Frederic Clotman

Summary

Country: Belgium

Publications

  1. ncbi request reprint The onecut transcription factor hepatocyte nuclear factor-6 controls B lymphopoiesis in fetal liver
    Caroline Bouzin
    Hormone and Metabolic Research Unit, Université catholique de Louvain and Institute of Cellular Pathology, Brussels, Belgium
    J Immunol 171:1297-303. 2003
  2. ncbi request reprint Hepatic artery malformations associated with a primary defect in intrahepatic bile duct development
    Frederic Clotman
    Hormone and Metabolic Research Unit, Université catholique de Louvain and Institute of Cellular Pathology, Avenue Hippocrate 75, box 7529, B 1200 Brussels, Belgium
    J Hepatol 39:686-92. 2003
  3. ncbi request reprint The Onecut transcription factors HNF-6/OC-1 and OC-2 regulate early liver expansion by controlling hepatoblast migration
    Sabrina Margagliotti
    Universite Catholique de Louvain, Christian de Duve Institute of Cellular Pathology, Avenue Hippocrate 75 7529, B 1200 Brussels, Belgium
    Dev Biol 311:579-89. 2007
  4. pmc Control of liver cell fate decision by a gradient of TGF beta signaling modulated by Onecut transcription factors
    Frederic Clotman
    Hormone and Metabolic Research Unit, Cell Biology Unit, Institute of Cellular Pathology and Université catholique de Louvain, Brussels, Belgium
    Genes Dev 19:1849-54. 2005
  5. ncbi request reprint Transcription factor HNF-6/OC-1 inhibits the stimulation of the HNF-3alpha/Foxa1 gene by TGF-beta in mouse liver
    Nicolas Plumb-Rudewiez
    Hormone and Metabolic Research Unit, Institute of Cellular Pathology and Université catholique de Louvain, Brussels, Belgium
    Hepatology 40:1266-74. 2004
  6. ncbi request reprint The transcription factor hepatocyte nuclear factor-6 controls the development of pancreatic ducts in the mouse
    Christophe E Pierreux
    Hormone and Metabolic Research Unit, Université catholique de Louvain and Institute of Cellular Pathology, Brussels, Belgium
    Gastroenterology 130:532-41. 2006
  7. ncbi request reprint The onecut transcription factor HNF6 is required for normal development of the biliary tract
    Frederic Clotman
    Hormone and Metabolic Research Unit, Institute of Cellular Pathology and Université catholique de Louvain, Avenue Hippocrate 75, B 1200 Brussels, Belgium
    Development 129:1819-28. 2002
  8. doi request reprint Role of metalloproteinases at the onset of liver development
    Sabrina Margagliotti
    Hormone and Metabolic Research Unit, Universite Catholique de Louvain, de Duve Institute, 1200 Brussels, Belgium
    Dev Growth Differ 50:331-8. 2008
  9. ncbi request reprint Control of hepatic differentiation by activin/TGFbeta signaling
    Frederic Clotman
    Hormone and Metabolic Research Unit, Institute of Cellular Pathology and Université catholique de Louvain, Brussels, Belgium
    Cell Cycle 5:168-71. 2006
  10. pmc Increased protein glycation in fructosamine 3-kinase-deficient mice
    Maria Veiga da-Cunha
    Laboratory of Physiological Chemistry, Christian de Duve Institute of Cellular Pathology, Universite Catholique de Louvain, Avenue Hippocrate 75, B 1200 Brussels, Belgium
    Biochem J 399:257-64. 2006

Collaborators

Detail Information

Publications10

  1. ncbi request reprint The onecut transcription factor hepatocyte nuclear factor-6 controls B lymphopoiesis in fetal liver
    Caroline Bouzin
    Hormone and Metabolic Research Unit, Université catholique de Louvain and Institute of Cellular Pathology, Brussels, Belgium
    J Immunol 171:1297-303. 2003
    ..This work identifies HNF-6 as the first noncell-intrinsic transcription factor known to control B lymphopoiesis specifically in fetal liver...
  2. ncbi request reprint Hepatic artery malformations associated with a primary defect in intrahepatic bile duct development
    Frederic Clotman
    Hormone and Metabolic Research Unit, Université catholique de Louvain and Institute of Cellular Pathology, Avenue Hippocrate 75, box 7529, B 1200 Brussels, Belgium
    J Hepatol 39:686-92. 2003
    ..Hepatic artery malformations are found in diseases in which fetal biliary structures persist after birth (ductal plate malformations). Here we investigated how hepatic artery malformations relate to abnormal bile duct development...
  3. ncbi request reprint The Onecut transcription factors HNF-6/OC-1 and OC-2 regulate early liver expansion by controlling hepatoblast migration
    Sabrina Margagliotti
    Universite Catholique de Louvain, Christian de Duve Institute of Cellular Pathology, Avenue Hippocrate 75 7529, B 1200 Brussels, Belgium
    Dev Biol 311:579-89. 2007
    ..This network operating at the onset of liver development contains candidate genes for investigation of liver carcinogenesis...
  4. pmc Control of liver cell fate decision by a gradient of TGF beta signaling modulated by Onecut transcription factors
    Frederic Clotman
    Hormone and Metabolic Research Unit, Cell Biology Unit, Institute of Cellular Pathology and Université catholique de Louvain, Brussels, Belgium
    Genes Dev 19:1849-54. 2005
    ..Thus, a gradient of activin/TGFbeta signaling modulated by Onecut factors is required to segregate the hepatocytic and the biliary lineages...
  5. ncbi request reprint Transcription factor HNF-6/OC-1 inhibits the stimulation of the HNF-3alpha/Foxa1 gene by TGF-beta in mouse liver
    Nicolas Plumb-Rudewiez
    Hormone and Metabolic Research Unit, Institute of Cellular Pathology and Université catholique de Louvain, Brussels, Belgium
    Hepatology 40:1266-74. 2004
    ..This identifies a new mechanism of interaction between liver-enriched transcription factors whereby one factor indirectly controls another by modulating the activity of a signaling pathway...
  6. ncbi request reprint The transcription factor hepatocyte nuclear factor-6 controls the development of pancreatic ducts in the mouse
    Christophe E Pierreux
    Hormone and Metabolic Research Unit, Université catholique de Louvain and Institute of Cellular Pathology, Brussels, Belgium
    Gastroenterology 130:532-41. 2006
    ..Here, we investigate the transcriptional mechanisms that control pancreatic duct development by addressing the role of the transcription factor hepatocyte nuclear factor (HNF)-6...
  7. ncbi request reprint The onecut transcription factor HNF6 is required for normal development of the biliary tract
    Frederic Clotman
    Hormone and Metabolic Research Unit, Institute of Cellular Pathology and Université catholique de Louvain, Avenue Hippocrate 75, B 1200 Brussels, Belgium
    Development 129:1819-28. 2002
    ..We conclude that HNF6 is essential for differentiation and morphogenesis of the biliary tract and that intrahepatic bile duct development is controlled by a HNF6-->HNF1beta cascade...
  8. doi request reprint Role of metalloproteinases at the onset of liver development
    Sabrina Margagliotti
    Hormone and Metabolic Research Unit, Universite Catholique de Louvain, de Duve Institute, 1200 Brussels, Belgium
    Dev Growth Differ 50:331-8. 2008
    ..We conclude that MMPs are required to initiate expansion of the liver during development and that our culture system provides a new model to study hepatoblast migration...
  9. ncbi request reprint Control of hepatic differentiation by activin/TGFbeta signaling
    Frederic Clotman
    Hormone and Metabolic Research Unit, Institute of Cellular Pathology and Université catholique de Louvain, Brussels, Belgium
    Cell Cycle 5:168-71. 2006
    ....
  10. pmc Increased protein glycation in fructosamine 3-kinase-deficient mice
    Maria Veiga da-Cunha
    Laboratory of Physiological Chemistry, Christian de Duve Institute of Cellular Pathology, Universite Catholique de Louvain, Avenue Hippocrate 75, B 1200 Brussels, Belgium
    Biochem J 399:257-64. 2006
    ..Taken together, these data indicate that FN3K serves as a protein repair enzyme and also in the metabolism of endogenously produced free fructose-epsilon-lysine...