Y Horsmans

Summary

Country: Belgium

Publications

  1. pmc Stable hepatitis C virus RNA detection by RT-PCR during four days storage
    Anne Isabelle de Moreau de Gerbehaye
    Department of Virology, Université Catholique de Louvain et Cliniques Universitaires Saint Luc, Brussels, Belgium
    BMC Infect Dis 2:22. 2002
  2. ncbi request reprint Interferon-induced depression in chronic hepatitis C
    Y Horsmans
    Department of Gastroenterology, Cliniques Universitaires Saint Luc Université Catholique de Louvain, Belgium
    J Antimicrob Chemother 58:711-3. 2006
  3. ncbi request reprint Intravenous omeprazole in critically ill patients: a randomized, crossover study comparing 40 with 80 mg plus 8 mg/hour on intragastric pH
    P F Laterre
    Department of Critical Care Medicine, Cliniques Universitaires St Luc, Brussels, Belgium
    Crit Care Med 29:1931-5. 2001
  4. ncbi request reprint [Multidetector CT and MRI of benign liver tumors]
    Be Van Beers
    Service d Imagerie Medicale, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Bruxelles, Belgique
    J Radiol 84:445-56; discussion 457-8. 2003
  5. ncbi request reprint Adult liver transplantation at UCL: update 2002
    J Lerut
    Liver Transplant Program, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, 1200 Brussels, Belgium
    Acta Gastroenterol Belg 67:188-96. 2004
  6. ncbi request reprint Hypervitaminosis A-induced liver fibrosis: stellate cell activation and daily dose consumption
    M C Nollevaux
    Department of Pathology, Cliniques Universitaires Saint Luc, University of Louvain, Brussels, Belgium
    Liver Int 26:182-6. 2006
  7. pmc Limited therapeutic efficacy of pioglitazone on progression of hepatic fibrosis in rats
    I A Leclercq
    Laboratoire de Gastroenterologie, Gastroenterology Unit, Universite Catholique de Louvain, GAEN 53 79, Avenue Mounier, 53, B 1200 Brussels, Belgium
    Gut 55:1020-9. 2006
  8. ncbi request reprint [Calcified portal vein thrombosis in the follow-up of surgical portocaval shunt: Sonographic findings and differential diagnosis]
    E Danse
    Departement de Radiologie, Cliniques Universitaires St Luc, Universite Catholique de Louvain, Av Hippocrate, 1200 Bruxelles, Belgique
    J Radiol 87:1696-9. 2006
  9. ncbi request reprint The PPARgamma agonist pioglitazone inhibits early neoplastic occurrence in the rat liver
    I Borbath
    Gastroenterology Laboratory, Cliniques Universitaires St Luc, Universite Catholique de Louvain, 10, Avenue Hippocrate, 1200 Brussels, Belgium
    Eur J Cancer 43:1755-63. 2007
  10. ncbi request reprint Non-invasive quantification of liver perfusion with dynamic computed tomography and a dual-input one-compartmental model
    R Materne
    Department of Radiology, Universite Catholique de Louvain, St Luc University Hospital, B 1200 Brussels, Belgium
    Clin Sci (Lond) 99:517-25. 2000

Collaborators

Detail Information

Publications36

  1. pmc Stable hepatitis C virus RNA detection by RT-PCR during four days storage
    Anne Isabelle de Moreau de Gerbehaye
    Department of Virology, Université Catholique de Louvain et Cliniques Universitaires Saint Luc, Brussels, Belgium
    BMC Infect Dis 2:22. 2002
    ..We evaluated the stability of HCV RNA in serum and clotted blood samples stored at room temperature or at 4 degrees C for 4 days with the aim of optimizing the standard procedures of processing and storage of samples...
  2. ncbi request reprint Interferon-induced depression in chronic hepatitis C
    Y Horsmans
    Department of Gastroenterology, Cliniques Universitaires Saint Luc Université Catholique de Louvain, Belgium
    J Antimicrob Chemother 58:711-3. 2006
    ..In conclusion, advances in HCV antiviral therapy and the comprehension and subsequent treatment of side effects induced by this therapy should allow us to treat more patients with greater success...
  3. ncbi request reprint Intravenous omeprazole in critically ill patients: a randomized, crossover study comparing 40 with 80 mg plus 8 mg/hour on intragastric pH
    P F Laterre
    Department of Critical Care Medicine, Cliniques Universitaires St Luc, Brussels, Belgium
    Crit Care Med 29:1931-5. 2001
    ..To compare intravenous omeprazole 40-mg single dose with 8 mg/hr after an 80-mg bolus injection on 24-hr intragastric pH in intensive care unit (ICU) ventilated patients...
  4. ncbi request reprint [Multidetector CT and MRI of benign liver tumors]
    Be Van Beers
    Service d Imagerie Medicale, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Bruxelles, Belgique
    J Radiol 84:445-56; discussion 457-8. 2003
    ..Several benign liver tumors, particularly hemangiomas and lesions of focal nodular hyperplasia, can be characterized with CT and MRI. Histologic examination is still needed to characterize some benign liver tumors...
  5. ncbi request reprint Adult liver transplantation at UCL: update 2002
    J Lerut
    Liver Transplant Program, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, 1200 Brussels, Belgium
    Acta Gastroenterol Belg 67:188-96. 2004
    ..6%) should be further incentives to tailor the immunosuppression to the individual patient and to direct the attention of the transplant physician to the long-term quality of life of the liver recipient...
  6. ncbi request reprint Hypervitaminosis A-induced liver fibrosis: stellate cell activation and daily dose consumption
    M C Nollevaux
    Department of Pathology, Cliniques Universitaires Saint Luc, University of Louvain, Brussels, Belgium
    Liver Int 26:182-6. 2006
    ..In the normal liver, vitamin A is stored in hepatic stellate cells (HSC), which are prone to becoming activated and acquiring a myofibroblast-like phenotype, producing large amounts of extracellular matrix...
  7. pmc Limited therapeutic efficacy of pioglitazone on progression of hepatic fibrosis in rats
    I A Leclercq
    Laboratoire de Gastroenterologie, Gastroenterology Unit, Universite Catholique de Louvain, GAEN 53 79, Avenue Mounier, 53, B 1200 Brussels, Belgium
    Gut 55:1020-9. 2006
    ..We evaluated the therapeutic antifibrotic potential of the PPARgamma agonist pioglitazone on established hepatic fibrosis...
  8. ncbi request reprint [Calcified portal vein thrombosis in the follow-up of surgical portocaval shunt: Sonographic findings and differential diagnosis]
    E Danse
    Departement de Radiologie, Cliniques Universitaires St Luc, Universite Catholique de Louvain, Av Hippocrate, 1200 Bruxelles, Belgique
    J Radiol 87:1696-9. 2006
    ....
  9. ncbi request reprint The PPARgamma agonist pioglitazone inhibits early neoplastic occurrence in the rat liver
    I Borbath
    Gastroenterology Laboratory, Cliniques Universitaires St Luc, Universite Catholique de Louvain, 10, Avenue Hippocrate, 1200 Brussels, Belgium
    Eur J Cancer 43:1755-63. 2007
    ..As pioglitazone has a low toxicity profile, we believe it would be interesting to evaluate its effect in chemoprevention of HCC in humans in a clinical setting...
  10. ncbi request reprint Non-invasive quantification of liver perfusion with dynamic computed tomography and a dual-input one-compartmental model
    R Materne
    Department of Radiology, Universite Catholique de Louvain, St Luc University Hospital, B 1200 Brussels, Belgium
    Clin Sci (Lond) 99:517-25. 2000
    ..1). Our results indicate that dynamic CT combined with a dual-input one-compartmental model provides a valid and reliable method for the non-invasive quantification of perfusion in the normal liver...
  11. ncbi request reprint The compensatory hyperplasia (liver regeneration) following ligation of a portal branch is initiated before the atrophy of the deprived lobes
    L Lambotte
    Experimental Surgery Unit, Universite Catholique de Louvain, Brussels, Belgium
    J Hepatol 32:940-5. 2000
    ..As this has not been demonstrated, the time course and magnitude of those two sequences of events were investigated and compared with the well-defined response to a partial hepatectomy...
  12. ncbi request reprint Gadolinium-enhanced arterial-phase MR imaging of hypervascular liver tumors: comparison between tailored and fixed scanning delays in the same patients
    R Materne
    Department of Radiology, Universite Catholique de Louvain, St Luc University Hospital, Brussels, Belgium
    J Magn Reson Imaging 11:244-9. 2000
    ....
  13. ncbi request reprint MR imaging of hypervascular liver tumors: timing optimization during the arterial phase
    B E van Beers
    Department of Radiology, Universite Catholique de Louvain, St Luc University Hospital, Brussels, Belgium
    J Magn Reson Imaging 9:562-7. 1999
    ..Timing based on the enhancement profile in the tumor rather than in the aorta should be performed only if rapid MR imaging is available with a time resolution of about 1.5 seconds to image the whole liver...
  14. ncbi request reprint Molecular events associated with accelerated proliferative response in rat livers when partial hepatectomy is preceded by a sham operation
    S Laurent
    Department of Gastroenterology, Universite Catholique de Louvain, 1200 Brussels, Belgium
    Eur J Clin Invest 35:140-7. 2005
    ..When a sham operation is performed 6 h before partial hepatectomy (PH), the regenerative response is accelerated suggesting that sham operation itself contributes to cellular events leading to proliferation...
  15. doi request reprint Treatment of chronic hepatitis C in elderly patients
    Y Horsmans
    Universite Catholique de Louvain, Cliniques Universitaires Saint Luc, Department of Gastroenterology, 10, Avenue Hippocrate, 1200 Brussels, Belgium
    Expert Opin Pharmacother 11:571-7. 2010
    ..The issue of age in cases of chronic hepatitis C (HCV) in the West is a major problem; the average age of patients with HCV is increasing and its prevalence increases with advancing age...
  16. ncbi request reprint Short report: interferon-alpha decreases 14C-aminopyrine breath test values in patients with chronic hepatitis C
    Y Horsmans
    Department of Gastroenterology, Cliniques Universitaires St Luc, Brussels, Belgium
    Aliment Pharmacol Ther 8:353-5. 1994
    ..CONCLUSION: Interferon therapy is associated with a significant and transient inhibition of cytochrome P-450 activity, which should be taken into account when prescribing concurrent therapy with drugs metabolized by this pathway...
  17. ncbi request reprint Weekly pegylated interferon alpha-2b vs daily interferon a-2b versus standard regimen of interferon a-2b in the treatment of patients with chronic hepatitis C virus infection
    Y Horsmans
    Department of Gastroenterology, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, Brussels, Belgium
    Acta Gastroenterol Belg 71:293-7. 2008
    ..Group A : daily interferon alfa-2b at a dose of 4 MIU + ribavirin, Group B : PEG-interferon alfa-2b at a dose of 100 mcg/week + ribavirin; Group C: interferon alfa-2b at a dose of 3 MIU TIW + ribavirin..
  18. ncbi request reprint Interaction between azathioprine and aminosalicylates: an in vivo study in patients with Crohn's disease
    O Dewit
    Department of Gastroenterology, Catholic University of Louvain, Brussels, Belgium
    Aliment Pharmacol Ther 16:79-85. 2002
    ..This could result in a higher risk of bone marrow depression when using the two drugs together...
  19. doi request reprint Foetal 'flat' bile acids reappear during human liver regeneration after surgery
    P Starkel
    Department of Gastroenterology, St Luc University Hospital, Brussels, Belgium
    Eur J Clin Invest 39:58-64. 2009
    ..These changes can be detected in urine. The aim of the present study was to investigate whether flat-BAs also reappear during human liver regeneration, and whether this change correlates with the magnitude of liver resection...
  20. ncbi request reprint Favorable outcome of orthotopic liver transplantation in a patient with subacute liver failure due to the emergence of a hepatitis B YMDD escape mutant virus
    P Starkel
    Department of Gastroenterology, Liver Transplant Program, St Luc University Hospital, Universite Catholique de Louvain, 1200 Brussels, Belgium
    J Hepatol 35:679-81. 2001
    ..Patients with end-stage liver disease due to chronic hepatitis B infection in whom a YMDD escape hepatitis B virus (HBV) mutant has emerged under lamivudine treatment are generally denied liver transplantation (OLT)...
  21. pmc After portal branch ligation in the rat, cellular proliferation is associated with selective induction of c-Ha-ras, p53, cyclin E, and Cdk2
    P Starkel
    Laboratories of Gastroenterology, Universite Catholique de Louvain, 1200 Brussels, Belgium
    Gut 49:119-30. 2001
    ..We also investigated the possible role of inhibitors of cell proliferation in the absence of progression towards the S phase in the atrophying lobes...
  22. ncbi request reprint Daily induction combination treatment with alpha 2b interferon and ribavirin or standard combination treatment in naive chronic hepatitis C patients. A multicentre randomized controlled trial
    H Van Vlierberghe
    Department of Gastroenterology and Hepatology, Ghent University Hospital, Ghent, Belgium
    J Viral Hepat 10:460-6. 2003
    ..Although an early virological response is observed more frequently in the induction treatment, end of treatment response and sustained responses did not differ...
  23. ncbi request reprint Expression of presumed specific early and late factors associated with liver regeneration in different rat surgical models
    S Laurent
    Gastroenterology Laboratories, , Brussels, Belgium
    Lab Invest 81:1299-307. 2001
    ..p53 and c-Ha-ras induction is closely associated with cell cycle progression whereas IL-1beta, but not TGF-beta1, appears to be one of the negative growth regulators that might play an important role in atrophy...
  24. ncbi request reprint Cryopreservation of rat precision-cut liver slices by ultrarapid freezing: influence on phase I and II metabolism and on cell viability upon incubation for 24 hours
    V P Vanhulle
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, , Brussels, Belgium
    Life Sci 68:2391-403. 2001
    ..The results of this study suggest that cryopreserved PCLS are able to maintain some phase I activities for 24 hours after thawing whereas some phase II metabolic capacities are not maintained...
  25. ncbi request reprint A health economic model to assess the cost-effectiveness of PEG IFN alpha-2a and ribavirin in patients with mild chronic hepatitis C
    S Gerkens
    Universite Catholique de Louvain, Cliniques Universitaires Saint Luc, Brussels, Belgium
    J Viral Hepat 14:523-36. 2007
    ....
  26. ncbi request reprint Hepatic perfusion parameters in chronic liver disease: dynamic CT measurements correlated with disease severity
    B E van Beers
    Department of Radiology, , St-Luc University Hospital, Ave. Hippocrate 10, B-1200 Brussels, Belgium
    AJR Am J Roentgenol 176:667-73. 2001
    ..001). No significant change in distribution volume was observed. CONCLUSION: Hepatic perfusion parameters measured with CT were significantly altered in cirrhosis and correlated with the severity of chronic liver disease...
  27. ncbi request reprint Immunolocalisation of cytochrome P-450 3A enzymes in human breast carcinoma: relationship with tumour differentiation and steroid receptors
    C Galant
    Department of Pathology, Saint Luc University Hospital, Catholic University of Louvain, Bruxelles, Belgium
    Pharmacol Toxicol 88:142-6. 2001
    ..Such expression in malignant breast cells appears inversely related to the proliferation index whereas no relation is found with tumour differentiation...
  28. ncbi request reprint Adult-to-adult living related liver transplantation: initial experience
    J P Lerut
    Liver Transplant Program, Cliniques Universitaires Saint-Luc, , 1200 Brussels, Belgium
    Acta Gastroenterol Belg 64:9-14. 2001
    ..All recipients had a complicated post-transplant course. Due to its complexity, both in donor and recipient, LRLT should only be developed very carefully in experienced liver transplant centers...
  29. ncbi request reprint Lamivudine for nephrotic syndrome related to hepatitis B virus (HBV) infection
    N Kanaan
    Department of Nephrology, Universite Catholique de Louvain, Cliniques Universitaires St Luc, Brussels, Belgium
    Clin Nephrol 65:208-10. 2006
    ..This observation documents for the first time in an adult the beneficial effect of lamivudine in glomerulonephritis related to HBV infection with HBV seroconversion and complete remission of the nephrotic syndrome...
  30. ncbi request reprint The surgical management of congenital liver cysts
    J F Gigot
    Department of Digestive Surgery, Saint-Luc University Hospital, Universite Catholique de Louvain (UCL, Hippocrate Avenue, 10, B-1200 Brussels, Belgium
    Surg Endosc 15:357-63. 2001
    ..A tailored approach is thus indicated for patients with congenital liver cystic disease. However, the laparoscopic approach appears to be the gold standard for the treatment of highly symptomatic or complicated simple liver cysts...
  31. ncbi request reprint Spontaneous regression of inflammatory pseudotumor of the liver : a case report
    P Druez
    Department of Gastro enterology, Hôpital St Joseph 6060 GILLY, Belgium
    Acta Gastroenterol Belg 68:101-3. 2005
  32. ncbi request reprint Guidelines for the management of chronic hepatitis C in patients infected after substance use
    G Robaeys
    Department of Gastroenterology and Hepatology, Ziekenhuis Oost Limburg, Genk, Schiepse Bos, 6, B 3600 Genk, Belgium
    Acta Gastroenterol Belg 68:38-45. 2005
  33. ncbi request reprint Effects of oligofructose on glucose and lipid metabolism in patients with nonalcoholic steatohepatitis: results of a pilot study
    C A Daubioul
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Universite Catholique de Louvain, Brussels, Belgium
    Eur J Clin Nutr 59:723-6. 2005
    ..Therefore, we have investigated the effect of daily ingestion of OFS in seven patients with nonalcoholic steatohepatitis (NASH), confirmed by liver biopsies...
  34. ncbi request reprint Midazolam and cortisol metabolism before and after CYP3A induction in humans
    S L Eeckhoudt
    , , Nutrition et Toxicologie, , , Brussels, Belgium
    Int J Clin Pharmacol Ther 39:293-9. 2001
    ..This suggests that the 6beta-OH cortisol urinary ratio test is a non-invasive alternative to the use of systemic midazolam clearance for monitoring the time-course of CYP3A induction...
  35. ncbi request reprint Assessment of hepatic perfusion parameters with dynamic MRI
    R Materne
    Department of Radiology, Universite Catholique de Louvain, St Luc University Hospital, Brussels, Belgium
    Magn Reson Med 47:135-42. 2002
    ..001], r = 0.79 for arterial blood flow [P = 0.01], and r = 0.91 for portal blood flow [P < 0.001]). Our results indicate that hepatic perfusion parameters can be assessed with dynamic MRI and compartmental modeling...
  36. ncbi request reprint Differential induction of midazolam metabolism in the small intestine and liver by oral and intravenous dexamethasone pretreatment in rat
    S L Eeckhoudt
    Department of Pharmaceutical Sciences, Catholic University of Louvain, B 1200 Brussels, Belgium
    Xenobiotica 32:975-84. 2002
    ..4. These results suggest that intestinal CYP3A enzymes in the rat differ from hepatic CYP3A1 and CYP3A2. They also demonstrate that systemic dexamethasone administration can induce intestinal microsome activity...