N Takahashi

Summary

Affiliation: Ghent University
Country: Belgium

Publications

  1. ncbi mgl-1, a mouse homologue of the Drosophila tumor-suppressor gene l(2)gl, maps to chromosome 11
    K Kuwabara
    First Department of Biochemistry, Niigata University School of Medicine, Japan
    Genomics 20:337-8. 1994
  2. pmc Leptin is an endogenous protective protein against the toxicity exerted by tumor necrosis factor
    N Takahashi
    Molecular Pathophysiology and Experimental Therapy Unit, Department of Molecular Biology, Flanders Interuniversity Institute for Technology, University of Ghent, B 9000 Ghent, Belgium
    J Exp Med 189:207-12. 1999
  3. ncbi Divergent effects of leptin in mice susceptible or resistant to obesity
    N Takahashi
    University of Pennsylvania School of Medicine, Division of Endocrinology, Diabetes and Metabolism, Philadelphia, Pennsylvania 19104, USA
    Horm Metab Res 34:691-7. 2002
  4. doi Actinobacillus actinomycetemcomitans lipopolysaccharide stimulates collagen phagocytosis by human gingival fibroblasts
    N Takahashi
    Department of Periodontology, Showa University School of Dentistry, Tokyo, Japan
    Oral Microbiol Immunol 23:259-64. 2008
  5. ncbi Induction of JAB/SOCS-1/SSI-1 and CIS3/SOCS-3/SSI-3 is involved in gp130 resistance in cardiovascular system in rat treated with cardiotrophin-1 in vivo
    I Hamanaka
    Department of Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Circ Res 88:727-32. 2001
  6. ncbi Association of serum endoglin with metastasis in patients with colorectal, breast, and other solid tumors, and suppressive effect of chemotherapy on the serum endoglin
    N Takahashi
    Department of Immunology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Clin Cancer Res 7:524-32. 2001
  7. ncbi The molecular basis of osteoclast differentiation and activation
    T Suda
    Department of Biochemistry, School of Dentistry, Showa University, Tokyo 142-8555, Japan
    Novartis Found Symp 232:235-47; discussion 247-50. 2001
  8. ncbi Osteoprotegerin produced by osteoblasts is an important regulator in osteoclast development and function
    N Udagawa
    Department of Biochemistry, School of Dentistry, Showa University, Tokyo, Japan
    Endocrinology 141:3478-84. 2000
  9. pmc Uncompensated polyuria in a mouse model of Bartter's syndrome
    N Takahashi
    Department of Pathology and Laboratory Medicine and Division of Nephrology, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 97:5434-9. 2000
  10. ncbi Inhibition of nuclear factor-kappaB-mediated transcription by association with the amino-terminal enhancer of split, a Groucho-related protein lacking WD40 repeats
    T Tetsuka
    Department of Molecular Genetics, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, Aichi 467 8601, Japan
    J Biol Chem 275:4383-90. 2000

Collaborators

Detail Information

Publications49

  1. ncbi mgl-1, a mouse homologue of the Drosophila tumor-suppressor gene l(2)gl, maps to chromosome 11
    K Kuwabara
    First Department of Biochemistry, Niigata University School of Medicine, Japan
    Genomics 20:337-8. 1994
  2. pmc Leptin is an endogenous protective protein against the toxicity exerted by tumor necrosis factor
    N Takahashi
    Molecular Pathophysiology and Experimental Therapy Unit, Department of Molecular Biology, Flanders Interuniversity Institute for Technology, University of Ghent, B 9000 Ghent, Belgium
    J Exp Med 189:207-12. 1999
    ..We conclude that leptin is involved in the protective mechanisms that allow an organism to cope with the potentially autoaggressive effects of its immune system...
  3. ncbi Divergent effects of leptin in mice susceptible or resistant to obesity
    N Takahashi
    University of Pennsylvania School of Medicine, Division of Endocrinology, Diabetes and Metabolism, Philadelphia, Pennsylvania 19104, USA
    Horm Metab Res 34:691-7. 2002
    ..These results indicate that differences in leptin responsiveness between strains might occur centrally or peripherally, leading to alteration in the patterns of food intake, thermogenesis and energy storage...
  4. doi Actinobacillus actinomycetemcomitans lipopolysaccharide stimulates collagen phagocytosis by human gingival fibroblasts
    N Takahashi
    Department of Periodontology, Showa University School of Dentistry, Tokyo, Japan
    Oral Microbiol Immunol 23:259-64. 2008
    ....
  5. ncbi Induction of JAB/SOCS-1/SSI-1 and CIS3/SOCS-3/SSI-3 is involved in gp130 resistance in cardiovascular system in rat treated with cardiotrophin-1 in vivo
    I Hamanaka
    Department of Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Circ Res 88:727-32. 2001
    ..These results suggest that JAB and CIS3 serve as endogenous inhibitors of CT-1-mediated JAK-STAT signaling in the cardiovascular system in vivo...
  6. ncbi Association of serum endoglin with metastasis in patients with colorectal, breast, and other solid tumors, and suppressive effect of chemotherapy on the serum endoglin
    N Takahashi
    Department of Immunology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Clin Cancer Res 7:524-32. 2001
    ..The results suggest that serum EDG may be a useful marker for monitoring early signs of metastasis and cancer relapse in a long-term follow-up of solid tumor patients...
  7. ncbi The molecular basis of osteoclast differentiation and activation
    T Suda
    Department of Biochemistry, School of Dentistry, Showa University, Tokyo 142-8555, Japan
    Novartis Found Symp 232:235-47; discussion 247-50. 2001
    ..TNF alpha and IL-1 alpha may play an important role in pathological bone resorption due to inflammation...
  8. ncbi Osteoprotegerin produced by osteoblasts is an important regulator in osteoclast development and function
    N Udagawa
    Department of Biochemistry, School of Dentistry, Showa University, Tokyo, Japan
    Endocrinology 141:3478-84. 2000
    ..These findings suggest that OPG produced by osteoblasts/stromal cells is a physiologically important regulator in osteoclast differentiation and function and that RANKL expressed by osteoblasts functions as a membrane-associated form...
  9. pmc Uncompensated polyuria in a mouse model of Bartter's syndrome
    N Takahashi
    Department of Pathology and Laboratory Medicine and Division of Nephrology, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 97:5434-9. 2000
    ..The NKCC2 mutant animals should be valuable for uncovering new pathophysiologic and therapeutic aspects of genetic disturbances in water and electrolyte recovery by the kidney...
  10. ncbi Inhibition of nuclear factor-kappaB-mediated transcription by association with the amino-terminal enhancer of split, a Groucho-related protein lacking WD40 repeats
    T Tetsuka
    Department of Molecular Genetics, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, Aichi 467 8601, Japan
    J Biol Chem 275:4383-90. 2000
    ..These data indicate that AES acts as a corepressor for NF-kappaB and suggest that AES may play a pivotal role in the regulation of NF-kappaB target genes...
  11. ncbi Aberrant overexpression of 53BP2 mRNA in lung cancer cell lines
    T Mori
    Department of Molecular Genetics, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, Japan
    FEBS Lett 465:124-8. 2000
    ....
  12. ncbi NF-kappaB subunit p65 binds to 53BP2 and inhibits cell death induced by 53BP2
    J P Yang
    Department of Molecular Genetics, Nagoya City University Medical School, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Oncogene 18:5177-86. 1999
    ..The previous findings that 53BP2 bound to p53 and Bcl-2 together with our present observations suggest that 53BP2 may play a central role in the regulation of apoptosis and cell growth...
  13. ncbi Substrate recognition by Ca2+/Calmodulin-dependent protein kinase kinase. Role of the arg-pro-rich insert domain
    H Tokumitsu
    Helix Research Institute, Inc, 1532 3 Yana, Kisarazu shi, Chiba 292 0812, Japan
    J Biol Chem 274:15803-10. 1999
    ..These results indicate that the RP-domain in CaM-KK is critical for recognition of downstream CaM-kinases but not for its catalytic activity (i.e. autophosphorylation) and PKB activation...
  14. ncbi Activated human T cells directly induce osteoclastogenesis from human monocytes: possible role of T cells in bone destruction in rheumatoid arthritis patients
    S Kotake
    Institute of Rheumatology, Tokyo Women's Medical University, Japan
    Arthritis Rheum 44:1003-12. 2001
    ..In addition, the present findings suggest that excess production of RANKL by activated T cells increases the level of sRANKL in synovial fluid and may contribute to osteoclastic bone resorption in RA patients...
  15. ncbi Genomic organization of the Shc-related phosphotyrosine adapters and characterization of the full-length Sck/ShcB: specific association of p68-Sck/ShcB with pp135
    T Kojima
    Department of Molecular Genetic Research, National Institute for Longevity Sciences NILS, Morioka cho, Oobu, Aichi, 474 8522, Japan
    Biochem Biophys Res Commun 284:1039-47. 2001
    ..The Sck-pp135 interaction was reduced by Src kinase inhibitors. These results suggest that Sck, but not N-Shc nor Shc, transmit signals in conjunction with pp135 following Src activation and/or calcium entry in the cell...
  16. ncbi Soluble interleukin-1 receptor accessory protein ameliorates collagen-induced arthritis by a different mode of action from that of interleukin-1 receptor antagonist
    R L Smeets
    Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Arthritis Rheum 52:2202-11. 2005
    ..To discern the mode of interleukin-1 (IL-1) inhibition of soluble IL-1 receptor accessory protein (sIL-1RAcP) by comparison with IL-1 receptor antagonist (IL-1Ra) in arthritis...
  17. ncbi PTC gene mutations and expression of SHH, PTC, SMO, and GLI-1 in odontogenic keratocysts
    K Ohki
    Department of Oral Medicine and Surgery, Division of Maxillofacial Surgery, Graduate School of Dentistry, Tohoku University, Sendai, Japan
    Int J Oral Maxillofac Surg 33:584-92. 2004
    ..These results suggest that PTC mutations are probably related not only to BCNS-associated OKCs but also to sporadic OKCs...
  18. ncbi Regulatory mechanisms of osteoblast and osteoclast differentiation
    T Katagiri
    Department of Biochemistry, School of Dentistry, Showa University, Japan
    Oral Dis 8:147-59. 2002
    ..These findings have opened new areas for exploring the molecular mechanisms of osteoblast and osteoclast differentiation...
  19. ncbi Isolation and proteomic characterization of the major proteins of the nucleolin-binding ribonucleoprotein complexes
    M Yanagida
    Department of Applied Biological Science, Tokyo University of Agriculture and Technology, Fuchu, Japan
    Proteomics 1:1390-404. 2001
    ..These results together suggest that the isolated NCL-binding RNP complex is a preribosomal particle present in the nucleolus of 293 cells...
  20. ncbi Angiogenesis and metastasis marker of human tumors
    B K Seon
    Department of Immunology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Rinsho Byori 49:1005-13. 2001
    ..Recently, we generated a recombinant human/mouse chimeric anti-EDG mAb to facilitate clinical application of the mAb...
  21. ncbi The filamentous type III secretion translocon of enteropathogenic Escherichia coli
    S J Daniell
    Centre for Molecular Microbiology and Infection, Department of Biological Sciences, Imperial College of Science, Technology and Medicine, London SW7 2AZ, UK
    Cell Microbiol 3:865-71. 2001
    ..In this paper we provide direct evidence for the association between an EPEC bacterial membrane needle complex and EspA filaments, defining a new class of filamentous TTSS...
  22. ncbi Antiangiogenic therapy of established tumors in human skin/severe combined immunodeficiency mouse chimeras by anti-endoglin (CD105) monoclonal antibodies, and synergy between anti-endoglin antibody and cyclophosphamide
    N Takahashi
    Department of Immunology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer Res 61:7846-54. 2001
    ..These mAbs should show stronger antitumor efficacy in patients whose tumors depend entirely on human blood vessels...
  23. ncbi Transforming growth factor beta affects osteoclast differentiation via direct and indirect actions
    J M Quinn
    Department of Medicine, St. Vincent's Institute of Medical Research and The University of Melbourne, Fitzroy, Victoria, Australia
    J Bone Miner Res 16:1787-94. 2001
    ..Such actions may be critical to the control of physiological and pathophysiological osteolysis...
  24. ncbi BAG-1M, an isoform of Bcl-2-interacting protein BAG-1, enhances gene expression driven by CMV promoter
    N Takahashi
    Department of Bioengineering, Faculty of Engineering, Soka University, Hachioji, Tokyo 192 8577, Japan
    Biochem Biophys Res Commun 286:807-14. 2001
    ..Our study demonstrates that both N-terminal DNA binding site and C-terminal Hsp70/Hsc70 binding site of BAG-1M play an important role in enhancing the CMV promoter activity...
  25. ncbi Bone morphogenetic protein 2 stimulates osteoclast differentiation and survival supported by receptor activator of nuclear factor-kappaB ligand
    K Itoh
    Department of Biochemistry, Showa University School of Dentistry, Tokyo 142-8555
    Endocrinology 142:3656-62. 2001
    ..The enhancement of RANKL-induced survival of osteoclasts by bone morphogenetic protein-2 appears unrelated to nuclear factor-kappaB activation...
  26. pmc IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis
    S Kotake
    The Institute of Rheumatology, Tokyo Women s Medical University, Tokyo 162 0054, Japan
    J Clin Invest 103:1345-52. 1999
    ....
  27. ncbi A new member of tumor necrosis factor ligand family, ODF/OPGL/TRANCE/RANKL, regulates osteoclast differentiation and function
    N Takahashi
    Department of Biochemistry, School of Dentistry, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo, 142 8555, Japan
    Biochem Biophys Res Commun 256:449-55. 1999
    ..Activation of NF-kB and c-Jun N-terminal kinase through the RANK-mediated signaling system appears to be involved in differentiation and activation of osteoclasts...
  28. pmc Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6
    T Tamura
    Department of Biochemistry, School of Dentistry, Showa University, Tokyo, Japan
    Proc Natl Acad Sci U S A 90:11924-8. 1993
    ..This may play an important physiological or pathological role in conditions associated with increased osteoclastic bone resorption...
  29. ncbi A mouse homologue of the Drosophila tumour-suppressor gene l(2)gl controlled by Hox-C8 in vivo
    D Tomotsune
    Department of Molecular Biology, School of Science, Nagoya University, Japan
    Nature 365:69-72. 1993
    ..Here we identify several candidate Hox gene targets, including a mouse homologue of the Drosophila tumour-suppressor gene l(2)gl, by immunopurification of DNA sequences bound to a Hox protein in native chromatin...
  30. ncbi A novel ATP-dependent inward rectifier potassium channel expressed predominantly in glial cells
    T Takumi
    Department of Pharmacology II, Faculty of Medicine Osaka University, Japan
    J Biol Chem 270:16339-46. 1995
    ..This is the first description of the cloning of a glial cell inward rectifier potassium channel, which may be responsible for K+ buffering action of glial cells in the brain...
  31. ncbi Response of interleukin-6-deficient mice to tumor necrosis factor-induced metabolic changes and lethality
    C Libert
    Laboratory of Molecular Biology, University, Gent, Belgium
    Eur J Immunol 24:2237-42. 1994
    ..The results indicate that IL-6 is not contributing in a major way to the pathogenesis leading to TNF-induced shock, and that neither IL-6 nor the APP studied are essential for a protective feedback system...
  32. pmc Amino acid substitutions in genetic variants of human serum albumin and in sequences inferred from molecular cloning
    N Takahashi
    Proc Natl Acad Sci U S A 84:4413-7. 1987
    ..The apparent amino acid substitutions inferred from comparison of individual cDNA sequences probably reflect artifacts in cloning or in cDNA sequence analysis rather than polymorphism of the coding sections of the albumin gene...
  33. ncbi Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilin
    N Takahashi
    Corporate Research and Development Laboratory, Ioa Nenryo, Kogya K K, Saitama, Japan
    Nature 337:473-5. 1989
    ..Thus we propose that the peptidyl-prolyl cis-trans isomerizing activity of PPIase may be involved in events, such as those occurring early in T-cell activation, that are suppressed by cyclosporin A...
  34. ncbi Two distinct forms of peptidylprolyl-cis-trans-isomerase are expressed separately in periplasmic and cytoplasmic compartments of Escherichia coli cells
    T Hayano
    Corporate Research and Development Laboratory, Tonen K K, Saitama, Japan
    Biochemistry 30:3041-8. 1991
    ..Thus, we propose that the folding of some exported proteins may be catalyzed by the periplasmic proline isomerase and, in turn, that some proteins which have isomerized may not be translocated efficiently...
  35. ncbi Catalysis of protein folding by cyclophilins from different species
    E R Schönbrunner
    Biochemisches Laboratorium, Universitat Bayreuth, Federal Republic of Germany
    J Biol Chem 266:3630-5. 1991
    ..It could be related with de novo protein folding or be involved in regulatory processes. Catalysis of folding is very efficient in the presence of the high cellular concentrations of prolyl isomerase...
  36. pmc Complementary DNA encoding the human T-cell FK506-binding protein, a peptidylprolyl cis-trans isomerase distinct from cyclophilin
    N Maki
    Corporate Research and Development Laboratory, Saitama, Japan
    Proc Natl Acad Sci U S A 87:5440-3. 1990
    ..This is in contrast to the result that as many as 20 copies of the cyclophilin gene and possible pseudogenes may be present in the mammalian genome...
  37. ncbi Molecular cloning and intrarenal localization of rat prostaglandin E2 receptor EP3 subtype
    K Takeuchi
    Second Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan
    Biochem Biophys Res Commun 194:885-91. 1993
    ....
  38. ncbi The human homologue of the murine Llglh gene (LLGL) maps within the Smith-Magenis syndrome region in 17p11.2
    K Koyama
    Department of Biochemistry, Cancer Institute, Tokyo, Japan
    Cytogenet Cell Genet 72:78-82. 1996
    ....
  39. ncbi Cloning and mapping of ZNF231, a novel brain-specific gene encoding neuronal double zinc finger protein whose expression is enhanced in a neurodegenerative disorder, multiple system atrophy (MSA)
    H Hashida
    Department of Neurology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Genomics 54:50-8. 1998
    ..Elevation of ZNF231 expression may be involved in the pathogenesis of multiple system atrophy. The gene for ZNF231 is located on chromosome 3p21...
  40. pmc Cocaine reward models: conditioned place preference can be established in dopamine- and in serotonin-transporter knockout mice
    I Sora
    Molecular Neurobiology Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 95:7699-704. 1998
    ..These results have substantial implications for understanding cocaine actions and for strategies to produce anticocaine medications...
  41. ncbi Tyrosine phosphorylation of p130Cas is involved in actin organization in osteoclasts
    I Nakamura
    Department of Biochemistry, School of Dentistry, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142, Japan
    J Biol Chem 273:11144-9. 1998
    ..These findings suggest that Src-dependent tyrosine phosphorylation of Cas is involved in the adhesion-induced actin organization associated with osteoclast activation...
  42. pmc Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL
    H Yasuda
    Research Institute of Life Science, Snow Brand Milk Products Co, Ltd, 519 Ishibashi machi, Shimotsuga gun, Tochigi 329 0512, Japan
    Proc Natl Acad Sci U S A 95:3597-602. 1998
    ..ODF was found to be identical to TRANCE/RANKL, which enhances T-cell growth and dendritic-cell function. ODF seems to be an important regulator in not only osteoclastogenesis but also immune system...
  43. pmc Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2
    S Yonemura
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto 606 01, Japan
    J Cell Biol 140:885-95. 1998
    ..From these findings, we conclude that ERM proteins bind to integral membrane proteins bearing a positively charged amino acid cluster in their juxta-membrane cytoplasmic domain...
  44. ncbi Murine vesicular monoamine transporter 2: molecular cloning and genomic structure
    N Takahashi
    Molecular Neurobiology Branch, Intramural Research Program, National Institute on Drug Abuse, NIH, Baltimore, MD 21224, USA
    Brain Res Mol Brain Res 49:7-14. 1997
    ....
  45. pmc Opiate receptor knockout mice define mu receptor roles in endogenous nociceptive responses and morphine-induced analgesia
    I Sora
    Molecular Neurobiology Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 94:1544-9. 1997
    ..These results implicate endogenous opioid-peptide actions at mu opiate receptors in several tests of nociceptive responsiveness and support mu receptor mediation of morphine-induced analgesia in tests of spinal and supraspinal analgesia...
  46. ncbi Association of a mutation in thiazide-sensitive Na-Cl cotransporter with familial Gitelman's syndrome
    K Takeuchi
    Second Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan
    J Clin Endocrinol Metab 81:4496-9. 1996
    ....
  47. ncbi The substrate-binding site in Escherichia coli cyclophilin A preferably recognizes a cis-proline isomer or a highly distorted form of the trans isomer
    M Konno
    Department of Chemistry, Faculty of Science Ochanomizu University, Tokyo, Japan
    J Mol Biol 256:897-908. 1996
    ..coli CyPA forming a complex with CsA. Thus, the extra amino acid residue of E. coli CyPA, polar Gln89, lies along the pathway to the hydrophobic pocket of CyPA and seems to prevent the access hydrophobic part of CsA to the cleft of CyPA...
  48. ncbi A novel ubiquitously distributed isoform of GIRK2 (GIRK2B) enhances GIRK1 expression of the G-protein-gated K+ current in Xenopus oocytes
    S Isomoto
    Department of Pharmacology II, Faculty of Medicine, Osaka University, Japan
    Biochem Biophys Res Commun 218:286-91. 1996
    ..Therefore, GIRK2B might also play other unrecognized roles in various tissues than to form a K+ channel with GIRK1...
  49. ncbi Genomic structure of the ME491/CD63 antigen gene and functional analysis of the 5'-flanking regulatory sequences
    H Hotta
    Department of Microbiology, Kobe University School of Medicine, Hyogo, Japan
    Biochem Biophys Res Commun 185:436-42. 1992
    ..Deletion mutant analysis of the 5'-flanking sequence has strongly suggested that a potential binding site for AP-1 plays an important role in positively regulating the gene expression...