Dora Baczyk

Summary

Publications

  1. doi Emerging role of SUMOylation in placental pathology
    D Baczyk
    Research Centre for Women s and Infants Health, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, 25 Orde Street, Toronto, Ontario M5T 3H7, Canada
    Placenta 34:606-12. 2013
  2. pmc DREAM mediated regulation of GCM1 in the human placental trophoblast
    Dora Baczyk
    Research Centre for Women s and Infants Health at the Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 8:e51837. 2013
  3. doi Calcium signaling in placenta
    Dora Baczyk
    Research Centre for Women s and Infants Health RCWIH at the Samuel Lunenfeld Research Institute of Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
    Cell Calcium 49:350-6. 2011
  4. pmc The molecular role of connexin 43 in human trophoblast cell fusion
    Caroline E Dunk
    Research Centre for Women s and Infants Health, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
    Biol Reprod 86:115. 2012
  5. doi Glial cell missing-1 mediates over-expression of tissue inhibitor of metalloproteinase-4 in severe pre-eclamptic placental villi
    Sascha Drewlo
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada
    Hum Reprod 26:1025-34. 2011
  6. pmc Translational analysis of mouse and human placental protein and mRNA reveals distinct molecular pathologies in human preeclampsia
    Brian Cox
    The Hospital for Sick Children, Program in Developmental and Stem Cell Biology, Toronto, Ontario, Canada
    Mol Cell Proteomics 10:M111.012526. 2011
  7. pmc Cell specific patterns of methylation in the human placenta
    Ariadna Grigoriu
    Department of Obstetrics and Gynecology, Maternal Fetal Medicine Division, Hospital for Sick Children, Toronto, ON, Canada
    Epigenetics 6:368-79. 2011
  8. pmc Nodal signals through activin receptor-like kinase 7 to inhibit trophoblast migration and invasion: implication in the pathogenesis of preeclampsia
    Lubna Nadeem
    Department of Biology, York University, Toronto, Ontario, Canada
    Am J Pathol 178:1177-89. 2011
  9. doi Fusion assays and models for the trophoblast
    Sascha Drewlo
    Womens and Infants Health, Samuel Lunenfeld Research Institute, Department of Obstetrics and Gynaecology, Mount Sinai Hospital, University of Toronto, Ontario, Canada
    Methods Mol Biol 475:363-82. 2008

Collaborators

Detail Information

Publications9

  1. doi Emerging role of SUMOylation in placental pathology
    D Baczyk
    Research Centre for Women s and Infants Health, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, 25 Orde Street, Toronto, Ontario M5T 3H7, Canada
    Placenta 34:606-12. 2013
    ..In this current study we hypothesized that placentas from sPE patients will display up regulation in the SUMO regulatory pathway...
  2. pmc DREAM mediated regulation of GCM1 in the human placental trophoblast
    Dora Baczyk
    Research Centre for Women s and Infants Health at the Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 8:e51837. 2013
    ..In conclusion, our data reveal a calcium-regulated pathway whereby GCM1-directed villous trophoblast differentiation is repressed by DREAM. This pathway may be relevant to disease prevention via calcium-supplementation...
  3. doi Calcium signaling in placenta
    Dora Baczyk
    Research Centre for Women s and Infants Health RCWIH at the Samuel Lunenfeld Research Institute of Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
    Cell Calcium 49:350-6. 2011
    ..A broader understanding of the role of Ca(2+) signaling during human reproduction may offer insight into impaired pregnancy outcomes...
  4. pmc The molecular role of connexin 43 in human trophoblast cell fusion
    Caroline E Dunk
    Research Centre for Women s and Infants Health, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
    Biol Reprod 86:115. 2012
    ..We conclude that Cx43-mediated GJIC and SLC1A5 interaction play important functional roles in trophoblast cell fusion...
  5. doi Glial cell missing-1 mediates over-expression of tissue inhibitor of metalloproteinase-4 in severe pre-eclamptic placental villi
    Sascha Drewlo
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada
    Hum Reprod 26:1025-34. 2011
    ..GCM1 expression is reduced in placental villi of women with sPE but the functional downstream consequences of reduced GCM1 expression are unknown...
  6. pmc Translational analysis of mouse and human placental protein and mRNA reveals distinct molecular pathologies in human preeclampsia
    Brian Cox
    The Hospital for Sick Children, Program in Developmental and Stem Cell Biology, Toronto, Ontario, Canada
    Mol Cell Proteomics 10:M111.012526. 2011
    ..We conclude that clinically similar preeclampsia patients exhibit divergent placental gene expression profiles thus implicating divergent molecular mechanisms in the origins of this disease...
  7. pmc Cell specific patterns of methylation in the human placenta
    Ariadna Grigoriu
    Department of Obstetrics and Gynecology, Maternal Fetal Medicine Division, Hospital for Sick Children, Toronto, ON, Canada
    Epigenetics 6:368-79. 2011
    ..These data are proof of principle for cell-type specific epigenetic regulation in placenta and demonstrate that the methylation profile of placenta is mainly driven by cytotrophoblasts...
  8. pmc Nodal signals through activin receptor-like kinase 7 to inhibit trophoblast migration and invasion: implication in the pathogenesis of preeclampsia
    Lubna Nadeem
    Department of Biology, York University, Toronto, Ontario, Canada
    Am J Pathol 178:1177-89. 2011
    ..These findings suggest that the Nodal/ALK7 pathway plays important roles in human placentation and that its abnormal signaling may contribute to the development of preeclampsia...
  9. doi Fusion assays and models for the trophoblast
    Sascha Drewlo
    Womens and Infants Health, Samuel Lunenfeld Research Institute, Department of Obstetrics and Gynaecology, Mount Sinai Hospital, University of Toronto, Ontario, Canada
    Methods Mol Biol 475:363-82. 2008
    ..Furthermore, we will present strategies to inhibit fusion in the different models. These techniques represent powerful tools to study the molecular mediators of cell fusion in the trophoblast...