Kevin T Morgan
Affiliation: Aventis Pharma
- The hepatic transcriptome as a window on whole-body physiology and pathophysiologyKevin T Morgan
Aventis Inc, Bridgewater, New Jersey 08876, USA
Toxicol Pathol 33:136-45. 2005..A download option appears at the bottom of this abstract. In order to access the full article online, you must either have an individual subscription or a member subscription accessed through (www.toxpath.org)...
- Complementary roles for toxicologic pathology and mathematics in toxicogenomics, with special reference to data interpretation and oscillatory dynamicsKevin T Morgan
Aventis Pharmaceuticals, Bridgewater, New Jersey, USA
Toxicol Pathol 32:13-25. 2004..An understanding of pathology by mathematicians involved in toxicogenomics is equally critical, as both mathematics and pathology are essential for transforming toxicogenomics data sets into useful knowledge...
- Frequent sampling reveals dynamic responses by the transcriptome to routine media replacement in HepG2 cellsKevin T Morgan
GlaxoSmithKline, Research Triangle Park, North Carolina 27709, USA
Toxicol Pathol 31:448-61. 2003..To access this file, click on the issue link for 31(4), then select this article. In order to access the full article online, you must either have an individual subscription or a member subscription accessed through www.toxpath.org...
- Application of cDNA microarray technology to in vitro toxicology and the selection of genes for a real-time RT-PCR-based screen for oxidative stress in Hep-G2 cellsKevin T Morgan
Aventis Pharmaceuticals, Raleigh, North Carolina 27604, USA
Toxicol Pathol 30:435-51. 2002..A download option appears at the bottom of this abstract. In order to access the full article online, you must either have an individual subscription or a member subscription accessed through www.toxpath.org...
- Formaldehyde-induced gene expression in F344 rat nasal respiratory epitheliumSusan D Hester
US Environmental Protection Agency, Research Triangle Park, NC, USA
Toxicology 187:13-24. 2003..Differential gene expression profiles may provide clues that could be used to define mechanisms involved in FA-induced nasal cancer...
- Toxicogenomics, drug discovery, and the pathologistGary A Boorman
Laboratory for Experimental Pathology, Environmental Toxicology Program, NIEHS, Research Triangle Park, NC 27709, USA
Toxicol Pathol 30:15-27. 2002..In return, you will gain a greater depth of understanding of cell and tissue function, both in health and disease...
- Correlation of simultaneous differential gene expression in the blood and heart with known mechanisms of adriamycin-induced cardiomyopathy in the ratH Roger Brown
Drug Safety, GlaxoSmithKline, Inc, Research Triangle Park, North Carolina 27709, USA
Toxicol Pathol 30:452-69. 2002..A download option appears at the bottom of this abstract. In order to access the full article online, you must either have an individual subscription or a member subscription accessed through www.toxpath.org...
- Normal gene expression in male F344 rat nasal transitional and respiratory epitheliumSusan D Hester
US EPA, Research Triangle Park, NC, USA
Gene 285:301-10. 2002..g. ion channels). Such baseline data will contribute to further understanding the normal physiology of these cells and facilitate the interpretation of responses by the nasal epithelial cells to xenobiotic treatment or disease...
- Transformation of SV40-immortalized human uroepithelial cells by 3-methylcholanthrene increases IFN- and Large T Antigen-induced transcriptsLynn M Crosby
Environmental Carcinogenesis Division, National Health Effects and Environmental Research Laboratory, US Environmental Protection Agency, Research Triangle Park, USA
Cancer Cell Int 10:4. 2010..We hope that our work will stimulate further study of this important phenomenon...
- Gene expression analysis reveals chemical-specific profilesKevin T Morgan
Toxicogenomics Mechanisms, GlaxoSmithKline, Inc, Research Triangle Park, NC 27709, USA
Toxicol Sci 67:155-6. 2002..Hamadeh, Pierre R. Bushel, Supriya Jayadev, Olimpia DiSorbo, Leping Li, Raymond Tennant, Raymond Stoll, J. Carl Barrett, Richard S. Paules, Kerry Blanchard, and Cynthia A. Afshari (pp. 232-240)...
- Integrated disinfection by-products (DBP) mixtures research: gene expression alterations in primary rat hepatocyte cultures exposed to DBP mixtures formed by chlorination and ozonation/postchlorinationLynn M Crosby
U S Environmental Protection Agency University of North Carolina Chapel Hill Cooperative Training Program, Research Triangle Park, North Carolina 27711, USA
J Toxicol Environ Health A 71:1195-215. 2008..A small subset of gene expression changes was identified that was observed in the response of hepatocytes to peroxisome proliferators, phthalate esters, and haloacetic acids, suggesting a peroxisome proliferative response...
- Effects of minimally toxic levels of carbonyl cyanide P-(trifluoromethoxy) phenylhydrazone (FCCP), elucidated through differential gene expression with biochemical and morphological correlationsSabu Kuruvilla
Oklahoma State University, Stillwater, Oklahoma 74078, USA
Toxicol Sci 73:348-61. 2003..These results suggest that gene expression changes may provide a sensitive indicator of uncoupling in response to chemical exposure...
- Etomoxir-induced oxidative stress in HepG2 cells detected by differential gene expression is confirmed biochemicallyChristine L Merrill
Department of Microbiology, Pathology and Parasitology, North Carolina State University, Raleigh 27606, USA
Toxicol Sci 68:93-101. 2002..This is the first report of oxidative stress caused by etomoxir...
- Normalization and analysis of DNA microarray data by self-consistency and local regressionThomas B Kepler
Santa Fe Institute, Santa Fe, NM 87501, USA
Genome Biol 3:RESEARCH0037. 2002..We find that these assumptions are not generally met, and that these simple methods can be improved...
- Temporal gene expression profiling indicates early up-regulation of interleukin-6 in isoproterenol-induced myocardial necrosis in ratIgor Mikaelian
Hoffmann La Roche Inc, Non Clinical Drug Safety, Nutley, New Jersey 07110, USA
Toxicol Pathol 36:256-64. 2008..These results suggest early involvement of Il6 in isoproterenol-induced myocardial necrosis and emphasize the value of early time points in transcriptomic studies...