P Roschger

Summary

Affiliation: University of Vienna
Country: Austria

Publications

  1. ncbi request reprint Normal mineralization and nanostructure of sclerotic bone in mice overexpressing Fra-1
    P Roschger
    Ludwig Boltzmann Institute of Osteology and Fourth Med Department, Hanusch Hospital and UKH Meidling, Vienna, Austria
    Bone 34:776-82. 2004
  2. ncbi request reprint Constant mineralization density distribution in cancellous human bone
    P Roschger
    Ludwig Boltzmann Institute of Osteology, 4th Medical Department, Hanusch Hospital and UKH Meidling, Vienna, Austria
    Bone 32:316-23. 2003
  3. pmc CRTAP deficiency leads to abnormally high bone matrix mineralization in a murine model and in children with osteogenesis imperfecta type VII
    N Fratzl-Zelman
    Ludwig Boltzmann Institute of Osteology, Hanusch Hospital, Vienna, Austria
    Bone 46:820-6. 2010
  4. ncbi request reprint Targeted overexpression of vitamin D receptor in osteoblasts increases calcium concentration without affecting structural properties of bone mineral crystals
    B M Misof
    Ludwig Boltzmann Institute of Osteology, 4th Med Dept, Hanusch Hospital and UKH Meidling, Vienna, Austria
    Calcif Tissue Int 73:251-7. 2003
  5. pmc Combination of nanoindentation and quantitative backscattered electron imaging revealed altered bone material properties associated with femoral neck fragility
    N Fratzl-Zelman
    Ludwig Boltzmann Institute of Osteology, Hanusch Hospital of WGKK and AUVA Trauma Center Meidling, 4th Medical Department, Hanusch Hospital, 1140 Vienna, Austria
    Calcif Tissue Int 85:335-43. 2009
  6. doi request reprint Mineralization density distribution of postmenopausal osteoporotic bone is restored to normal after long-term alendronate treatment: qBEI and sSAXS data from the fracture intervention trial long-term extension (FLEX)
    P Roschger
    Ludwig Boltzmann Institute of Osteology, Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, 4th Medical Department, Hanusch Hospital, Vienna, Austria
    J Bone Miner Res 25:48-55. 2010
  7. ncbi request reprint Combined treatment with PTH (1-34) and OPG increases bone volume and uniformity of mineralization in aged ovariectomized rats
    A Valenta
    Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, 4th Medical Department, Hanusch Hospital Heinrich Collin Str 30 A 1140 Vienna, Austria
    Bone 37:87-95. 2005
  8. ncbi request reprint Structural development of the mineralized tissue in the human L4 vertebral body
    P Roschger
    Ludwig Boltzmann Institute of Osteology, 4th Medical Department, Hanusch Hospital and UKH-Meidling, Vienna, Austria
    J Struct Biol 136:126-36. 2001
  9. doi request reprint Effect of teriparatide on early bone loss after kidney transplantation
    D Cejka
    Department of Internal Medicine III, Division of Nephrology and Dialysis, Medical University Vienna, Vienna, Austria
    Am J Transplant 8:1864-70. 2008
  10. doi request reprint Cortical bone composition and orientation as a function of animal and tissue age in mice by Raman spectroscopy
    Sonja Gamsjaeger
    Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, 4th Medical Department, Hanusch Hospital, Vienna, Austria
    Bone 47:392-9. 2010

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Normal mineralization and nanostructure of sclerotic bone in mice overexpressing Fra-1
    P Roschger
    Ludwig Boltzmann Institute of Osteology and Fourth Med Department, Hanusch Hospital and UKH Meidling, Vienna, Austria
    Bone 34:776-82. 2004
    ..The bone nanostructure did not show abnormalities in Fra-1 transgenic or Fos-/-. These results provide a rationale for the development of therapeutic applications involving Fra-1-induced bone formation...
  2. ncbi request reprint Constant mineralization density distribution in cancellous human bone
    P Roschger
    Ludwig Boltzmann Institute of Osteology, 4th Medical Department, Hanusch Hospital and UKH Meidling, Vienna, Austria
    Bone 32:316-23. 2003
    ..Because we find the BMDD to be essentially constant in healthy adult humans, qBEI provides a sensitive means to detect even small changes in mineralization due to bone disease or therapeutic intervention...
  3. pmc CRTAP deficiency leads to abnormally high bone matrix mineralization in a murine model and in children with osteogenesis imperfecta type VII
    N Fratzl-Zelman
    Ludwig Boltzmann Institute of Osteology, Hanusch Hospital, Vienna, Austria
    Bone 46:820-6. 2010
    ..Finally, in OI type VII patients the increased portion of primary bone is most likely reflecting a disturbed bone development...
  4. ncbi request reprint Targeted overexpression of vitamin D receptor in osteoblasts increases calcium concentration without affecting structural properties of bone mineral crystals
    B M Misof
    Ludwig Boltzmann Institute of Osteology, 4th Med Dept, Hanusch Hospital and UKH Meidling, Vienna, Austria
    Calcif Tissue Int 73:251-7. 2003
    ....
  5. pmc Combination of nanoindentation and quantitative backscattered electron imaging revealed altered bone material properties associated with femoral neck fragility
    N Fratzl-Zelman
    Ludwig Boltzmann Institute of Osteology, Hanusch Hospital of WGKK and AUVA Trauma Center Meidling, 4th Medical Department, Hanusch Hospital, 1140 Vienna, Austria
    Calcif Tissue Int 85:335-43. 2009
    ..This pilot study suggests that a stiffening process in the organic matrix component contributes to bone fragility independently of mineral content...
  6. doi request reprint Mineralization density distribution of postmenopausal osteoporotic bone is restored to normal after long-term alendronate treatment: qBEI and sSAXS data from the fracture intervention trial long-term extension (FLEX)
    P Roschger
    Ludwig Boltzmann Institute of Osteology, Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, 4th Medical Department, Hanusch Hospital, Vienna, Austria
    J Bone Miner Res 25:48-55. 2010
    ..Even with longer treatment durations of up to 10 years, though, no negative effects on bone matrix mineralization were observed...
  7. ncbi request reprint Combined treatment with PTH (1-34) and OPG increases bone volume and uniformity of mineralization in aged ovariectomized rats
    A Valenta
    Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, 4th Medical Department, Hanusch Hospital Heinrich Collin Str 30 A 1140 Vienna, Austria
    Bone 37:87-95. 2005
    ....
  8. ncbi request reprint Structural development of the mineralized tissue in the human L4 vertebral body
    P Roschger
    Ludwig Boltzmann Institute of Osteology, 4th Medical Department, Hanusch Hospital and UKH-Meidling, Vienna, Austria
    J Struct Biol 136:126-36. 2001
    ..CaMaxFreq and mean particle thickness increase rapidly during the first years and reach saturation. Remarkably, when these parameters are plotted versus logarithm of age, they appear linear...
  9. doi request reprint Effect of teriparatide on early bone loss after kidney transplantation
    D Cejka
    Department of Internal Medicine III, Division of Nephrology and Dialysis, Medical University Vienna, Vienna, Austria
    Am J Transplant 8:1864-70. 2008
    ..We conclude that teriparatide does not improve BMD early after kidney transplantation. Neither histological analysis nor bone markers provide evidence of improved bone turnover or mineralization...
  10. doi request reprint Cortical bone composition and orientation as a function of animal and tissue age in mice by Raman spectroscopy
    Sonja Gamsjaeger
    Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, 4th Medical Department, Hanusch Hospital, Vienna, Austria
    Bone 47:392-9. 2010
    ....
  11. ncbi request reprint Alendronate increases degree and uniformity of mineralization in cancellous bone and decreases the porosity in cortical bone of osteoporotic women
    P Roschger
    Ludwig Boltzmann Institute of Osteology, Fourth Medical Department, Hanusch Krankenhaus and Unfallkrankenhaus Meidling, Vienna, Austria
    Bone 29:185-91. 2001
    ..It also decreases the porosity of the corticalis. Together these effects may contribute to the observed reduction in fractures...
  12. ncbi request reprint Graded microstructure and mechanical properties of human crown dentin
    W Tesch
    Ludwig Boltzmann Institute of Osteology, 4th Medical Department, Hanusch Hospital, Vienna, Austria
    Calcif Tissue Int 69:147-57. 2001
    ..Hence, the observed variations of mechanical and structural properties in an area between 0 and 1.5 mm below the DEJ define crown dentin as a gradient material optimized for its mechanical function...
  13. pmc Lathyrism-induced alterations in collagen cross-links influence the mechanical properties of bone material without affecting the mineral
    E P Paschalis
    Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, 1st Medical Department, Hanusch Hospital, Vienna, Austria
    Bone 49:1232-41. 2011
    ..Interestingly, the collagen cross-link ratio in bone forming areas had the same profile as seen in actively bone forming trabecular surfaces in human iliac crest biopsies of osteoporotic patients...
  14. doi request reprint Evidence of reduced bone turnover and disturbed mineralization process in a boy with Stickler syndrome
    A Al Kaissi
    Ludwig Boltzmann Institute of Osteology, Hanusch Hospital of WGKK, 4th Medical Department, Vienna, Austria
    Calcif Tissue Int 86:126-31. 2010
    ..Such a severe undermineralization of bone matrix might essentially contribute to the compromised mechanical competence of the skeleton found in this patient...
  15. ncbi request reprint Mineralized microstructure of calcified avian tendons: a scanning small angle X-ray scattering study
    H S Gupta
    Ludwig Boltzmann Institute of Osteology, 4th Med Dept, Hanusch Hospital, Vienna, Austria
    Calcif Tissue Int 72:567-76. 2003
    ....
  16. doi request reprint Normative data on mineralization density distribution in iliac bone biopsies of children, adolescents and young adults
    N Fratzl-Zelman
    Ludwig Boltzmann Institute of Osteology, Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, 4th Med Department, Hanusch Hospital, Heinrich Collin Str 30, 1140 Vienna, Austria
    Bone 44:1043-8. 2009
    ..The larger inter-individual variability compared to adults is most likely related to alterations of the bone turnover rate during growth...
  17. ncbi request reprint Bone mineralization density distribution in health and disease
    P Roschger
    4th Medical Department, Hanusch Hospital, Heinrich Collin Street 30, A 1140, Vienna, Austria
    Bone 42:456-66. 2008
    ....
  18. pmc Relationship of bone mineralization density distribution (BMDD) in cortical and cancellous bone within the iliac crest of healthy premenopausal women
    B M Misof
    Ludwig Boltzmann Institute of Osteology at Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, First Medical Department, Hanusch Hospital, Heinrich Collin Str 30, 1140, Vienna, Austria
    Calcif Tissue Int 95:332-9. 2014
    ..This normative dataset of healthy premenopausal women will provide a reference standard by which disease- and treatment-specific effects can be assessed at the level of cortical bone BMDD...
  19. doi request reprint Bone matrix quality and plasma homocysteine levels
    S Blouin
    4th Medical Department, Ludwig Boltzmann Institute of Osteology, Hanusch Hospital of WGKK, AUVA Trauma Centre Meidling, Hanusch Hospital, Austria
    Bone 44:959-64. 2009
    ..The results of the present study offer a mechanism by which homocysteine affects bone quality, but caution should be exercised since all patients examined had sustained fracture...
  20. ncbi request reprint Age- and genotype-dependence of bone material properties in the osteogenesis imperfecta murine model (oim)
    B Grabner
    Ludwig Boltzmann Institute of Osteology, Fourth Medical Department, Hanusch Hospital and UKH Meidling, Vienna, Austria
    Bone 29:453-7. 2001
    ..A second model for possible collagen-mineral association in oim material would consist of two families of mineral crystals, one being smaller and the other being much larger than the crystals found in normal mouse long bones...
  21. ncbi request reprint [Osteoporosis and metabolic bone diseases; clinical relationship]
    K Klaushofer
    4 Medizinischen Abteilung, Ludwig Boltzmann Institut für Osteologie des Hanusch Krankenhauses, Wien
    Wien Med Wochenschr 149:463-71. 1999
    ....
  22. doi request reprint Bone matrix mineralization is preserved during early perimenopausal stage in healthy women: a paired biopsy study
    B M Misof
    Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, 1st Medical Department, Hanusch Hospital, Kundratstr 37, A 1120, Vienna, Austria
    Osteoporos Int 27:1795-803. 2016
    ..This suggests that the reported early perimenopausal reductions in bone mineral density are caused by factors other than decreases in the degree of mineralization...
  23. ncbi request reprint Raman imaging of two orthogonal planes within cortical bone
    M Kazanci
    Max Planck Institute of Colloids and Interfaces, Department of Biomaterials, 14424 Potsdam, Germany, and Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK, Vienna, Austria
    Bone 41:456-61. 2007
    ..The present study provides fresh insights into the organization of a lamellar bone tissue from two orthogonal orientations...
  24. doi request reprint Effects of tumor-induced osteomalacia on the bone mineralization process
    K Nawrot-Wawrzyniak
    Ludwig Boltzmann Institute of Osteology at Hanusch Hospital of WGKK, 1140, Vienna, Austria
    Calcif Tissue Int 84:313-23. 2009
    ..6%) were dramatically increased. We suggest that the elevated levels of FGF23 and/or low phosphate concentrations disturb the mineralization kinetics in vivo without affecting matrix mineralization of pre-existing bone packets...
  25. pmc Synchrotron radiation micro X-ray fluorescence spectroscopy of thin structures in bone samples: comparison of confocal and color X-ray camera setups
    M Rauwolf
    Atominstitut, TU Wien, Vienna, Austria
    J Synchrotron Radiat 24:307-311. 2017
    ..69 keV for its Kα XRF line) the color X-ray camera provided a higher resolution in the plane, for Zn (a trace element in bone) only the confocal SR-µXRF setup was able to sufficiently image the distribution...
  26. doi request reprint How long should women with postmenopausal osteoporosis be treated with a bisphosphonate?
    K Kerschan-Schindl
    Department of Physical Medicine and Rehabilitation, Medical University of Vienna, Austria
    Horm Metab Res 45:621-8. 2013
    ..Beyond that, life style factors such as regular physical activity as well as a sufficient intake of calcium and vitamin D or, if necessary supplementation of calcium and/or vitamin D play an essential part in fracture prevention. ..
  27. ncbi request reprint Prophylactic bisphosphonate treatment prevents bone fractures after liver transplantation
    M Bodingbauer
    Division of Transplantation, Department of Surgery, Medical University of Vienna, Vienna, Austria
    Am J Transplant 7:1763-9. 2007
    ..Prophylactic treatment with the bisphosphonate zoledronic acid reduces bone turnover and fractures after liver transplantation...
  28. ncbi request reprint Two different correlations between nanoindentation modulus and mineral content in the bone-cartilage interface
    H S Gupta
    Department of Biomaterials, Max Planck Institute of Colloids and Interfaces, Germany
    J Struct Biol 149:138-48. 2005
    ..2D material property maps of the ZCC were generated from the mechanical-mineral correlation, showing that bands of high and low stiffness were found between the bone and tidemark, and between the ZCC and the unmineralized cartilage...
  29. ncbi request reprint The bone mineralization density distribution as a fingerprint of the mineralization process
    D Ruffoni
    Max Planck Institute of Colloids and Interfaces, Department of Biomaterials, 14424 Potsdam, Germany
    Bone 40:1308-19. 2007
    ..This is of important clinical interest because it helps to find therapeutic approaches directly targeting the primary etiological defects to correct the patients' BMDD towards normal BMDD...
  30. ncbi request reprint Association of COLIA1 Sp1 alleles with defective bone nodule formation in vitro and abnormal bone mineralization in vivo
    T L Stewart
    Department of Medicine and Therapeutics, University of Aberdeen Medical School, Aberdeen, AB25 2ZD, UK
    Calcif Tissue Int 77:113-8. 2005
    ..This suggests that the increased bone fragility in carriers of the COLIA1 Sp1 allele may result in part from defects in bone mineralization...
  31. ncbi request reprint Lead accumulation in tidemark of articular cartilage
    N Zoeger
    Vienna University of Technology, Atominstitut, Stadionallee 2, 1020 Vienna, Austria
    Osteoarthritis Cartilage 14:906-13. 2006
    ..Determination of the spatial distribution of the toxic element lead (Pb) and other trace elements in normal articular cartilage and subchondral bone from adult humans with no history of work-related exposure to Pb...
  32. ncbi request reprint Synchrotron diffraction study of deformation mechanisms in mineralized tendon
    H S Gupta
    Max Planck Institute of Colloids and Interfaces, Department of Biomaterials, 14424 Potsdam, Germany
    Phys Rev Lett 93:158101. 2004
    ..Scanning electron microscopy measurements lead us to conclude that the inhomogeneous mineralization in mineralized tendon is at the origin of the high fracture strain...
  33. ncbi request reprint Bone osteonal tissues by Raman spectral mapping: orientation-composition
    M Kazanci
    Max Planck Institute of Colloids and Interfaces, Department of Biomaterials, 14424 Potsdam, Germany
    J Struct Biol 156:489-96. 2006
    ..Moreover, the results of the present study demonstrate the versatility of the analytical technique, and provide insights into the organization of bone tissue at the ultrastructural level...
  34. ncbi request reprint Characteristics of mineral particles in the human bone/cartilage interface
    I Zizak
    Erich Schmid Institute of Materials Science and Metal Physics Institute, Austrian Academy of Sciences and University of Leoben, Jahnstr 12, A 8700, Leoben, Austria
    J Struct Biol 141:208-17. 2003
    ..The tight bonding of mineralized cartilage to bone suggests a mechanical role for the interface of the two elastically different tissues, bone and cartilage...
  35. ncbi request reprint Determination of bone and tissue concentrations of teicoplanin mixed with hydroxyapatite cement to repair cortical defects
    K Eggenreich
    Institute of Pharmaceutical Chemistry and Pharmaceutical Technology, Karl Franzens University, Schubertstrasse 1, A 8010 Graz, Austria
    J Biochem Biophys Methods 53:51-9. 2002
    ..The stability of teicoplanin in bone cement was determined fluorodensitometrically...