Oscar J Pozo

Summary

Affiliation: Ghent University
Country: Belgium

Publications

  1. ncbi request reprint Different quantitation approaches for xenobiotics in human urine samples by liquid chromatography/electrospray tandem mass spectrometry
    Juan V Sancho
    Analytical Chemistry, Experimental Sciences Department, ESTCE, University Jaume I, E 12071, Castellon, Spain
    Rapid Commun Mass Spectrom 16:639-45. 2002
  2. ncbi request reprint Presence of endogenous interferences in the urinary detection of selected anabolic steroids by liquid chromatography/electrospray tandem mass spectrometry
    Oscar J Pozo
    DoCoLab, UGent, Department of Clinical Chemistry, Microbiology and Immunology, Technologiepark 30, B 9052 Zwijnaarde, Belgium
    Rapid Commun Mass Spectrom 21:2785-96. 2007
  3. ncbi request reprint Development and validation of a qualitative screening method for the detection of exogenous anabolic steroids in urine by liquid chromatography-tandem mass spectrometry
    Oscar J Pozo
    DoCoLab, Department of Clinical Chemistry, Microbiology and Immunology, University of Ghent, Technologiepark 30, 9052, Zwijnaarde, Belgium
    Anal Bioanal Chem 389:1209-24. 2007
  4. ncbi request reprint Elucidation of urinary metabolites of fluoxymesterone by liquid chromatography-tandem mass spectrometry and gas chromatography-mass spectrometry
    Oscar J Pozo
    DoCoLab, UGent, Department of Clinical Chemistry, Microbiology and Immunology, Technologiepark 30, B 9052 Zwijnaarde, Belgium
    J Mass Spectrom 43:394-408. 2008
  5. doi request reprint Efficient approach for the comprehensive detection of unknown anabolic steroids and metabolites in human urine by liquid chromatography-electrospray-tandem mass spectrometry
    Oscar J Pozo
    DoCoLab, Gent University, Department of Clinical Chemistry, Microbiology and Immunology, Technologiepark 30, B 9052 Zwijnaarde, Belgium
    Anal Chem 80:1709-20. 2008
  6. doi request reprint Direct quantification of steroid glucuronides in human urine by liquid chromatography-electrospray tandem mass spectrometry
    Oscar J Pozo
    DoCoLab, UGent, Department of Clinical Chemistry, Microbiology and Immunology, Technologiepark 30, Zwijnaarde, Belgium
    J Chromatogr A 1183:108-18. 2008
  7. doi request reprint Collision-induced dissociation of 3-keto anabolic steroids and related compounds after electrospray ionization. Considerations for structural elucidation
    Oscar J Pozo
    DoCoLab, UGent, Department of Clinical Chemistry, Microbiology and Immunology, Technologiepark 30, B 9052 Zwijnaarde, Belgium
    Rapid Commun Mass Spectrom 22:4009-24. 2008
  8. doi request reprint Evaluation of different scan methods for the urinary detection of corticosteroid metabolites by liquid chromatography tandem mass spectrometry
    Oscar J Pozo
    DoCoLab, UGent, Department of Clinical Chemistry, Microbiology and Immunology, Technologiepark 30, B 9052 Zwijnaarde, Belgium
    J Mass Spectrom 44:929-44. 2009
  9. doi request reprint Quantification of testosterone undecanoate in human hair by liquid chromatography-tandem mass spectrometry
    Oscar J Pozo
    DoCoLab, UGent, Department of Clinical Chemistry, Microbiology and Immunology, Zwijnaarde, Belgium
    Biomed Chromatogr 23:873-80. 2009
  10. doi request reprint Detection and structural investigation of metabolites of stanozolol in human urine by liquid chromatography tandem mass spectrometry
    Oscar J Pozo
    DoCoLab, UGent, Department of Clinical Chemistry, Microbiology and Immunology, Technologiepark 30, B 9052 Zwijnaarde, Belgium
    Steroids 74:837-52. 2009

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Different quantitation approaches for xenobiotics in human urine samples by liquid chromatography/electrospray tandem mass spectrometry
    Juan V Sancho
    Analytical Chemistry, Experimental Sciences Department, ESTCE, University Jaume I, E 12071, Castellon, Spain
    Rapid Commun Mass Spectrom 16:639-45. 2002
    ..The hyphenated technique LC/LC/ESI-MS/MS is proved to be a powerful analytical tool, allowing the rapid, sensitive and selective determination of 4-nitrophenol and 3-methyl-4-nitrophenol in human urine without any sample treatment...
  2. ncbi request reprint Presence of endogenous interferences in the urinary detection of selected anabolic steroids by liquid chromatography/electrospray tandem mass spectrometry
    Oscar J Pozo
    DoCoLab, UGent, Department of Clinical Chemistry, Microbiology and Immunology, Technologiepark 30, B 9052 Zwijnaarde, Belgium
    Rapid Commun Mass Spectrom 21:2785-96. 2007
    ..Using this approach, several endogenous interferences have been elucidated in this case study. The knowledge about the structures of these interferences has been found useful to circumvent their detection in the screening method for AS...
  3. ncbi request reprint Development and validation of a qualitative screening method for the detection of exogenous anabolic steroids in urine by liquid chromatography-tandem mass spectrometry
    Oscar J Pozo
    DoCoLab, Department of Clinical Chemistry, Microbiology and Immunology, University of Ghent, Technologiepark 30, 9052, Zwijnaarde, Belgium
    Anal Bioanal Chem 389:1209-24. 2007
    ..Limits of detection between 1 and 10 ng/ml were obtained for most analytes which fulfil current requirements. The applicability of the method was shown by analysing positive samples...
  4. ncbi request reprint Elucidation of urinary metabolites of fluoxymesterone by liquid chromatography-tandem mass spectrometry and gas chromatography-mass spectrometry
    Oscar J Pozo
    DoCoLab, UGent, Department of Clinical Chemistry, Microbiology and Immunology, Technologiepark 30, B 9052 Zwijnaarde, Belgium
    J Mass Spectrom 43:394-408. 2008
    ..The presence of these compounds has also been confirmed by the analysis of five other positive fluoxymesterone urine samples...
  5. doi request reprint Efficient approach for the comprehensive detection of unknown anabolic steroids and metabolites in human urine by liquid chromatography-electrospray-tandem mass spectrometry
    Oscar J Pozo
    DoCoLab, Gent University, Department of Clinical Chemistry, Microbiology and Immunology, Technologiepark 30, B 9052 Zwijnaarde, Belgium
    Anal Chem 80:1709-20. 2008
    ..Finally, the applicability of the developed approach for the analysis of dietary supplements was checked by the analysis of a prohormone where several impurities and/or degradation products were found...
  6. doi request reprint Direct quantification of steroid glucuronides in human urine by liquid chromatography-electrospray tandem mass spectrometry
    Oscar J Pozo
    DoCoLab, UGent, Department of Clinical Chemistry, Microbiology and Immunology, Technologiepark 30, Zwijnaarde, Belgium
    J Chromatogr A 1183:108-18. 2008
    ..97. A slope close to 1 was obtained for all analytes except for AG possibly due to losses during the extraction process prior to GC-MS...
  7. doi request reprint Collision-induced dissociation of 3-keto anabolic steroids and related compounds after electrospray ionization. Considerations for structural elucidation
    Oscar J Pozo
    DoCoLab, UGent, Department of Clinical Chemistry, Microbiology and Immunology, Technologiepark 30, B 9052 Zwijnaarde, Belgium
    Rapid Commun Mass Spectrom 22:4009-24. 2008
    ..A correlation between the steroid structure and the product ions obtained has been postulated. The application of these correlations can be useful in the elucidation of feasible structures for unknown steroids and/or their metabolites...
  8. doi request reprint Evaluation of different scan methods for the urinary detection of corticosteroid metabolites by liquid chromatography tandem mass spectrometry
    Oscar J Pozo
    DoCoLab, UGent, Department of Clinical Chemistry, Microbiology and Immunology, Technologiepark 30, B 9052 Zwijnaarde, Belgium
    J Mass Spectrom 44:929-44. 2009
    ..A combination of the reported methods seems to be the approach of choice in order to have a global overview about the excreted corticosteroid metabolites...
  9. doi request reprint Quantification of testosterone undecanoate in human hair by liquid chromatography-tandem mass spectrometry
    Oscar J Pozo
    DoCoLab, UGent, Department of Clinical Chemistry, Microbiology and Immunology, Zwijnaarde, Belgium
    Biomed Chromatogr 23:873-80. 2009
    ..2 ng/g. The applicability of the method was checked by the analysis of three samples from patients using T-C11. A peak for the analyte was detected in all samples with concentrations between 0.4 and 8.4 ng/g...
  10. doi request reprint Detection and structural investigation of metabolites of stanozolol in human urine by liquid chromatography tandem mass spectrometry
    Oscar J Pozo
    DoCoLab, UGent, Department of Clinical Chemistry, Microbiology and Immunology, Technologiepark 30, B 9052 Zwijnaarde, Belgium
    Steroids 74:837-52. 2009
    ..Finally, a tentative structure for each detected metabolite has been proposed based on the product ion spectra measured with accurate masses using UPLC-QTOF MS...
  11. ncbi request reprint Ionization of anabolic steroids by adduct formation in liquid chromatography electrospray mass spectrometry
    Oscar J Pozo
    DoCoLab, UGent, Department of Clinical Chemistry, Microbiology and Immunology, Technologiepark 30, B 9052 Zwijnaarde, Belgium
    J Mass Spectrom 42:497-516. 2007
    ..Despite the ionization limitations due to their chemical structure, most of tested anabolic steroids could be ionized using the adduct formation approach...
  12. doi request reprint Combination of liquid-chromatography tandem mass spectrometry in different scan modes with human and chimeric mouse urine for the study of steroid metabolism
    Oscar J Pozo
    DoCoLab, UGent, Department of Clinical Chemistry, Microbiology and Immunology, Technologiepark 30, Zwijnaarde, Belgium
    Drug Test Anal 1:554-67. 2009
    ..The metabolic nature of the unreported metabolites was also confirmed. A global strategy for the detection of steroid metabolites combining both human and chimeric mouse urine is proposed...
  13. doi request reprint Steroid metabolism in chimeric mice with humanized liver
    Leen Lootens
    Department of Clinical Chemistry, Microbiology and Immunology, Doping control laboratory DoCoLab, Ghent University, Technologiepark 30, Zwijnaarde, Belgium
    Drug Test Anal 1:531-7. 2009
    ..It is hoped that, in future, this promising chimeric mouse model might assist the discovery of new and possible longer detectable metabolites of (designer) steroids...
  14. doi request reprint Detection and characterization of a new metabolite of 17alpha-methyltestosterone
    Oscar J Pozo
    DoCoLab, Ghent University, Department of Clinical Chemistry, Microbiology and Immunology, Zwijnaarde, Belgium
    Drug Metab Dispos 37:2153-62. 2009
    ..6-Ene-epimethyltestosterone was found in all samples, showing its applicability in the detection of methyltestosterone misuse...
  15. doi request reprint Comparison between triple quadrupole, time of flight and hybrid quadrupole time of flight analysers coupled to liquid chromatography for the detection of anabolic steroids in doping control analysis
    Oscar J Pozo
    DoCoLab, UGent, Department of Clinical Chemistry, Microbiology and Immunology, Technologiepark 30, B 9052 Zwijnaarde, Belgium
    Anal Chim Acta 684:98-111. 2011
    ..Additionally, the intake of methandienone was confirmed by the post-target detection of a long-term metabolite...
  16. doi request reprint uPA+/+-SCID mouse with humanized liver as a model for in vivo metabolism of exogenous steroids: methandienone as a case study
    Leen Lootens
    Doping Control Laboratory, Zwijnaarde, Belgium
    Clin Chem 55:1783-93. 2009
    ..In this study we investigated whether uPA(+/+)-SCID mice carrying functional primary human hepatocytes in their liver would provide a suitable alternative small animal model for the investigation of human steroid metabolism in vivo...
  17. ncbi request reprint Development of a qualitative liquid chromatography/tandem mass spectrometric method for the detection of narcotics in urine relevant to doping analysis
    Koen Deventer
    Ghent University Ugent, Department of Clinical Chemistry, Microbiology and Immunology, Doping control laboratory DoCoLab, Technologiepark 30, B 9052 Zwijnaarde, Belgium
    Rapid Commun Mass Spectrom 21:3015-23. 2007
    ..Finally, the described method was applied to the analysis of urine samples previously found to contain narcotics by our routine gas chromatography/mass spectrometry (GC/MS) method...
  18. doi request reprint Quantitative detection of inhaled salmeterol in human urine and relevance to doping control analysis
    Koen Deventer
    DoCoLab, Department of Clinical Chemistry, Microbiology and Immunology, UGent, Zwijnaarde, Gent, Belgium
    Ther Drug Monit 33:627-31. 2011
    ..Analysis of 47 routine doping samples, declared to contain salmeterol during routine analysis, did not exhibit concentrations that could be considered originating from supratherapeutic doses...
  19. doi request reprint In vitro metabolism study of a black market product containing SARM LGD-4033
    Lore Geldof
    Doping control laboratory DoCoLab, Ghent University Ugent, Department of Clinical Chemistry, Microbiology and Immunology, Technologiepark 30B, Zwijnaarde, B 9052, Belgium
    Drug Test Anal . 2016
    ..The parent compound and M2 were also detected as glucuronide-conjugates. Copyright © 2015 John Wiley & Sons, Ltd...
  20. ncbi request reprint Liquid chromatography/tandem mass spectrometry determination of (4S,2RS)-2,5,5-trimethylthiazolidine-4-carboxylic acid, a stable adduct formed between D-(-)-penicillamine and acetaldehyde (main biological metabolite of ethanol), in plasma, liver and brain
    Elena Serrano
    Research Institute for Pesticides and Water, University Jaume I, 12071 Castellon, Spain
    Rapid Commun Mass Spectrom 21:1221-9. 2007
    ..Due to its excellent selectivity and sensitivity, the method developed in this work provides an excellent tool for the specific determination of this cyclic amino acid in biological samples...
  21. ncbi request reprint Residue determination of glyphosate, glufosinate and aminomethylphosphonic acid in water and soil samples by liquid chromatography coupled to electrospray tandem mass spectrometry
    María Ibáñez
    Research Institute for Pesticides and Water, University Jaume I, E 12071 Castellon, Spain
    J Chromatogr A 1081:145-55. 2005
    ..The method developed has been applied to the determination of these compounds in real water and soil samples from different areas. All the detections were confirmed by acquiring two transitions for each compound...
  22. ncbi request reprint Use of quadrupole time-of-flight mass spectrometry in the elucidation of unknown compounds present in environmental water
    María Ibáñez
    Analytical Chemistry, Experimental Sciences Department, University Jaume I, E 12071 Castellon, Spain
    Rapid Commun Mass Spectrom 19:169-78. 2005
    ..Although other compounds could not be unequivocally identified based on the data available within this study, details about the possible structures of some are given...
  23. ncbi request reprint Comparison of different mass spectrometric techniques combined with liquid chromatography for confirmation of pesticides in environmental water based on the use of identification points
    Felix Hernandez
    Analytical Chemistry, Experimental Sciences Department, University Jaume I, E 12071, Castellon, Spain
    Anal Chem 76:4349-57. 2004
    ..Additionally, the application of TOF and QTOF techniques made it possible to detect some nontarget organic contaminants, which were not included in the screening method...
  24. ncbi request reprint Liquid chromatography and tandem mass spectrometry: a powerful approach for the sensitive and rapid multiclass determination of pesticides and transformation products in water
    Juan V Sancho
    Analytical Chemistry, Experimental Sciences Dept, University Jaume I, P O Box 224, E 12080 Castellón, Spain
    Analyst 129:38-44. 2004
    ..The use of methanol as organic modifier and the increase of injection volume are also studied. The applicability of the developed method to a monitoring programme is demonstrated by applying it to the analysis of hundreds of samples...
  25. ncbi request reprint Rapid determination of fosetyl-aluminum residues in lettuce by liquid chromatography/electrospray tandem mass spectrometry
    Felix Hernandez
    University Jaume I, Experimental Sciences Department, Analytical Chemistry, E 12071, Castellon, Spain
    J AOAC Int 86:832-8. 2003
    ..The developed method allows the accurate and rapid determination of low levels of fosetyl-Al residues in lettuce with very little sample handling and good sensitivity; it was shown to be robust by the analysis of almost 100 samples...
  26. ncbi request reprint Direct determination of paclobutrazol residues in pear samples by liquid chromatography-electrospray tandem mass spectrometry
    Juan V Sancho
    Analytical Chemistry, Experimental Sciences Department, University Jaume I, E 12071, Castellon, Spain
    J Agric Food Chem 51:4202-6. 2003
    ..Two MS-MS transitions were selected, one for quantification (294 > 70) and the other for confirmation of the analyte (296 > 70). All the experiments were performed in compliance with good laboratory practices...
  27. ncbi request reprint Direct determination of alkyl phosphates in human urine by liquid chromatography/electrospray tandem mass spectrometry
    Felix Hernandez
    Analytical Chemistry, Experimental Sciences Department, ESTCE, University Jaume I, E 12071 Castellon, Spain
    Rapid Commun Mass Spectrom 16:1766-73. 2002
    ..Good correlation between application of the product in the field (citrus orchards), concentration levels of dialkyl phosphates and levels of the chlorpyrifos-specific metabolite (1,3,5-trichloro-2-pyridinol) was obtained...
  28. ncbi request reprint Direct analysis of abscisic acid in crude plant extracts by liquid chromatography--electrospray/tandem mass spectrometry
    Aurelio Gómez-Cadenas
    Department of Experimental Sciences, Universitat Jaume I, Campus Riu Sec, E 12071 Castelló, Spain
    Phytochem Anal 13:228-34. 2002
    ....
  29. ncbi request reprint Evaluation of different quantitative approaches for the determination of noneasily ionizable molecules by different atmospheric pressure interfaces used in liquid chromatography tandem mass spectrometry: abamectin as case of study
    Susana Grimalt
    Research Institute for Pesticides and Water, University Jaume I, E 12071, Castellon, Spain
    J Am Soc Mass Spectrom 16:1619-30. 2005
    ..The sensitivity increased with the Ion Sabre APCI, although it was still five times lower than with ESI. Other adduct formers such as Co2+ and Ni2+ also were tested with unsatisfactory results...
  30. ncbi request reprint Efficient approach for the reliable quantification and confirmation of antibiotics in water using on-line solid-phase extraction liquid chromatography/tandem mass spectrometry
    Oscar J Pozo
    Research Institute for Pesticides and Water, University Jaume I, E 12071 Castellon, Spain
    J Chromatogr A 1103:83-93. 2006
    ..Finally, the potential of QTOF instruments to confirm positive samples has also been evaluated and compared with triple quadrupole analysers...
  31. ncbi request reprint Use of liquid chromatography coupled to quadrupole time-of-flight mass spectrometry to investigate pesticide residues in fruits
    Susana Grimalt
    Research Institute for Pesticides and Water, University Jaume I, E 12071 Castellon, Spain
    Anal Chem 79:2833-43. 2007
    ..The work performed in this paper illustrates the suitability and excellent confirmatory potential of LC-QTOF MS for pesticides residues analysis in food samples...
  32. ncbi request reprint Re-evaluation of glyphosate determination in water by liquid chromatography coupled to electrospray tandem mass spectrometry
    María Ibáñez
    Research Institute for Pesticides and Water, University Jaume I, E 12071 Castellon, Spain
    J Chromatogr A 1134:51-5. 2006
    ....
  33. ncbi request reprint Quantification and confirmation of anionic, cationic and neutral pesticides and transformation products in water by on-line solid phase extraction-liquid chromatography-tandem mass spectrometry
    Jose M Marin
    Research Institute for Pesticides and Water, University Jaume I, Avda Sos Baynat s n, E 12071 Castellon, Spain
    J Chromatogr A 1133:204-14. 2006
    ..The developed methodology was applied to real ground and surface water samples showing the interest of including TPs in monitoring methods, as several of them were found at concentrations higher than that of parent compounds...
  34. ncbi request reprint Investigating the presence of pesticide transformation products in water by using liquid chromatography-mass spectrometry with different mass analyzers
    Felix Hernandez
    Research Institute for Pesticides and Water, University Jaume I, Avda Sos Baynat s n E 12071 Castellón, Spain
    J Mass Spectrom 43:173-84. 2008
    ....
  35. ncbi request reprint The even-electron rule in electrospray mass spectra of pesticides
    E Michael Thurman
    University of Almeria, Department of Analytical Chemistry, Almeria, Spain
    Rapid Commun Mass Spectrom 21:3855-68. 2007
    ..SO(2)CH(3), .NO(2), .CH(3), .Cl, .SCH(3), .CH(2)CH, and .OH...
  36. ncbi request reprint Study of different atmospheric-pressure interfaces for LC-MS/MS determination of acrylamide in water at sub-ppb levels
    Jose M Marin
    Research Institute for Pesticides and Water, University Jaume I, Avda Sos Baynat s n E 12071 Castellón, Spain
    J Mass Spectrom 41:1041-8. 2006
    ..Besides, the acquisition of two different MS/MS transitions allowed not only the quantification but also the confirmation of acrylamide in water at concentration levels around 0.1 microg/l...
  37. ncbi request reprint An ion-pairing liquid chromatography/tandem mass spectrometric method for the determination of ethephon residues in vegetables
    Jose M Marin
    Research Institute for Pesticides and Water, University Jaume I, P O Box 8029 AP, 12071 Castellon, Spain
    Rapid Commun Mass Spectrom 20:419-26. 2006
    ..02 mg/kg for all matrices investigated. The acquisition of five specific MS/MS transitions for ethephon allowed the simultaneous and reliable quantification and confirmation of the analyte in the samples...
  38. ncbi request reprint Use of liquid chromatography quadrupole time-of-flight mass spectrometry in the elucidation of transformation products and metabolites of pesticides. Diazinon as a case study
    María Ibáñez
    Research Institute for Pesticides and Water, University Jaume I, 12071, Castellon, Spain
    Anal Bioanal Chem 384:448-57. 2006
    ..In MS mode, mass errors were below 3 mDa, leading to an empirical formula for each compound. MS/MS spectra with accurate mass were used for the final elucidation of the compounds detected...