Burkhard Kloesch

Summary

Affiliation: University of Vienna
Country: Austria

Publications

  1. ncbi request reprint In Vitro Study of a Liposomal Curcumin Formulation (Lipocurc™): Toxicity and Biological Activity in Synovial Fibroblasts and Macrophages
    Burkhard Kloesch
    Department for Degenerative Joint Diseases, Ludwig Boltzmann Cluster for Arthritis and Rehabilitation, Vienna, Austria
    In Vivo 30:413-9. 2016
  2. doi request reprint Hydrogen sulfide inhibits endothelial nitric oxide formation and receptor ligand-mediated Ca(2+) release in endothelial and smooth muscle cells
    Burkhard Kloesch
    Ludwig Boltzmann Institute for Rheumatology and Balneology, Cluster Rheumatology, Balneology and Rehabilitation, Vienna, Austria Electronic address
    Pharmacol Rep 68:37-43. 2016
  3. doi request reprint Anti-inflammatory and apoptotic effects of the polyphenol curcumin on human fibroblast-like synoviocytes
    Burkhard Kloesch
    Ludwig Boltzmann Cluster Rheumatology, Balneology and Rehabilitation, Ludwig Boltzmann Institute of Rheumatology and Balneology, Kurbadstrasse 14, 1100 Vienna, Austria
    Int Immunopharmacol 15:400-5. 2013
  4. doi request reprint Inhibitors of p38 and ERK1/2 MAPkinase and hydrogen sulphide block constitutive and IL-1β-induced IL-6 and IL-8 expression in the human chondrocyte cell line C-28/I2
    B Kloesch
    Ludwig Boltzmann Institute for Rheumatology and Balneology, Kurbadstrasse 14, 1100 Vienna, Austria
    Rheumatol Int 32:729-36. 2012
  5. doi request reprint H2S transiently blocks IL-6 expression in rheumatoid arthritic fibroblast-like synoviocytes and deactivates p44/42 mitogen-activated protein kinase
    Burkhard Kloesch
    Ludwig Boltzmann Institute for Rheumatology and Balneology, Vienna, Austria
    Cell Biol Int 34:477-84. 2010
  6. doi request reprint Dimethyl sulphoxide and dimethyl sulphone are potent inhibitors of IL-6 and IL-8 expression in the human chondrocyte cell line C-28/I2
    Burkhard Kloesch
    Ludwig Boltzmann Institute for Rheumatology and Balneology, Kurbadstrasse 14, 1100 Vienna, Austria
    Life Sci 89:473-8. 2011
  7. doi request reprint High concentrations of hydrogen sulphide elevate the expression of a series of pro-inflammatory genes in fibroblast-like synoviocytes derived from rheumatoid and osteoarthritis patients
    Burkhard Kloesch
    Ludwig Boltzmann Institute for Rheumatology and Balneology, Kurbadstrasse 14, 1100 Vienna, Austria
    Immunol Lett 141:197-203. 2012
  8. ncbi request reprint Antiproliferative and Pro-apoptotic Activities of a Novel Resveratrol Prodrug Against Jurkat CD4+ T-Cells
    Katrin Goldhahn
    Department of Degenerative Joint Diseases, Ludwig Boltzmann Cluster of Arthritis and Rehabilitation, Vienna, Austria Division of Rheumatology, Department for Internal Medicine III, Medical University Vienna, Vienna, Austria
    Anticancer Res 36:683-9. 2016
  9. ncbi request reprint P29 Bivalent effects of hydrogen sulfide on IL-6 and IL-1β expression in the human monocyte cell line U937
    Silvia Loebsch
    Ludwig Boltzmann Cluster for Rheumatology, Balneology and Rehabilitation, Ludwig Boltzmann Institute for Rheumatology and Balneology, Vienna, Austria
    Nitric Oxide 31:S47-8. 2013
  10. ncbi request reprint P22 Effect of hydrogen sulfide on Ca(2+) signaling in endothelial and smooth muscle cells
    Burkhard Kloesch
    Ludwig Boltzmann Cluster for Rheumatology, Balneology and Rehabilitation, Ludwig Boltzmann Institute of Rheumatology and Balneology, Vienna, Austria
    Nitric Oxide 31:S44. 2013

Collaborators

  • Kurt Schmidt
  • Lawrence Helson
  • Katrin Goldhahn
  • Guenter Steiner
  • Silvia Loebsch
  • Thomas Erker
  • Daniela Sieghart
  • Klaus Schmetterer
  • Norbert Handler
  • Michael Hintersteininger
  • Hans Kiener
  • Tatjana Becker

Detail Information

Publications13

  1. ncbi request reprint In Vitro Study of a Liposomal Curcumin Formulation (Lipocurc™): Toxicity and Biological Activity in Synovial Fibroblasts and Macrophages
    Burkhard Kloesch
    Department for Degenerative Joint Diseases, Ludwig Boltzmann Cluster for Arthritis and Rehabilitation, Vienna, Austria
    In Vivo 30:413-9. 2016
    ..In this study, we evaluated the biological effects of a liposomal curcumin formulation (Lipocurc™) on human synovial fibroblasts (SW982) and mouse macrophages (RAW264)...
  2. doi request reprint Hydrogen sulfide inhibits endothelial nitric oxide formation and receptor ligand-mediated Ca(2+) release in endothelial and smooth muscle cells
    Burkhard Kloesch
    Ludwig Boltzmann Institute for Rheumatology and Balneology, Cluster Rheumatology, Balneology and Rehabilitation, Vienna, Austria Electronic address
    Pharmacol Rep 68:37-43. 2016
    ..In this study, we investigated the effects of H2S on Ca(2+) signaling in endothelial and smooth muscle cells with special emphasis given to the role of H2S in modulating endothelial NO formation...
  3. doi request reprint Anti-inflammatory and apoptotic effects of the polyphenol curcumin on human fibroblast-like synoviocytes
    Burkhard Kloesch
    Ludwig Boltzmann Cluster Rheumatology, Balneology and Rehabilitation, Ludwig Boltzmann Institute of Rheumatology and Balneology, Kurbadstrasse 14, 1100 Vienna, Austria
    Int Immunopharmacol 15:400-5. 2013
    ..This study investigated possible anti-inflammatory and apoptotic effects of curcumin on the human synovial fibroblast cell line MH7A, and on fibroblast-like synoviocytes (FLS) derived from patients with rheumatoid arthritis (RA)...
  4. doi request reprint Inhibitors of p38 and ERK1/2 MAPkinase and hydrogen sulphide block constitutive and IL-1β-induced IL-6 and IL-8 expression in the human chondrocyte cell line C-28/I2
    B Kloesch
    Ludwig Boltzmann Institute for Rheumatology and Balneology, Kurbadstrasse 14, 1100 Vienna, Austria
    Rheumatol Int 32:729-36. 2012
    ..Presented data seem to be important in evaluating the beneficial functions of MAPK inhibitors and H(2)S in immune-pathophysiological processes...
  5. doi request reprint H2S transiently blocks IL-6 expression in rheumatoid arthritic fibroblast-like synoviocytes and deactivates p44/42 mitogen-activated protein kinase
    Burkhard Kloesch
    Ludwig Boltzmann Institute for Rheumatology and Balneology, Vienna, Austria
    Cell Biol Int 34:477-84. 2010
    ..Presented data seem of importance for studying (patho-) physiological functions of H2S and also for re-evaluating sulfur spa therapy as one of the oldest forms of therapy for rheumatic disorders...
  6. doi request reprint Dimethyl sulphoxide and dimethyl sulphone are potent inhibitors of IL-6 and IL-8 expression in the human chondrocyte cell line C-28/I2
    Burkhard Kloesch
    Ludwig Boltzmann Institute for Rheumatology and Balneology, Kurbadstrasse 14, 1100 Vienna, Austria
    Life Sci 89:473-8. 2011
    ....
  7. doi request reprint High concentrations of hydrogen sulphide elevate the expression of a series of pro-inflammatory genes in fibroblast-like synoviocytes derived from rheumatoid and osteoarthritis patients
    Burkhard Kloesch
    Ludwig Boltzmann Institute for Rheumatology and Balneology, Kurbadstrasse 14, 1100 Vienna, Austria
    Immunol Lett 141:197-203. 2012
    ..But scientific reports about the beneficial effects of H(2)S as well as about the underlying molecular mechanisms are controversial and rare...
  8. ncbi request reprint Antiproliferative and Pro-apoptotic Activities of a Novel Resveratrol Prodrug Against Jurkat CD4+ T-Cells
    Katrin Goldhahn
    Department of Degenerative Joint Diseases, Ludwig Boltzmann Cluster of Arthritis and Rehabilitation, Vienna, Austria Division of Rheumatology, Department for Internal Medicine III, Medical University Vienna, Vienna, Austria
    Anticancer Res 36:683-9. 2016
    ..In the present study, we compared the antiproliferative and pro-apoptotic effects of resveratrol with FEHH4-1 on Jurkat T-cells...
  9. ncbi request reprint P29 Bivalent effects of hydrogen sulfide on IL-6 and IL-1β expression in the human monocyte cell line U937
    Silvia Loebsch
    Ludwig Boltzmann Cluster for Rheumatology, Balneology and Rehabilitation, Ludwig Boltzmann Institute for Rheumatology and Balneology, Vienna, Austria
    Nitric Oxide 31:S47-8. 2013
    ..Therefore, we investigated the effects of the H2S donor sodium hydrogen sulfide (NaHS) on IL-6 and IL-1β expression in the human leukemic monocyte cell line U937...
  10. ncbi request reprint P22 Effect of hydrogen sulfide on Ca(2+) signaling in endothelial and smooth muscle cells
    Burkhard Kloesch
    Ludwig Boltzmann Cluster for Rheumatology, Balneology and Rehabilitation, Ludwig Boltzmann Institute of Rheumatology and Balneology, Vienna, Austria
    Nitric Oxide 31:S44. 2013
    ....
  11. ncbi request reprint P46 Hydrogen sulfide inhibits IL-1β stimulation of fibroblast-like synoviocytes from osteoarthritis patients in a 3-D model
    Daniela Sieghart
    Ludwig Boltzmann Cluster for Rheumatology, Balneology and Rehabilitation, Ludwig Boltzmann Institute of Rheumatology and Balneology, Vienna, Austria
    Nitric Oxide 31:S55. 2013
    ..The objective of this study was to analyze the possible anti-inflammatory potential of hydrogen sulfide (H2S) on activated FLS cultured in three-dimensional micromass culture...
  12. ncbi request reprint Enhanced Antiproliferative and Pro-apoptotic Activities of a Novel Curcumin-related Compound in Jurkat Leukemia T-Cells
    Katrin Goldhahn
    Ludwig Boltzmann Institute for Rheumatology and Balneology, Cluster Rheumatology, Balneology and Rehabilitation, Vienna, Austria
    Anticancer Res 35:2675-80. 2015
    ..Two compounds (HP109/HP102) were selected for evaluation of their anti-proliferative and pro-apoptotic potential in Jurkat T-cells...
  13. doi request reprint A8.8 Controllable hydrogen sulfide donors and their anti-inflammatory potential in the murine macrophage cell line RAW264.7
    Burkhard Kloesch
    Ludwig Boltzmann Cluster for Rheumatology, Balneology and Rehabilitation, Ludwig Boltzmann Institute for Rheumatology and Balneology, Vienna, Austria
    Ann Rheum Dis 73:A79. 2014
    ..In this study we report about the biological evaluation of a new class of H2S donors releasing H2S upon activation by cysteine or reduced glutathione (GSH)...