Kathelijne Peremans

Summary

Affiliation: Ghent University
Country: Belgium

Publications

  1. ncbi Biodistribution and displacement studies of the selective 5-HT2A receptor antagonist 123I-5-I-R91150 in the normal dog
    K Peremans
    Department of Medical Imaging, Faculty of Veterinary Medicine, Ghent University, Ghent, Belgium
    Nucl Med Commun 23:1019-27. 2002
  2. ncbi Soft tissue metastasis of an osteosarcoma of the humerus in a four-legged patient
    Kathelijne Peremans
    Department of Medical Imaging, Faculty of Veterinary Medicine, University of Ghent, Salisburylaan, 133, 9820 Merelbeke, Belgium
    Eur J Nucl Med Mol Imaging 30:188. 2003
  3. ncbi Effects of aging on brain perfusion and serotonin-2A receptor binding in the normal canine brain measured with single photon emission tomography
    Kathelijne Peremans
    Department of Medical Imaging, Faculty of Veterinary Medicine, Ghent University Salisburylaan 133, B 9820 Merelbeke, Belgium
    Prog Neuropsychopharmacol Biol Psychiatry 26:1393-404. 2002
  4. ncbi Estimates of regional cerebral blood flow and 5-HT2A receptor density in impulsive, aggressive dogs with 99mTc-ECD and 123I-5-I-R91150
    Kathelijne Peremans
    Department of Medical Imaging, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820, Merelbeke, Belgium
    Eur J Nucl Med Mol Imaging 30:1538-46. 2003
  5. doi Thyroid stimulation with recombinant human thyrotropin in healthy cats, cats with non-thyroidal illness and in cats with low serum thyroxin and azotaemia after treatment of hyperthyroidism
    Ingrid M van Hoek
    Department of Medicine and Clinical Biology of Small Animals, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
    J Feline Med Surg 12:117-21. 2010
  6. doi 5-HT2A receptors in the feline brain: 123I-5-I-R91150 kinetics and the influence of ketamine measured with micro-SPECT
    Tim Waelbers
    Department of Medicine and Clinical Biology of Small Animals, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
    J Nucl Med 54:1428-33. 2013
  7. doi Normal regional distribution of cerebral blood flow in dogs: comparison between (99m) Tc-ethylcysteinate dimer and (99m) Tc- hexamethylpropylene amine oxime single photon emission computed tomography
    Antita Adriaens
    Faculty of Veterinary Medicine, Department of Small Animal Medicine, Ghent University, Merelbeke, Belgium
    Vet Radiol Ultrasound 54:403-7. 2013
  8. pmc Effect of recombinant human thyrotropin on the uptake of radioactive iodine (¹²³I) in dogs with thyroid tumors
    Miguel Campos
    Department of Medicine, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
    PLoS ONE 7:e50344. 2012
  9. doi Crosstalk between the microbiome and cancer cells by quorum sensing peptides
    Evelien Wynendaele
    Drug Quality and Registration DruQuaR Group, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, Ghent B 9000, Belgium
    Peptides 64:40-8. 2015
  10. pmc The effect of morphine on regional cerebral blood flow measured by 99mTc-ECD SPECT in dogs
    Antita Adriaens
    Department of Medicine and Clinical Biology of Small Animals, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
    PLoS ONE 9:e109680. 2014

Collaborators

Detail Information

Publications58

  1. ncbi Biodistribution and displacement studies of the selective 5-HT2A receptor antagonist 123I-5-I-R91150 in the normal dog
    K Peremans
    Department of Medical Imaging, Faculty of Veterinary Medicine, Ghent University, Ghent, Belgium
    Nucl Med Commun 23:1019-27. 2002
    ..This study demonstrates that the specific 5-HT(2A) iodinated ligand can be used for imaging and semi-quantification of the 5-HT(2A) receptors in the canine brain in vivo by using SPET...
  2. ncbi Soft tissue metastasis of an osteosarcoma of the humerus in a four-legged patient
    Kathelijne Peremans
    Department of Medical Imaging, Faculty of Veterinary Medicine, University of Ghent, Salisburylaan, 133, 9820 Merelbeke, Belgium
    Eur J Nucl Med Mol Imaging 30:188. 2003
  3. ncbi Effects of aging on brain perfusion and serotonin-2A receptor binding in the normal canine brain measured with single photon emission tomography
    Kathelijne Peremans
    Department of Medical Imaging, Faculty of Veterinary Medicine, Ghent University Salisburylaan 133, B 9820 Merelbeke, Belgium
    Prog Neuropsychopharmacol Biol Psychiatry 26:1393-404. 2002
    ..These results suggest that age related effects should be considered in functional canine brain imaging...
  4. ncbi Estimates of regional cerebral blood flow and 5-HT2A receptor density in impulsive, aggressive dogs with 99mTc-ECD and 123I-5-I-R91150
    Kathelijne Peremans
    Department of Medical Imaging, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820, Merelbeke, Belgium
    Eur J Nucl Med Mol Imaging 30:1538-46. 2003
    ..This study supports a role for the serotonergic system in canine impulsive aggression...
  5. doi Thyroid stimulation with recombinant human thyrotropin in healthy cats, cats with non-thyroidal illness and in cats with low serum thyroxin and azotaemia after treatment of hyperthyroidism
    Ingrid M van Hoek
    Department of Medicine and Clinical Biology of Small Animals, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
    J Feline Med Surg 12:117-21. 2010
    ..Thyroid/salivary gland uptake ratio (T/S uptake ratio) differed only significantly between groups 1 and 3. Stimulation with rhTSH is valuable to differentiate euthyroidism from iatrogenic hypothyroidism in cats...
  6. doi 5-HT2A receptors in the feline brain: 123I-5-I-R91150 kinetics and the influence of ketamine measured with micro-SPECT
    Tim Waelbers
    Department of Medicine and Clinical Biology of Small Animals, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
    J Nucl Med 54:1428-33. 2013
    ....
  7. doi Normal regional distribution of cerebral blood flow in dogs: comparison between (99m) Tc-ethylcysteinate dimer and (99m) Tc- hexamethylpropylene amine oxime single photon emission computed tomography
    Antita Adriaens
    Faculty of Veterinary Medicine, Department of Small Animal Medicine, Ghent University, Merelbeke, Belgium
    Vet Radiol Ultrasound 54:403-7. 2013
    ..Both tracers can be used to visualize regional cerebral blood flow in dogs, however, due to the observed regional differences, they are not entirely interchangeable. ..
  8. pmc Effect of recombinant human thyrotropin on the uptake of radioactive iodine (¹²³I) in dogs with thyroid tumors
    Miguel Campos
    Department of Medicine, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
    PLoS ONE 7:e50344. 2012
    ..Further studies are necessary to determine the best protocol of rhTSH administration to optimize thyroid tumor RAIU...
  9. doi Crosstalk between the microbiome and cancer cells by quorum sensing peptides
    Evelien Wynendaele
    Drug Quality and Registration DruQuaR Group, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, Ghent B 9000, Belgium
    Peptides 64:40-8. 2015
    ..Our findings thus indicate that the human microbiome, through their quorum sensing peptides, may be one of the factors responsible for cancer metastasis. ..
  10. pmc The effect of morphine on regional cerebral blood flow measured by 99mTc-ECD SPECT in dogs
    Antita Adriaens
    Department of Medicine and Clinical Biology of Small Animals, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
    PLoS ONE 9:e109680. 2014
    ..No significant differences were noted for the other regions or at other time points. In conclusion, a single bolus of morphine generated a changing rCBF pattern at different time points. ..
  11. doi Renal dimensions at ultrasonography in healthy Ragdoll cats with normal kidney morphology: correlation with age, gender and bodyweight
    Katrien Debruyn
    1Department of Veterinary Medical Imaging and Small Animals Orthopaedics, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
    J Feline Med Surg 15:1046-51. 2013
    ..The CM ratio was solely influenced by the presence of a medullary rim sign (P <0.0001). Further research, however, is needed to investigate the usefulness of the CM ratio for the detection of kidney disease by ultrasonography. ..
  12. pmc Chemical-functional diversity in cell-penetrating peptides
    Sofie Stalmans
    Drug Quality and Registration DruQuaR Group, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium
    PLoS ONE 8:e71752. 2013
    ..e. positive charge and amphipathicity, the shape, structure complexity and the 3D-pattern of constituting atoms influence the cellular uptake capacity of peptides. ..
  13. doi Scintigraphic thyroid volume calculation in hyperthyroid cats
    Veerle Volckaert
    Ghent University, Faculty of Veterinary Medicine, Merelbeke, Belgium
    J Feline Med Surg 14:889-94. 2012
    ..Subjective shape assessment of the thyroid lobes, assigned as cylindrical or spherical, and the use of corresponding formulas, did not appear to be useful...
  14. doi Neuro-imaging the serotonin 2A receptor as a valid biomarker for canine behavioural disorders
    Simon Vermeire
    Department of Veterinary Medical Imaging and Small Animal Orthopaedics, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
    Res Vet Sci 91:465-72. 2011
    ..The 5HT-2A binding index of the right frontal cortex appears to be a valid biomarker in differentiating the studied canine behavioural disorders...
  15. doi Serotonin 2A receptor, serotonin transporter and dopamine transporter alterations in dogs with compulsive behaviour as a promising model for human obsessive-compulsive disorder
    Simon Vermeire
    Department of Veterinary Medical Imaging and Small Animal Orthopaedics, Ghent University, Merelbeke, Belgium
    Psychiatry Res 201:78-87. 2012
    ....
  16. doi Single photon emission computed tomography (SPECT) imaging of the dopamine transporter in healthy dogs
    Simon Vermeire
    Department of Veterinary Medical Imaging and Small Animal Orthopaedics, Faculty of Veterinary Medicine, Ghent University, 9820 Merelbeke, Belgium
    Vet J 188:356-8. 2011
    ..By determining the pseudo-equilibrium and the normal DAT binding indices of normally behaving dogs, this study paves the way for future research on the relationship between abnormal canine behaviour and a disturbed dopaminergic system...
  17. doi Transsplenic portal scintigraphy using 99mTc-pertechnetate for the diagnosis of portosystemic shunts in cats: a retrospective review of 12 patients
    Eva Vandermeulen
    1Department of Veterinary Diagnostic Imaging and Small Animal Orthopaedics, Ghent University, Belgium
    J Feline Med Surg 15:1123-31. 2013
    ..This retrospective study of 12 cases gives an overview of the potential of TSPS in the diagnostic work-up of PSS in cats (2005-2012). ..
  18. doi The effect of prolonged exposure to morphine on canine cerebral 5-HT2A receptors measured with (123)I-R91150 SPECT
    Antita Adriaens
    Medicine and Clinical Biology of Small Animals, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
    Eur Neuropsychopharmacol 24:1133-8. 2014
    ..The decreased cerebral 5-HT2A receptor availability following prolonged morphine exposure provides further evidence for an interaction between the opioid and serotonergic system. ..
  19. doi Comparison of renal ultrasonographic measurements between healthy cats of three cat breeds: Ragdoll, British Shorthair and Sphynx
    Katrien Debruyn
    Department of Veterinary Medical Imaging and Small Animals Orthopaedics, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
    J Feline Med Surg 15:478-82. 2013
    ..79 ± 0.22 cm), and thus a lower corticomedullary ratio (left: 0.80 ± 0.23, right: 1.01 ± 0.32). For the cortical thickness, no significant difference was observed between the left (0.71 ± 0.14 cm) and right kidney (0.74 ± 0.14 cm)...
  20. ncbi Pre- and posttreatment ultrasonography of the thyroid gland in hyperthyroid cats
    Virginie Barberet
    Department of Medical Imaging, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
    Vet Radiol Ultrasound 51:324-30. 2010
    ..Further studies are necessary to determine whether ultrasonography could contribute to the detection of a relapsing course of hyperthyroidism...
  21. ncbi Regional brain perfusion in epileptic dogs evaluated by technetium-99m-ethyl cysteinate dimer SPECT
    Valentine Martlé
    Department of Small Animal Medicine and Clinical Biology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
    Vet Radiol Ultrasound 50:655-9. 2009
    ..Interictal SPECT did not reveal cortical or cerebellar perfusion alterations. The subcortical area may play an important role in the pathophysiology of canine idiopathic epilepsy...
  22. doi Interference of iohexol with radioiodine thyroid uptake in the hyperthyroid cat
    Kathelijne Peremans
    Medical Imaging Department, Faculty of Veterinary Science, University Ghent, Merelbeke, Belgium
    J Feline Med Surg 10:460-5. 2008
    ..In this study, albeit including a small number of cats, outcome did not seem to be significantly affected...
  23. pmc Evaluation of Feline Renal Perfusion with Contrast-Enhanced Ultrasonography and Scintigraphy
    Emmelie Stock
    Department of Medical Imaging of Domestic Animals, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke, Belgium
    PLoS ONE 11:e0164488. 2016
    ..Renal scintigraphy could not detect perfusion changes induced by AT II. This study shows that CEUS is able to detect changes in feline renal perfusion induced by AT II infusion...
  24. pmc Quorum Sensing Peptides Selectively Penetrate the Blood-Brain Barrier
    Evelien Wynendaele
    Drug Quality and Registration DruQuaR Group, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium
    PLoS ONE 10:e0142071. 2015
    ..Our results thus support the potential role of some quorum sensing peptides in different neurological disorders, thereby enlarging our knowledge about the microbiome-brain axis. ..
  25. pmc Cell-Penetrating Peptides Selectively Cross the Blood-Brain Barrier In Vivo
    Sofie Stalmans
    Drug Quality and Registration DruQuaR Group, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium
    PLoS ONE 10:e0139652. 2015
    ..The observed BBB influx transport properties cannot be correlated with their cell-penetrating ability, and therefore, good CPP properties do not imply efficient brain influx. ..
  26. pmc In Vivo Evaluation of Blood Based and Reference Tissue Based PET Quantifications of [11C]DASB in the Canine Brain
    Nick Van Laeken
    Department of Radiopharmacy, Ghent University, Ghent, Belgium
    PLoS ONE 11:e0148943. 2016
    ..9266 x + 0.0257; R2 = 0.9722). Therefore, this model can be put forward as a non-invasive standard model for future PET-experiments with [11C]DASB in dogs. ..
  27. doi Effect of background region of interest and time-interval selection on glomerular filtration ratio estimation by percentage dose uptake of (99m)Tc-DTPA in comparison with (51)Cr-EDTA clearance in healthy cats
    Katrien Debruyn
    Department of Veterinary Medical Imaging and Small Animal Orthopaedics, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
    J Feline Med Surg 15:698-705. 2013
    ..The caudolateral bg ROI in the 60-180 s time interval showed the highest correlation coefficient (r = 0.882) between (99m)Tc-DTPA and (51)Cr-EDTA, although a significant difference (P <0.05) was present between both techniques. ..
  28. doi Regional brain perfusion in 12 cats measured with technetium-99m-ethyl cysteinate dimer pinhole single photon emission computed tomography (SPECT)
    Tim Waelbers
    Department of Medicine and Clinical Biology of Small Animals, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
    J Feline Med Surg 15:105-10. 2013
    ..The highest tracer uptake was noticed in the subcortical structures, and the lowest in the frontal cortex and the cerebellum. Also left-right asymmetry in the temporal cortex and a rostrocaudal gradient of 5% were observed...
  29. doi Brainpeps: the blood-brain barrier peptide database
    Sylvia Van Dorpe
    Drug Quality and Registration group, Faculty of Pharmaceutical Sciences, Ghent University, Belgium
    Brain Struct Funct 217:687-718. 2012
    ..Moreover, the relationships between the different BBB transport methods have been clarified and visualized...
  30. doi Blood-brain barrier transport kinetics of the cyclic depsipeptide mycotoxins beauvericin and enniatins
    Lien Taevernier
    Drug Quality and Registration DruQuaR Group, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, B 9000 Ghent, Belgium
    Toxicol Lett 258:175-84. 2016
    ..Negligible efflux (<0.005min(-1)) from the brain was observed in the 15min post-intracerebroventricular injection. ..
  31. pmc Mucosal and blood-brain barrier transport kinetics of the plant N-alkylamide spilanthol using in vitro and in vivo models
    Lieselotte Veryser
    Drug Quality and Registration DruQuaR Group, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, B 9000, Ghent, Belgium
    BMC Complement Altern Med 16:177. 2016
    ..A prominent active NAA is spilanthol. The general goal was to quantitatively investigate the gut mucosa and blood-brain barrier (BBB) permeability pharmacokinetic properties of spilanthol...
  32. pmc In vivo quantification of the [(11)C]DASB binding in the normal canine brain using positron emission tomography
    Olivia Taylor
    Department of Medical Imaging and Small Animal Orthopedics, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820, Merelbeke, Belgium
    BMC Vet Res 11:308. 2015
    ..The second objective was to provide less invasive and more convenient alternative methods to the arterial sampling-based kinetic analysis...
  33. ncbi Blood-brain barrier transport of short proline-rich antimicrobial peptides
    Sofie Stalmans
    Drug Quality and Registration DruQuaR Group, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, B 9000 Ghent, Belgium
    Protein Pept Lett 21:399-406. 2014
    ..We conclude that the investigated short, proline-rich antimicrobial peptides show an influx into the brain, which make them a promising antibacterial treatment of cerebral infections...
  34. doi Ultrasonographic measurements of adrenal glands in cats with hyperthyroidism
    Anais Combes
    Faculty of Veterinary Medicine, Department of Medical Imaging, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
    Vet Radiol Ultrasound 53:210-6. 2012
    ..Hyperthyroidism should be an alternative to hyperadrenocorticism, hyperaldosteronism, and acromegaly in cats with bilateral moderate adrenomegaly...
  35. doi Evaluation of serotonin-2A receptor occupancy with 123I-5-I-R91150 and single-photon emission tomography before and after low-dose pipamperone administration in the canine brain
    Kathelijne Peremans
    Medical Imaging Department, Faculty of Veterinary Medicine, Laboratory of Radiopharmacy, Ghent University, Ghent, Belgium
    Nucl Med Commun 29:724-9. 2008
    ..To conduct a cost-efficient pilot study on the effect of low-dose pipamperone on the serotonin-2A receptor binding in a large animal model with conventional single-photon emission tomography modalities...
  36. doi Hydrophilic interaction LC of peptides: columns comparison and clustering
    Sylvia Van Dorpe
    Drug Quality and Registration group, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium
    J Sep Sci 33:728-39. 2010
    ..Thus, these columns, belonging to different clusters, were found to be the best performing systems in pharmaceutical peptide analysis for the selected peptide set...
  37. doi Desirability function combining metabolic stability and functionality of peptides
    Sylvia Van Dorpe
    Drug Quality and Registration DruQuaR Group, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, B 9000 Ghent, Belgium
    J Pept Sci 17:398-404. 2011
    ..To conclude, the multi-criteria decision method was proven to be useful in biomedical research, where a selection of the best candidate based on opposing characteristics is often required...
  38. doi Human skin permeation of emerging mycotoxins (beauvericin and enniatins)
    Lien Taevernier
    Drug Quality and Registration DruQuaR Group, Department of Pharmaceutical Analysis, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, Ghent, Belgium
    J Expo Sci Environ Epidemiol 26:277-87. 2016
    ..3209 ng/(kg BW × day) for ENN B1. This knowledge is needed for the risk assessment after skin exposure of contaminated food, feed, indoor surfaces and airborne particles with mycotoxins. ..
  39. doi Effect of thyroid volume on radioiodine therapy outcome in hyperthyroid cats
    Veerle Volckaert
    Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
    J Feline Med Surg 18:144-9. 2016
    ..Bilateral hyperthyroidism and its potential effect on a final low TT4 outcome should therefore be addressed when informing owners of the possible outcomes of radioiodine therapy for their cat. ..
  40. pmc The quorum sensing peptides PhrG, CSP and EDF promote angiogenesis and invasion of breast cancer cells in vitro
    Bart De Spiegeleer
    Drug Quality and Registration DruQuaR Group, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium
    PLoS ONE 10:e0119471. 2015
    ..Our results offer not only new insights on the possible role of the microbiome, but also further opportunities in cancer prevention and therapy by competing with these endogenous molecules and/or by modifying people's life style. ..
  41. doi Blood-brain transfer and antinociception of linear and cyclic N-methyl-guanidine and thiourea-enkephalins
    Mathieu Verbeken
    Drug Quality and Registration DruQuaR Group, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, B 9000 Ghent, Belgium
    Peptides 63:10-21. 2015
    ....
  42. pmc A rapid stability-indicating, fused-core HPLC method for simultaneous determination of β-artemether and lumefantrine in anti-malarial fixed dose combination products
    Sultan Suleman
    Drug Quality and Registration DruQuaR Group, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, Ghent, B 9000, Belgium
    Malar J 12:145. 2013
    ..Moreover, quality control is hampered by lack of suitable analytical methods. Thus, there is a need for a rapid and simple, but stability-indicating method for the simultaneous assay of β-artemether and lumefantrine FDC products...
  43. doi The influence of morphine on cerebral 5-HT2A availability in dogs: a SPECT study
    Antita M Adriaens
    Medicine and Clinical Biology of Small Animals, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
    J Nucl Med 53:1969-73. 2012
    ..The aim of this study was to assess the influence of systemic morphine on cerebral serotonin 2A receptor (5-HT(2A)) binding in dogs using SPECT with the 5-HT(2A) radioligand (123)I-5I-R91150...
  44. doi Vaginal distribution and retention of a multiparticulate drug delivery system, assessed by gamma scintigraphy and magnetic resonance imaging
    Samata Mehta
    Laboratory of Pharmaceutical Technology, Ghent University, Harelbekestraat 72, B 9000 Ghent, Belgium
    Int J Pharm 426:44-53. 2012
    ..A conventional cream formulation was used as reference in both studies...
  45. doi Impurity profiling quality control testing of synthetic peptides using liquid chromatography-photodiode array-fluorescence and liquid chromatography-electrospray ionization-mass spectrometry: the obestatin case
    Bart De Spiegeleer
    Drug Quality and Registration group, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, B 9000 Ghent, Belgium
    Anal Biochem 376:229-34. 2008
    ..Therefore, we strongly recommend appropriate quality control testing before using any peptides for biomedical research purposes...
  46. ncbi Serotonin transporter and dopamine transporter imaging in the canine brain
    Kathelijne Peremans
    Department of Medical Imaging, Faculty of Veterinary Sciences, Ghent University, B 9000 Ghent, Belgium
    Nucl Med Biol 33:907-13. 2006
    ..Second, we studied the effect of SSRIs (sertraline, citalopram and escitalopram) on the SERT and DAT in two dogs. The position of the canine model in the study of the SERT and DAT is discussed and compared with other animal models...
  47. doi In vitro metabolic stability of obestatin: kinetics and identification of cleavage products
    Valentijn Vergote
    Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, B 9000 Ghent, Belgium
    Peptides 29:1740-8. 2008
    ..Our results indicate that the major instability of obestatin peptides, as currently used in biomedical investigations, should be taken into account in the interpretation of the obtained results...
  48. doi Inter- and intraobserver variability of (semi-)quantitative parameters commonly used in feline thyroid scintigraphy
    Veerle Volckaert
    Department of Medical Imaging, Faculty of Veterinary Medicine, Ghent University Ugent, Ghent, Belgium Electronic address
    Res Vet Sci 105:87-91. 2016
    ..On the contrary, inter- and intraobserver variability was clearly larger for the T/B ratio. These findings suggest the preferential use of the T/S ratio or %TcU, especially in facilities with a less experienced staff. ..
  49. doi Regional brain perfusion changes during standard and microburst vagus nerve stimulation in dogs
    Valentine Martlé
    Department of Small Animal Medicine and Clinical Biology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium Electronic address
    Epilepsy Res 108:616-22. 2014
    ..Additionally, a novel stimulation paradigm (microburst VNS) was used and compared with standard VNS...
  50. doi Ultrasonography of the feline kidney: Technique, anatomy and changes associated with disease
    Katrien Debruyn
    Department of Medical Imaging and Orthopedics of Small Animals, Faculty of VeterinaryMedicine, University of Ghent, Salisburylaan 133, 9820 Merelbeke, Belgium
    J Feline Med Surg 14:794-803. 2012
    ....
  51. doi The use of [123I]-2-iodo-L-phenylalanine as an early radiotherapy evaluation tool: in vitro R1M rabdomyosarcoma cell and in vivo mouse experiments
    Veerle Kersemans
    Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium
    Cancer Biother Radiopharm 23:192-201. 2008
    ..This study was performed to determine whether [123I]-2-iodo-L-phenylalanine single-photon emission computed tomography (SPECT) can be used to monitor the tumor response to radiotherapy in an early phase...
  52. doi The Impact of Accelerated HF-rTMS on the Subgenual Anterior Cingulate Cortex in Refractory Unipolar Major Depression: Insights From 18FDG PET Brain Imaging
    Chris Baeken
    Ghent University, Department of Psychiatry and Medical Psychology, Ghent, Belgium Department of Psychiatry, Universitair Ziekenhuis Brussel UZ Brussel, Vrije Universiteit Brussel VUB, Laarbeeklaan 101, 1090 Brussels, Belgium Ghent University, Ghent Experimental Psychiatry GHEP Lab, Ghent, Belgium Electronic address
    Brain Stimul 8:808-15. 2015
    ..No studies yet examined the clinical effects of such accelerated stimulation treatment paradigms on sgACC regional glucose metabolism (CMRglc), nor the predictive value of the latter for clinical outcome...
  53. ncbi A review of small animal imaging planar and pinhole spect Gamma camera imaging
    Kathelijne Peremans
    Department of Medical Imaging, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
    Vet Radiol Ultrasound 46:162-70. 2005
    ..Current research is focusing on refining PH SPECT methodology, so specific regarding technical aspects and applications of PH SPECT will be reviewed...
  54. ncbi LC-UV/MS characterization and DOE optimization of the iodinated peptide obestatin
    Valentijn Vergote
    Drug Quality and Registration DruQuaR Group, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, B 9000 Ghent, Belgium
    J Pharm Biomed Anal 46:127-36. 2008
    ..The applicability of our research was demonstrated by non-carrier-added (125)I-radioiodination. To our knowledge, this is the first time an LC separation of mono-iodinated peptide isomers has been reported...
  55. ncbi Imaging of mild traumatic brain injury using 57Co and 99mTc HMPAO SPECT as compared to other diagnostic procedures
    Kurt Audenaert
    Department of Psychiatry and Medical Psychology, Ghent University Hospital, Ghent, Belgium
    Med Sci Monit 9:MT112-7. 2003
    ..This study was undertaken to compare the applicability of SPECT using 57Co as a Ca-tracer in patients with mild traumatic brain injury...
  56. doi Analytical characterization and comparison of the blood-brain barrier permeability of eight opioid peptides
    Sylvia Van Dorpe
    Drug Quality and Registration DruQuaR Group, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, B 9000 Ghent, Belgium
    Peptides 31:1390-9. 2010
    ..All peptides were stable in mouse plasma and brain, with generally higher stability in brain, except for EM-1 and EM-2 which showed plasma half-life stabilities of a few minutes only...
  57. doi Effect of recombinant human thyroid stimulating hormone on serum thyroxin and thyroid scintigraphy in euthyroid cats
    Ingrid M van Hoek
    Department of Medicine and Clinical Biology of Small Animals, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
    J Feline Med Surg 11:309-14. 2009
    ..We can conclude that 25 microg rhTSH increases pertechnetate uptake in the thyroid glands of cats, this should be taken into account when thyroid scintigraphy after rhTSH administration is interpreted...
  58. doi Quantitative transdermal behavior of pellitorine from Anacyclus pyrethrum extract
    Lieselotte Veryser
    Drug Quality and Registration DruQuaR Group, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, B 9000 Ghent, Belgium
    Phytomedicine 21:1801-7. 2014
    ..Due to these findings and as a regulatory consequence, products containing reasonable concentrations of pellitorine are recommended to be classified as a medicinal product...