Christophe F Deroanne

Summary

Country: Belgium

Publications

  1. ncbi request reprint EphrinA1 inactivates integrin-mediated vascular smooth muscle cell spreading via the Rac/PAK pathway
    Christophe Deroanne
    Institute of Signaling, Developmental Biology and Cancer Research, CNRS UMR 6543, Centre Antoine Lacassagne, 33 Avenue de Valombrose, 06189 Nice, France
    J Cell Sci 116:1367-76. 2003
  2. ncbi request reprint Cdc42 downregulates MMP-1 expression by inhibiting the ERK1/2 pathway
    Christophe F Deroanne
    Laboratory of Connective Tissues Biology, CBIG GIGA Research Center, University of Liege, Tour de Pathologie, B23 3, B 4000 Sart Tilman, Belgium
    J Cell Sci 118:1173-83. 2005
  3. pmc RhoGDIα-dependent balance between RhoA and RhoC is a key regulator of cancer cell tumorigenesis
    T T Giang Ho
    Laboratory of Connective Tissues Biology, GIGA Cancer, University of Liege, B 4000 Sart Tilman, Belgium
    Mol Biol Cell 22:3263-75. 2011
  4. ncbi request reprint The antitumoral effect of endostatin and angiostatin is associated with a down-regulation of vascular endothelial growth factor expression in tumor cells
    Amin Hajitou
    Laboratory of Tumor and Development Biology, and, Laboratory of Connective Tissues Biology, University of Liege, Sart Tilman, 4000 Liege, Belgium
    FASEB J 16:1802-4. 2002
  5. doi request reprint RhoA-GDP regulates RhoB protein stability. Potential involvement of RhoGDIalpha
    T T Giang Ho
    Laboratory of Connective Tissues Biology, GIGA R, University of Liege, Tour de Pathologie, Sart Tilman, Belgium
    J Biol Chem 283:21588-98. 2008
  6. ncbi request reprint Histone deacetylases inhibitors as anti-angiogenic agents altering vascular endothelial growth factor signaling
    Christophe F Deroanne
    Research Center in Experimental Cancerology, University of Liege, Sart Tilman, B 4000 Liege, Belgium
    Oncogene 21:427-36. 2002
  7. pmc Newly identified biologically active and proteolysis-resistant VEGF-A isoform VEGF111 is induced by genotoxic agents
    Pierre Mineur
    Laboratory of Connective Tissues Biology, University of Liege, B 4000 Liege, Belgium
    J Cell Biol 179:1261-73. 2007
  8. pmc MMP-9 regulates both positively and negatively collagen gel contraction: a nonproteolytic function of MMP-9
    Olivier D Defawe
    Division of Vascular Surgery, Department of Surgery, University of Washington, Seattle, WA, USA
    Cardiovasc Res 66:402-9. 2005
  9. doi request reprint Metallothionein-dependent up-regulation of TGF-β2 participates in the remodelling of the myxomatous mitral valve
    Alexia Hulin
    Laboratory of Connective Tissues Biology, GIGA Cancer, University of Liege, Tour de Pathologie, B23 3, B 4000 Sart Tilman, Belgium
    Cardiovasc Res 93:480-9. 2012
  10. ncbi request reprint Histone deacetylase 7 silencing alters endothelial cell migration, a key step in angiogenesis
    Denis Mottet
    Metastasis Research Laboratory, University of Liege, Belgium
    Circ Res 101:1237-46. 2007

Collaborators

Detail Information

Publications17

  1. ncbi request reprint EphrinA1 inactivates integrin-mediated vascular smooth muscle cell spreading via the Rac/PAK pathway
    Christophe Deroanne
    Institute of Signaling, Developmental Biology and Cancer Research, CNRS UMR 6543, Centre Antoine Lacassagne, 33 Avenue de Valombrose, 06189 Nice, France
    J Cell Sci 116:1367-76. 2003
    ..In this way, ephrinA1, alone or in synergy with S1P, can participate in blood vessel destabilization, a prerequisite for angiogenesis...
  2. ncbi request reprint Cdc42 downregulates MMP-1 expression by inhibiting the ERK1/2 pathway
    Christophe F Deroanne
    Laboratory of Connective Tissues Biology, CBIG GIGA Research Center, University of Liege, Tour de Pathologie, B23 3, B 4000 Sart Tilman, Belgium
    J Cell Sci 118:1173-83. 2005
    ..Therefore, Cdc42 contributes to ECM homeostasis and connective tissue integrity...
  3. pmc RhoGDIα-dependent balance between RhoA and RhoC is a key regulator of cancer cell tumorigenesis
    T T Giang Ho
    Laboratory of Connective Tissues Biology, GIGA Cancer, University of Liege, B 4000 Sart Tilman, Belgium
    Mol Biol Cell 22:3263-75. 2011
    ..This study demonstrates the dynamic balance inside the RhoGTPase network and illustrates its biological relevance in cancer progression...
  4. ncbi request reprint The antitumoral effect of endostatin and angiostatin is associated with a down-regulation of vascular endothelial growth factor expression in tumor cells
    Amin Hajitou
    Laboratory of Tumor and Development Biology, and, Laboratory of Connective Tissues Biology, University of Liege, Sart Tilman, 4000 Liege, Belgium
    FASEB J 16:1802-4. 2002
    ..This work provides evidence that endostatin and angiostatin act on tumor cells themselves...
  5. doi request reprint RhoA-GDP regulates RhoB protein stability. Potential involvement of RhoGDIalpha
    T T Giang Ho
    Laboratory of Connective Tissues Biology, GIGA R, University of Liege, Tour de Pathologie, Sart Tilman, Belgium
    J Biol Chem 283:21588-98. 2008
    ..Our results highlight RhoGDIalpha-dependent cross-talks that regulate the stability of RhoGTPases...
  6. ncbi request reprint Histone deacetylases inhibitors as anti-angiogenic agents altering vascular endothelial growth factor signaling
    Christophe F Deroanne
    Research Center in Experimental Cancerology, University of Liege, Sart Tilman, B 4000 Liege, Belgium
    Oncogene 21:427-36. 2002
    ..These observations provide a conspicuous demonstration that HDAC inhibitors are potent anti-angiogenic factors altering VEGF signaling...
  7. pmc Newly identified biologically active and proteolysis-resistant VEGF-A isoform VEGF111 is induced by genotoxic agents
    Pierre Mineur
    Laboratory of Connective Tissues Biology, University of Liege, B 4000 Liege, Belgium
    J Cell Biol 179:1261-73. 2007
    ..Its potent angiogenic activity and remarkable resistance to proteolysis makes VEGF111 a potential adverse factor during chemotherapy but a beneficial therapeutic tool for ischemic diseases...
  8. pmc MMP-9 regulates both positively and negatively collagen gel contraction: a nonproteolytic function of MMP-9
    Olivier D Defawe
    Division of Vascular Surgery, Department of Surgery, University of Washington, Seattle, WA, USA
    Cardiovasc Res 66:402-9. 2005
    ..To investigate potential mechanisms for this observation, we investigated the role of MMP-9 in smooth muscle cell (SMC)-mediated collagen gel contraction, an in vitro model of constrictive remodeling...
  9. doi request reprint Metallothionein-dependent up-regulation of TGF-β2 participates in the remodelling of the myxomatous mitral valve
    Alexia Hulin
    Laboratory of Connective Tissues Biology, GIGA Cancer, University of Liege, Tour de Pathologie, B23 3, B 4000 Sart Tilman, Belgium
    Cardiovasc Res 93:480-9. 2012
    ..Our goal was to identify dysregulated genes in human MMV and then to evaluate their functional role in the progression of the disease...
  10. ncbi request reprint Histone deacetylase 7 silencing alters endothelial cell migration, a key step in angiogenesis
    Denis Mottet
    Metastasis Research Laboratory, University of Liege, Belgium
    Circ Res 101:1237-46. 2007
    ..Because angiogenesis is required for tumor progression, HDAC7 may represent a rational target for therapeutic intervention against cancer...
  11. pmc Lipin-1 regulates cancer cell phenotype and is a potential target to potentiate rapamycin treatment
    Laura Brohée
    Laboratory of Connective Tissues Biology, GIGA Cancer, University of Liege, Tour de Pathologie, Sart Tilman, Belgium
    Oncotarget 6:11264-80. 2015
    ..These data indicate that lipin-1 controls main cellular processes involved in cancer progression and that its targeting, alone or in combination with other treatments, could open new avenues in anticancer therapy. ..
  12. ncbi request reprint Cell survival and preservation of siRNA-mediated protein knock-down upon serum-free cryopreservation (-80 degrees C)
    Charles A Lambert
    Laboratory of Connective Tissues Biology, University of Liege, Liege, Belgium
    Gravit Space Biol Bull 18:103-4. 2005
  13. doi request reprint P2X1 ion channels promote neutrophil chemotaxis through Rho kinase activation
    Christelle Lecut
    GIGA Research Human Genetics Unit, University of Liege, Liege, Belgium
    J Immunol 183:2801-9. 2009
    ..These ion channels may therefore play a significant role in host defense and inflammation...
  14. pmc Zoledronic acid up-regulates bone sialoprotein expression in osteoblastic cells through Rho GTPase inhibition
    Michael Chaplet
    Metastasis Research Laboratory, Center of Experimental Cancer Research, University of Liege, 4000 Liege, Belgium
    Biochem J 384:591-8. 2004
    ..Our study demonstrates that ZOL induces BSP expression in osteoblast-like cells through inactivation of Rho GTPases and provides a potential mechanism to explain the favourable effects of ZOL treatment on bone mass and integrity...
  15. doi request reprint Role of TGF-beta1-independent changes in protein neosynthesis, p38alphaMAPK, and cdc42 in hydrogen peroxide-induced senescence-like morphogenesis
    Aline Chretien
    Research Unit on Cellular Biology, University of Namur, B 5000 Namur, Belgium
    Free Radic Biol Med 44:1732-51. 2008
    ..This study further clarified the mechanisms of senescence-like morphogenesis in addition to the previously demonstrated role of TGF-beta1 signaling pathways...
  16. ncbi request reprint The small Rho GTPase Rac1 controls normal human dermal fibroblasts proliferation with phosphorylation of the oncoprotein c-myc
    Ekaterina Nikolova
    Cell and Tissue Laboratory, URPHYM, University of Namur FUNDP, B 5000 Namur, Belgium
    Biochem Biophys Res Commun 359:834-9. 2007
    ..Thus Rac1 activates proliferation of normal fibroblasts through stimulation of c-myc phosphorylation without affecting ERK1/2 activity...
  17. ncbi request reprint The inhibition of the expression of the small Rho GTPase Rac1 induces differentiation with no effect on cell proliferation in growing human adult keratinocytes
    Ekaterina Nikolova
    Cell and Tissue Laboratory, URPHYM, University of Namur FUNDP, B 5000 Namur, Belgium
    J Cell Biochem 103:857-64. 2008
    ..Thus, in growing human keratinocytes, Rac1 could impede the expression of premature differentiation markers, probably by exerting positive control on c-myc activity and its binding to specific promoters...