J Arnout

Summary

Affiliation: Katholieke Universiteit Leuven
Country: Belgium

Publications

  1. ncbi request reprint Beta-2-glycoprotein I dependent lupus anticoagulants form stable bivalent antibody beta-2-glycoprotein I complexes on phospholipid surfaces
    J Arnout
    Center for Molecular and Vascular Biology, University of Leuven, Belgium
    Thromb Haemost 79:79-86. 1998
  2. ncbi request reprint Lupus anticoagulant testing in Europe: an analysis of results from the first European Concerted Action on Thrombophilia (ECAT) survey using plasmas spiked with monoclonal antibodies against human beta2-glycoprotein I
    J Arnout
    Center for Molecular and Vascular Biology, University of Leuven, Belgium
    Thromb Haemost 81:929-34. 1999
  3. ncbi request reprint Mechanism of action of beta2-glycoprotein I-dependent lupus anticoagulants
    J Arnout
    Center for Molecular and Vascular Biology, University of Leuven, Belgium
    Lupus 7:S23-8. 1998
  4. ncbi request reprint Understanding the antiphospholipid syndrome and its treatment
    Jef Arnout
    Center for Molecular and Vascular Biology, University of Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Curr Hematol Rep 4:385-90. 2005
  5. ncbi request reprint Monoclonal antibodies against beta-2-glycoprotein I: use as reference material for lupus anticoagulant tests
    J Arnout
    Center for Molecular and Vascular Biology, University of Leuven, Belgium
    Thromb Haemost 79:955-8. 1998
  6. ncbi request reprint Risk for thrombosis linked to the target antigen of a lupus anticoagulant?
    J Arnout
    Center for Molecular and Vascular Biology, University of Leuven, Leuven Belgium, Campus Gasthuisberg, Leuven, Belgium
    J Thromb Haemost 2:697-9. 2004
  7. ncbi request reprint Antiphospholipid syndrome: diagnostic aspects of lupus anticoagulants
    J Arnout
    Center for Molecular and Vascular Biology, University of Leuven, Belgium
    Thromb Haemost 86:83-91. 2001
  8. ncbi request reprint Mechanism and kinetics of factor VIII inactivation: study with an IgG4 monoclonal antibody derived from a hemophilia A patient with inhibitor
    M G Jacquemin
    Center for Molecular and Vascular Biology, Katholieke Universiteit Leuven, Leuven, Belgium
    Blood 92:496-506. 1998
  9. ncbi request reprint Antifactor VIII antibody inhibiting allogeneic but not autologous factor VIII in patients with mild hemophilia A
    K Peerlinck
    Center for Molecular and Vascular Biology, Katholieke Universiteit Leuven, Leuven, Belgium
    Blood 93:2267-73. 1999
  10. ncbi request reprint Congenital disorders of glycosylation type Ia and IIa are associated with different primary haemostatic complications
    C Van Geet
    Department of Paediatrics, University Hospital Gasthuisberg, Leuven, Belgium
    J Inherit Metab Dis 24:477-92. 2001

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Beta-2-glycoprotein I dependent lupus anticoagulants form stable bivalent antibody beta-2-glycoprotein I complexes on phospholipid surfaces
    J Arnout
    Center for Molecular and Vascular Biology, University of Leuven, Belgium
    Thromb Haemost 79:79-86. 1998
    ..In summary, these experiments indicate that the beta2GPI-dependent LA effect depends on the formation of bivalent beta2GPI-antibody complexes on phospholipid surfaces...
  2. ncbi request reprint Lupus anticoagulant testing in Europe: an analysis of results from the first European Concerted Action on Thrombophilia (ECAT) survey using plasmas spiked with monoclonal antibodies against human beta2-glycoprotein I
    J Arnout
    Center for Molecular and Vascular Biology, University of Leuven, Belgium
    Thromb Haemost 81:929-34. 1999
    ....
  3. ncbi request reprint Mechanism of action of beta2-glycoprotein I-dependent lupus anticoagulants
    J Arnout
    Center for Molecular and Vascular Biology, University of Leuven, Belgium
    Lupus 7:S23-8. 1998
    ....
  4. ncbi request reprint Understanding the antiphospholipid syndrome and its treatment
    Jef Arnout
    Center for Molecular and Vascular Biology, University of Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Curr Hematol Rep 4:385-90. 2005
    ..Retrospective studies have suggested that patients with APS and thrombosis need a high-intensity anticoagulant treatment. A few small prospective studies support treatment with a targeted INR of 2 to 3...
  5. ncbi request reprint Monoclonal antibodies against beta-2-glycoprotein I: use as reference material for lupus anticoagulant tests
    J Arnout
    Center for Molecular and Vascular Biology, University of Leuven, Belgium
    Thromb Haemost 79:955-8. 1998
    ....
  6. ncbi request reprint Risk for thrombosis linked to the target antigen of a lupus anticoagulant?
    J Arnout
    Center for Molecular and Vascular Biology, University of Leuven, Leuven Belgium, Campus Gasthuisberg, Leuven, Belgium
    J Thromb Haemost 2:697-9. 2004
  7. ncbi request reprint Antiphospholipid syndrome: diagnostic aspects of lupus anticoagulants
    J Arnout
    Center for Molecular and Vascular Biology, University of Leuven, Belgium
    Thromb Haemost 86:83-91. 2001
    ..These LA positive monoclonal antibodies may be helpful in further improving the laboratory diagnosis of LA...
  8. ncbi request reprint Mechanism and kinetics of factor VIII inactivation: study with an IgG4 monoclonal antibody derived from a hemophilia A patient with inhibitor
    M G Jacquemin
    Center for Molecular and Vascular Biology, Katholieke Universiteit Leuven, Leuven, Belgium
    Blood 92:496-506. 1998
    ..BO2C11 is the first human monoclonal anti-fVIII IgG antibody that has been isolated and allows the study of fVIII inactivation at the molecular level...
  9. ncbi request reprint Antifactor VIII antibody inhibiting allogeneic but not autologous factor VIII in patients with mild hemophilia A
    K Peerlinck
    Center for Molecular and Vascular Biology, Katholieke Universiteit Leuven, Leuven, Belgium
    Blood 93:2267-73. 1999
    ..The inhibition of wild-type FVIII by LE antibody is enhanced by vWF and is associated with an antibody-dependent reduced rate of FVIIIa release from vWF...
  10. ncbi request reprint Congenital disorders of glycosylation type Ia and IIa are associated with different primary haemostatic complications
    C Van Geet
    Department of Paediatrics, University Hospital Gasthuisberg, Leuven, Belgium
    J Inherit Metab Dis 24:477-92. 2001
    ..The reduced GP Ib-mediated platelet reactivity with vessel wall components in the CDG IIa patient under flow conditions provides a basis for his bleeding tendency...
  11. ncbi request reprint Current status and implications of autoimmune antiphospholipid antibodies in relation to thrombotic disease
    J Arnout
    Center for Molecular and Vascular Biology, University of Leuven, Belgium
    J Thromb Haemost 1:931-42. 2003
    ..The final section discusses when to test for such antibodies, how to test and how to consider treatment of patients with the antiphospholipid syndrome...
  12. ncbi request reprint A vitamin K antagonist rapidly reverses a blue toe syndrome in a patient with lupus anticoagulant and antiprothrombin antibodies
    E De Cuypere
    Division of Bleeding and Vascular Disorders and Center for Molecular and Vascular Biology, University of Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Acta Clin Belg 57:74-8. 2002
    ..Our group has previously proposed that membrane-associated immune complexes contribute towards clinical symptoms in the antiphospholipid syndrome. The case presented strengthens that concept...
  13. ncbi request reprint Activation of both coagulation and fibrinolysis in childhood hemolytic uremic syndrome
    C Van Geet
    Department of Pediatrics, Center for Molecular and Vascular Biology, University Hospital Gasthuisberg, Leuven, Belgium
    Kidney Int 54:1324-30. 1998
    ..Yet, individual coagulation factors were normal in the vast majority of patients and therapy with anticoagulants did not alter the course. Recent studies indicate that impaired fibrinolysis might be of importance...
  14. ncbi request reprint The hemostatic system
    J M Stassen
    Thromb X NV, Leuven, Belgium
    Curr Med Chem 11:2245-60. 2004
    ..Plasmin clears the blood vessels by degrading fibrin. Fibrinolysis is controlled by plasminogen activators inhibitor (PAI-1), alpha2-antiplasmin and alpha2-macroglobulin, and thrombin-activatable fibrinolysis inhibitor (TAFI)...
  15. ncbi request reprint Attempts to make sense of the antiphospholipid syndrome
    J Vermylen
    Centre for Molecular and Vascular Biology, University of Leuven, Herestraat 49, B 3000 Leuven, Belgium
    J Thromb Haemost 5:1-4. 2007
    ..As such, Professor Vermylen was involved in both laboratory research and patient care...
  16. ncbi request reprint Genetic variation of the extra-large stimulatory G protein alpha-subunit leads to Gs hyperfunction in platelets and is a risk factor for bleeding
    K Freson
    Center for Molecular and Vascular Biology, University Hospital Gasthuisberg, University of Leuven, Belgium
    Thromb Haemost 86:733-8. 2001
    ..This paternally inherited XLsalpha insertion represents a new genetic cause of an inherited bleeding tendency, although to a variable degree...
  17. ncbi request reprint Major coagulation disturbances during fractionated plasma separation and adsorption
    B K I Meijers
    Department of Medicine, Division of Nephrology, University Hospital Leuven, Leuven, Belgium
    Am J Transplant 7:2195-9. 2007
    ..Direct contact between fractionated plasma and the Prometh02 anion exchanger causes significant adsorption of procoagulant and anti-coagulant factors, associated with clinically relevant adverse events...
  18. doi request reprint Comparison of fresh frozen plasma and prothrombin complex concentrate for the reversal of oral anticoagulants in patients undergoing cardiopulmonary bypass surgery: a randomized study
    R Demeyere
    Department of Anaesthesiology, University Hospital Gasthuisberg, Leuven, Belgium
    Vox Sang 99:251-60. 2010
    ..Fresh frozen plasma (FFP) and prothrombin complex concentrates (PCC) reverse oral anticoagulants. We compared PCC and FFP intraoperative administration in patients undergoing heart surgery with cardiopulmonary bypass (CPB)...
  19. ncbi request reprint Effects of enteric-coated, low-dose aspirin on parameters of platelet function
    A Van Hecken
    Center for Clinical Pharmacology, University Hospital Gasthuisberg, Leuven, Belgium
    Aliment Pharmacol Ther 16:1683-8. 2002
    ..Aspirin is widely used as an anti-thrombotic drug; however, it has been suggested that enteric-coated formulations of aspirin may be less bioavailable and less effective as anti-thrombotic agents...
  20. ncbi request reprint A patient with Hodgkin's lymphoma, antiphospholipid syndrome and severe mitral insufficiency
    S Cherrier-De Wilde
    Department of Hematology University of Leuven, Herestraat 49, 3000 Leuven, Belgium
    Acta Clin Belg 61:183-7. 2006
    ..The possible link between these symptoms being antiphospholipid antibodies, is discussed briefly...
  21. ncbi request reprint Deficiency or inhibition of Gas6 causes platelet dysfunction and protects mice against thrombosis
    A Angelillo-Scherrer
    The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Leuven, Belgium
    Nat Med 7:215-21. 2001
    ..Thus, Gas6 is a platelet-response amplifier that plays a significant role in thrombosis. These findings warrant further evaluation of the possible therapeutic use of Gas6 inhibition for prevention of thrombosis...
  22. ncbi request reprint Fluorescent chemical cleavage of mismatches for efficient screening of the factor VIII gene
    K Freson
    Center for Human Genetics, University of Leuven, Belgium
    Hum Mutat 11:470-9. 1998
    ..Fifteen of these mutations are new. Thus virtually all kind of mutations are detectable by this method. Moreover, the analysis of the gene can be completed in 2 days...
  23. ncbi request reprint Thrombogenicity of beta 2-glycoprotein I-dependent antiphospholipid antibodies in a photochemically induced thrombosis model in the hamster
    Milosz Jankowski
    Center for Molecular and Vascular Biology, University of Leuven, Belgium
    Blood 101:157-62. 2003
    ..Cellular activation via the Fc portion of these immune complexes, however, is not essential, because F(ab')(2) fragments of 5H2 still promote thrombus formation...
  24. ncbi request reprint Quality assessment of oral anticoagulation in Belgium, as practiced by a group of general practitioners
    Neree Claes
    Department of General Practice, Catholic University Leuven, Belgium
    Acta Cardiol 60:247-52. 2005
    ..This study aims to evaluate the quality of management of oral anticoagulation by Belgian GPs and to verify the relation between time in range and a set of potentially influencing co-variables...
  25. ncbi request reprint The Belgian Improvement Study on Oral Anticoagulation Therapy: a randomized clinical trial
    Neree Claes
    Department of General Practice, Catholic University Leuven, Kapucijnenvoer, 33 Blok J, B 3000 Leuven, Leuven, Belgium
    Eur Heart J 26:2159-65. 2005
    ..To improve the quality of oral anticoagulation management by GPs and to compare different models and interventions, a randomized clinical trial was performed...
  26. ncbi request reprint Antiphospholipid syndrome
    Jef Arnout
    University of Leuven, Leuven, Belgium
    Hematol J 5:S1-5. 2004
  27. ncbi request reprint Heparin influences human platelet behavior in cardiac surgery with or without cardiopulmonary bypass
    Steven Laga
    Department of Cardiac Surgery, Catholic University Hospitals Leuven, Leuven, Belgium
    Artif Organs 29:541-6. 2005
    ..Platelet function reduces significantly after heparin administration. Hemodilution and predominantly heparin are the causes of platelet dysfunction after cardiac surgery...
  28. ncbi request reprint Dimers of beta 2-glycoprotein I increase platelet deposition to collagen via interaction with phospholipids and the apolipoprotein E receptor 2'
    Bianca C H Lutters
    Department of Haematology, University Medical Center, and Institute of Biomembranes, Utrecht University, 3508GA Utrecht, The Netherlands
    J Biol Chem 278:33831-8. 2003
    ..These results demonstrate that dimeric beta 2GPI induces increased platelet adhesion and thrombus formation, which depends on activation via apoER2'...