Affiliation: University of Innsbruck
- Bloodstream infection following 217 consecutive systemic-enteric drained pancreas transplantsNatalie Berger
Department of General and Transplant Surgery, Medical University, Innsbruck, Austria
BMC Infect Dis 6:127. 2006..Combined kidney pancreas transplantation (PTx) evolved as excellent treatment for diabetic nephropathy. Infections remain common and serious complications...
- ACE genotype and ACE inhibitor response in kidney disease: a perspectiveGert Mayer
Division of Nephrology, University of Innsbruck, Austria
Am J Kidney Dis 40:227-35. 2002..Nonetheless, the rapidly evolving area of pharmacogenomics soon will also affect therapeutic decisions in the field of nephrology and hypertension...
- Markers of cellular senescence in zero hour biopsies predict outcome in renal transplantationChristian Koppelstaetter
Division of Nephrology, Department of Internal Medicine, Medical University Innsbruck, Innsbruck, Austria
Aging Cell 7:491-7. 2008..We conclude that the molecular aging marker CDKN2A in combination with chronological donor age predict renal allograft function after 1 year significantly better than chronological donor age alone...
- Failure of BCL-2 up-regulation in proximal tubular epithelial cells of donor kidney biopsy specimens is associated with apoptosis and delayed graft functionChristoph Schwarz
Department of Internal Medicine III, Division of Nephrology, University of Vienna, Austria
Lab Invest 82:941-8. 2002..These data suggest that failure of proximal tubular cells to respond to injury by up-regulation of survival factors from the Bcl-2 family contributes to postischemic ARF in patients after cadaveric renal transplantation...
- Reliability of t7-based mRNA linear amplification validated by gene expression analysis of human kidney cells using cDNA microarraysMichael Rudnicki
Department of Nephrology, University Hospital of Innsbruck, Innsbruck, Austria
Nephron Exp Nephrol 97:e86-95. 2004..868. These results indicate that linear amplification using RiboAmp kit yields amplified RNA with a high degree of linearity and reproducibility...
- Neutrophil transmigration in renal proximal tubular LLC-PK1 cellsMichael Joannidis
Department of General Internal Medicine, University Hospital, Innsbruck, Austria
Cell Physiol Biochem 14:101-12. 2004..The present study was performed to investigate whether incubation of tubular epithelia with cytokines or endotoxin (LPS) does stimulate adhesion and migration of leukocytes through these epithelia in vitro...
- Effect of iron treatment on circulating cytokine levels in ESRD patients receiving recombinant human erythropoietinGunter Weiss
Department of Internal Medicine and Division of Nephrology, University Hospital of Innsbruck, Innsbruck, Austria
Kidney Int 64:572-8. 2003..However, iron catalyzes the formation of toxic radicals, which might promote vascular damage, is a nutrient for microorganisms, and negatively affects immune pathways, thus increasing the risk for severe infections...
- Membranous nephropathy in a patient with hereditary complete complement C4 deficiencyKarl Lhotta
Division of Clinical Nephrology, Department of Internal Medicine, Innsbruck University Hospital, Anichstrasse 35, A 6020 Innsbruck, Austria
Nephrol Dial Transplant 19:990-3. 2004
- Age and renal transplantation: an interim analysisGabriele Schratzberger
University Hospital, Department of Internal Medicine, Division of Nephrology, Innsbruck, Austria
Nephrol Dial Transplant 18:471-6. 2003
- Proteinuria and hemoglobin levels in patients with primary glomerular diseaseNina Mähr
Division of Nephrology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Innsbruck, Austria
Am J Kidney Dis 46:424-31. 2005..Anemia in association with nephrotic syndrome has been described in small patient series and case reports. Whether nephrotic patients develop anemia has not been formally investigated...
- Effect of tissue fixatives on telomere length determination by quantitative PCRChristian Koppelstaetter
Division of Nephrology, Department of Internal Medicine, Medical University Innsbruck, Anichstrasse 35, Innsbruck 6020, Austria
Mech Ageing Dev 126:1331-3. 2005..Unfortunately therefore, many easily accessible tissue samples from pathology laboratories are unsuitable for this technique...
- Cigarette smoking and vascular pathology in renal biopsiesKarl Lhotta
Clinical Nephrology Division, Department of Internal Medicine, Innsbruck University Hospital, Innsbruck, Austria
Kidney Int 61:648-54. 2002..The exact pathomechanism of nicotine-induced renal damage is, however, unknown. Autopsy studies and functional investigations suggest that the renal vasculature is primarily affected by smoking...
- Telomere length of in vivo expanded CD4(+)CD25 (+) regulatory T-cells is preserved in cancer patientsDominik Wolf
Department of Hematology and Oncology, Innsbruck Medical University, Anichstr 35, 6020 Innsbruck, Austria
Cancer Immunol Immunother 55:1198-208. 2006..It remains unclear whether this is due to redistribution or active proliferation. The latter would require the upregulation of telomerase activity, whose regulation also remains unknown for Treg...
- Late referral defined by renal function: association with morbidity and mortalityKarl Lhotta
Division of Nephrology, Department of Internal Medicine, Innsbruck University Hospital, Innsbruck, Austria
J Nephrol 16:855-61. 2003..Many patients with chronic renal failure are referred very late to nephrology units. Late referral (LR) is reported to be associated with increased morbidity and mortality...
- Evaluation of the living kidney donorHendrik Koller
Division of Nephrology, Leopold Franzens University Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
Nephrol Dial Transplant 19:iv41-4. 2004..Such an approach, however, necessitates a post-donation follow-up programme to be offered...
- Oncostatin M-induced effects on EMT in human proximal tubular cells: differential role of ERK signalingVerena Pollack
Division of Nephrology, Department of Internal Medicine, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
Am J Physiol Renal Physiol 293:F1714-26. 2007..Furthermore, functional ERK1/2 signaling is necessary for basal claudin-2 expression...
- Regional variability in the incidence of end-stage renal disease: an epidemiological approachFlorian Wimmer
Division of Nephrology, Division of Clinical Epidemiology, Innsbruck University Hospital, Austria
Nephrol Dial Transplant 18:1562-7. 2003..Regional variability in the incidence of end-stage renal disease (ESRD) in Austria is reported. Our aim was to investigate the reason for low rates in the state of Tyrol...
- Differential effects of rapamycin in anti-GBM glomerulonephritisKathrin Hochegger
Division of Nephrology, Tyrolean Cancer Research Institute, Innsbruck Medical University, Innsbruck, Austria
J Am Soc Nephrol 19:1520-9. 2008..Once disease is established, however, rapamycin seems to worsen glomerulonephritis by disturbing the endothelial cell/vascular endothelial growth factor system in the kidney...
- In vitro treatment of dendritic cells with tacrolimus: impaired T-cell activation and IP-10 expressionMartin Tiefenthaler
Department of Nephrology, University of Innsbruck, Innsbruck, Austria
Nephrol Dial Transplant 19:553-60. 2004..We used a therapeutic dose (2.4 x 10(-9 )M) of tacrolimus to investigate its effect on human monocyte-derived DC...
- Chronic allograft failure: a disease we don't understand and can't cure?Gabriele Schratzberger
Division of Nephrology, Department of Internal Medicine, Anichstrasse 35, A 6020 Innsbruck, Austria
Nephrol Dial Transplant 17:1384-90. 2002
- Antiproteinuric versus antihypertensive effects of high-dose ACE inhibitor therapyMartin Haas
Department of Internal Medicine III, Division of Nephrology, University Vienna, Austria
Am J Kidney Dis 40:458-63. 2002..We conducted this study to determine whether an increase in ACE-inhibitor dose above the maximal antihypertensive effect has additional antiproteinuric potential...
- Genome-wide gene-expression patterns of donor kidney biopsies distinguish primary allograft functionPeter Hauser
Department of Nephrology, University of Vienna, Austria
Lab Invest 84:353-61. 2004..Thus, suppression of inflammation in the cadaveric donor might be a cheap and promising intervention for postischemic acute renal failure...
- Cigarette smoking and chronic allograft nephropathyNina Zitt
Clinical Division of Nephrology, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
Nephrol Dial Transplant 22:3034-9. 2007..Smoking has been demonstrated to decrease patient and graft survival after kidney transplantation. Data on histological changes associated with smoking in renal allografts are lacking...
- ERK1/2-driven and MKP-mediated inhibition of EGF-induced ERK5 signaling in human proximal tubular cellsRita Sarközi
Clinical Division of Nephrology, Department of Internal Medicine, Medical University of Innsbruck, Innsbruck, Austria
J Cell Physiol 211:88-100. 2007..These results suggest the existence of an ERK1/2-driven negative feed-back regulation of ERK5 signaling in EGF-stimulated HK-2 cells, which is mediated by MKP-3, DUSP5 and/or MKP-1...
- Gene-expression profiles and age of donor kidney biopsies obtained before transplantation distinguish medium term graft functionAlexander Kainz
Department of Nephrology, KH Elisabethinen Linz, and Medical University of Vienna, Vienna, Austria
Transplantation 83:1048-54. 2007..Donor factors such as age profoundly influence long-term graft function after cadaveric renal transplantation, but the molecular signature of these aspects in the allograft remains unknown...
- CD4+CD25+ regulatory T cells inhibit experimental anti-glomerular basement membrane glomerulonephritis in miceDominik Wolf
Clinical Division of Hematology and Oncology, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
J Am Soc Nephrol 16:1360-70. 2005..This report provides first evidence that Treg are potent suppressors of anti-GBM GN. Treg therefore might be of therapeutic value for the treatment of severe GN in humans...
- Apoptosis of human polymorphonuclear neutrophils accelerated by dialysis membranes via the activation of the complement systemHendrik Koller
Medizinishe Universität Innsbruck, Universitatsklinik fur Innere Medizin, Klinische Abteilung für Nephrologie, Anichstrasse 35, A 6020 Innsbruck, Austria
Nephrol Dial Transplant 19:3104-11. 2004..The objective of this study was to study the effect of HD membranes on apoptosis induction in polymorphonuclear neutrophils (PMN)...
- Alterations in gene expression in cadaveric vs. live donor kidneys suggest impaired tubular counterbalance of oxidative stress at implantationAlexander Kainz
Department of Nephrology, University of Vienna, Vienna, Austria
Am J Transplant 4:1595-604. 2004..These data suggest that CAD kidneys exhibit a distinctly different set of transcripts in the TI compartment but not in the G compartment when compared with LIV kidneys...
- [Remission of chronic kidney diseases. A realistic goal?]Gert Mayer
Wien Klin Wochenschr 115:405-6. 2003
- Effects of microinjection of synthetic Bcl-2 domain peptides on apoptosis of renal tubular epithelial cellsElisabeth Peherstorfer
Division of Nephrology and Dialysis, Department of Internal Medicine III, University of Vienna, A 1090 Vienna, Austria
Am J Physiol Renal Physiol 283:F190-6. 2002..Analogs to these regulatory peptides could therefore provide valuable lead compounds in the therapeutical context...
- One-year growth hormone therapy improves granulocyte function without major effects on nutritional and anthropometric parameters in malnourished hemodialysis patientsHarald Kotzmann
Division of Endocrinology and Metabolism, Department of Medicine III, University of Vienna, Austria
Nephron Clin Pract 93:C75-82. 2003..In short-term trials anabolic effects of rhGH therapy have been demonstrated in patients on chronic hemodialysis...
- Detrimental effects of controlled reperfusion on renal function after porcine autotransplantation are fully compensated by the use of Carolina rinse solutionPeter Wamser
Department of Surgery, University of Vienna, General Hospital, Wahringer Gurtel 18 20, 1090 Vienna, Austria
Transpl Int 16:191-6. 2003..The flushing of organs with CR prior to controlled reperfusion significantly improves ClCr as well as urine output...
- Expression of granzyme A in human polymorphonuclear neutrophilsKathrin Hochegger
Clinical Division of Nephrology, Innsbruck Medical University, Innsbruck, Austria
Immunology 121:166-73. 2007..In conclusion, we provide clear evidence that GzmA is constitutively expressed in human PMNs and can be up-regulated upon stimulation. These findings may also indicate a role for GzmA in PMNs in defence against invading pathogens...
- Regular physical exercise improves endothelial function in heart transplant recipientsAlice Schmidt
Department of Clinical Pharmacology, University of Vienna, Austria
Clin Transplant 16:137-43. 2002..We have studied whether endothelial function can be improved in HTX patients participating in a regular physical training program as demonstrated in patients with chronic heart failure, hypertension and coronary artery disease...
- Renal hemodynamic effects of somatostatin are not related to inhibition of endogenous insulin releaseAlice Schmidt
Department of Clinical Pharmacology, Division of Nephrology and Dialysis, and Institute of Medical Physics, University of Vienna, Vienna, Austria
Kidney Int 61:1788-93. 2002..Since insulin can cause vasodilation, we hypothesized that removal of basal insulin release by somatostatin may contribute to somatostatin-induced renal vasoconstriction...
- Pharmacokinetic analysis of docetaxel during haemodialysis in a patient with locally advanced non-small cell lung cancerKathrin Hochegger
Nephrol Dial Transplant 22:289-90. 2007
- Role of alpha/beta and gamma/delta T cells in renal ischemia-reperfusion injuryKathrin Hochegger
Clinical Division of Nephrology, Clinical Department of Internal Medicine, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
Am J Physiol Renal Physiol 293:F741-7. 2007..This report provides further evidence that alpha/beta T cells are major effector cells in renal IRI, whereas gamma/delta T cells play a role as mediator cells in the first 72 h of renal IRI...
- Impact of ENPP1 genotype on arterial calcification in patients with end-stage renal failurePhilipp Eller
Department of Internal Medicine, Division of General Internal Medicine, Innsbruck Medical University, Innsbruck, Austria
Nephrol Dial Transplant 23:321-7. 2008..Inactivating mutations of ENPP1 are associated with generalized arterial calcification of infancy. We hypothesized the ENPP1 K121Q variant to be associated with increased vascular calcification in patients with end-stage renal failure...
- [Primary glomerulonephritis]Gabriele Schratzberger
Klinische Abteilung für Nephrologie, Universitatsklinik fur Innere Medizin, Medizinische Universitat Innsbruck, Innsbruck, Osterreich
Wien Klin Wochenschr 118:57-66; quiz 67. 2006
- p21 and mTERT are novel markers for determining different ischemic time periods in renal ischemia-reperfusion injuryKathrin Hochegger
Innsbruck Medical University, Clinical Division of Nephrology, Anichstrasse 35, A 6020 Innsbruck, Austria
Am J Physiol Renal Physiol 292:F762-8. 2007..Taken together, we detected mTERT and p21 as "indicator" genes for short and long ischemic intervals, respectively. These two proteins might also be possible new therapeutic targets in the treatment and prevention of acute renal failure...
- Clearance of C4d deposition after successful treatment of acute humoral rejection in follow-up biopsies: a report of three casesHendrik Koller
Department of Nephrology, University Hospital of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
Transpl Int 17:177-81. 2004..We conclude that successful treatment of AHR is followed by complete resolution of serological and histological markers of AHR, displayed by the disappearance of C4d...
- Effects of 12 months of recombinant growth hormone therapy on parameters of bone metabolism and bone mineral density in patients on chronic hemodialysisHarald Kotzmann
Division of Endocrinology and Metabolism, Department of Medicine III, Ludwig Boltzmann Institute for Experimental Endocrinology, University of Vienna, Vienna, Austria
J Nephrol 17:87-94. 2004....
- Effects of AT1 and AT2 receptor blockade on angiotensin II induced apoptosis of human renal proximal tubular epithelial cellsClaudia Weidekamm
Division of Nephrology and Dialysis, Department of Internal Medicine III, University of Vienna
Wien Klin Wochenschr 114:725-9. 2002....
- The immunomodulator FTY720 interferes with effector functions of human monocyte-derived dendritic cellsHansgeorg Muller
Department of Nephrology, Innsbruck Medical School, Innsbruck, Austria
Eur J Immunol 35:533-45. 2005..This might represent a new aspect of the overall immunosuppressive action of FTY720 and makes DC potential targets of further sphingolipid-derived drugs...
- Role of mast cells in experimental anti-glomerular basement membrane glomerulonephritisKathrin Hochegger
Innsbruck Medical University, Clinical Division of Nephrology, Innsbruck, Austria
Eur J Immunol 35:3074-82. 2005..Our report provides the first direct evidence that MC are protective in anti-GBM GN, possibly by modulating the influx of effector T cells and macrophages to inflammatory sites in the kidney...
- Detection of coregulation in differential gene expression profilesPaul Perco
Institute for Biomolecular Structural Chemistry, University of Vienna, Campus Vienna Biocenter 6, 1030 Vienna, Austria
Biosystems 82:235-47. 2005....
- Eurotransplant kidney allocation system (ETKAS): rationale and implementationGert Mayer
Nephrol Dial Transplant 21:2-3. 2006
- Antioxidant treatment of therapy-resistant idiopathic membranous nephropathy with probucol: a pilot studyMartin Haas
Division of Nephrology and Dialysis, University of Vienna, Austria
Wien Klin Wochenschr 114:143-7. 2002..Since the pathophysiology might be similar to idiopathic membranous nephropathy in humans, we performed a prospective multicenter trial to investigate the efficacy of the lipid peroxidation scavenger, probucol...
- Antioxidant therapy in glomerular diseaseMartin Haas
Wien Klin Wochenschr 114:138-40. 2002
- An update on the relationship between the kidney, salt and hypertensionGert Mayer
Division of Nephrology and Hypertensiology, Department of Internal Medicine IV, Innsbruck, Austria
Wien Med Wochenschr 158:365-9. 2008..As a conclusion, we have to remember that an elevation of arterial pressure can only be maintained if renal function as indicated by pressure natriuresis is impaired...