Niel Hens

Summary

Affiliation: Hasselt University
Country: Belgium

Publications

  1. pmc Differences in gut microbiota composition between obese and lean children: a cross-sectional study
    Liene Bervoets
    Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Antwerp, Belgium
    Gut Pathog 5:10. 2013
  2. pmc Evaluating audio computer assisted self-interviews in urban South African communities: evidence for good suitability and reduced social desirability bias of a cross-sectional survey on sexual behaviour
    Roxanne Beauclair
    The South African Department of Science and Technology National Research Foundation DST NRF Centre of Excellence in Epidemiological Modelling and Analysis SACEMA, Stellenbosch University, 19 Jonkershoek Road, Stellenbosch 7600, South Africa
    BMC Med Res Methodol 13:11. 2013
  3. doi request reprint Robust reconstruction and analysis of outbreak data: influenza A(H1N1)v transmission in a school-based population
    Niel Hens
    Interuniversity Institute for Biostatistics and Statistical Bioinformatics, Hasselt University, Diepenbeek, Belgium
    Am J Epidemiol 176:196-203. 2012
  4. pmc Age-disparity, sexual connectedness and HIV infection in disadvantaged communities around Cape Town, South Africa: a study protocol
    Wim Delva
    South African Centre for Epidemiological Modelling and Analysis, Stellenbosch University, 19 Jonkershoek Road, Stellenbosch 7600, South Africa
    BMC Public Health 11:616. 2011
  5. pmc Dynamics of HPV vaccination initiation in Flanders (Belgium) 2007-2009: a Cox regression model
    Eva Lefevere
    Herman Deleeck Centre for Social Policy, Antwerp University, St Jacobstraat 2, 2000 Antwerpen, Belgium
    BMC Public Health 11:470. 2011
  6. doi request reprint The correlated and shared gamma frailty model for bivariate current status data: an illustration for cross-sectional serological data
    N Hens
    Interuniversity Institute for Biostatistics and Statistical Bioinformatics, Hasselt University, Diepenbeek, Limburg, Belgium
    Stat Med 28:2785-800. 2009
  7. doi request reprint Seventy-five years of estimating the force of infection from current status data
    N Hens
    Interuniversity Institute of Biostatistics and Statistical Bioinformatics, Hasselt University, B 3590 Diepenbeek, Belgium
    Epidemiol Infect 138:802-12. 2010
  8. pmc Mining social mixing patterns for infectious disease models based on a two-day population survey in Belgium
    Niel Hens
    Interuniversity Institute for Biostatistics and Statistical Bioinformatics I BioStat, Hasselt University and Catholic University of Leuven, Agoralaan 1, 3590 Diepenbeek, Belgium
    BMC Infect Dis 9:5. 2009
  9. pmc Estimating the impact of school closure on social mixing behaviour and the transmission of close contact infections in eight European countries
    Niel Hens
    Interuniversity Institute for Biostatistics and Statistical Bioinformatics, Hasselt University, Agoralaan 1, B3590 Diepenbeek, Belgium
    BMC Infect Dis 9:187. 2009
  10. doi request reprint Estimating the effective reproduction number for pandemic influenza from notification data made publicly available in real time: a multi-country analysis for influenza A/H1N1v 2009
    Niel Hens
    Interuniversity Institute for Biostatistics and Statistical Bioinformatics, Hasselt University, Belgium
    Vaccine 29:896-904. 2011

Collaborators

Detail Information

Publications39

  1. pmc Differences in gut microbiota composition between obese and lean children: a cross-sectional study
    Liene Bervoets
    Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Antwerp, Belgium
    Gut Pathog 5:10. 2013
    ..Secondly, associations between analysed gut bacterial species, dietary compounds, energy intake and biochemical blood parameters are evaluated...
  2. pmc Evaluating audio computer assisted self-interviews in urban South African communities: evidence for good suitability and reduced social desirability bias of a cross-sectional survey on sexual behaviour
    Roxanne Beauclair
    The South African Department of Science and Technology National Research Foundation DST NRF Centre of Excellence in Epidemiological Modelling and Analysis SACEMA, Stellenbosch University, 19 Jonkershoek Road, Stellenbosch 7600, South Africa
    BMC Med Res Methodol 13:11. 2013
    ..However, little is known about the suitability and accuracy of ACASI in urban communities with high HIV prevalence in South Africa. To test this, we conducted a sexual behaviour survey in Cape Town, South Africa, using ACASI methods...
  3. doi request reprint Robust reconstruction and analysis of outbreak data: influenza A(H1N1)v transmission in a school-based population
    Niel Hens
    Interuniversity Institute for Biostatistics and Statistical Bioinformatics, Hasselt University, Diepenbeek, Belgium
    Am J Epidemiol 176:196-203. 2012
    ..33 secondary cases per primary case to 0.43 secondary cases per primary case. These results provide quantitative evidence for the change in influenza transmission that is to be expected from school closure...
  4. pmc Age-disparity, sexual connectedness and HIV infection in disadvantaged communities around Cape Town, South Africa: a study protocol
    Wim Delva
    South African Centre for Epidemiological Modelling and Analysis, Stellenbosch University, 19 Jonkershoek Road, Stellenbosch 7600, South Africa
    BMC Public Health 11:616. 2011
    ....
  5. pmc Dynamics of HPV vaccination initiation in Flanders (Belgium) 2007-2009: a Cox regression model
    Eva Lefevere
    Herman Deleeck Centre for Social Policy, Antwerp University, St Jacobstraat 2, 2000 Antwerpen, Belgium
    BMC Public Health 11:470. 2011
    ..During this period the initiative for vaccination was taken by the girl, her family or the general practitioner/pediatrician/gynecologist...
  6. doi request reprint The correlated and shared gamma frailty model for bivariate current status data: an illustration for cross-sectional serological data
    N Hens
    Interuniversity Institute for Biostatistics and Statistical Bioinformatics, Hasselt University, Diepenbeek, Limburg, Belgium
    Stat Med 28:2785-800. 2009
    ..We show that applying a shared rather than a correlated frailty model to cross-sectionally collected serological data on hepatitis A and B leads to biased estimates for the baseline hazard and variance parameters...
  7. doi request reprint Seventy-five years of estimating the force of infection from current status data
    N Hens
    Interuniversity Institute of Biostatistics and Statistical Bioinformatics, Hasselt University, B 3590 Diepenbeek, Belgium
    Epidemiol Infect 138:802-12. 2010
    ..We also provide guidance on deciding which method(s) to apply to estimate the force of infection, given a particular set of data...
  8. pmc Mining social mixing patterns for infectious disease models based on a two-day population survey in Belgium
    Niel Hens
    Interuniversity Institute for Biostatistics and Statistical Bioinformatics I BioStat, Hasselt University and Catholic University of Leuven, Agoralaan 1, 3590 Diepenbeek, Belgium
    BMC Infect Dis 9:5. 2009
    ..In contrast to other European surveys conducted simultaneously, each respondent recorded contacts over two days. Special attention was given to holiday periods, and respondents with large numbers of professional contacts...
  9. pmc Estimating the impact of school closure on social mixing behaviour and the transmission of close contact infections in eight European countries
    Niel Hens
    Interuniversity Institute for Biostatistics and Statistical Bioinformatics, Hasselt University, Agoralaan 1, B3590 Diepenbeek, Belgium
    BMC Infect Dis 9:187. 2009
    ..Of particular interest is the potential impact of school closure as a means of controlling pandemic influenza (and potentially other pathogens)...
  10. doi request reprint Estimating the effective reproduction number for pandemic influenza from notification data made publicly available in real time: a multi-country analysis for influenza A/H1N1v 2009
    Niel Hens
    Interuniversity Institute for Biostatistics and Statistical Bioinformatics, Hasselt University, Belgium
    Vaccine 29:896-904. 2011
    ..In this paper, we show how and in which situations the recorded history of cumulated case counts provides valuable information to estimate the effective reproductive number in an early phase and for a large number of countries...
  11. ncbi request reprint Modelling multisera data: the estimation of new joint and conditional epidemiological parameters
    N Hens
    Center for Statistics, Hasselt University, Campus Diepenbeek, Agoralaan Gebouw D, Diepenbeek, Belgium
    Stat Med 27:2651-64. 2008
    ..Furthermore, we show how to test for association and whether the infection-specific age-dependent FOI curves are proportional and consequently whether separable mixing in the population holds...
  12. pmc Estimating the impact of vaccination using age-time-dependent incidence rates of hepatitis B
    N Hens
    Center for Statistics, Hasselt University, Diepenbeek, Belgium
    Epidemiol Infect 136:341-51. 2008
    ..Moreover, we have shown that conditional on an assumed baseline susceptibility percentage, a smooth force-of-infection profile can be obtained from which two local maxima were observed at ages 9 and 24 years...
  13. doi request reprint Analysing the composition of outpatient antibiotic use: a tutorial on compositional data analysis
    Christel Faes
    Interuniversity Institute for Biostatistics and Statistical Bioinformatics, University of Hasselt, Hasselt, Belgium
    J Antimicrob Chemother 66:vi89-94. 2011
    ..The methods are applied to two related research questions, namely the assessment of changes in the relative volume of use of different antibiotic subclasses over time and changes in the absolute volume of antibiotic use...
  14. doi request reprint Estimating vaccination coverage for the trivalent measles-mumps-rubella vaccine from trivariate serological data
    Nele Goeyvaerts
    Interuniversity Institute for Biostatistics and Statistical Bioinformatics, Hasselt University, Agoralaan 1 Gebouw D, B3590, Diepenbeek, Belgium
    Stat Med 31:1432-49. 2012
    ..For both Belgium and Ireland, all models reveal that the vaccination coverage achieved during the first 15 years since the introduction of measles, mumps, and rubella immunization is insufficient to eliminate measles...
  15. doi request reprint Structural differences in mixing behaviour informing the role of asymptomatic infection and testing symptom heritability
    Eva Santermans
    Interuniversity Institute for Biostatistics and Statistical Bioinformatics, Hasselt University, Belgium Electronic address
    Math Biosci . 2016
    ..In conclusion, incorporating social contact data from both asymptomatic and symptomatic individuals allows inferring on parameters associated with asymptomatic infection based on disease data from symptomatic cases only...
  16. doi request reprint Estimating dynamic transmission model parameters for seasonal influenza by fitting to age and season-specific influenza-like illness incidence
    Nele Goeyvaerts
    Interuniversity Institute for Biostatistics and Statistical Bioinformatics, Hasselt University, Agoralaan Gebouw D, B3590 Diepenbeek, Belgium Centre for Health Economics Research and Modelling Infectious Diseases, Vaccine and Infectious Disease Institute, University of Antwerp, Universiteitsplein 1, B2610 Wilrijk, Belgium Electronic address
    Epidemics 13:1-9. 2015
    ..Our results demonstrate the importance of between-season variability in influenza transmission and our estimates are in line with the classification of influenza seasons according to intensity and vaccine matching...
  17. pmc Model structure analysis to estimate basic immunological processes and maternal risk for parvovirus B19
    Nele Goeyvaerts
    Interuniversity Institute for Biostatistics and Statistical Bioinformatics, Hasselt University, Diepenbeek, Belgium
    Biostatistics 12:283-302. 2011
    ..When prevaccination serological data are available, the framework developed in this paper could prove worthwhile to investigate these different scenarios for other infections as well, such as cytomegalovirus...
  18. doi request reprint Persistence of antimicrobial resistance in respiratory streptococci
    Robin Bruyndonckx
    Interuniversity Institute for Biostatistics and Statistical Bioinformatics I BioStat, University of Hasselt, Agoralaan 1, Hasselt, Belgium Laboratory of Medical Microbiology, Vaccine and Infectious Disease Institute VAXINFECTIO, University of Antwerp, Universiteitsplein 1, Wilrijk, Belgium Electronic address
    J Glob Antimicrob Resist 8:6-12. 2016
    ....
  19. pmc Animal Ownership and Touching Enrich the Context of Social Contacts Relevant to the Spread of Human Infectious Diseases
    Yimer Wasihun Kifle
    Center for Health Economics Research and Modeling of Infectious Diseases CHERMID, Vaccine and Infectious Disease Institute, University of Antwerp, Antwerp, Belgium Interuniversity Institute for Biostatistics and Statistical Bioinformatics I BioStat, Hasselt University, Diepenbeek, Belgium
    PLoS ONE 10:e0133461. 2015
    ..We show that in Belgium animal-human interactions involving young children (0-9 years) and adults (25-54 years) have the highest potential to cause a major zoonotic outbreak. ..
  20. doi request reprint Exploring the association between resistance and outpatient antibiotic use expressed as DDDs or packages
    Robin Bruyndonckx
    Interuniversity Institute for Biostatistics and Statistical Bioinformatics I BioStat, Hasselt University, Hasselt, Belgium
    J Antimicrob Chemother 70:1241-4. 2015
    ..The objective of this study was to explore the association between resistance and outpatient antibiotic use, expressed as either DDDs per 1000 inhabitants per day (DID) or packages per 1000 inhabitants per day (PID)...
  21. doi request reprint Measuring trends of outpatient antibiotic use in Europe: jointly modelling longitudinal data in defined daily doses and packages
    Robin Bruyndonckx
    Interuniversity Institute for Biostatistics and Statistical Bioinformatics I BioStat, University of Hasselt, Diepenbeek, Belgium
    J Antimicrob Chemother 69:1981-6. 2014
    ....
  22. doi request reprint Application of mixed-effects models to study the country-specific outpatient antibiotic use in Europe: a tutorial on longitudinal data analysis
    Girma Minalu
    Interuniversity Institute for Biostatistics and Statistical Bioinformatics, University of Hasselt, Hasselt, Belgium
    J Antimicrob Chemother 66:vi79-87. 2011
    ....
  23. doi request reprint Multi-disease analysis of maternal antibody decay using non-linear mixed models accounting for censoring
    Nele Goeyvaerts
    Interuniversity Institute for Biostatistics and Statistical Bioinformatics, Hasselt University, Agoralaan 1 Building D, 3590, Diepenbeek, Belgium
    Stat Med 34:2858-71. 2015
    ..For some pairs, computational issues occurred with increasing correlation matrix complexity, which underlines the importance of further developing estimation methods for MNMMs...
  24. doi request reprint A mathematical model for HIV and hepatitis C co-infection and its assessment from a statistical perspective
    Amparo Yovanna Castro Sanchez
    Interuniversity Institute for Biostatistics and Statistical Bioinformatics, Hasselt University, Agoralaan 1, B3590 Diepenbeek, Belgium
    Epidemics 5:56-66. 2013
    ..The parameters associated with contact rates (sharing syringes) and the transmission rates per syringe-sharing event are shown to play a major role...
  25. doi request reprint Simulation-based evaluation of the performance of the F test in a linear multilevel model setting with sparseness at the level of the primary unit
    Robin Bruyndonckx
    Interuniversity Institute for Biostatistics and Statistical Bioinformatics I BioStat, Hasselt University, Martelarenlaan 42, Hasselt, Belgium
    Biom J 58:1054-70. 2016
    ..We conclude that in the presence of singletons, one should be careful in using the F test to determine the significance of the fixed effects, and propose the permutation test (under REML) as an alternative. ..
  26. doi request reprint Serology indicates cytomegalovirus infection is associated with varicella-zoster virus reactivation
    Benson Ogunjimi
    Centre for Health Economics Research and Modeling Infectious Diseases, Vaccine and Infectious Disease Institute, University of Antwerp, Antwerp, Belgium Interuniversity Institute for Biostatistics and Statistical Bioinformatics, Hasselt University, Hasselt, Belgium
    J Med Virol 86:812-9. 2014
    ..The combined results thus suggest that both CMV-dependent and CMV-independent immunosenescence occurs. This is supported by an in-depth analysis of VZV, measles and parvovirus B19 antibody titers...
  27. pmc Eight years of the Great Influenza Survey to monitor influenza-like illness in Flanders
    Yannick Vandendijck
    Interuniversity Institute for Biostatistics and Statistical Bioinformatics, Hasselt University, Diepenbeek, Belgium
    PLoS ONE 8:e64156. 2013
    ..The advantages are the speed at which information is available and the fact that data is gathered directly in the community at an individual level...
  28. doi request reprint Efficacy of daily intake of Lactobacillus casei Shirota on respiratory symptoms and influenza vaccination immune response: a randomized, double-blind, placebo-controlled trial in healthy elderly nursing home residents
    Karolien Van Puyenbroeck
    Department of Primary and Interdisciplinary Care, University of Antwerp, Antwerp, Belgium
    Am J Clin Nutr 95:1165-71. 2012
    ..Age is associated with immune dysregulation, which results in an increased infection rate and reduced effectiveness of vaccination...
  29. doi request reprint Inferring rubella outbreak risk from seroprevalence data in Belgium
    Steven Abrams
    Interuniversity Institute for Biostatistics and Statistical Bioinformatics, UHasselt Hasselt University, Diepenbeek, Belgium Electronic address
    Vaccine 34:6187-6192. 2016
    ..We estimated the rubella outbreak risk in Belgium to be low, however maintaining high levels of immunisation and surveillance are of utmost importance to avoid future outbreaks...
  30. pmc Spatiotemporal Evolution of Ebola Virus Disease at Sub-National Level during the 2014 West Africa Epidemic: Model Scrutiny and Data Meagreness
    Eva Santermans
    Interuniversity Institute for Biostatistics and Statistical Bioinformatics, Hasselt University, Diepenbeek, Belgium
    PLoS ONE 11:e0147172. 2016
    ..The rapid recognition and quantitative assessment of localised areas of higher transmission can inform the optimal deployment of public health resources...
  31. pmc The French Connection: The First Large Population-Based Contact Survey in France Relevant for the Spread of Infectious Diseases
    Guillaume Beraud
    Médecine Interne et Maladies Infectieuses, Centre Hospitalier de Poitiers, Poitiers, France EA2694, Université Droit et Santé Lille 2, Lille, France Interuniversity Institute for Biostatistics and statistical Bioinformatics, Hasselt University, Hasselt, Belgium
    PLoS ONE 10:e0133203. 2015
    ..To date, no such data existed for France. Although infectious diseases are frequently seasonal, the temporal variation of contact patterns has not been documented hitherto...
  32. doi request reprint Estimating vaccine coverage from serial trivariate serologic data in the presence of waning immunity
    James G Wood
    From the aSchool of Public Health and Community Medicine, UNSW, Sydney, Australia bInteruniversity Institute for Biostatistics and Statistical Bioinformatics, Hasselt University, Diepenbeek, Belgium cCentre for Health Economics Research and Modeling Infectious Diseases, Vaccine and Infectious Disease Institute, University of Antwerp, Campus Drie Eiken, Antwerp, Belgium dNational Centre for Immunisation Research and Surveillance, Sydney, Australia and eDiscipline of Paediatrics and School of Public Health, University of Sydney, Sydney, Australia
    Epidemiology 26:381-9. 2015
    ..Here, we extend previous methods by accounting for temporal antibody decline in estimating vaccine coverage for measles-mumps-rubella vaccine using serial serosurvey data...
  33. pmc Active learning to understand infectious disease models and improve policy making
    Lander Willem
    Centre for Health Economics Research and Modeling of Infectious Diseases, Vaccine and Infectious Disease Institute, University of Antwerp, Antwerp, Belgium Department of Mathematics and Computer Science, University of Antwerp, Antwerp, Belgium Interuniversitary Institute for Biostatistics and statistical Bioinformatics, Hasselt University, Diepenbeek, Belgium
    PLoS Comput Biol 10:e1003563. 2014
    ..Surrogate models can be readily explored at no computational expense, and can also be used as emulator to improve rapid policy making in various settings. ..
  34. doi request reprint Model based estimates of long-term persistence of inactivated hepatitis A vaccine-induced antibodies in adults
    Niel Hens
    Centre for Health Economic Research and Modeling Infectious Diseases CHERMID, Vaccine and Infectious Disease Institute WHO Collaborating Centre, University of Antwerp, Wilrijk, Belgium Center for Statistics CenStat, Interuniversity Institute of Biostatistics and statistical Bioinformatics I BioStat, Hasselt University, Diepenbeek, Belgium
    Vaccine 32:1507-13. 2014
    ....
  35. doi request reprint On the estimation of the reproduction number based on misreported epidemic data
    Amin Azmon
    Center for Statistics CENSTAT, Interuniversity Institute for Biostatistics and Statistical Bioinformatics I BioStat, Hasselt University, Diepenbeek, Belgium
    Stat Med 33:1176-92. 2014
    ..As an application of our method, we analyzed confirmed daily A(H1N1) v2009 cases made publicly available by the World Health Organization for Mexico and the USA...
  36. doi request reprint Modeling heterogeneity for count data: A study of maternal mortality in health facilities in Mozambique
    Osvaldo Loquiha
    Department of Mathematics and Informatics, Universidade Eduardo Mondlane, Av Julius Nyerere, Campus, 3453, P O Box 257, Maputo, Mozambique
    Biom J 55:647-60. 2013
    ..The final model shows that the maternal mortality rate mainly depends on the geographical location of the health facility, the percentage of women admitted with HIV and the percentage of referrals from the health facility. ..
  37. doi request reprint A sensitivity analysis for shared-parameter models for incomplete longitudinal outcomes
    An Creemers
    I Biostat, Universiteit Hasselt, Diepenbeek, Belgium
    Biom J 52:111-25. 2010
    ..While our focus is on longitudinal outcomes with incomplete outcome data, the ideas developed in this paper are of use whenever a shared-parameter model could be considered...
  38. ncbi request reprint Model selection for incomplete and design-based samples
    N Hens
    Center for Statistics, Universiteit Hasselt, Campus Diepenbeek, Agoralaan Gebouw D, B 3590 Diepenbeek, Belgium
    Stat Med 25:2502-20. 2006
    ..The use of the weighted AIC-criterion is illustrated on data from the Belgian Health Interview Survey, which motivated this research. Simulations show its performance in a variety of settings...
  39. pmc Parvovirus B19 infection in five European countries: seroepidemiology, force of infection and maternal risk of infection
    J Mossong
    Laboratoire Nationale de Santé, Luxembourg, Luxembourg
    Epidemiol Infect 136:1059-68. 2008
    ..69% in England & Wales, 43.5% and 1.24% in Finland, 39.9% and 0.92% in Italy and 36.8% and 1.58% in Poland, respectively. Our study indicates substantial epidemiological differences in Europe regarding parvovirus B19 infection...