M A Petty
Affiliation: Aventis Pharma
- Elements of cerebral microvascular ischaemiaM A Petty
CNS Pharmacology, Aventis Pharmaceuticals, Inc, Route 202 206, P O Box 6800, Bridgewater, NJ 08807, USA
Brain Res Brain Res Rev 36:23-34. 2001..The recent progress made in defining the mechanisms involved in the initiation of ischaemic events, as described in this review, may lead to the identification of new strategies for intervention in the ischaemic cascade...
- Junctional complexes of the blood-brain barrier: permeability changes in neuroinflammationMargaret A Petty
CNS Pharmacology, Aventis Pharmaceuticals Inc, Route 202 206, P O Box 6800, Bridgewater, NJ 08807, USA
Prog Neurobiol 68:311-23. 2002..An understanding of these molecular substrates in BBB regulation may lead to new approaches for enhancing CNS drug delivery and ameliorating brain edema after injury and inflammation...
- In vivo neuroprotective effects of ACEA 1021 confirmed by magnetic resonance imaging in ischemic strokeMargaret A Petty
Systems Pharmacology, Mail Stop 303A, Aventis Pharmaceuticals Inc, Route 202 206, PO Box 6800, Bridgewater, NJ 08807, USA
Eur J Pharmacol 474:53-62. 2003..v., 5 min after occlusion; 30 mg/kg, s.c., 1 and 4 h post-middle cerebral artery occlusion) decreased infarct size by 42%. The consistent anti-ischemic effects of ACEA 1021 make it a valuable compound for exploratory stroke research...
- ACEA 1021: flip or flop?Margaret A Petty
CNS Pharmacology, Aventis Pharmaceuticals, Inc, JR2 303A, Bridgewater, NJ 08807 0800, USA
CNS Drug Rev 10:337-48. 2004..In order to properly evaluate the true potential for ACEA 1021 in acute and chronic CNS disorders additional longer term safety and efficacy data in humans are needed...
- White matter ischaemiaM A Petty
CNS Research, Hoechst Marion Roussel, Bridgewater, NJ 08807, USA
Brain Res Brain Res Rev 31:58-64. 1999..Various points along the white matter damage cascade could be specifically targeted as a potential means of inhibiting the development of axonal irreversible injury...