo and in vitro
    Inge Depoortere
    Centre for Gastroenterological Research, Department of Pathophysiology, University of Leuven, Gasthuisberg O and N, B 3000, Leuven, Belgium
    Eur J Pharmacol 515:160-8. 2005
    ..We compared the gastroprokinetic effects of ghrelin, the ghrelin receptor agonist, growth hormone releasing peptide 6 (GHRP-6), and motilin in rats in vivo and in vitro...
  8. ncbi request reprint Mechanisms involved in the loss of excitatory post-stimulus responses by inflammation
    Inge Depoortere
    Department of Pathophysiology, Center for Gastroenterological Research, University of Leuven, Gasthuisberg O and N, 3000 Leuven, Belgium
    Naunyn Schmiedebergs Arch Pharmacol 367:245-52. 2003
    ..Therefore we characterized rebound responses in non-inflamed and inflamed tissue by comparing the effect of antagonists/blockers of putative (nitric oxide [NO], ATP, substance P, prostaglandins) and new (serotonin) neurotransmitters...
  9. ncbi request reprint Interaction of the growth hormone-releasing peptides ghrelin and growth hormone-releasing peptide-6 with the motilin receptor in the rabbit gastric antrum
    Inge Depoortere
    Department of Pathophysiology, Centre for Gastroenterological Research, University of Leuven, Leuven, Belgium
    J Pharmacol Exp Ther 305:660-7. 2003
    ....
  10. doi request reprint Desensitization and internalization of the human motilin receptor is independent of the C-terminal tail
    Anna Mitselos
    Centre for Gastroenterological Research, Catholic University of Leuven, B 3000 Leuven, Belgium
    Peptides 29:1167-75. 2008
    ..Truncation favors internalization via either phosphorylation-independent pathways or via phosphorylation of alternative sites in the receptor...
  11. pmc Colitis affects the smooth muscle and neural response to motilin in the rabbit antrum
    Inge Depoortere
    Centre for Gastroenterological Research, Catholic University of Leuven, Leuven, Belgium
    Br J Pharmacol 159:384-93. 2010
    ..This study investigated the effects of colitis on the contractile effects of motilin, an important endocrine regulator of gastric motility, in the antrum...
  12. ncbi request reprint Differences in motilin receptor desensitization after stimulation with motilin or motilides are due to alternative receptor trafficking
    Anna Mitselos
    Centre for Gastroenterological Research, Catholic University of Leuven, Gasthuisberg O and N 1, bus 701, B 3000 Leuven, Belgium
    Biochem Pharmacol 75:1115-28. 2008
    ..We therefore compared the mechanisms involved in the intracellular trafficking of the MTLR after stimulation with motilin, erythromycin-A (EM-A) or ABT-229...
  13. ncbi request reprint Evidence for the presence of motilin, ghrelin, and the motilin and ghrelin receptor in neurons of the myenteric plexus
    Luo Xu
    Center for Gastroenterological Research, University of Leuven, Gasthuisberg O and N, B 3000 Leuven, Belgium
    Regul Pept 124:119-25. 2005
    ....
  14. pmc Sensing of fatty acids for octanoylation of ghrelin involves a gustatory G-protein
    Sara Janssen
    Translational Research Center for Gastrointestinal Disorders, Catholic University of Leuven, Leuven, Belgium
    PLoS ONE 7:e40168. 2012
    ..We investigated whether the gustatory G-protein, α-gustducin, and the free fatty acid receptors GPR40 and GPR120 are involved in the fatty acid sensing mechanisms of the ghrelin cell...
  15. ncbi request reprint Motilin and erythromycin-A share a common binding site in the third transmembrane segment of the motilin receptor
    Luo Xu
    Department of Pathophysiology, Centre for Gastroenterological Research, University of Leuven, Gasthuisberg O and N bus 701, B 3000 Leuven, Belgium
    Biochem Pharmacol 70:879-87. 2005
    ....
  16. pmc Specific hunger- and satiety-induced tuning of guinea pig enteric nerve activity
    Lina Roosen
    Laboratory for Enteric Neuroscience LENS, Leuven, Belgium
    J Physiol 590:4321-33. 2012
    ....
  17. pmc Bitter taste receptors and α-gustducin regulate the secretion of ghrelin with functional effects on food intake and gastric emptying
    Sara Janssen
    Department of Pathophysiology, Translational Research Center for Gastrointestinal Disorders, Catholic University of Leuven, 3000 Leuven, Belgium
    Proc Natl Acad Sci U S A 108:2094-9. 2011
    ..Modulation of endogenous ghrelin levels by tastants may provide novel therapeutic applications for the treatment of weight -and gastrointestinal motility disorders...
  18. doi request reprint Motilin and ghrelin as prokinetic drug targets
    Betty De Smet
    Center for Gastrointestinal Research, University of Leuven, Belgium
    Pharmacol Ther 123:207-23. 2009
    ..Future studies will need to point out whether the motilin-ghrelin receptor family will make it as a new class of gastroprokinetics...
  19. doi request reprint Role of ghrelin in the relationship between hyperphagia and accelerated gastric emptying in diabetic mice
    Pieter Jan Verhulst
    Centre for Gastroenterological Research, Catholic University of Leuven, Leuven, Belgium
    Gastroenterology 135:1267-76. 2008
    ..We investigated the causative role of ghrelin herein by comparing changes in ghrelin receptor knockout (growth hormone secretagogue receptor [GHS-R](-/-)) and wild-type (GHS-R(+/+)) mice with STZ-induced diabetes...
  20. ncbi request reprint The motilin pharmacophore in CHO cells expressing the human motilin receptor
    Leen Thielemans
    Department of Pathophysiology, Gut Hormone Lab, Center for Gastroenterological Research, Katholieke Universiteit Leuven, Leuven B 3000, Belgium
    Biochem Biophys Res Commun 293:1223-7. 2002
    ..Conservation of the motilin pharmacophore in evolution indicates an important physiological role of motilin...
  21. pmc The Gustatory Signaling Pathway and Bitter Taste Receptors Affect the Development of Obesity and Adipocyte Metabolism in Mice
    Bert Avau
    Translational Research Center for Gastrointestinal Disorders, Gut Peptide Research Lab, University of Leuven, Gasthuisberg O and N1, Box 701, 3000 Leuven, Belgium
    PLoS ONE 10:e0145538. 2015
    ..Intra-gastric bitter treatment inhibits weight gain, possibly by directly affecting adipocyte metabolism. ..
  22. ncbi request reprint Influence of motilin on gastric fundus tone and on meal-induced satiety in man: role of cholinergic pathways
    Rosario Cuomo
    Department of Internal Medicine, Division of Gastroenterology, University Hospital Gasthuisberg, University of Leuven, Leuven, Belgium
    Am J Gastroenterol 101:804-11. 2006
    ..It has been speculated that it is due to the contractile effect of motilin agonists on the proximal stomach, but the pathway involved and the symptomatic consequences have been incompletely elucidated...
  23. doi request reprint Supplementation of oligofructose, but not sucralose, decreases high-fat diet induced body weight gain in mice independent of gustducin-mediated gut hormone release
    Sandra Steensels
    Department of Clinical and Experimental Medicine, KU Leuven, Leuven, Belgium
    Mol Nutr Food Res . 2016
    ..We studied if supplementation of artificial (sucralose) or prebiotic (oligofructose; OFS) sweeteners target gustducin-mediated signaling pathways to alter gut hormone release and reduce obesity-associated disorders...
  24. ncbi request reprint The role of nutrient sensing in the metabolic changes after gastric bypass surgery
    Sandra Steensels
    S Steensels, Clinical and Experimental Medicine, Katholieke Universiteit Leuven, Leuven, 3000, Belgium
    J Endocrinol . 2016
    ..Elevated plasma GLP1 and PYY levels might mediate this effect, although α-gustducin differentially affects several regulatory systems in the foregut and hindgut, tuning gut hormone release...
  25. pmc Shifting the circadian rhythm of feeding in mice induces gastrointestinal, metabolic and immune alterations which are influenced by ghrelin and the core clock gene Bmal1
    Jorien Laermans
    Gut Peptide Research Lab, Translational Research Center for Gastrointestinal Disorders, KU Leuven University of Leuven, Leuven, Belgium
    PLoS ONE 9:e110176. 2014
    ..We aimed to investigate whether ghrelin triggers the changes in body weight and gastric emptying that occur during RF. Moreover, the effect of genetic deletion of the core clock gene Bmal1 on these physiological adaptations was studied...
  26. doi request reprint Nutrient sensing in the gut: new roads to therapeutics?
    Sara Janssen
    Translational Research Center for Gastrointestinal Disorders, Gut Peptide Research Lab, Catholic University of Leuven, 3000 Leuven, Belgium
    Trends Endocrinol Metab 24:92-100. 2013
    ....
  27. doi request reprint The migrating motor complex: control mechanisms and its role in health and disease
    Eveline Deloose
    Translational Research Center for Gastrointestinal Disorders, University of Leuven, Herestraat 49, O and N1, Box 701, 3000 Leuven, Belgium
    Nat Rev Gastroenterol Hepatol 9:271-85. 2012
    ..Measuring the motility of the gastrointestinal tract can be important for the diagnosis of gastrointestinal disorders. In this Review we summarize current knowledge of the MMC, especially its role in health and disease...
  28. ncbi request reprint Sequence, distribution and quantification of the motilin precursor in the cat
    Luo Xu
    Center for Pathophysilogy, Gastroenterological Research, University of Leuven, Gasthuisberg ON, B 3000 Leuven, Belgium
    Peptides 24:1387-95. 2003
    ..Moderate levels were found in the thyroid. These data suggest that the physiological role of motilin may extend beyond its effect on gastrointestinal motility...
  29. pmc Targeting extra-oral bitter taste receptors modulates gastrointestinal motility with effects on satiation
    Bert Avau
    Translational Research Center for Gastrointestinal Disorders, University of Leuven, Leuven, Belgium
    Sci Rep 5:15985. 2015
    ..These findings suggest a potential role for intestinal TAS2Rs as therapeutic targets to alter gastrointestinal motility and hence to interfere with hunger signalling. ..
  30. doi request reprint GI functions of GPR39: novel biology
    Inge Depoortere
    Catholic University of Leuven, Leuven, Belgium
    Curr Opin Pharmacol 12:647-52. 2012
    ..GPR39 signaling also inhibits apoptosis and mediates neural synaptic signaling. Novel ligands of GPR39 are warranted to reveal the main physiological role of this receptor...
  31. pmc Can small non-peptide motilin agonists force a breakthrough as gastroprokinetic drugs?
    Inge Depoortere
    Translational Research Center for Gastrointestinal Disorders, Catholic University of Leuven, Herestraat 49, Leuven, Belgium
    Br J Pharmacol 167:760-2. 2012
    ..The approach used by Broad et al. with human tissue is a validated model to identify motilin receptor agonists with therapeutic value...
  32. pmc The Sweetener-Sensing Mechanisms of the Ghrelin Cell
    Sandra Steensels
    Gut Peptide Lab, Translational Research Center for Gastrointestinal Disorders TARGID, University of Leuven KU Leuven, 3000 Leuven, Belgium
    Nutrients 8:. 2016
    ..In conclusion, α-gustducin-mediated sweet taste receptor signaling does not play a functional role in the sensing of carbohydrates, or low- or high-intensity sweeteners by the ghrelin cell...
  33. pmc Critical role of stress in increased oesophageal mucosa permeability and dilated intercellular spaces
    Ricard Farre
    Center for Gastroenterological Research, Catholic University Leuven, Belgium
    Gut 56:1191-7. 2007
    ..In the rat, acute stress increases gastric and intestinal mucosa permeability. We investigated whether acute stress can also increase oesophageal mucosa permeability and contribute to the dilation of mucosa intercellular spaces...
  34. doi request reprint Differential brain responses to gradual intragastric nutrient infusion and gastric balloon distension: A role for gut peptides?
    Huynh Giao Ly
    Laboratory for Brain Gut Axis Studies LABGAS, Translational Research Center for Gastrointestinal Disorders TARGID, Department of Clinical and Experimental Medicine, University of Leuven, Leuven, Belgium Electronic address
    Neuroimage . 2016
    ..We aimed to directly compare brain responses to gradual balloon distension and intragastric nutrient infusion and to explore the role of differential gut peptide release in these responses...
  35. pmc Ghrelin's second life: From appetite stimulator to glucose regulator
    Pieter Jan Verhulst
    Pieter Jan Verhulst, Inge Depoortere, Translational Research Center for Gastrointestinal Disorders, Catholic University of Leuven, 3000 Leuven, Belgium
    World J Gastroenterol 18:3183-95. 2012
    ....
  36. doi request reprint Targeting the ghrelin receptor to regulate food intake
    Inge Depoortere
    Centre for Gastroenterological Research, Gasthuisberg, O and N, Box 701, B 3000 Leuven, Belgium
    Regul Pept 156:13-23. 2009
    ..Better understanding of the mechanisms by which ghrelin exerts its effect may enable the development of new treatments for obesity but also for conditions of cachexia...
  37. ncbi request reprint Central, but not peripheral application of motilin increases c-Fos expression in hypothalamic nuclei in the rat brain
    Mei Wu
    Medical College, University of Qingdao, 38 Dengzhou Road, 266021 Qingdao, People s Republic of China
    Histochem Cell Biol 123:139-45. 2005
    ..At present, we cannot exclude the fact that the results observed with motilin in rodents are due to cross-interaction with other related (e.g. ghrelin) or not yet identified receptors...
  38. doi request reprint Effect of motilin on the discharge of rat hippocampal neurons responding to gastric distension and its potential mechanism
    Luo Xu
    Department of Pathophysiology, Medical College of Qingdao University, 38 Dengzhou Road, Qingdao, Shandong 266021, PR China
    Peptides 29:585-92. 2008
    ..Our findings suggested that motilin excited the GD-responsive neurons in the hippocampal CA1 region and the excitatory effect of motilin may be mediated by the endogenous NO...
  39. ncbi request reprint In vitro evaluation of motilin agonism by macrolide immunosuppressive drugs
    Bruno van Vlem
    Renal Division, Department of Internal Medicine, Ghent University Hospital, Ghent, Belgium
    Nephrol Dial Transplant 17:973-7. 2002
    ..The aim of this study was to investigate in vitro the possible interaction of tacrolimus and sirolimus with motilin receptors in the rabbit antrum and duodenum...
  40. ncbi request reprint Altered gastrointestinal and metabolic function in the GPR39-obestatin receptor-knockout mouse
    Dieder Moechars
    Johnson and Johnson Pharmaceutical Research and Development, a division of Janssen Pharmaceutica NV, Turnhoutseweg 30, 2340 Beerse, Belgium
    Gastroenterology 131:1131-41. 2006
    ..Recently the peptide obestatin was identified as a natural ligand for GPR39. The objective of this study was to gain insight into the biological function of the GPR39 receptor...
  41. ncbi request reprint Effects of ghrelin on hypothalamic glucose responding neurons in rats
    Xi Chen
    Department of Physiology, Qingdao University School of Medicine, Qingdao 266021, P R China
    Brain Res 1055:131-6. 2005
    ....