M Hengstschlager

Summary

Affiliation: University of Vienna
Country: Austria

Publications

  1. ncbi Tuberous sclerosis gene products in proliferation control
    M Hengstschlager
    Obstetrics and Gynecology, Prenatal Diagnosis and Therapy, University of Vienna, Wahringer Gurtel 18 20, A 1090, Vienna, Austria
    Mutat Res 488:233-9. 2001
  2. ncbi Prenatal diagnosis of tetrasomy 9p with Dandy-Walker malformation
    Markus Hengstschlager
    Obstetrics and Gynecology, Prenatal Diagnosis and Therapy, Medical University of Vienna, Vienna, Austria
    Prenat Diagn 24:623-6. 2004
  3. ncbi Patient with partial trisomy 9q and learning disability but no pyloric stenosis
    Markus Hengstschlager
    Obstetrics and Gynaecology Department, Prenatal Diagnosis and Therapy, University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Dev Med Child Neurol 46:57-9. 2004
  4. ncbi Prenatal diagnosis of a supernumerary aberrant chromosome 9
    M Hengstschlager
    Obstetrics and Gynecology, Prenatal Diagnosis and Therapy, University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Arch Gynecol Obstet 268:248-50. 2003
  5. ncbi Prenatal diagnosis of a de novo inversion of chromosome (2)(p21q11)
    M Hengstschlager
    Obstetrics and Gynecology, Prenatal Diagnosis and Therapy, University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Arch Gynecol Obstet 268:230-2. 2003
  6. ncbi Sex chromosome aberrations and transsexualism
    Markus Hengstschlager
    Prenatal Diagnosis and Therapy, Department of Obstetrics and Gynecology, University of Vienna, Austria
    Fertil Steril 79:639-40. 2003
  7. ncbi Tuberous sclerosis complex genes: from flies to human genetics
    M Hengstschlager
    Obstetrics and Gynecology, University of Vienna, Prenatal Diagnosis and Therapy, Wahringer Gurtel, Austria
    Arch Dermatol Res 293:383-6. 2001
  8. ncbi Cyclin-dependent kinases at the G1-S transition of the mammalian cell cycle
    M Hengstschlager
    Obstetrics and Gynecology, Department of Prenatal Diagnosis and Therapy, University of Vienna, Wahringer Gurtel 18 20, A 1090, Vienna, Austria
    Mutat Res 436:1-9. 1999
  9. ncbi Fetal cells in the peripheral blood of pregnant women express thymidine kinase: a new marker for detection
    M Hengstschlager
    Department of Prenatal Diagnosis and Therapy, University of Vienna, Austria
    FEBS Lett 404:299-302. 1997
  10. ncbi The TSC1 gene product, hamartin, negatively regulates cell proliferation
    A Miloloza
    Obstetrics and Gynecology, University of Vienna, Prenatal Diagnosis and Therapy, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Hum Mol Genet 9:1721-7. 2000

Collaborators

  • G Lubec
  • J Attems
  • R S Yeung
  • C Gundacker
  • E Wintersberger
  • M Nishino
  • J M Peters
  • A Pollak
  • Atala Anthony
  • Johannes C Huber
  • T Laml
  • M Rosner
  • A Freilinger
  • N Siegel
  • C Fuchs
  • A Valli
  • M Hanneder
  • J E Oh
  • H Dolznig
  • K Schipany
  • T Soucek
  • S Burgstaller
  • G Hudelist
  • K Braun
  • K Karlmark Raja
  • J H Shin
  • G Hölzl
  • W Blaicher
  • M Feichtinger
  • M Mikula
  • G Bernaschek
  • A Preitschopf
  • U Madel
  • W Feichtinger
  • A Atala
  • C E Bishop
  • A Miloloza
  • C Lindengrün
  • R Kroiss
  • D Gschwantler-Kaulich
  • W J Köstler
  • K Pischinger
  • A Fink-Retter
  • K Czerwenka
  • C F Singer
  • T Wagner
  • C Blaukopf
  • M Tea
  • R Mueller
  • E Kubista
  • S J Korsmeyer
  • G Krupitza
  • E R Kramer
  • O Pusch
  • J Deutinger
  • M R Ulm
  • B Ulm
  • M Nellist
  • D Halley
  • C Geisen
  • C Gieffers
  • T Moroy
  • J E DeClue
  • R Wienecke

Detail Information

Publications43

  1. ncbi Tuberous sclerosis gene products in proliferation control
    M Hengstschlager
    Obstetrics and Gynecology, Prenatal Diagnosis and Therapy, University of Vienna, Wahringer Gurtel 18 20, A 1090, Vienna, Austria
    Mutat Res 488:233-9. 2001
    ..Elucidation of the cellular functions of these proteins will form the basis of a better understanding of how mutations in these genes cause the disease and for the development of new therapeutic strategies...
  2. ncbi Prenatal diagnosis of tetrasomy 9p with Dandy-Walker malformation
    Markus Hengstschlager
    Obstetrics and Gynecology, Prenatal Diagnosis and Therapy, Medical University of Vienna, Vienna, Austria
    Prenat Diagn 24:623-6. 2004
    ..To add to the knowledge of chromosomal abnormalities associated with Dandy-Walker malformation...
  3. ncbi Patient with partial trisomy 9q and learning disability but no pyloric stenosis
    Markus Hengstschlager
    Obstetrics and Gynaecology Department, Prenatal Diagnosis and Therapy, University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Dev Med Child Neurol 46:57-9. 2004
    ..This study provides new information for future genetic counselling, especially in cases of prenatal diagnosis of partial trisomy 9q...
  4. ncbi Prenatal diagnosis of a supernumerary aberrant chromosome 9
    M Hengstschlager
    Obstetrics and Gynecology, Prenatal Diagnosis and Therapy, University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Arch Gynecol Obstet 268:248-50. 2003
    ..This report provides evidence that the absence of trisomy 9 in 9q34 does not prevent abnormal facial development...
  5. ncbi Prenatal diagnosis of a de novo inversion of chromosome (2)(p21q11)
    M Hengstschlager
    Obstetrics and Gynecology, Prenatal Diagnosis and Therapy, University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Arch Gynecol Obstet 268:230-2. 2003
    ..This is the first description of a de novo inversion (2)(p21q11) in a fetus with multiple malformations...
  6. ncbi Sex chromosome aberrations and transsexualism
    Markus Hengstschlager
    Prenatal Diagnosis and Therapy, Department of Obstetrics and Gynecology, University of Vienna, Austria
    Fertil Steril 79:639-40. 2003
  7. ncbi Tuberous sclerosis complex genes: from flies to human genetics
    M Hengstschlager
    Obstetrics and Gynecology, University of Vienna, Prenatal Diagnosis and Therapy, Wahringer Gurtel, Austria
    Arch Dermatol Res 293:383-6. 2001
  8. ncbi Cyclin-dependent kinases at the G1-S transition of the mammalian cell cycle
    M Hengstschlager
    Obstetrics and Gynecology, Department of Prenatal Diagnosis and Therapy, University of Vienna, Wahringer Gurtel 18 20, A 1090, Vienna, Austria
    Mutat Res 436:1-9. 1999
    ..Recent findings provide evidence that the overall mechanism of initiation of replication is conserved in mammalian cells...
  9. ncbi Fetal cells in the peripheral blood of pregnant women express thymidine kinase: a new marker for detection
    M Hengstschlager
    Department of Prenatal Diagnosis and Therapy, University of Vienna, Austria
    FEBS Lett 404:299-302. 1997
    ..We further describe the first successful application of a cytofluorometric thymidine kinase assay to detect fetal cells in the maternal circulation by virtue of their high thymidine kinase activity...
  10. ncbi The TSC1 gene product, hamartin, negatively regulates cell proliferation
    A Miloloza
    Obstetrics and Gynecology, University of Vienna, Prenatal Diagnosis and Therapy, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Hum Mol Genet 9:1721-7. 2000
    ..Further investigations revealed that hamartin affects cell proliferation via deregulation of G(1) phase. Our data have a clear impact on understanding the role of hamartin during development of this disease...
  11. doi mTOR phosphorylated at S2448 binds to raptor and rictor
    M Rosner
    Medical Genetics, Medical University of Vienna, Wahringer Gurtel 18 20, 1090, Vienna, Austria
    Amino Acids 38:223-8. 2010
    ..Our data allow new insights into the role of mTOR phosphorylation for the regulation of its kinase activity...
  12. doi CDKs as therapeutic targets for the human genetic disease tuberous sclerosis?
    M Rosner
    Medical University of Vienna, Vienna, Austria
    Eur J Clin Invest 39:1033-5. 2009
    ..Taken together, these findings strengthen the argument that besides mTOR-inhibitors, such as rapamycin analogues, p27 and CDKs could also be considered targets for hamartoma therapeutics in tuberous sclerosis...
  13. doi Skp2 inversely correlates with p27 and tuberin in transformed cells
    M Rosner
    Medical Genetics, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Amino Acids 37:257-62. 2009
    ..These data allow new important insights into this molecular network of cell cycle control...
  14. pmc Inactivation of the cyclin-dependent kinase inhibitor p27 upon loss of the tuberous sclerosis complex gene-2
    T Soucek
    Obstetrics and Gynecology, University of Vienna, Department of Prenatal Diagnosis and Therapy, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Proc Natl Acad Sci U S A 95:15653-8. 1998
    ..These findings provide insights into the molecular mechanism of how loss of TSC2 induces cell cycle entry and allow a better understanding of its tumor suppressor function...
  15. doi Embryoid body formation of human amniotic fluid stem cells depends on mTOR
    A Valli
    Department of Medical Genetics, Medical University of Vienna, Vienna, Austria
    Oncogene 29:966-77. 2010
    ..These findings demonstrate hAFSCs to be a new and powerful biological system to recapitulate the three-dimensional and tissue level contexts of in vivo development and identify the mTOR pathway to be essential for this process...
  16. ncbi Cytoplasmic/nuclear localization of tuberin in different cell lines
    M Rosner
    Medical Genetics, Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria
    Amino Acids 33:575-9. 2007
    ..Akt also regulates the cytoplasmic/nuclear localization of the cyclin-dependent kinase inhibitor p27. In this study the localization of these two Akt-regulated proteins was analysed in different cell lines...
  17. doi Different cytoplasmic/nuclear distribution of S6 protein phosphorylated at S240/244 and S235/236
    M Rosner
    Institute of Medical Genetics, Medical University of Vienna, Währinger Strasse 10, 1090, Vienna, Austria
    Amino Acids 40:595-600. 2011
    ..Our findings provide new insights into the regulation of S6 phosphorylation and S6 protein localization in mammalian cells...
  18. ncbi Prenatal diagnosis of a de novo supernumerary marker derived from chromosome 16
    M Hengstschlager
    Obstetrics and Gynecology, Prenatal Diagnosis and Therapy, University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Prenat Diagn 21:477-80. 2001
    ..Here the prenatal diagnosis of a de novo supernumerary marker chromosome 16 is described and the relevant literature discussed...
  19. doi Tuberin, p27 and mTOR in different cells
    S Burgstaller
    Medical Genetics, Obstetrics and Gynecology, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Amino Acids 36:297-302. 2009
    ....
  20. ncbi Cytoskeleton changes following differentiation of N1E-115 neuroblastoma cell line
    J E Oh
    Department of Pediatrics, Medical University of Vienna, Vienna, Austria
    Amino Acids 31:289-98. 2006
    ..We herein identified differentiation-related expressional patterns thus providing new evidence for the role of CPs in the process of neuronal differentiation...
  21. ncbi Role of the tuberous sclerosis gene-2 product in cell cycle control. Loss of the tuberous sclerosis gene-2 induces quiescent cells to enter S phase
    T Soucek
    Obstetrics and Gynecology, University of Vienna, Department of Prenatal Diagnosis and Therapy, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    J Biol Chem 272:29301-8. 1997
    ....
  22. doi Nucleocytoplasmic localization of p70 S6K1, but not of its isoforms p85 and p31, is regulated by TSC2/mTOR
    M Rosner
    Institute of Medical Genetics, Medical University of Vienna, Austria
    Oncogene 30:4509-22. 2011
    ..These findings provide new important insights into the temporal and spatial dynamics of TSC2/mTOR/S6K regulation...
  23. ncbi 14-3-3 proteins are involved in the regulation of mammalian cell proliferation
    M Rosner
    Medical Genetics, Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria
    Amino Acids 30:105-9. 2006
    ..These data provide new insights into mammalian cell proliferation control and allow a better understanding of the functions of 14-3-3 proteins...
  24. ncbi Proteins interacting with the tuberous sclerosis gene products
    M Rosner
    Obstetrics and Gynecology, Prenatal Diagnosis and Therapy, Medical University of Vienna, Vienna, Austria
    Amino Acids 27:119-28. 2004
    ..In this review, we summarize the current knowledge on hamartin- and tuberin-interacting proteins and discuss their role for the understanding of the functions of the TSC gene products...
  25. doi p70 S6K1 nuclear localization depends on its mTOR-mediated phosphorylation at T389, but not on its kinase activity towards S6
    M Rosner
    Institute of Medical Genetics, Medical University of Vienna, Währinger Strasse 10, 1090, Vienna, Austria
    Amino Acids 42:2251-6. 2012
    ..These findings provide important insights into the regulation of p70 S6K1 and allow a more detailed understanding of subcellular enzyme localization processes...
  26. doi Proliferation potential of human amniotic fluid stem cells differently responds to mercury and lead exposure
    C Gundacker
    Institute of Medical Genetics, Medical University of Vienna, Währinger Straße 10, 1090 Vienna, Austria
    Amino Acids 43:937-49. 2012
    ..These findings allow new insights into the functional consequences of Pb and Hg for mammalian stem cells and into the cell biological behavior of AFS cells in response to toxicants...
  27. ncbi Ras mediates cell survival by regulating tuberin
    A Freilinger
    Medical Genetics, Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria
    Oncogene 27:2072-83. 2008
    ..This is the first description of a functional interaction between the tumor suppressor tuberin and the oncogene Ras in regulating apoptosis...
  28. doi Evidence for cell cycle-dependent, rapamycin-resistant phosphorylation of ribosomal protein S6 at S240/244
    M Rosner
    Institute of Medical Genetics, Medical University of Vienna, Währinger Strasse 10, 1090, Vienna, Austria
    Amino Acids 39:1487-92. 2010
    ..Our data allow new insights into the regulation of S6 phosphorylation and provide evidence for the existence of rapamycin-resistant S6 phosphorylating kinase activities...
  29. ncbi Tuberin negatively affects BCL-2's cell survival function
    A Freilinger
    Medical Genetics, Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria
    Amino Acids 30:391-6. 2006
    ..These findings warrant further investigations to elucidate the molecular mechanism underlying tuberin's negative effects on cell survival...
  30. ncbi Deregulated expression of CDK2- or CDK3-associated kinase activities enhances c-Myc-induced apoptosis
    K Braun
    Obstetrics and Gynecology, Department of Prenatal Diagnosis and Therapy, University of Vienna, Austria
    DNA Cell Biol 17:789-98. 1998
    ..In this report, we provide evidence for a not yet described property of CDK2 or CDK3 besides their activity in promoting proliferation: these G1-CDKs can promote apoptosis by interfering with the cell's response to survival factors...
  31. ncbi Nuclear/cytoplasmic localization of Akt activity in the cell cycle
    M Rosner
    Medical Genetics, Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria
    Amino Acids 32:341-5. 2007
    ..These data provide new insights into the regulation of Akt activity and have implications for future studies on the regulation of the wide variety of different nuclear and cytoplasmic Akt substrates...
  32. ncbi Investigation of the cell cycle regulation of cdk3-associated kinase activity and the role of cdk3 in proliferation and transformation
    K Braun
    Obstetrics and Gynecology, University of Vienna, Department of Prenatal Diagnosis and Therapy, Austria
    Oncogene 17:2259-69. 1998
    ..Our data provide first insights into the regulation of cdk3-associated kinase activity and suggest a model how cdk3 participates in the regulation of the G1-S transition...
  33. ncbi The neuronal differentiation process involves a series of antioxidant proteins
    J E Oh
    Department of Pediatrics, Medical University of Vienna, Vienna, Austria
    Amino Acids 29:273-82. 2005
    ..This finding not only shows concomitant determination of AOXP but also serves as an analytical tool and forms the basis for design of future studies addressing AOXP and differentiation per se...
  34. pmc Identification of leukaemic cells in bone marrow and blood samples by a new cytofluorometric assay
    M Hengstschlager
    Institute of Molecular Biology, University of Vienna, Vienna Biocenter, Austria
    Br J Cancer 73:1237-40. 1996
    ..Using a new cytofluorometric assay for thymidine kinase in single cells, we were able to identify leukaemic cells in a surplus of normal ones. Our results demonstrate the benefits of this assay for leukaemia diagnosis...
  35. ncbi Different regulation of thymidine kinase during the cell cycle of normal versus DNA tumor virus-transformed cells
    M Hengstschlager
    Institute of Molecular Biology, Vienna Biocenter, University of Vienna, Austria
    J Biol Chem 269:13836-42. 1994
    ..Obviously, DNA tumor viruses suppress transcriptional down-regulation of the endogenous DNA precursor pathway enzyme TK during the eukaryotic cell cycle, maybe to improve conditions for their own replication...
  36. doi Neurogenic differentiation of amniotic fluid stem cells
    M Rosner
    Institute of Medical Genetics, Medical University of Vienna, Währinger Strasse 10, 1090, Vienna, Austria
    Amino Acids 42:1591-6. 2012
    ..Here, we review the current knowledge on the neurogenic differentiation potential of AFS cells...
  37. ncbi Activation of the human anaphase-promoting complex by proteins of the CDC20/Fizzy family
    E R Kramer
    Research Institute of Molecular Pathology IMP, Vienna, Austria
    Curr Biol 8:1207-10. 1998
    ..The temporally distinct association of hCDC20 and hCDH1 with APC suggests that these proteins are, respectively, mitosis-specific and G1-specific activating subunits of APC...
  38. ncbi Tuberin activates the proapoptotic molecule BAD
    A Freilinger
    Medical Genetics, Obstetrics and Gynecology, Medical University of Vienna, Wahringer Gurtel, Vienna, Austria
    Oncogene 25:6467-79. 2006
    ..A mutation of TSC2--as it occurs in TSC patients--attenuates this proapoptotic potential, underscoring the relevance of our findings for human pathophysiology...
  39. ncbi Dandy-Walker malformation as sonographic marker for fetal triploidy
    W Blaicher
    Universitatsklinik fur Frauenheilkunde, Abteilung für Pränatale Diagnostik und Therapie, Allgemeines Krankenhaus Wien, Osterreich, Germany
    Ultraschall Med 23:129-33. 2002
    ..We conclude that the Dandy-Walker malformation and Dandy-Walker variant should be considered as additional sonographic markers for fetal triploidy...
  40. ncbi Genetic disorders in premature ovarian failure
    T Laml
    University of Vienna Medical School, Department of Obstetrics and Gynaecology, Austria
    Hum Reprod Update 8:483-91. 2002
    ..In conclusion, the relationship between genetic disorders and POF is clearly demonstrated in this review. Therefore, in the case of families affected by POF a thorough screening, including cytogenetic analysis, should be performed...
  41. ncbi Akt regulates nuclear/cytoplasmic localization of tuberin
    M Rosner
    Medical Genetics, Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria
    Oncogene 26:521-31. 2007
    ....
  42. ncbi Human amniotic fluid stem cells: a new perspective
    N Siegel
    Medical Genetics, Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria
    Amino Acids 35:291-3. 2008
    ..It will be a major aim for the future to define the potential of this new source of stem cells for therapies related to specific diseases...
  43. ncbi Intratumoral IGF-I protein expression is selectively upregulated in breast cancer patients with BRCA1/2 mutations
    G Hudelist
    Clinical Division of Special Gynecology, Department of Gynecology and Obstetrics, Medical University of Vienna, and Otto Wagner Hospital, Vienna, Austria
    Endocr Relat Cancer 14:1053-62. 2007
    ....