Martine De Vos

Summary

Affiliation: Ghent University Hospital
Country: Belgium

Publications

  1. doi request reprint Consecutive fecal calprotectin measurements to predict relapse in patients with ulcerative colitis receiving infliximab maintenance therapy
    Martine De Vos
    Department of Gastroenterology, Ghent University Hospital, Ghent, Belgium
    Inflamm Bowel Dis 19:2111-7. 2013
  2. doi request reprint Joint involvement associated with inflammatory bowel disease
    M De Vos
    Ghent University, Ghent, Belgium
    Dig Dis 27:511-5. 2009
  3. doi request reprint Joint involvement in inflammatory bowel disease: managing inflammation outside the digestive system
    Martine De Vos
    Ghent University, Department Gastroenterology, University Hospital, De Pintelaan 185, B 9000 Gent, Belgium
    Expert Rev Gastroenterol Hepatol 4:81-9. 2010
  4. doi request reprint Novel development in extraintestinal manifestations and spondylarthropathy
    M De Vos
    Ghent University Hospital, Department of Gastroenterology, Ghent, Belgium
    Best Pract Res Clin Gastroenterol 25:S19-26. 2011
  5. pmc An intravital microscopic study of the hepatic microcirculation in cirrhotic mice models: relationship between fibrosis and angiogenesis
    Eline Vanheule
    Department of Hepatology and Gastroenterology, Ghent University Hospital, Ghent, Belgium
    Int J Exp Pathol 89:419-32. 2008
  6. doi request reprint Degree of bone marrow oedema in sacroiliac joints of patients with axial spondyloarthritis is linked to gut inflammation and male sex: results from the GIANT cohort
    Liesbet Van Praet
    Department of Rheumatology, Ghent University Hospital, Ghent, Belgium
    Ann Rheum Dis 73:1186-9. 2014
  7. doi request reprint Role of placental growth factor in mesenteric neoangiogenesis in a mouse model of portal hypertension
    Christophe Van Steenkiste
    Faculty of Medicine and Health Sciences, Department of Hepatology and Gastroenterology, Ghent University, Ghent, Belgium
    Gastroenterology 137:2112-24.e1-6. 2009
  8. doi request reprint Absence of placental growth factor blocks dextran sodium sulfate-induced colonic mucosal angiogenesis, increases mucosal hypoxia and aggravates acute colonic injury
    Pieter Hindryckx
    Department of Gastroenterology, Ghent University, De Pintelaan 185, Gent, Belgium
    Lab Invest 90:566-76. 2010
  9. pmc Comparison of three research models of portal hypertension in mice: macroscopic, histological and portal pressure evaluation
    Anja M Geerts
    Department of Hepatology and Gastroenterology, Ghent Univerity Hospital, Ghent, Belgium
    Int J Exp Pathol 89:251-63. 2008
  10. ncbi request reprint Decreased leukocyte recruitment in the mesenteric microcirculation of rats with cirrhosis is partially restored by treatment with peginterferon: an in vivo study
    Anja M Geerts
    Department of Hepatology and Gastroenterology, Ghent University Hospital, Belgium
    J Hepatol 46:804-15. 2007

Detail Information

Publications57

  1. doi request reprint Consecutive fecal calprotectin measurements to predict relapse in patients with ulcerative colitis receiving infliximab maintenance therapy
    Martine De Vos
    Department of Gastroenterology, Ghent University Hospital, Ghent, Belgium
    Inflamm Bowel Dis 19:2111-7. 2013
    ..This study examined whether fecal calprotectin can be used in daily practice as a marker to monitor patients with ulcerative colitis (UC) receiving infliximab maintenance therapy...
  2. doi request reprint Joint involvement associated with inflammatory bowel disease
    M De Vos
    Ghent University, Ghent, Belgium
    Dig Dis 27:511-5. 2009
    ..Clinical, genetical, immunological and therapeutic evidence support the tight junction between gut and joint inflammation in two linked diseases, IBD and SpA, belonging to the 'immune-mediated inflammatory diseases'...
  3. doi request reprint Joint involvement in inflammatory bowel disease: managing inflammation outside the digestive system
    Martine De Vos
    Ghent University, Department Gastroenterology, University Hospital, De Pintelaan 185, B 9000 Gent, Belgium
    Expert Rev Gastroenterol Hepatol 4:81-9. 2010
    ..Animal models may help to identify the most promising therapeutic strategies including in the near future modulation of adhesion molecules, costimulatory molecules and the Th17 pathway...
  4. doi request reprint Novel development in extraintestinal manifestations and spondylarthropathy
    M De Vos
    Ghent University Hospital, Department of Gastroenterology, Ghent, Belgium
    Best Pract Res Clin Gastroenterol 25:S19-26. 2011
    ..This review will focus on the recent scientific progress in our understanding of the link between SpA and IBD. Based on this, potential novel therapeutic strategies are discussed...
  5. pmc An intravital microscopic study of the hepatic microcirculation in cirrhotic mice models: relationship between fibrosis and angiogenesis
    Eline Vanheule
    Department of Hepatology and Gastroenterology, Ghent University Hospital, Ghent, Belgium
    Int J Exp Pathol 89:419-32. 2008
    ..Thus present study shows that there is angiogenesis in the liver during cirrhogenesis, and this is probably due partially to an increased production of VEGF...
  6. doi request reprint Degree of bone marrow oedema in sacroiliac joints of patients with axial spondyloarthritis is linked to gut inflammation and male sex: results from the GIANT cohort
    Liesbet Van Praet
    Department of Rheumatology, Ghent University Hospital, Ghent, Belgium
    Ann Rheum Dis 73:1186-9. 2014
    ..Bone marrow oedema (BMO) of the sacroiliac joints (SIJs) is a hallmark of axial spondyloarthritis (SpA). However, the relationship between the extent of BMO and disease phenotype is poorly understood...
  7. doi request reprint Role of placental growth factor in mesenteric neoangiogenesis in a mouse model of portal hypertension
    Christophe Van Steenkiste
    Faculty of Medicine and Health Sciences, Department of Hepatology and Gastroenterology, Ghent University, Ghent, Belgium
    Gastroenterology 137:2112-24.e1-6. 2009
    ..We investigated the role of placental growth factor (PlGF) and tested the effects of monoclonal antibodies against PlGF (alphaPlGF) in a mouse model of portal hypertension...
  8. doi request reprint Absence of placental growth factor blocks dextran sodium sulfate-induced colonic mucosal angiogenesis, increases mucosal hypoxia and aggravates acute colonic injury
    Pieter Hindryckx
    Department of Gastroenterology, Ghent University, De Pintelaan 185, Gent, Belgium
    Lab Invest 90:566-76. 2010
    ....
  9. pmc Comparison of three research models of portal hypertension in mice: macroscopic, histological and portal pressure evaluation
    Anja M Geerts
    Department of Hepatology and Gastroenterology, Ghent Univerity Hospital, Ghent, Belgium
    Int J Exp Pathol 89:251-63. 2008
    ..Well-described mice models will facilitate use of knock-out or transgenic mice and lead to a better understanding of the underlying molecular pathways in the field of portal hypertension and cirrhosis...
  10. ncbi request reprint Decreased leukocyte recruitment in the mesenteric microcirculation of rats with cirrhosis is partially restored by treatment with peginterferon: an in vivo study
    Anja M Geerts
    Department of Hepatology and Gastroenterology, Ghent University Hospital, Belgium
    J Hepatol 46:804-15. 2007
    ..We investigated the effect of peginterferon-alpha2a (PegIFN-alpha(2a)) in vivo on the leukocyte recruitment in the mesenteric microcirculation of cirrhotic rats after lipopolysaccharide exposure...
  11. doi request reprint Hydroxylase inhibition abrogates TNF-alpha-induced intestinal epithelial damage by hypoxia-inducible factor-1-dependent repression of FADD
    Pieter Hindryckx
    Department of Gastroenterology, Ghent University, Ghent, Belgium
    J Immunol 185:6306-16. 2010
    ..Hydroxylase inhibition could represent a promising alternative treatment strategy for hypoxic inflammatory diseases, including inflammatory bowel disease...
  12. doi request reprint Inverse correlation between metallothioneins and hypoxia-inducible factor 1 alpha in colonocytes and experimental colitis
    Lindsey Devisscher
    Department of Gastroenterology, Ghent University, De Pintelaan 185, 1K12IE, B 9000 Ghent, Belgium
    Biochem Biophys Res Commun 416:307-12. 2011
    ..05). The present study underscores the inverse relation between HIF-1α and MT expression in colonocytes and during experimental colitis. The manipulation of MTs may represent a novel therapeutic strategy for patients suffering from IBD...
  13. pmc Involvement of endoplasmic reticulum stress in inflammatory bowel disease: a different implication for colonic and ileal disease?
    Sara Bogaert
    Department of Gastroenterology, Ghent University, Ghent, Belgium
    PLoS ONE 6:e25589. 2011
    ..The three branches (ATF6, IRE1 and PERK) of the unfolded protein response (UPR) have different roles and are not necessarily activated simultaneously...
  14. doi request reprint Mucosal healing predicts sustained clinical remission in patients with early-stage Crohn's disease
    Filip Baert
    Department of Gastroenterology, H Hartziekenhuis Roeselare Menen vzw, Roeselare, Belgium
    Gastroenterology 138:463-8; quiz e10-1. 2010
    ..Few prospective data are available to support the clinical relevance of mucosal healing in patients with Crohn's disease. This study examined whether complete healing, determined by endoscopy, predicts a better outcome in Crohn's disease...
  15. doi request reprint Measurement of porto-systemic shunting in mice by novel three-dimensional micro-single photon emission computed tomography imaging enabling longitudinal follow-up
    Christophe Van Steenkiste
    Department of Hepatology and Gastroenterology, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium
    Liver Int 30:1211-20. 2010
    ....
  16. doi request reprint Inhibition of placental growth factor activity reduces the severity of fibrosis, inflammation, and portal hypertension in cirrhotic mice
    Christophe Van Steenkiste
    Department of Hepatology and Gastroenterology, Ghent University Hospital, Ghent, Belgium
    Hepatology 53:1629-40. 2011
    ....
  17. doi request reprint Intrarectal nitric oxide administration prevents cellular infiltration but not colonic injury during dextran sodium sulfate colitis
    Joan Vermeiren
    Faculty of Bioscience Engineering, Laboratory of Microbial Ecology and Technology, Ghent University, Ghent, Belgium
    Dig Dis Sci 57:1832-7. 2012
    ..During inflammation in the gastrointestinal tract, the production of nitric oxide (NO) is mediated by the mucosal conversion of L-arginine. Recently, it was shown that the gut microbiota can also produce NO...
  18. doi request reprint Intrarectal administration of oxygenated perfluorodecalin promotes healing of murine colitis by targeting inflammatory hypoxia
    Pieter Hindryckx
    Department of Gastroenterology, Ghent University Hospital, Ghent, Belgium
    Lab Invest 91:1266-76. 2011
    ..As such, O(2)-PFD enemas could be an attractive treatment option for patients with distal inflammatory bowel disease...
  19. pmc Differential mucosal expression of Th17-related genes between the inflamed colon and ileum of patients with inflammatory bowel disease
    Sara Bogaert
    Department of Gastroenterology, Ghent University, Ghent, Belgium
    BMC Immunol 11:61. 2010
    ..Inflammation was quantified by measuring expression of the inflammatory mediators IL8 and TNF...
  20. doi request reprint Chronic cigarette smoke exposure induces microbial and inflammatory shifts and mucin changes in the murine gut
    Liesbeth Allais
    Department of Medical and Forensic Pathology, Ghent University, Ghent, Belgium
    Environ Microbiol 18:1352-63. 2016
    ..We infer that the modulating role of chronic smoke exposure as a latently present risk factor in the gut may be driven by the altered epithelial mucus profiles and changes in microbiome composition and immune factors. ..
  21. doi request reprint Systemic levels of IL-23 are strongly associated with disease activity in rheumatoid arthritis but not spondyloarthritis
    Lode Melis
    Department of Rheumatology, Ghent University Hospital, Belgium
    Ann Rheum Dis 69:618-23. 2010
    ..This study aimed to evaluate the role of Th17-associated cytokines in spondyloarthritis pathogenesis by measuring their levels in the joints and circulation as well as correlating them with disease activity parameters...
  22. doi request reprint Invariant natural killer T cells are natural regulators of murine spondylarthritis
    Peggy Jacques
    Ghent University, 9000 Ghent, Belgium
    Arthritis Rheum 62:988-99. 2010
    ..To investigate the role of invariant natural killer T (iNKT) cells in TNF(DeltaARE/+) mice, an animal model of spondylarthritis (SpA) with both gut and joint inflammation...
  23. doi request reprint Dialister as a Microbial Marker of Disease Activity in Spondyloarthritis
    Raul Y Tito
    Katholieke Universiteit Leuven and Vlaams Instituut voor Biotechnologie Center for the Biology of Disease, Leuven, Belgium, and Vrije Universiteit Brussel, Brussels, Belgium
    Arthritis Rheumatol . 2016
    ..This study was undertaken to assess the relationship between intestinal microbial composition, gut histology, and disease activity markers in SpA...
  24. ncbi request reprint Clinical and genetic factors associated with sacroiliitis in Crohn's disease
    Harald Peeters
    Department of Gastroenterology, Ghent University Hospital, Gent, Belgium
    J Gastroenterol Hepatol 23:132-7. 2008
    ..Association of SI with CARD15 polymorphisms has recently been suggested. In a multicenter study, we investigated the association of SI in CD patients with clinical phenotypes, other EIM and CARD15 polymorphisms...
  25. pmc Evidence for significant overlap between common risk variants for Crohn's disease and ankylosing spondylitis
    Debby Laukens
    Department of Gastroenterology, Ghent University, Ghent, Belgium
    PLoS ONE 5:e13795. 2010
    ..To gain insight into the genetic overlap between CD and ankylosing spondylitis (AS), these markers were tested for association in AS patients...
  26. ncbi request reprint Subfulminant hepatitis B during treatment with adalimumab in a patient with rheumatoid arthritis and chronic hepatitis B
    Xavier Verhelst
    Department of Gastroenterology and Hepatology, Ghent University Hospital, De Pintelaan 185, Ghent B 9000, Belgium
    Eur J Gastroenterol Hepatol 22:494-9. 2010
    ..Administration of antiviral prophylaxis proves beneficial in prevention of reactivation in hepatitis B surface antigen positive patients...
  27. ncbi request reprint Human metallothionein expression under normal and pathological conditions: mechanisms of gene regulation based on in silico promoter analysis
    Debby Laukens
    Department of Gastroenterology, Ghent University, Gent, Belgium
    Crit Rev Eukaryot Gene Expr 19:301-17. 2009
    ..Here, we review the aberrant expression of MTs in human diseases and the mechanisms that regulate MT1 expression based on an in silico evaluation of transcription factor binding sites...
  28. doi request reprint Spondyloarthropathies: progress and challenges
    Peggy Jacques
    University Hospital Ghent, Department of Rheumatology, Ghent, Belgium
    Best Pract Res Clin Rheumatol 22:325-37. 2008
    ..In addition, some marked differences appear to exist in the ability of the different TNF-blocking agents to modulate extra-articular disease manifestations...
  29. doi request reprint Influence of somatostatin and octreotide on liver microcirculation in an experimental mouse model of cirrhosis studied by intravital fluorescence microscopy
    Eline Vanheule
    Department of Hepatology and Gastroenterology, Ghent University Hospital, Ghent, Belgium
    Liver Int 28:107-16. 2008
    ..In vitro endothelin-1 (ET-1)-induced contraction of HSCs can be reduced by somatostatin (SST); however, intrahepatic in vivo effects have never been studied...
  30. doi request reprint Boosting the hypoxia-induced adaptive response in inflammatory bowel disease: a novel concept of treatment
    Pieter Hindryckx
    Department of Gastroenterology, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium
    Inflamm Bowel Dis 17:2019-22. 2011
    ..This mini-review focuses on inhibition of hydroxylases as a potential novel treatment option for inflammatory bowel disease. Current knowledge, as well as future directions, are summarized and discussed...
  31. ncbi request reprint Rapamycin prevents mesenteric neo-angiogenesis and reduces splanchnic blood flow in portal hypertensive mice
    Anja M Geerts
    Department of Hepatology and Gastroenterology, Ghent University Hospital, Ghent, Belgium
    Hepatol Res 38:1130-9. 2008
    ..Rapamycin prevents angiogenesis in the mesenteric tissue and decreases the mesenteric blood flow in portal hypertensive mice, at least in part through an anti-VEGF activity and influence on the mTOR signalling pathway...
  32. ncbi request reprint Reduced Mucosa-associated Butyricicoccus Activity in Patients with Ulcerative Colitis Correlates with Aberrant Claudin-1 Expression
    Sarah Devriese
    Department of Gastroenterology, Ghent University, Ghent, Belgium
    J Crohns Colitis . 2016
    ..Since butyrate influences intestinal barrier integrity, we further investigated the relationship between the abundance of mucosa-associated Butyricicoccus and the expression of butyrate-regulated tight junction [TJ] genes...
  33. doi request reprint Haematopoietic prolyl hydroxylase-1 deficiency promotes M2 macrophage polarization and is both necessary and sufficient to protect against experimental colitis
    Sophie Van Welden
    Department of Gastroenterology, Ghent University, 9000, Ghent, Belgium
    J Pathol . 2016
    ..Taken together, our results further support the development of selective PHD1-inhibitors for ulcerative colitis and identify haematopoietic cells as their primary target...
  34. pmc Differential expression of prolyl hydroxylase 1 in patients with ulcerative colitis versus patients with Crohn's disease/infectious colitis and healthy controls
    Sophie Van Welden
    Department of Gastroenterology, Ghent University Hospital, De Pintelaan 185, 3K12 IE, Ghent B 9000, Belgium
    J Inflamm (Lond) 10:36. 2013
    ..In this study, we explored the colonic mucosal expression of the different PHD-isoforms (PHD1, 2 and 3) in order to identify the key isoform(s) involved in the pathogenesis of IBD...
  35. doi request reprint Tauroursodeoxycholic acid inhibits experimental colitis by preventing early intestinal epithelial cell death
    Debby Laukens
    Department of Gastroenterology, Ghent University, Gent, Belgium
    Lab Invest 94:1419-30. 2014
    ..These data, together with the previously reported beneficial effect in colitis, suggest that TUDCA could be an add-on strategy to current immunosuppressive treatment of UC patients. ..
  36. doi request reprint C-ANCA/proteinase 3-positive colitis in children: a distinctive form of inflammatory bowel disease or vasculitis with colitis as initial presentation?
    Stephanie Van Biervliet
    Paediatric Gastroenterology Department of Clinical Chemistry, Microbiology and Immunology, Laboratory of Clinical Biology Adult Gastroenterology, Ghent University Hospital, Belgium
    J Pediatr Gastroenterol Nutr 57:489-92. 2013
    ..Anti-neutrophil cytoplasmic antibodies (ANCAs) detected by indirect immunofluorescence have been found in patients with inflammatory bowel disease (IBD). Nevertheless, specific antibodies against proteinase-3 (PR3) are rare in this context...
  37. doi request reprint Expression of SGLT1, Bcl-2 and p53 in primary pancreatic cancer related to survival
    Veerle F Casneuf
    Department of Gastroenterology, Ghent University Hospital De Pintelaan, Ghent, Belgium
    Cancer Invest 26:852-9. 2008
    ..High SGLT1 expression in primary tumors was correlated with high Bcl-2 expression, not with p53 expression. This supports our hypothesis that SGLT1 and Bcl-2 expression could serve as prognostic markers in pancreatic cancer...
  38. ncbi request reprint Gut inflammation and spondyloarthropathies
    Filip De Keyser
    Department of Rheumatology, Ghent University Hospital, De Pintelaan 185, Ghent B 9000, Belgium
    Curr Rheumatol Rep 4:525-32. 2002
    ..The recent introduction and positioning of anti-tumor necrosis factor-alpha therapy in patients with ankylosing spondylitis and other types of SpA is, in large part, based on this concept...
  39. ncbi request reprint The intimate relationship between gut and joint in spondyloarthropathies
    Peggy Jacques
    Department of Internal Medicine, Rheumatology, University Hospital of Ghent, Ghent, Belgium
    Curr Opin Rheumatol 19:353-7. 2007
    ..The aim of this article is to highlight recent progress in the combined joint and gut disease in spondyloarthropathies...
  40. ncbi request reprint Immunogenicity of infliximab: how to handle the problem?
    Filip Baert
    Department of Gastroenterology, University Hospital Leuven, Herestraat 49, 3000 Leuven, Belgium
    Acta Gastroenterol Belg 70:163-70. 2007
    ..Antibody formation is associated with allergic reactions and loss of response...
  41. doi request reprint Ursodeoxycholic acid and its taurine/glycine conjugated species reduce colitogenic dysbiosis and equally suppress experimental colitis in mice
    Lien Van den Bossche
    Department of Gastroenterology, Ghent University, Ghent, Belgium
    Appl Environ Microbiol . 2017
    ..We conclude that UDCA, which is an FDA-approved drug for cholestatic liver disorders, could be an attractive treatment option to reduce dysbiosis and improve inflammation in human IBD...
  42. ncbi request reprint Prevalence of CT features of axial spondyloarthritis in patients with Crohn's disease
    Isabelle De Kock
    Department of Radiology, Ghent University Hospital, Ghent, Belgium
    Acta Radiol . 2016
    ..The sacroiliac joint and spine are seen on abdominal computed tomography (CT) and may show structural lesions as part of spondyloarthritis...
  43. pmc Heterogeneity of the gut microbiome in mice: guidelines for optimizing experimental design
    Debby Laukens
    Department of Gastroenterology, Ghent University, B 9000 Ghent, Belgium
    FEMS Microbiol Rev 40:117-32. 2016
    ..The purpose of this review is to summarize the factors that influence microbiota composition in mice and to provide guidelines to improve the reproducibility of animal experiments. ..
  44. doi request reprint Clinical impact of capsule endoscopy on further strategy and long-term clinical outcome in patients with obscure bleeding
    Pieter Hindryckx
    Department of Internal Medicine, University Hospital Ghent, Ghent, Belgium
    Gastrointest Endosc 68:98-104. 2008
    ..Capsule endoscopy (CE) is highly effective in detecting small-bowel lesions in patients with obscure GI bleeding (OGIB). Little is known about the impact of CE on further management and outcomes in patients with OGIB...
  45. ncbi request reprint Is combined 18F-fluorodeoxyglucose-positron emission tomography/computed tomography superior to positron emission tomography or computed tomography alone for diagnosis, staging and restaging of pancreatic lesions?
    Veerle Casneuf
    Dept of Gastroenterology, De Pintelaan 185, 9000 Gent, Belgium
    Acta Gastroenterol Belg 70:331-8. 2007
    ..To evaluate whether combined 18F-FDG PET/CT has an additive value over 18F-FDG-PET or CT alone for diagnosis, staging and restaging of pancreatic lesions...
  46. doi request reprint Microscopic gut inflammation in axial spondyloarthritis: a multiparametric predictive model
    Liesbet Van Praet
    Department of Rheumatology, Ghent University Hospital, De Pintelaan 185, Ghent 9000, Belgium
    Ann Rheum Dis 72:414-7. 2013
    ..To assess the rates and explore predictors of microscopic gut inflammation in a cohort of patients with axial and peripheral spondyloarthritis (SpA)...
  47. doi request reprint Decreased colonization of fecal Clostridium coccoides/Eubacterium rectale species from ulcerative colitis patients in an in vitro dynamic gut model with mucin environment
    Joan Vermeiren
    Laboratory of Microbial Ecology and Technology, Ghent University, Gent, Belgium
    FEMS Microbiol Ecol 79:685-96. 2012
    ..The M-SHIME model revealed depletion in butyrate producing microbial communities not restricted to the luminal but also in the mucosal samples from UC patients compared to HV...
  48. doi request reprint Genome-Wide Copy Number Variation Scan Identifies Complement Component C4 as Novel Susceptibility Gene for Crohn's Disease
    Isabelle Cleynen
    Department of Clinical and Experimental Medicine, TARGID, KU Leuven, Leuven, Belgium Department of Electrical Engineering ESAT, STADIUS Center for Dynamical Systems, Signal Processing and Data Analytics, KU Leuven, Leuven, Belgium iMinds Department of Medical Information Technologies, KU Leuven, Leuven, Belgium Department of Human Genetics, KU Leuven, Leuven, Belgium Department of Gastroenterology, Ghent University Hospital, Gent, Belgium Erasmus Hospital, Free University of Brussels, Department of Gastroenterology, Brussels, Belgium Unit of Animal Genomics, Groupe Interdisciplinaire de Génoprotéomique Appliquée GIGA R and Faculty of Veterinary Medicine, University of Liege, Liege, Belgium Division of Gastroenterology, Centre Hospitalier Universitaire, Universite de Liege, Liege, Belgium Division of Gastroenterology, UZ Leuven, Leuven, Belgium and Department of Electrical Engineering and Computer Science, Bioinformatics Statistical Genetics, Montefiore Institute, Universty of Liège, Liege, Belgium
    Inflamm Bowel Dis 22:505-15. 2016
    ..In addition to single nucleotide polymorphisms typically studied in genome-wide scans, copy number variation is responsible for a large proportion of human genetic variation...
  49. doi request reprint Effects of vagus nerve stimulation on pro- and anti-inflammatory cytokine induction in patients with refractory epilepsy
    Veerle De Herdt
    Laboratory for Clinical and Experimental Neurophysiology, Reference Center for Refractory Epilepsy, Department of Neurology, Ghent University Hospital, 9000 Gent, Belgium
    J Neuroimmunol 214:104-8. 2009
    ..The present study shows that cytokine induction by PBMC isolated from patients with refractory epilepsy is altered by long-term vagus nerve stimulation...
  50. ncbi request reprint Extrapancreatic inflammation on abdominal computed tomography as an early predictor of disease severity in acute pancreatitis: evaluation of a new scoring system
    Jan J De Waele
    Intensive Care Unit, Ghent University Hospital, De Pintelaan 185, 9000 Gent, Belgium
    Pancreas 34:185-90. 2007
    ..To introduce a new scoring system based on signs of systemic inflammation on computed tomography (CT) [ExtraPancreatic Inflammation on CT (EPIC) score] and evaluate this score as an early prognostic tool...
  51. pmc Evidence for a potential role of metallothioneins in inflammatory bowel diseases
    Anouk Waeytens
    Department of Gastroenterology, Ghent University, De Pintelaan 185, 9000 Gent, Belgium
    Mediators Inflamm 2009:729172. 2009
    ..Reports on MT expression in IBD are contradictory but clearly demonstrate a deviant MT expression supporting the idea that these aberrations in IBD require further clarification...
  52. pmc The Effect of Cigarette Smoke Exposure on the Development of Inflammation in Lungs, Gut and Joints of TNFΔARE Mice
    Liesbeth Allais
    Department of Medical and Forensic Pathology, Ghent University, Ghent, Belgium
    PLoS ONE 10:e0141570. 2015
    ..In conclusion, CS exposure does not modulate gut and joint inflammation in TNFΔARE mice. The lung responses towards CS in TNFΔARE mice however depend on the duration of CS exposure. ..
  53. ncbi request reprint Demographic and clinical parameters influencing the short-term outcome of anti-tumor necrosis factor (infliximab) treatment in Crohn's disease
    Severine Vermeire
    Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium
    Am J Gastroenterol 97:2357-63. 2002
    ..The aim of this study was to assess whether demographic or clinical parameters influence short-term response to infliximab...
  54. ncbi request reprint Increased angiogenesis and permeability in the mesenteric microvasculature of rats with cirrhosis and portal hypertension: an in vivo study
    Anja M Geerts
    Department of Hepatology and Gastroenterology, Ghent University Hospital, Ghent, Belgium
    Liver Int 26:889-98. 2006
    ..The present study visualises in vivo structural changes (angiogenesis and vascular hyperpermeability) and examines the presence of VEGF and eNOS in the mesenteric microvasculature of animal models of PHT with and without cirrhosis...
  55. ncbi request reprint Spondyloarthropathy and gut inflammation
    Martine De Vos
    Ghent University Hospital, Department of Gastroenterology 1K12IE, De Pintelaan 185, 9000 Ghent, Belgium
    J Pediatr Gastroenterol Nutr 39:S736-7. 2004
  56. ncbi request reprint NOD2/CARD15 does not influence response to infliximab in Crohn's disease
    Severine Vermeire
    Department of Gastroenterology, UZ Gasthuisberg, Leuven, Belgium
    Gastroenterology 123:106-11. 2002
    ..It is not clear which factors influence treatment outcome. We assessed whether variants in NOD2/CARD15 are predictive for differences in clinical response...
  57. ncbi request reprint Macrophages expressing the scavenger receptor CD163: a link between immune alterations of the gut and synovial inflammation in spondyloarthropathy
    Dominique Baeten
    Department of Rheumatology, OK121B, Ghent University Hospital, De Pintelaan 185, 9000 Gent, Belgium
    J Pathol 196:343-50. 2002
    ..The correlation with inflammatory parameters, the expression of HLA-DR, the production of TNFalpha but not IL-10, and the reduction by anti-TNFalpha therapy support a role for CD163+ macrophages in the synovial inflammation in SpA...