Ludovicus Staelens

Summary

Affiliation: Ghent University
Country: Belgium

Publications

  1. ncbi request reprint In vivo evaluation of [123I]-4-iodo-N-(4-(4-(2-methoxyphenyl)-piperazin-1-yl)butyl)-benzamide: a potential sigma receptor ligand for SPECT studies
    Ludovicus Staelens
    Department of Radiopharmacy, Faculty of Pharmaceutical Sciences, Gent University, Harelbekestraat 72, B 9000 Gent, Belgium
    Nucl Med Biol 32:193-200. 2005
  2. ncbi request reprint In vivo evaluation of [(123)I]-3-(4-iodobenzyl)-1,2,3,4-tetrahydro-8-hydroxychromeno[3,4-c]pyridin-5-one: a presumed dopamine D4 receptor ligand for SPECT studies
    Ludovicus Staelens
    Department of Radiopharmacy, Faculty of Pharmaceutical Sciences, Gent University, B 9000 Gent, Belgium
    Nucl Med Biol 32:293-9. 2005
  3. ncbi request reprint Valine-based biphenylsulphonamide matrix metalloproteinase inhibitors as tumor imaging agents
    Ruth Oltenfreiter
    Faculty of Pharmaceutical Sciences, Department of Radiopharmacy, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium
    Appl Radiat Isot 64:677-85. 2006
  4. ncbi request reprint New radioiodinated carboxylic and hydroxamic matrix metalloproteinase inhibitor tracers as potential tumor imaging agents
    Ruth Oltenfreiter
    Department of Radiopharmacy, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium
    Nucl Med Biol 31:459-68. 2004
  5. ncbi request reprint Synthesis, radiosynthesis, in vitro and preliminary in vivo evaluation of biphenyl carboxylic and hydroxamic matrix metalloproteinase (MMP) inhibitors as potential tumor imaging agents
    Ruth Oltenfreiter
    Laboratory of Radiopharmacy, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium
    Appl Radiat Isot 62:903-13. 2005
  6. ncbi request reprint Tryptophane-based biphenylsulfonamide matrix metalloproteinase inhibitors as tumor imaging agents
    Ruth Oltenfreiter
    Laboratory of Radiopharmacy, Ghent University, Ghent, Belgium
    Cancer Biother Radiopharm 20:639-47. 2005
  7. ncbi request reprint In vitro and in vivo evaluation of [123I]-VEGF165 as a potential tumor marker
    Bart Cornelissen
    Laboratory for Radiopharmacy, Ghent University, Belgium
    Nucl Med Biol 32:431-6. 2005
  8. ncbi request reprint Optimization by experimental design of precursor synthesis and radiolabeling of 2-iodo-L-phenylalanine, a novel amino acid for tumor imaging
    Veerle Kersemans
    Laboratory of Radiopharmacy, Universiteit Ghent, Ghent, Belgium
    Cancer Biother Radiopharm 21:235-42. 2006
  9. ncbi request reprint (123)I-Interleukin-2 uptake in squamous cell carcinoma of the head and neck carcinoma
    David Loose
    Department of Head and Neck Surgery, Ghent University Hospital, Ghent, Belgium
    Eur J Nucl Med Mol Imaging 35:281-6. 2008

Collaborators

Detail Information

Publications9

  1. ncbi request reprint In vivo evaluation of [123I]-4-iodo-N-(4-(4-(2-methoxyphenyl)-piperazin-1-yl)butyl)-benzamide: a potential sigma receptor ligand for SPECT studies
    Ludovicus Staelens
    Department of Radiopharmacy, Faculty of Pharmaceutical Sciences, Gent University, Harelbekestraat 72, B 9000 Gent, Belgium
    Nucl Med Biol 32:193-200. 2005
    ..In conclusion, our findings indicate that [123I]-BPB is not a suitable tracer for visualisation of D3 receptors while its potential for sigma receptor imaging is severely hampered by its affinity for dopamine receptors...
  2. ncbi request reprint In vivo evaluation of [(123)I]-3-(4-iodobenzyl)-1,2,3,4-tetrahydro-8-hydroxychromeno[3,4-c]pyridin-5-one: a presumed dopamine D4 receptor ligand for SPECT studies
    Ludovicus Staelens
    Department of Radiopharmacy, Faculty of Pharmaceutical Sciences, Gent University, B 9000 Gent, Belgium
    Nucl Med Biol 32:293-9. 2005
    ..In conclusion, our findings indicate that [(123)I]-ITCP is neither a dopamine D4 receptor ligand nor a sigma receptor ligand. The exact nature of [(123)I]-ITCP binding in the brain remains to be elucidated...
  3. ncbi request reprint Valine-based biphenylsulphonamide matrix metalloproteinase inhibitors as tumor imaging agents
    Ruth Oltenfreiter
    Faculty of Pharmaceutical Sciences, Department of Radiopharmacy, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium
    Appl Radiat Isot 64:677-85. 2006
    ..In vivo evaluation of these radioiodinated carboxylic and hydroxamic MMP inhibitor tracers revealed that MMP inhibitors could have potential as tumor imaging agents, but that further research is necessary...
  4. ncbi request reprint New radioiodinated carboxylic and hydroxamic matrix metalloproteinase inhibitor tracers as potential tumor imaging agents
    Ruth Oltenfreiter
    Department of Radiopharmacy, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium
    Nucl Med Biol 31:459-68. 2004
    ..These results warrant further studies of radioiodinated carboxylic and hydroxamic MMP inhibitor tracers as potential SPECT tumor imaging agents...
  5. ncbi request reprint Synthesis, radiosynthesis, in vitro and preliminary in vivo evaluation of biphenyl carboxylic and hydroxamic matrix metalloproteinase (MMP) inhibitors as potential tumor imaging agents
    Ruth Oltenfreiter
    Laboratory of Radiopharmacy, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium
    Appl Radiat Isot 62:903-13. 2005
    ..In vivo biodistribution in NMRI mice showed no long-term accumulation in organs and the possibility to accumulate in the tumor in a later phase of this study...
  6. ncbi request reprint Tryptophane-based biphenylsulfonamide matrix metalloproteinase inhibitors as tumor imaging agents
    Ruth Oltenfreiter
    Laboratory of Radiopharmacy, Ghent University, Ghent, Belgium
    Cancer Biother Radiopharm 20:639-47. 2005
    ....
  7. ncbi request reprint In vitro and in vivo evaluation of [123I]-VEGF165 as a potential tumor marker
    Bart Cornelissen
    Laboratory for Radiopharmacy, Ghent University, Belgium
    Nucl Med Biol 32:431-6. 2005
    ..12. These results suggest that [(123)I]-VEGF is a potentially suitable tracer for tumor therapy evaluation...
  8. ncbi request reprint Optimization by experimental design of precursor synthesis and radiolabeling of 2-iodo-L-phenylalanine, a novel amino acid for tumor imaging
    Veerle Kersemans
    Laboratory of Radiopharmacy, Universiteit Ghent, Ghent, Belgium
    Cancer Biother Radiopharm 21:235-42. 2006
    ..The reaction presents an interesting alternative for a cumbersome multistep, stereo-specific synthesis...
  9. ncbi request reprint (123)I-Interleukin-2 uptake in squamous cell carcinoma of the head and neck carcinoma
    David Loose
    Department of Head and Neck Surgery, Ghent University Hospital, Ghent, Belgium
    Eur J Nucl Med Mol Imaging 35:281-6. 2008
    ....