Genomes and Genes
Dominique M A Bullens
Affiliation: Katholieke Universiteit Leuven
- Diagnosing serious infections in acutely ill children in ambulatory care (ERNIE 2 study protocol, part A): diagnostic accuracy of a clinical decision tree and added value of a point-of-care C-reactive protein test and oxygen saturationJan Y Verbakel
Department of General Practice, KU Leuven, Kapucijnenvoer 33, 3000 Leuven, Belgium
BMC Pediatr 14:207. 2014..To reduce the number of false positives, point-of-care tests might be useful, providing an immediate result at bedside. The most probable candidate is C-reactive protein, as well as a pulse oximetry...
- IL-17A in human respiratory diseases: innate or adaptive immunity? Clinical implicationsDominique M A Bullens
Pediatrics Division, University Hospitals Leuven, 3000 Leuven, Belgium
Clin Dev Immunol 2013:840315. 2013..We furthermore briefly discuss the possibility to reduce local IL-17A production as a treatment option for respiratory diseases...
- Elevated expression of both mRNA and protein levels of IL-17A in sputum of stable Cystic Fibrosis patientsAnn Decraene
Laboratory of Pneumology, KULeuven, Herestraat, Leuven, Belgium
Respir Res 11:177. 2010....
- Influence of Toll-like-receptor ligands on the dendritic cell-T cell interactions: therapeutic options for allergic diseases? Mini-reviewDominique M A Bullens
Clinical Immunology, Department of Experimental Medicine, Katholieke Universiteit Leuven, Herestraat 49, Leuven, Belgium
Inflamm Allergy Drug Targets 7:211-6. 2008..Furthermore we discuss the activation of DC by TLR-ligands and their differential cytokine induction. Finally, we discuss preclinical studies and potentially therapeutic options using TLR-ligands for allergic diseases...
- Type III IFN-lambda mRNA expression in sputum of adult and school-aged asthmaticsDominique M A Bullens
Clinical Immunology, Department of Experimental Medicine, Katholieke Universiteit Leuven KULeuven, Leuven, Belgium
Clin Exp Allergy 38:1459-67. 2008..The increased susceptibility of asthmatics to rhinovirus infection has recently been related to deficient IFN-lambda 1 (IL-29) and IFN-lambda 2/3 (IL-28) production by bronchial epithelial cells and macrophages...
- Measuring T cell cytokines in allergic upper and lower airway inflammation: can we move to the clinic?Dominique M A Bullens
Clinical Immunology, Department of Experimental Medicine, Katholieke Universiteit Leuven, KULeuven, Leuven, Belgium
Inflamm Allergy Drug Targets 6:81-90. 2007..Finally, we discuss whether measuring these T cell cytokines in the airways might be of diagnostic importance or could help to follow-up patients with allergy/asthma...
- IL-17 mRNA in sputum of asthmatic patients: linking T cell driven inflammation and granulocytic influx?Dominique M A Bullens
Department of Experimental Medicine, Clinical Immunology, Katholieke Universiteit Leuven, KULeuven, Leuven, Belgium
Respir Res 7:135. 2006..Neutrophilic infiltration in the airways is prominent in severe asthma exacerbations and may contribute to airway gland hypersecretion, bronchial hyper-reactivity and airway wall remodelling in asthma...
- House dust mite-specific T cells in healthy non-atopic childrenD M A Bullens
Clinical Immunology, Department of Pathophysiology, Catholic University of Leuven KULeuven, Leuven, Belgium
Clin Exp Allergy 35:1535-41. 2005..Recent studies have demonstrated that allergen-specific T cells can also be found in the blood of healthy individuals. Both IL-10 and IFN-gamma might modulate the induction and maintenance of allergen-specific tolerance...
- Selective nasal allergen provocation induces substance P-mediated bronchial hyperresponsivenessGreet Hens
University Hospital Leuven, Division of Otorhinolaryngology, Kapucijnevoer 33, 3000 Leuven, Belgium
Am J Respir Cell Mol Biol 44:517-23. 2011..Nasal allergen provocation rapidly induces bronchial hyperresponsiveness via pulmonary up-regulation of SP and activation of NK1 receptors...
- T-cell mediated late increase in bronchial tone after allergen provocation in a murine asthma modelIsabelle Meyts
Division of Clinical Immunology, Katholieke Universiteit Leuven, Belgium
Clin Immunol 128:248-58. 2008..We conclude that allergen inhalation in sensitized mice induces airway narrowing similar to the late asthmatic reactions in humans and that this phenomenon is based on activation of CD4(+) T cells...
- Effects of interleukin 4 on CD25+CD4+ regulatory T cell functionPhilippe Maerten
Laboratory of Experimental Immunology, University Hospital, Katholieke Universiteit Leuven, Belgium
J Autoimmun 25:112-20. 2005..In conclusion, our data suggest that the anti-inflammatory function of IL-4 could partly be mediated by effects on Tregs function...
- Crucial role of transient receptor potential ankyrin 1 and mast cells in induction of nonallergic airway hyperreactivity in miceValerie Hox
Laboratory of Clinical Immunology, Department of Microbiology and Immunology, KULeuven, Leuven, Belgium
Am J Respir Crit Care Med 187:486-93. 2013..Swimmers exposed to hypochlorite (ClO(-))-containing water show a higher risk of developing AHR. We developed a mouse model in which instillation of ClO(-) before ovalbumin (OVA) induces AHR without bronchial inflammatory cells...
- Effects of high altitude and cold air exposure on airway inflammation in patients with asthmaSven F Seys
Department of Immunology and Microbiology, Laboratory of Clinical Immunology, KU Leuven, Leuven, Belgium
Thorax 68:906-13. 2013....
- Effect of nasal anti-inflammatory treatment in chronic obstructive pulmonary diseaseIna Callebaut
Clinical Immunology, Department of Microbiology and Immunology, Catholic University of Leuven, Belgium
Am J Rhinol Allergy 27:273-7. 2013..This study was designed to examine the effects of nasal anti-inflammatory treatment on sinonasal symptoms and cough in COPD patients...
- Functional expression of 4-1BB (CD137) in the inflammatory tissue in Crohn's diseasePhilippe Maerten
Clinical Immunology, University Hospital, Katholieke Universiteit Leuven, Leuven, Belgium
Clin Immunol 112:239-46. 2004..Taken together, our data suggest that 4-1BB/4-1BBL interactions contribute to the persistence of gut inflammation in CD...
- Contribution of regulatory T cells and effector T cell deletion in tolerance induction by costimulation blockadeBert Verbinnen
Division of Clinical Immunology, University Hospital, Catholic University of Leuven, Leuven, Belgium
J Immunol 181:1034-42. 2008..At later time points (>30 days after splenocyte transfer), clonal deletion of host-reactive T cells was found to be a major mechanism responsible for tolerance...
- Impaired barrier function in patients with house dust mite-induced allergic rhinitis is accompanied by decreased occludin and zonula occludens-1 expressionBrecht Steelant
Clinical Immunology, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium
J Allergy Clin Immunol 137:1043-53.e1-5. 2016..Tight junction (TJ) defects have recently been associated with asthma and chronic rhinosinusitis. The expression, function, and regulation of nasal epithelial TJs remain unknown in patients with allergic rhinitis (AR)...
- Placental growth factor contributes to bronchial neutrophilic inflammation and edema in allergic asthmaSonja Bobic
Department of Otorhinolaryngology and Head and Neck Surgery, Catholic University Hospitals, Kapucijnevoer 33, Leuven, Belgium
Am J Respir Cell Mol Biol 46:781-9. 2012..PlGF and its receptor VEGFR1 are up-regulated in allergic asthma and play a proinflammatory role by inducing tissue edema, and increasing tissue neutrophilia and the production of IL-17...
- Remission-inducing effect of anti-TNF monoclonal antibody in TNBS colitis: mechanisms beyond neutralization?Chong Shen
Laboratory of Experimental Immunology, Katholike Universiteit Leuven, Belgium
Inflamm Bowel Dis 13:308-16. 2007..The aim was to investigate the pathogenic role of TNF in hapten-induced colitis models and to study the relationship between apoptosis induction and disease remission...