H Nohl

Summary

Affiliation: University of Veterinary Medicine
Country: Austria

Publications

  1. ncbi The bifunctional activity of ubiquinone in lysosomal membranes
    Hans Nohl
    Institute of Pharmacology and Toxicology, Veterinary University Vienna, Austria
    Biogerontology 3:125-31. 2002
  2. ncbi Are mitochondria a spontaneous and permanent source of reactive oxygen species?
    Hans Nohl
    Fundamental Pharmacology and Toxicology, University of Veterinary Medicine Vienna, Vienna, Austria
    Redox Rep 8:135-41. 2003
  3. ncbi Mitochondria recycle nitrite back to the bioregulator nitric monoxide
    H Nohl
    Institute of Pharmacology and Toxicology, University of Veterinary Medicine, Vienna, Austria
    Acta Biochim Pol 47:913-21. 2000
  4. ncbi Lipid radicals: properties and detection by spin trapping
    K Stolze
    Institute of Pharmacology and Toxicology, Veterinary University of Vienna, Austria
    Acta Biochim Pol 47:923-30. 2000
  5. ncbi The existence and significance of a mitochondrial nitrite reductase
    Hans Nohl
    Research Institute for Biochemical Pharmacology and Toxicology, University of Veterinary Medicine of Vienna, Vienna, Austria
    Redox Rep 10:281-6. 2005
  6. ncbi The mystery of reactive oxygen species derived from cell respiration
    Hans Nohl
    Basic Research in Pharmacology and Toxicology, University of Veterinary Medicine Vienna, Vienna, Austria
    Acta Biochim Pol 51:223-9. 2004
  7. ncbi Caroverine, a multifunctional drug with antioxidant functions
    Hans Nohl
    Department of Pharmacology and Toxicology Institute for Applied Botany, Veterinary University of Vienna, Vienna, Austria
    Biofactors 19:79-85. 2003
  8. ncbi Ubiquinol and the papaverine derivative caroverine prevent the expression of tumour- promoting factors in adenoma and carcinoma colon cancer cells induced by dietary fat
    Hans Nohl
    Research Institute of Biochemical Pharmacology and Toxicology, University of Veterinary Medicine Vienna, Austria
    Biofactors 25:87-95. 2005
  9. ncbi The biomolecule ubiquinone exerts a variety of biological functions
    Hans Nohl
    Fundamental Pharmacology and Toxicology, University of Veterinary Medicine Vienna, Veterinarplatz 1, A 1210 Vienna, Austria
    Biofactors 18:23-31. 2003
  10. ncbi Cell respiration and formation of reactive oxygen species: facts and artefacts
    H Nohl
    Department of Basic Research in Pharmacology and Toxicology, University of Veterinary Medicine Vienna, Veterinarplatz 1, A 1210 Vienna, Austria
    Biochem Soc Trans 31:1308-11. 2003

Collaborators

Detail Information

Publications66

  1. ncbi The bifunctional activity of ubiquinone in lysosomal membranes
    Hans Nohl
    Institute of Pharmacology and Toxicology, Veterinary University Vienna, Austria
    Biogerontology 3:125-31. 2002
    ..The role of this novel proton-pumping redox chain and the significance of the associated ROS formation has to be elucidated...
  2. ncbi Are mitochondria a spontaneous and permanent source of reactive oxygen species?
    Hans Nohl
    Fundamental Pharmacology and Toxicology, University of Veterinary Medicine Vienna, Vienna, Austria
    Redox Rep 8:135-41. 2003
    ..Concomitantly superoxide radicals were released from these mitochondria, strongly suggesting the involvement of the ubiquinol/cytochrome bc(1) redox couple in this process...
  3. ncbi Mitochondria recycle nitrite back to the bioregulator nitric monoxide
    H Nohl
    Institute of Pharmacology and Toxicology, University of Veterinary Medicine, Vienna, Austria
    Acta Biochim Pol 47:913-21. 2000
    ..The high affinity of NO to the heme-iron of cytochrome oxidase will result in an impairment of mitochondrial energy-production. "Nitrite tolerance" of angina pectoris patients using NO-donors may be explained in that way...
  4. ncbi Lipid radicals: properties and detection by spin trapping
    K Stolze
    Institute of Pharmacology and Toxicology, Veterinary University of Vienna, Austria
    Acta Biochim Pol 47:923-30. 2000
    ..The observed ESR parameters were similar to those of alkoxyl radical adducts, which were independently synthesized in model experiments using Fe3+-catalyzed nucleophilic addition of methanol or t-butanol to the respective spin trap...
  5. ncbi The existence and significance of a mitochondrial nitrite reductase
    Hans Nohl
    Research Institute for Biochemical Pharmacology and Toxicology, University of Veterinary Medicine of Vienna, Vienna, Austria
    Redox Rep 10:281-6. 2005
    ..In this paper, we describe the identity and the function of mitochondrial nitrite reductase and the consequences of NO-recycling in the metabolic compartment of mitochondria...
  6. ncbi The mystery of reactive oxygen species derived from cell respiration
    Hans Nohl
    Basic Research in Pharmacology and Toxicology, University of Veterinary Medicine Vienna, Vienna, Austria
    Acta Biochim Pol 51:223-9. 2004
    ..However, changing the physical membrane state affected the highly susceptible interaction of the ubiquinol/bc(1) redox complex such that ROS formation became possible...
  7. ncbi Caroverine, a multifunctional drug with antioxidant functions
    Hans Nohl
    Department of Pharmacology and Toxicology Institute for Applied Botany, Veterinary University of Vienna, Vienna, Austria
    Biofactors 19:79-85. 2003
    ..The strong antioxidant activity of Caroverine is therefore based both on the partial prevention of the formation and the highly active scavenging of hydroxyl radicals...
  8. ncbi Ubiquinol and the papaverine derivative caroverine prevent the expression of tumour- promoting factors in adenoma and carcinoma colon cancer cells induced by dietary fat
    Hans Nohl
    Research Institute of Biochemical Pharmacology and Toxicology, University of Veterinary Medicine Vienna, Austria
    Biofactors 25:87-95. 2005
    ..Both cell lines were observed to increase VEGF and COX-II expression based on mRNA. Expression of VEGF was inhibited by caroverine and ubiquinon...
  9. ncbi The biomolecule ubiquinone exerts a variety of biological functions
    Hans Nohl
    Fundamental Pharmacology and Toxicology, University of Veterinary Medicine Vienna, Veterinarplatz 1, A 1210 Vienna, Austria
    Biofactors 18:23-31. 2003
    ..Furthermore, we have addressed the antioxidant role of ubiquinone and found that the efficiency of this activity is widely dependent on the type of biomembrane where ubiquinone exerts its chain-breaking activity...
  10. ncbi Cell respiration and formation of reactive oxygen species: facts and artefacts
    H Nohl
    Department of Basic Research in Pharmacology and Toxicology, University of Veterinary Medicine Vienna, Veterinarplatz 1, A 1210 Vienna, Austria
    Biochem Soc Trans 31:1308-11. 2003
    ..The site of single-electron deviation to dioxygen was found to be ubiquinol interacting with the Rieske iron-sulphur protein and low-potential cytochrome b of the bc (1) complex...
  11. ncbi Lysosomal ROS formation
    Hans Nohl
    Research Institute for Biochemical Pharmacology and Toxicology, University of Veterinary Medicine Vienna, Vienna, Austria
    Redox Rep 10:199-205. 2005
    ..The role of this novel proton-pumping redox chain and the significance of the associated ROS formation has to be elucidated...
  12. ncbi Critical aspects of the antioxidant function of coenzyme Q in biomembranes
    H Nohl
    Institute of Pharmacology and Toxicology, Veterinary University Vienna, Austria
    Biofactors 9:155-61. 1999
    ..The present study not only provides data which document this discrepancy but also contributes experimental data on the existence of ubiquinol derived pro-oxidants, which give an explanation of this phenomenon...
  13. ncbi Intracellular generation of reactive oxygen species by mitochondria
    Hans Nohl
    Research Institute of Pharmacology and Toxicology, University of Veterinary Medicine Vienna, Veterinarplatz 1, A 1210 Vienna, Austria
    Biochem Pharmacol 69:719-23. 2005
    ..However, if electron flow from ubiquinol to the bc(1) complex is hindered due to changes in lipid fluidity, single electrons may transfer to dioxygen and produce H(2)O(2) via superoxide radicals...
  14. ncbi Antioxidant-derived prooxidant formation from ubiquinol
    H Nohl
    Institute of Pharmacology and Toxicology, Veterinary University of Vienna, Austria
    Free Radic Biol Med 25:666-75. 1998
    ..This discrepancy reveals that the antioxidative activity of coenzyme Q is compulsorily linked to the formation of split products counteracting the membrane protective effect of this natural antioxidant...
  15. ncbi The exogenous NADH dehydrogenase of heart mitochondria is the key enzyme responsible for selective cardiotoxicity of anthracyclines
    H Nohl
    Institute of Pharmacology and Toxicology, Veterinary University Vienna, Austria
    Z Naturforsch C 53:279-85. 1998
    ..This organ-specific enzyme initiates a sequence of one electron transfer reactions ending up in the establishment of oxidative stress...
  16. ncbi Suppression of tumour-promoting factors in fat-induced colon carcinogenesis by the antioxidants caroverine and ubiquinone
    Hans Nohl
    Research Institute of Biochemical Pharmacology and Toxicology, University of Veterinary Medicine Vienna, A 1210 Vienna, Austria
    Anticancer Res 25:2793-800. 2005
    ..Various radicals are formed on mixing LT97 or SW480 cells with LOOH. The expression of tumour-promoting factors was inhibited by caroverine and ubiquinone, which may be justified as active chemopreventive agents...
  17. ncbi Effects of tocopheryl quinone on the heart: model experiments with xanthine oxidase, heart mitochondria, and isolated perfused rat hearts
    L Gille
    Institute of Pharmacology and Toxicology, Veterinary University Vienna, Vienna, Austria
    Free Radic Biol Med 30:865-76. 2001
    ..Our results demonstrate that TQ derivatives may induce pro-oxidative and antioxidative effects depending on the distribution of TQ derivatives in the heart tissue and the interacting redox system...
  18. ncbi Mitochondrial superoxide radical formation is controlled by electron bifurcation to the high and low potential pathways
    Katrin Staniek
    Institute of Pharmacology and Toxicology, Veterinary University Vienna, Austria
    Free Radic Res 36:381-7. 2002
    ..The regulator, which controls leakage of electrons to oxygen, appears to be the electron-branching activity of the cytochrome bc1 complex...
  19. ncbi The ubiquinol/bc1 redox couple regulates mitochondrial oxygen radical formation
    L Gille
    Institute of Pharmacology and Toxicology, Veterinary University Vienna, Austria
    Arch Biochem Biophys 388:34-8. 2001
    ..The regulator which controls leakage of electrons to oxygen appears to be the electron branching activity of the bc1 complex...
  20. ncbi The existence and significance of redox-cycling ubiquinone in lysosomes
    H Nohl
    Institute of Pharmacology and Toxicology, Veterinary University Vienna, , A-1210 Vienna, Austria
    Protoplasma 217:9-14. 2001
    ..Oxygen was found to be the terminal electron acceptor thereby also regulating acidification of the lysosomal matrix. The role of the proton-pumping redox chain has to be elucidated...
  21. ncbi Experimental evidence suggesting that nitric oxide diffuses from tissue into blood but not from blood into tissue
    A V Kozlov
    L Boltzman Institute for Experimental and Clinical Traumatology, Vienna, Austria
    Biochim Biophys Acta 1536:177-84. 2001
    ..In contrast, NO formed in tissue diffuses into blood. The latter indicates that NO formed in tissues may exert its biological activities systematically...
  22. ncbi Induction of lipid peroxidation in biomembranes by dietary oil components
    Natalia Udilova
    Basic Pharmacology and Toxicology, Veterinary University of Vienna, A 1210 Vienna, Austria
    Food Chem Toxicol 41:1481-9. 2003
    ..Dietary consumption of heated oils may lead to oxidative damage and to cell death in the colon. This may contribute to the enhanced risk of colon cancer due to regenerative cell proliferation...
  23. ncbi The multiple functions of coenzyme Q
    H Nohl
    Institute of Pharmacology and Toxicology, Veterinary University of Vienna, , Vienna, A-1210, Austria
    Bioorg Chem 29:1-13. 2001
    ..Another novel finding documents the bioenergetic role of UQ in lysosomal proton intransport. A lysosomal chain of redox couples will be presented, which includes UQ and which requires oxygen as the terminal electron acceptor...
  24. ncbi Kynurenic acid influences the respiratory parameters of rat heart mitochondria
    H Baran
    Institute of Pharmacology and Toxicology, Veterinary University Vienna, Austria
    Pharmacology 62:119-23. 2001
    ....
  25. ncbi Very stable superoxide radical adducts of 5-ethoxycarbonyl- 3,5-dimethyl-pyrroline N-oxide (3,5-EDPO) and its derivatives
    Klaus Stolze
    Research Institute of Biochemical Pharmacology and Toxicology, University of Veterinary Medicine Vienna, Veterinarplatz 1, A 1210 Vienna, Austria
    Biochem Pharmacol 69:1351-61. 2005
    ..12-55 min). In addition, various other spin adducts obtained from oxygen-centered as well as carbon-centered radicals (e.g. derived from methanol or linoleic acid hydroperoxide) were also detected...
  26. ncbi Spin adducts of superoxide, alkoxyl, and lipid-derived radicals with EMPO and its derivatives
    Klaus Stolze
    Institute of Pharmacology and Toxicology, Veterinary University of Vienna, Austria
    Biol Chem 383:813-20. 2002
    ..Thus, within this series EMPO is the best spin trap for the detection of superoxide; OcMPO, on the other hand, is most suitable for the detection of lipid alkoxyl radicals...
  27. ncbi The biochemical, pathophysiological, and medical aspects of ubiquinone function
    H Nohl
    Institute of Pharmacology and Toxicology, Veterinary University of Vienna, Austria
    Ann N Y Acad Sci 854:394-409. 1998
    ..In addition, reaction products emerging from the antioxidant activity of ubiquinol were found to stimulate the formation of inorganic as well as organic oxygen radicals...
  28. ncbi Spin trapping of superoxide, alkyl- and lipid-derived radicals with derivatives of the spin trap EPPN
    Klaus Stolze
    Basic Pharmacology and Toxicology, Institute of Applied Botany, University of Veterinary Medicine Vienna, Veterinarplatz 1, A 1210 Vienna, Austria
    Biochem Pharmacol 66:1717-26. 2003
    ....
  29. ncbi Evaluation of the antioxidant capacity of ubiquinol and dihydrolipoic acid
    H Nohl
    Institute of Pharmacology and Toxicology, Veterinary University Vienna, Austria
    Z Naturforsch C 53:250-3. 1998
    ..The efficiency of the antioxidative capacity of the latter was found to be diminished through prooxidant activities of the antioxidant-derived metabolites...
  30. ncbi Organ specific formation of nitrosyl complexes under intestinal ischemia/reperfusion in rats involves NOS-independent mechanism(s)
    A V Kozlov
    L. Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria
    Shock 15:366-71. 2001
    ..NO involved in nitrosylation under intestinal ischemia/reperfusion is probably formed by NO synthase-independent mechanism(s)...
  31. ncbi The antioxidant activity of caroverine
    Natalia Udilova
    Institute of Pharmacology and Toxicology, University of Veterinary Medicine Vienna, Veterinaerplatz 1, A 1210 Vienna, Austria
    Biochem Pharmacol 65:59-65. 2003
    ..OH radicals occurs at an extremely high rate constant (k=1.9 x 10(10)M(-1)s(-1)). The strong antioxidant activity of caroverine is therefore based both on the partial prevention and highly active scavenging of hydroxyl radicals...
  32. ncbi The protection of bioenergetic functions in mitochondria by new synthetic chromanols
    Katrin Staniek
    Research Institute for Biochemical Pharmacology and Toxicology, University of Veterinary Medicine Vienna, Veterinarplatz 1, A 1210 Vienna, Austria
    Biochem Pharmacol 70:1361-70. 2005
    ..In conclusion, new chromanol-type antioxidants, especially twin-chromanol, were able to improve bioenergetic and biochemical parameters of mitochondria exposed to oxidative stress...
  33. ncbi Cytotoxicity of novel derivatives of the spin trap EMPO
    Nataliya Rohr-Udilova
    Research Institute of Biochemical Pharmacology and Molecular Toxicology, Veterinary University of Vienna, Veterinaerplatz 1, A 1210 Vienna, Austria
    Bioorg Med Chem Lett 16:541-6. 2006
    ..In conclusion, up to 50mM i-PrMPO (t(1/2)=18.8 min) and up to 10 mM s-BuMPO (t(1/2)=26.3 min) can be recommended for further investigation of superoxide in biological systems...
  34. ncbi Kynurenines and the respiratory parameters on rat heart mitochondria
    H Baran
    Institute of Pharmacology and Toxicology, Veterinary University Vienna, A 1210 Vienna, Austria
    Life Sci 72:1103-15. 2003
    ..On the other hand, beside the effect of 3-hydroxyanthranilic acid and 3-hydroxykynurenine on respiratory parameters, their oxidative reactivity may contribute to impairment of mitochondria function, too...
  35. ncbi Dietary lipid hydroperoxides induce expression of vascular endothelial growth factor (VEGF) in human colorectal tumor cells
    Daniela Jurek
    Institute of Cancer Research, Medical University Vienna, Vienna, Austria
    FASEB J 19:97-9. 2005
    ..Therefore, our results for the first time implicate dietary lipid hydroperoxide as a key risk factor in colon carcinogenesis...
  36. ncbi ESR analysis of spin adducts of alkoxyl and lipid-derived radicals with the spin trap Trazon
    Klaus Stolze
    Institute of Pharmacology and Toxicology, University of Veterinary Medicine Vienna, Veterinarplatz 1, A 1210 Vienna, Austria
    Biochem Pharmacol 63:1465-70. 2002
    ..Two stereochemically different spin adducts were formed in a ratio typical of the alcohol used, thus allowing structural classification of the alkoxyl radical trapped...
  37. ncbi Spin adduct formation from lipophilic EMPO-derived spin traps with various oxygen- and carbon-centered radicals
    Klaus Stolze
    Research Institute of Pharmacology and Toxicology, University of Veterinary Medicine Vienna, Veterinarplatz 1, A 1210 Vienna, Austria
    Biochem Pharmacol 69:297-305. 2005
    ..Spin adducts of other carbon- and oxygen-centered radicals were also investigated...
  38. ncbi Nitric oxide synthase inhibitors affect nitric oxide synthesis in normoxic but not in ischemic organs during intestinal ischemia and early reperfusion
    Andrey V Kozlov
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, University of Veterinary Medicine, Vienna, Austria
    J Lab Clin Med 140:303-11. 2002
    ..The protective effect of L-arginine supplementation during I/R(i) is probably related to increasing intravascular NO formation...
  39. ncbi Increased kynurenic acid in the brain after neonatal asphyxia
    H Baran
    Institute of Pharmacology and Toxicology, Veterinary Medical University Vienna, Austria
    Life Sci 69:1249-56. 2001
    ....
  40. ncbi Skeletal muscles, heart, and lung are the main sources of oxygen radicals in old rats
    Andrey V Kozlov
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria
    Biochim Biophys Acta 1740:382-9. 2005
    ..This study identifies heart, lung, and skeletal muscle as the tissues with increased RONS formation as a function of age...
  41. ncbi Ubichromanol: a prodrug to support mitochondrial ubiquinone functions?
    Lars Gille
    Molecular Pharmacology and Toxicology Unit, Department of Natural Sciences, University of Veterinary Medicine Vienna, Vienna, Austria
    Biofactors 32:83-90. 2008
    ....
  42. ncbi Distribution of tocopheryl quinone in mitochondrial membranes and interference with ubiquinone-mediated electron transfer
    Wolfgang Gregor
    Research Institute for Biochemical Pharmacology and Molecular Toxicology, University of Veterinary Medicine Vienna, Austria
    Biochem Pharmacol 71:1589-601. 2006
    ..On the other hand, both microsomal and mitochondrial enzymes contribute to the reduction of TQ to tocopheryl hydroquinone, which has been suggested to play an antioxidative role itself...
  43. ncbi Free radical trapping properties of several ethyl-substituted derivatives of 5-ethoxycarbonyl-5-methyl-1-pyrroline N-oxide (EMPO)
    Klaus Stolze
    Molecular Pharmacology and Toxicology Unit, Department of Natural Science, University of Veterinary Medicine Vienna, Veterinarplatz 1, A 1210 Vienna, Austria
    Bioorg Med Chem 15:2827-36. 2007
    ..Considerably different stabilities of the superoxide adducts (ranging from about 12 to 55 min) as well as the formation of other radical adducts were observed...
  44. ncbi Release and hemodynamic influence of nitro-glycerine-derived nitric oxide in endotoxemic rats
    Andrey V Kozlov
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Donaueschingenstr 13, A 1200 Vienna, Austria
    Vascul Pharmacol 43:411-4. 2005
    ....
  45. ncbi Different effects of endotoxic shock on the respiratory function of liver and heart mitochondria in rats
    Andrey V Kozlov
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Donaueschingenstrasse 13, A 1200 Vienna, Austria
    Am J Physiol Gastrointest Liver Physiol 290:G543-9. 2006
    ....
  46. ncbi Spin trapping of C- and O-centered radicals with methyl-, ethyl-, pentyl-, and phenyl-substituted EMPO derivatives
    Klaus Stolze
    Research Institute of Biochemical Pharmacology and Molecular Toxicology, University of Veterinary Medicine Vienna, Veterinarplatz 1, A 1210 Vienna, Austria
    Bioorg Med Chem 14:3368-76. 2006
    ..Methyl groups at position 3 or 4 stabilized the superoxide adducts considerably. Spin adducts from other oxygen- and carbon-centered radicals (e.g., derived from methanol or linoleic acid hydroperoxide) are also described...
  47. ncbi Oxidized vitamin E and ubiquinone: competition for binding sites of the mitochondrial cytochrome bc1 complex?
    Lars Gille
    Research Institute of Pharmacology and Toxicology of Oxygen Radicals, University of Veterinary Medicine Vienna, Veterinarplatz 1, A 1210 Vienna, Austria
    Ann N Y Acad Sci 1031:341-3. 2004
  48. ncbi Synthesis and characterization of EMPO-derived 5,5-disubstituted 1-pyrroline N-oxides as spin traps forming exceptionally stable superoxide spin adducts
    Klaus Stolze
    Basic Pharmacology and Toxicology, University of Veterinary Medicine Vienna, Veterinarplatz 1, A 1210 Vienna, Austria
    Biol Chem 384:493-500. 2003
    ....
  49. pmc Various intracellular compartments cooperate in the release of nitric oxide from glycerol trinitrate in liver
    Andrey V Kozlov
    Department of Pharmacology and Toxicology Institute for Applied Botany, University of Veterinary Medicine, Vienna, Austria
    Br J Pharmacol 139:989-97. 2003
    ....
  50. ncbi Epr analysis reveals three tissues responding to endotoxin by increased formation of reactive oxygen and nitrogen species
    Andrey V Kozlov
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria
    Free Radic Biol Med 34:1555-62. 2003
    ..In summary, low-temperature EPR combined with CP-H infusion allowed detection of local RONS formation in tissues. Increased formation of RONS in response to endotoxin challenge is organ specific...
  51. ncbi Spin adducts of several N-2-(2-alkoxycarbonyl-propyl)-alpha-pyridylnitrone derivatives with superoxide, alkyl and lipid-derived radicals
    Klaus Stolze
    Research Institute for Pharmacology and Toxicology, University of Veterinary Medicine Vienna, Veterinarplatz 1, A 1210 Vienna, Austria
    Biochem Pharmacol 68:185-94. 2004
    ..All of them can easily be synthesized from commercially available compounds in two or three steps...
  52. ncbi Redox-interaction of alpha-tocopheryl quinone with isolated mitochondrial cytochrome bc1 complex
    Lars Gille
    Research Institute for Pharmacology and Toxicology of Oxygen Radicals, University of Veterinary Medicine Vienna, Veterinärpl 1, A 1210 Vienna, Austria
    Biochem Pharmacol 68:373-81. 2004
    ..These findings suggest that the irreversible oxidation of vitamin E to TQ in mitochondrial membranes causes a downregulation of respiratory activities as well as a lower O(2)(*)(-) formation rate by the cytochrome bc(1) complex...
  53. ncbi Mechanisms of vasodilatation induced by nitrite instillation in intestinal lumen: possible role of hemoglobin
    Andrey V Kozlov
    L Boltzmann Institute for Experimental and Clinical Traumatology, Donaueschingen strasse 13, A 1200 Vienna, Austria
    Antioxid Redox Signal 7:515-21. 2005
    ..The exact mechanism underlying vasodilatation observed when the concentration of NO-bound Hb was > 10 microM is, however, not clear yet and requires further studies...
  54. ncbi Influence of cryopreservation on mitochondrial functions in equine spermatozoa
    D Schober
    Molecular Pharmacology and Toxicology Unit, Department of Natural Sciences, University of Veterinary Medicine Vienna, Veterinarplatz 1, A 1210, Vienna, Austria
    Theriogenology 68:745-54. 2007
    ..1) suggesting a partial rupture of cellular and outer mitochondrial membranes. Our data indicate that also widely used cryopreservation protocols for equine spermatozoa need adjustment to optimize post thaw mitochondrial functions...
  55. ncbi Thiazolidinediones, like metformin, inhibit respiratory complex I: a common mechanism contributing to their antidiabetic actions?
    Barbara Brunmair
    Department of Medicine III, Division of Endocrinology and Metabolism, University of Vienna, Vienna, Austria
    Diabetes 53:1052-9. 2004
    ..05 each). As both metformin and TZDs inhibit complex I activity and cell respiration in vitro, similar mitochondrial actions could contribute to their antidiabetic effects...
  56. doi Lipid hydroperoxides from processed dietary oils enhance growth of hepatocarcinoma cells
    Nataliya V Rohr-Udilova
    Institute of Cancer Research, Department of Medicine I, Medical University Vienna, Vienna, Austria
    Mol Nutr Food Res 52:352-9. 2008
    ..2 cells, indicating the protective role of HO-1 induction. This is the first evidence that lipid hydroperoxides of dietary origin may be an important driving force for carcinogenesis in the liver...
  57. ncbi Paramagnetic species in the plasma of dogs with lymphoma prior to and after treatment with doxorubicin. An ESR study
    Lars Gille
    Institute of Pharmacology and Toxicology, Veterinary University Vienna, Veterinärpl 1, A 1210 Vienna, Austria
    Biochem Pharmacol 64:1737-44. 2002
    ..Therefore, these findings provide an additional rationale for potential benefit of iron chelators during doxorubicin chemotherapy...
  58. ncbi The role of respiration, reactive oxygen species and oxidative stress in mother cell-specific ageing of yeast strains defective in the RAS signalling pathway
    Gino Heeren
    Department of Cell Biology, University of Salzburg, Hellbrunnerstrasse 34, A 5020 Salzburg, Austria
    FEMS Yeast Res 5:157-67. 2004
    ..Our results indicate that oxidative stress resulting from a disturbance of redox balance can play a major role in mother cell-specific lifespan determination of yeast cells...
  59. ncbi Cytotoxicity of the novel spin trapping compound 5-ethoxycarbonyl-3,5-dimethyl-pyrroline N-oxide (3,5-EDPO) and its derivatives
    Nataliya Rohr-Udilova
    Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Bioorg Med Chem Lett 17:5698-703. 2007
    ..In conclusion, 4,5-EDPO, cis-3,5-EDPO and 3,5-DiPPO can be recommended for further investigation of superoxide in biological systems...
  60. ncbi Opposite effects of endotoxin on mitochondrial and endoplasmic reticulum functions
    Andrey V Kozlov
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology in the AUVA Research Center, Donaueschingen Street 13, A 1200 Vienna, Austria
    Biochem Biophys Res Commun 352:91-6. 2007
    ..We hypothesize that upregulation of this enzyme protects mitochondria against mitochondrial ROS, but does not protect other cellular compartments such as endoplasmic reticulum and plasma membrane causing necrosis...
  61. ncbi Reactive oxygen species are involved in the stimulation of the mitochondrial permeability transition by dihydrolipoate
    Sarune Morkunaite-Haimi
    Department of Applied Chemistry and Microbiology, Viikki Biocentre I, University of Helsinki, P O Box 56, FIN 00014 Helsinki, Finland
    Biochem Pharmacol 65:43-9. 2003
    ..These data indicate that the stimulation of MPT by DHLA is due to DHLA-derived prooxidants, i.e. stimulated production of O(2)(.-) and possibly other free radicals...
  62. ncbi Fenofibrate impairs rat mitochondrial function by inhibition of respiratory complex I
    Barbara Brunmair
    Department of Medicine III, Division of Endocrinology and Metabolism, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    J Pharmacol Exp Ther 311:109-14. 2004
    ..Our findings support the notion that individual fibrates induce mitochondrial dysfunction via different molecular mechanisms and show that fenofibrate predominantly acts by inhibition of complex I of the respiratory chain...
  63. ncbi Gene transfer of CuZn superoxide dismutase enhances the synthesis of vascular endothelial growth factor
    Jolanta Grzenkowicz-Wydra
    Department of Cell Biochemistry, Faculty of Biotechnology, Jagiellonian University, Krakow, Poland
    Mol Cell Biochem 264:169-81. 2004
    ..This data suggest the feasibility of stimulation of angiogenesis by overexpression of SOD1...
  64. ncbi Combination of iron overload plus ethanol and ischemia alone give rise to the same endogenous free iron pool
    Odile Sergent
    Laboratoire de Biologie Cellulaire et Vegetale, UPRES 3891, UFR des Sciences Pharmaceutiques et Biologiques, University of Rennes 1, 2 AVE du Pr Léon Bernard, CS, 34317 35043, Rennes Cedex, France
    Biometals 18:567-75. 2005
    ....
  65. ncbi Are the biological properties of kaempferol determined by its oxidation products?
    Katharina F Pirker
    ARC Seibersdorf Research GmbH, Department of Environmental Research, Seibersdorf, Austria
    Free Radic Res 40:513-21. 2006
    ..Hence, the biological properties of kaempferol are likely to be determined by the chemistry of its oxidation products...
  66. ncbi Antioxidant, prooxidant and cytotoxic activity of hydroxylated resveratrol analogues: structure-activity relationship
    Marek Murias
    Institute of Pharmaceutical Chemistry, University of Vienna, A 1090 Vienna, Austria
    Biochem Pharmacol 69:903-12. 2005
    ..These findings suggest that the increased cytotoxicity of ortho-hydroxystilbenes is related to the presence of ortho-semiquinones formed during metabolism or autoxidation...