Markus Galanski

Summary

Affiliation: University of Vienna
Country: Austria

Publications

  1. pmc Synthesis and in vitro antitumor potency of (cyclohexane-1,2-diamine)platinum(II) complexes with aminotris(methylenephosphonic acid) as bone-seeking ligand
    Markus Galanski
    Institute of Inorganic Chemistry, University of Vienna, Waehringerstr 42, Vienna A 1090, Austria
    Bioinorg Chem Appl . 2005
  2. ncbi request reprint Update of the preclinical situation of anticancer platinum complexes: novel design strategies and innovative analytical approaches
    Markus Galanski
    Institute of Inorganic Chemistry Bioinorganic, Environmental and Radiochemistry, University of Vienna, Vienna, Austria
    Curr Med Chem 12:2075-94. 2005
  3. ncbi request reprint Synthesis, crystal structure and cytotoxicity of new oxaliplatin analogues indicating that improvement of anticancer activity is still possible
    Markus Galanski
    Institute of Inorganic Chemistry, University of Vienna, Waehringerstr 42, A 1090 Vienna, Austria
    Eur J Med Chem 39:707-14. 2004
  4. ncbi request reprint Rational development of oxaliplatin analogues --synthesis and preliminary structure-activity relationships
    M Galanski
    University of Vienna, Institute of Inorganic Chemistry Bioinorganic, Environmental and Radiochemistry, Wahringer Strasse 42, 1090 Vienna, Austria
    Int J Clin Pharmacol Ther 43:575-6. 2005
  5. ncbi request reprint Synthesis, characterization, and in vitro antitumor activity of osteotropic diam(m)ineplatinum(II) complexes bearing a N,N-bis(phosphonomethyl)glycine ligand
    Markus Galanski
    Institute of Inorganic Chemistry, University of Vienna, Vienna, Austria
    J Med Chem 46:4946-51. 2003
  6. ncbi request reprint Searching for the magic bullet: anticancer platinum drugs which can be accumulated or activated in the tumor tissue
    Markus Galanski
    Institute of Inorganic Chemistry, University of Vienna, Vienna, Austria
    Anticancer Agents Med Chem 7:55-73. 2007
  7. ncbi request reprint Recent developments in the field of anticancer platinum complexes
    Markus Galanski
    Institute of Inorganic Chemistry Bioinorganic, Environmental and Radiochemistry, University of Vienna, Vienna, Austria
    Recent Pat Anticancer Drug Discov 1:285-95. 2006
  8. doi request reprint Impact of metal coordination on cytotoxicity of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (triapine) and novel insights into terminal dimethylation
    Christian R Kowol
    University of Vienna, Institute of Inorganic Chemistry, Wahringer Strasse 42, A 1090 Vienna, Austria
    J Med Chem 52:5032-43. 2009
  9. ncbi request reprint Metal-based paullones as putative CDK inhibitors for antitumor chemotherapy
    Wolfgang F Schmid
    Institute of Inorganic Chemistry, University of Vienna, Wahringerstr 42, A 1090 Vienna, Austria
    J Med Chem 50:6343-55. 2007
  10. pmc Unsymmetric mono- and dinuclear platinum(IV) complexes featuring an ethylene glycol moiety: synthesis, characterization, and biological activity
    Verena Pichler
    Institute of Inorganic Chemistry, University of Vienna, Waehringer Strasse 42, A 1090 Vienna, Austria
    J Med Chem 55:11052-61. 2012

Collaborators

Detail Information

Publications72

  1. pmc Synthesis and in vitro antitumor potency of (cyclohexane-1,2-diamine)platinum(II) complexes with aminotris(methylenephosphonic acid) as bone-seeking ligand
    Markus Galanski
    Institute of Inorganic Chemistry, University of Vienna, Waehringerstr 42, Vienna A 1090, Austria
    Bioinorg Chem Appl . 2005
    ..5 - 2 fold higher, which is explainable by a different coordination mode of the phosphonic acid ligands (acetato versus phosphonato)...
  2. ncbi request reprint Update of the preclinical situation of anticancer platinum complexes: novel design strategies and innovative analytical approaches
    Markus Galanski
    Institute of Inorganic Chemistry Bioinorganic, Environmental and Radiochemistry, University of Vienna, Vienna, Austria
    Curr Med Chem 12:2075-94. 2005
    ..It focuses also on innovative synthetic strategies leading to novel classes of platinum complexes. A small part of the review is dedicated to new analytical approaches which have been supplied to or emerged in this field of research...
  3. ncbi request reprint Synthesis, crystal structure and cytotoxicity of new oxaliplatin analogues indicating that improvement of anticancer activity is still possible
    Markus Galanski
    Institute of Inorganic Chemistry, University of Vienna, Waehringerstr 42, A 1090 Vienna, Austria
    Eur J Med Chem 39:707-14. 2004
    ....
  4. ncbi request reprint Rational development of oxaliplatin analogues --synthesis and preliminary structure-activity relationships
    M Galanski
    University of Vienna, Institute of Inorganic Chemistry Bioinorganic, Environmental and Radiochemistry, Wahringer Strasse 42, 1090 Vienna, Austria
    Int J Clin Pharmacol Ther 43:575-6. 2005
  5. ncbi request reprint Synthesis, characterization, and in vitro antitumor activity of osteotropic diam(m)ineplatinum(II) complexes bearing a N,N-bis(phosphonomethyl)glycine ligand
    Markus Galanski
    Institute of Inorganic Chemistry, University of Vienna, Vienna, Austria
    J Med Chem 46:4946-51. 2003
    ..Within the series of complexes under investigation, potency decreases depending on the coordinated amine ligand in the following order: trans-R,R-chxn > trans-S,S-chxn > NH(3) > or = cis-R,S-chxn > en...
  6. ncbi request reprint Searching for the magic bullet: anticancer platinum drugs which can be accumulated or activated in the tumor tissue
    Markus Galanski
    Institute of Inorganic Chemistry, University of Vienna, Vienna, Austria
    Anticancer Agents Med Chem 7:55-73. 2007
    ....
  7. ncbi request reprint Recent developments in the field of anticancer platinum complexes
    Markus Galanski
    Institute of Inorganic Chemistry Bioinorganic, Environmental and Radiochemistry, University of Vienna, Vienna, Austria
    Recent Pat Anticancer Drug Discov 1:285-95. 2006
    ....
  8. doi request reprint Impact of metal coordination on cytotoxicity of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (triapine) and novel insights into terminal dimethylation
    Christian R Kowol
    University of Vienna, Institute of Inorganic Chemistry, Wahringer Strasse 42, A 1090 Vienna, Austria
    J Med Chem 52:5032-43. 2009
    ..Selected compounds were investigated for the capacity of inhibiting ribonucleotide reductase by incorporation of (3)H-cytidine into DNA...
  9. ncbi request reprint Metal-based paullones as putative CDK inhibitors for antitumor chemotherapy
    Wolfgang F Schmid
    Institute of Inorganic Chemistry, University of Vienna, Wahringerstr 42, A 1090 Vienna, Austria
    J Med Chem 50:6343-55. 2007
    ..3)H-Thymidine incorporation assays revealed the compounds to lower the rate of DNA synthesis, and flow cytometric analyses showed cell cycle arrest mainly in G 0/ G 1 phase...
  10. pmc Unsymmetric mono- and dinuclear platinum(IV) complexes featuring an ethylene glycol moiety: synthesis, characterization, and biological activity
    Verena Pichler
    Institute of Inorganic Chemistry, University of Vienna, Waehringer Strasse 42, A 1090 Vienna, Austria
    J Med Chem 55:11052-61. 2012
    ..To gain further insights into the mode of action, drug uptake, DNA synthesis inhibition, cell cycle effects, and induction of apoptosis were determined for two characteristic substances...
  11. doi request reprint Water-soluble cationic derivatives of indirubin, the active anticancer component from Indigo naturalis
    Werner Ginzinger
    University of Vienna, Institute of Inorganic Chemistry, Wahringer Str 42, A 1090 Vienna, Austria
    Chem Biodivers 9:2175-85. 2012
    ..In addition, the cytotoxic potency of new stable oxime ethers with a choline moiety and their influence on the cell cycle were tested in human cancer cell lines...
  12. doi request reprint A SAR study of novel antiproliferative ruthenium and osmium complexes with quinoxalinone ligands in human cancer cell lines
    Werner Ginzinger
    University of Vienna, Institute of Inorganic Chemistry, Wahringer Strasse 42, A 1090 Vienna, Austria
    J Med Chem 55:3398-413. 2012
    ..For selected compounds, the capacity to induce apoptosis was confirmed by fluorescence microscopy and flow-cytometric analysis, whereas cell cycle effects are only moderate...
  13. ncbi request reprint Effect of metal ion complexation and chalcogen donor identity on the antiproliferative activity of 2-acetylpyridine N,N-dimethyl(chalcogen)semicarbazones
    Christian R Kowol
    Institute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Waehringer Str 42, A 1090 Vienna, Austria
    J Inorg Biochem 101:1946-57. 2007
    ....
  14. doi request reprint Synthesis, characterization, and cytotoxic activity of novel potentially pH-sensitive nonclassical platinum(II) complexes featuring 1,3-dihydroxyacetone oxime ligands
    Yulia Yu Scaffidi-Domianello
    Institute of Inorganic Chemistry, University of Vienna, Wahringer Strasse 42, A 1090 Vienna, Austria
    Inorg Chem 50:10673-81. 2011
    ..4. A pH-dependent evaluation of antiproliferative effects of the two latter complexes at pH 7.4 and pH 6.0 revealed an activation under slightly acidic conditions, which might be of interest for further in vivo studies...
  15. doi request reprint Novel cis- and trans-configured bis(oxime)platinum(II) complexes: synthesis, characterization, and cytotoxic activity
    Yulia Yu Scaffidi-Domianello
    Institute of Inorganic Chemistry, University of Vienna, Wahringer Strasse 42, A 1090 Vienna, Austria
    Inorg Chem 49:5669-78. 2010
    ..The previously reported observation that the trans geometry yields a more active complex in the case of [PtCl(2)(Me(2)C=NOH)(2)] could be confirmed for at least two structural analogues...
  16. doi request reprint An electrochemical study of antineoplastic gallium, iron and ruthenium complexes with redox noninnocent alpha-N-heterocyclic chalcogensemicarbazones
    Christian R Kowol
    Institute of Inorganic Chemistry, University of Vienna, Wahringerstrasse 42, A 1090 Vienna, Austria
    Inorg Chem 47:11032-47. 2008
    ..The influence of water on the redox potentials of the complexes is reported and the physiological relevance of the electrochemical data for cytotoxicity as well as for ribonucleotide reductase inhibitory capacity are discussed...
  17. doi request reprint Tuning of lipophilicity and cytotoxic potency by structural variation of anticancer platinum(IV) complexes
    Michael R Reithofer
    University of Vienna, Institute of Inorganic Chemistry, Waehringer Str 42, A 1090 Vienna, Austria
    J Inorg Biochem 105:46-51. 2011
    ..Only minor effects for complexes featuring polar end groups were detected...
  18. doi request reprint Novel endothall-containing platinum(IV) complexes: synthesis, characterization, and cytotoxic activity
    Michael R Reithofer
    University of Vienna, Institute of Inorganic Chemistry, Wahringer Strasse 42, A 1090 Vienna
    Chem Biodivers 5:2160-70. 2008
    ....
  19. ncbi request reprint Novel di- and tetracarboxylatoplatinum(IV) complexes. Synthesis, characterization, cytotoxic activity, and DNA platination
    Michael R Reithofer
    Institute of Inorganic Chemistry, University of Vienna, Austria
    J Med Chem 50:6692-9. 2007
    ..DNA platination studies of selected complexes revealed a high DNA platination capacity in parallel to a high cytotoxic potential and vice versa...
  20. pmc Influence of extracellular pH on the cytotoxicity, cellular accumulation, and DNA interaction of novel pH-sensitive 2-aminoalcoholatoplatinum(II) complexes
    Seied Mojtaba Valiahdi
    Institute of Inorganic Chemistry, University of Vienna, Waehringer Strasse 42, 1090, Vienna, Austria
    J Biol Inorg Chem 18:249-60. 2013
    ..5. These results confirm the increased reactivity and in vitro activity of these compounds under slightly acidic conditions, encouraging further evaluation of ring-closed aminoalcoholatoplatinum(II) derivatives in solid tumors in vivo...
  21. doi request reprint Novel oximato-bridged platinum(II) di- and trimer(s): synthetic, structural, and in vitro anticancer activity studies
    Yulia Yu Scaffidi-Domianello
    Institute of Inorganic Chemistry, University of Vienna, Wahringer Strasse 42, A 1090 Vienna, Austria
    Inorg Chem 51:7153-63. 2012
    ....
  22. pmc Anticancer activity of methyl-substituted oxaliplatin analogs
    Ute Jungwirth
    Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Vienna, Austria
    Mol Pharmacol 81:719-28. 2012
    ..Hence, they might be promising metal-based anticancer drug candidates for further (pre)clinical evaluation...
  23. ncbi request reprint Redox-active antineoplastic ruthenium complexes with indazole: correlation of in vitro potency and reduction potential
    Michael A Jakupec
    Institute of Inorganic Chemistry, University of Vienna, Waehringer Strasse 42, A 1090 Vienna, Austria
    J Med Chem 48:2831-7. 2005
    ..Differences in the cellular uptake (probably resulting from different lipophilicity) contribute to this correlation but cannot solely account for it...
  24. pmc {(1R,2R,4R)-4-methyl-1,2-cyclohexanediamine}oxalatoplatinum(II): a novel enantiomerically pure oxaliplatin derivative showing improved anticancer activity in vivo
    Sergey A Abramkin
    University of Vienna, Institute of Inorganic Chemistry, Währinger Strasse 42, A 1090 Vienna, Austria
    J Med Chem 53:7356-64. 2010
    ..These data support further (pre)clinical development of the methyl-substituted oxaliplatin analogue with improved anticancer activity...
  25. pmc Theoretical investigations and density functional theory based quantitative structure-activity relationships model for novel cytotoxic platinum(IV) complexes
    Hristo P Varbanov
    Institute of Inorganic Chemistry, University of Vienna, Wahringer Strasse 42, A 1090 Vienna, Austria
    J Med Chem 56:330-44. 2013
    ..Reliable and robust QSAR models with good explanatory and predictive properties were obtained for both the cisplatin sensitive cell line CH1 and the intrinsically cisplatin resistant cell line SW480, with a set of four descriptors...
  26. doi request reprint Cellular accumulation and DNA interaction studies of cytotoxic trans-platinum anticancer compounds
    Caroline Bartel
    Institute of Inorganic Chemistry, University of Vienna, Austria
    J Biol Inorg Chem 17:465-74. 2012
    ..Whereas incubation with cis compounds did not induce degradation of DNA, the trans complexes led to pronounced strand cleavage...
  27. doi request reprint Influence of ascorbic acid on the activity of the investigational anticancer drug KP1019
    Caroline Bartel
    Institute of Inorganic Chemistry, University of Vienna, Austria
    J Biol Inorg Chem 16:1205-15. 2011
    ..Conclusively, our results indicate that application of high doses of ascorbic acid might increase the anticancer effects of KP1019...
  28. ncbi request reprint The first metal-based paullone derivative with high antiproliferative activity in vitro
    Anatoly Dobrov
    Institute of Inorganic Chemistry, University of Vienna, Waehringerstrasse 42, A 1090 Vienna, Austria
    Inorg Chem 45:1945-50. 2006
    ..The gallium complex was found to be 1.5-18-fold more cytotoxic than HL, with an average IC50 value of 2.0 microM...
  29. doi request reprint Novel tetracarboxylatoplatinum(IV) complexes as carboplatin prodrugs
    Hristo P Varbanov
    University of Vienna, Institute of Inorganic Chemistry, Waehringer Strasse 42, A 1090 Vienna, Austria
    Dalton Trans 41:14404-15. 2012
    ..It seems that not only the reduction potential, but also the rate of reduction has a tremendous influence on the cytotoxic properties. This has to be taken into account for the development of novel anticancer platinum(IV) agents...
  30. ncbi request reprint Tumour-inhibiting platinum(II) complexes with aminoalcohol ligands: biologically important transformations studied by micellar electrokinetic chromatography, nuclear magnetic resonance spectroscopy and mass spectrometry
    Petra Schluga
    Institute of Inorganic Chemistry Bioinorganic, Environmental and Radiochemistry, University of Vienna, Waehringer Str 42, A 1090 Vienna, Austria
    Analyst 130:1383-9. 2005
    ..This apparently takes place due to the shifting of the equilibrium towards the ring-opened species, induced by adduct formation between SDS and the platinum complex that was confirmed by electrospray ionization mass spectrometry...
  31. doi request reprint In vitro anticancer activity and biologically relevant metabolization of organometallic ruthenium complexes with carbohydrate-based ligands
    Isabella Berger
    Institute of Inorganic Chemistry, University of Vienna, Waehringer Str 42, 1090 Vienna, Austria
    Chemistry 14:9046-57. 2008
    ..In vitro studies revealed that the 3,5,6-bicyclophosphite-1,2-O-cyclohexylidene-alpha-D-glucofuranoside complex is the most cytotoxic compound in human cancer cell lines (IC50 values from 30 to 300 microM depending on the cell line)...
  32. pmc Diamminetetrakis(carboxylato)platinum(IV) complexes--synthesis, characterization, and cytotoxicity
    Björn R Hoffmeister
    University of Vienna, Institute of Inorganic Chemistry, Wahringer Strasse 42, AT 1090 Vienna
    Chem Biodivers 9:1840-8. 2012
    ..Astonishingly, raise in lipophilicity of the complexes, as found in the case of cisplatin analogs, did not result in a significant enhancement of the cytotoxic effect...
  33. doi request reprint Bulky N(,N)-(di)alkylethane-1,2-diamineplatinum(II) compounds as precursors for generating unsymmetrically substituted platinum(IV) complexes
    Verena Pichler
    Institute of Inorganic Chemistry, University of Vienna, Währinger Straße 42, A 1090 Vienna, Austria
    Inorg Chem 52:8151-62. 2013
    ....
  34. doi request reprint Lectin conjugates as biospecific contrast agents for MRI. Coupling of Lycopersicon esculentum agglutinin to linear water-soluble DTPA-loaded oligomers
    Irena Pashkunova-Martic
    Institute of Inorganic Chemistry, University of Vienna, Vienna, Austria
    Mol Imaging Biol 13:432-42. 2011
    ..The capacity for specific binding was assessed, and the MRI properties were examined in order to evaluate the use of these oligomers as components of selective perfusional contrast agents...
  35. doi request reprint Novel bis(carboxylato)dichlorido(ethane-1,2-diamine)platinum(IV) complexes with exceptionally high cytotoxicity
    Michael R Reithofer
    University of Vienna, Institute of Inorganic Chemistry, Waehringer Strasse 42, A 1090 Vienna, Austria
    J Inorg Biochem 102:2072-7. 2008
    ..Structure-activity relationships showed that the cytotoxicity increased with increasing lipophilicity of the alcoholate moiety yielding IC50 values in the low micromolar or even low nanomolar range...
  36. ncbi request reprint Synthesis and structure-activity relationships of mono- and dialkyl-substituted oxaliplatin derivatives
    Ladislav Habala
    Institute of Inorganic Chemistry Bioinorganic, Environmental and Radiochemistry, University of Vienna, Waehringerstr 42, A 1090 Vienna, Austria
    Eur J Med Chem 40:1149-55. 2005
    ..With respect to the antiproliferative properties, the 4-methyl-, cis-4,5-dimethyl-, and especially the 4,4-dimethyl-trans-cyclohexane-1,2-diamine(oxalato)platinum(II) complexes are the most promising candidates to be further evaluated...
  37. pmc Synthesis and characterization of novel bis(carboxylato)dichloridobis(ethylamine)platinum(IV) complexes with higher cytotoxicity than cisplatin
    Hristo Varbanov
    University of Vienna, Institute of Inorganic Chemistry, Wahringer Strasse 42, A 1090 Vienna, Austria
    Eur J Med Chem 46:5456-64. 2011
    ..Remarkably the most active (and also most lipophilic) compounds, having 4-propyloxy-4-oxobutanoato and 4-(2-propyloxy)-4-oxobutanoato axial ligands, showed IC(50) values down to the low nanomolar range...
  38. ncbi request reprint The first ruthenium-based paullones: syntheses, X-ray diffraction structures, and spectroscopic and antiproliferative properties in vitro
    Wolfgang F Schmid
    Institute of Inorganic Chemistry, Wahringerstr 42, A 1090 Vienna, Austria
    Inorg Chem 46:3645-56. 2007
    ..The novel complexes show an intercalative mode of interaction with DNA, which may render them attractive alternatives to metal compounds with a coordinative mode of interaction...
  39. pmc A novel class of bis- and tris-chelate diam(m)inebis(dicarboxylato)platinum(IV) complexes as potential anticancer prodrugs
    Hristo P Varbanov
    Institute of Inorganic Chemistry, University of Vienna, Waehringer Strasse 42, 1090 Vienna, Austria
    J Med Chem 57:6751-64. 2014
    ..The most promising drug candidate, 4b (Pt(DACH)(mal)2), demonstrated low in vivo toxicity but profound anticancer activity against both the L1210 leukemia and CT-26 colon carcinoma models. ..
  40. doi request reprint Mono-carboxylated diaminedichloridoplatinum(IV) complexes--selective synthesis, characterization, and cytotoxicity
    Verena Pichler
    University of Vienna, Institute of Inorganic Chemistry, Waehringer Strasse 42, A 1090, Vienna, Austria
    Dalton Trans 40:8187-92. 2011
    ..Remarkably, the most lipophilic complexes showed IC(50) values down to the low micromolar or even nanomolar range...
  41. pmc The first example of MEEKC-ICP-MS coupling and its application for the analysis of anticancer platinum complexes
    Anna K Bytzek
    Institute of Inorganic Chemistry, University of Vienna, Vienna, Austria
    Electrophoresis 31:1144-50. 2010
    ..The migration behavior of the Pt(II) and Pt(IV) compounds under investigation is correlated to their different chemical structures...
  42. doi request reprint Tumor microenvironment in focus: LA-ICP-MS bioimaging of a preclinical tumor model upon treatment with platinum(IV)-based anticancer agents
    Sarah Theiner
    Institute of Inorganic Chemistry, University of Vienna, Vienna, Austria
    Metallomics 7:1256-64. 2015
    ..To the best of our knowledge, this is the first LA-ICP-MS study on spatially-resolved platinum accumulation in tissues after repetitive platinum-based anticancer drug treatment of mice bearing a preclinical tumor model...
  43. pmc Comparative in vitro and in vivo pharmacological investigation of platinum(IV) complexes as novel anticancer drug candidates for oral application
    Sarah Theiner
    Institute of Inorganic Chemistry, University of Vienna, Waehringer Strasse 42, 1090, Vienna, Austria
    J Biol Inorg Chem 20:89-99. 2015
    ..Consequently, our data indicate that the prediction of in vivo anticancer activity by cell culture experiments is not trivial, especially for orally applied drugs. ..
  44. doi request reprint Solid-phase synthesis of oxaliplatin-TAT peptide bioconjugates
    Sergey Abramkin
    Institute of Inorganic Chemistry, University of Vienna, Vienna, Austria
    Dalton Trans 41:3001-5. 2012
    ..Both conjugates are active in the low micromolar range in CH1 and SW480 human cancer cells, requiring much lower concentrations than the untargeted analogs for equal effects...
  45. doi request reprint The role of the equatorial ligands for the redox behavior, mode of cellular accumulation and cytotoxicity of platinum(IV) prodrugs
    Simone Göschl
    Institute of Inorganic Chemistry, University of Vienna, Waehringer Strasse 42, A 1090 Vienna, Austria
    J Inorg Biochem 160:264-74. 2016
    ..Studies with ATP depletion mediated by oligomycin and low glucose partially confirmed these observations, but their feasibility was severely limited in the adherent cell culture setting. ..
  46. ncbi request reprint Platinum metallodrug-protein binding studies by capillary electrophoresis-inductively coupled plasma-mass spectrometry: characterization of interactions between Pt(II) complexes and human serum albumin
    Andrei R Timerbaev
    Institute of Inorganic Chemistry, University of Vienna, Vienna, Austria
    Electrophoresis 25:1988-95. 2004
    ..Also apparent was a two-step mechanism of the binding reaction. Results demonstrated the suitability of CE-ICP-MS as a rapid assay for high-throughput studying of drug/HSA interactions...
  47. ncbi request reprint Synthesis, structure, spectroscopic and in vitro antitumour studies of a novel gallium(III) complex with 2-acetylpyridine (4)N-dimethylthiosemicarbazone
    Vladimir B Arion
    Institute of Inorganic Chemistry of the University of Vienna, Waehringerstr 42, A 1090 Vienna, Austria
    J Inorg Biochem 91:298-305. 2002
    ..In vitro cytotoxic activity exceeds that of all other tested gallium(III) complexes and is slightly higher than that of HL...
  48. doi request reprint Capillary zone electrophoresis and capillary zone electrophoresis-electrospray ionization mass spectrometry studies on the behavior of anticancer cis- and trans-[dihalidobis(2-propanone oxime)platinum(II)] complexes in aqueous solutions
    Gerlinde Grabmann
    University of Vienna, Institute of Inorganic Chemistry, Vienna, Austria
    J Chromatogr A 1267:156-61. 2012
    ..Degradation of the trans isomers was significantly faster compared to their cis-configured counterparts also leading to different products which were characterized by hyphenation of CZE to ESI-MS...
  49. ncbi request reprint Tumor-inhibiting platinum(II) complexes with aminoalcohol ligands: comparison of the mode of action by capillary electrophoresis and electrospray ionization-mass spectrometry
    Christian G Hartinger
    Department of Inorganic Chemistry, University of Vienna, Vienna, Austria
    Electrophoresis 24:2038-44. 2003
    ..Also addressed was the interpretation of binding behavior as based on the structural features of the intact complexes, namely differing inclination to intramolecular chelation...
  50. ncbi request reprint The effect of cytoprotective agents in platinum anticancer therapy
    Michael A Jakupec
    Institute of Inorganic Chemistry, University of Vienna, Waehringer Strasse 42, A 1090 Vienna, Austria
    Met Ions Biol Syst 42:179-208. 2004
  51. ncbi request reprint Analysis of anticancer platinum(II)-complexes by microemulsion electrokinetic chromatography: separation of diastereomers and estimation of octanol-water partition coefficients
    Christina Rappel
    Institute of Inorganic Chemistry, University of Vienna, Vienna, Austria
    Electrophoresis 26:878-84. 2005
    ....
  52. doi request reprint Synthesis and structures of novel 1-methylcytosinato-bridged (ethylenediamine)platinum(II) and platinum(III) dinuclear complexes
    Vesna M Djinovic
    University of Vienna, Institute of Inorganic Chemistry, Wahringer Strasse 42, A 1090, Vienna, Austria
    Dalton Trans 39:3633-43. 2010
    ..The Pt-Pt distances in the platinum(iii) dimers are 2.5982(4) in 5 and 2.5569(3) A in 6...
  53. ncbi request reprint Antitumour metal compounds: more than theme and variations
    Michael A Jakupec
    Institute of Inorganic Chemistry, University of Vienna, Waehringer Strasse 42, 1090 Vienna, Austria
    Dalton Trans . 2008
    ..Other approaches focus on complexes with tumour-targeting properties, thereby maximizing the impact on cancer cells and minimizing the problem of adverse side effects, and complexes with biologically active ligands...
  54. doi request reprint Behavior of platinum(iv) complexes in models of tumor hypoxia: cytotoxicity, compound distribution and accumulation
    Ekaterina Schreiber-Brynzak
    Institute of Inorganic Chemistry, University of Vienna, Waehringer Strasse 42, 1090 Vienna, Austria
    Metallomics 8:422-33. 2016
    ....
  55. doi request reprint LA-ICP-MS imaging in multicellular tumor spheroids - a novel tool in the preclinical development of metal-based anticancer drugs
    Sarah Theiner
    Institute of Inorganic Chemistry, University of Vienna, Waehringer Strasse 42, 1090 Vienna, Austria
    Metallomics 8:398-402. 2016
    ..This corresponds to the proliferating outermost layers of cells and the necrotic core, respectively, indicating enhanced platinum sequestration in these regions. ..
  56. doi request reprint Influence of reducing agents on the cytotoxic activity of platinum(IV) complexes: induction of G2/M arrest, apoptosis and oxidative stress in A2780 and cisplatin resistant A2780cis cell lines
    Verena Pichler
    University of Vienna, Faculty of Chemistry, Institute of Inorganic Chemistry, Waehringer Strasse 42, 1090 Vienna, Austria
    Metallomics 7:1078-90. 2015
    ..These results confirm the connection between reduction and activity, and prove the strong impact of the reduction site on the activity of Pt(IV) complexes. ..
  57. doi request reprint Tetracarboxylatoplatinum(IV) complexes featuring monodentate leaving groups - A rational approach toward exploiting the platinum(IV) prodrug strategy
    Doris Hofer
    Institute of Inorganic Chemistry, University of Vienna, Waehringer Strasse 42, A 1090 Vienna, Austria
    J Inorg Biochem 153:259-71. 2015
    ....
  58. doi request reprint Bis- and Tetrakis(carboxylato)platinum(IV) complexes with mixed axial ligands - synthesis, characterization, and cytotoxicity
    Björn R Hoffmeister
    Institute of Inorganic Chemistry, University of Vienna, Waehringer Strasse 42, AT 1090 Vienna phone 43 1 427752600 fax 43 1 427752680
    Chem Biodivers 12:559-74. 2015
    ....
  59. ncbi request reprint [Development, importance and perspectives. Tumor inhibiting metal compounds]
    Markus Galanski
    Universitat Wien, Institut für Anoganische Chemie Bioanorganische, Umwelt Radiochemie
    Pharm Unserer Zeit 35:118-23. 2006
  60. ncbi request reprint Recent developments in the field of tumor-inhibiting metal complexes
    M Galanski
    Department of Inorganic Chemistry, University of Vienna, Vienna, Austria
    Curr Pharm Des 9:2078-89. 2003
    ....
  61. doi request reprint Lectin-Gd-loaded chitosan hydrogel nanoparticles: a new biospecific contrast agent for MRI
    Irena Pashkunova-Martic
    Institute of Inorganic Chemistry, University of Vienna, Wahringer Strasse 42, 1090 Vienna, Austria
    Mol Imaging Biol 13:16-24. 2011
    ..Here, we report on the synthesis of new selective lectin-gadolinium (Gd)-loaded chitosan nanoparticles with a prolonged clearance time and a much higher relaxivity in comparison to other preparations...
  62. doi request reprint Analysis of quaternary ammonium and phosphonium ionic liquids by reversed-phase high-performance liquid chromatography with charged aerosol detection and unified calibration
    Anja Stojanovic
    University of Vienna, Department of Inorganic Chemistry, Waehringer Strasse 42, A 1090 Vienna, Austria
    J Chromatogr A 1209:179-87. 2008
    ..Anomalies of CAD observed for the detection of some aromatic anions (thiosalicylate and benzoate) are discussed...
  63. ncbi request reprint Comparison of the binding behavior of oxaliplatin, cisplatin and analogues to 5'-GMP in the presence of sulfur-containing molecules by means of capillary electrophoresis and electrospray mass spectrometry
    A Kung
    Institute of Inorganic Chemistry, University of Vienna, Waehringerstrasse 42, A 1090, Vienna, Austria
    J Inorg Biochem 86:691-8. 2001
    ..Displacement of L-Met by 5'-GMP does not occur. Differences concerning the mode of action of oxaliplatin are expected. Characterization of the analytes was performed by UV, NMR and mass spectrometry...
  64. ncbi request reprint Design, synthesis, physical and chemical characterisation, and biological interactions of lectin-targeted latex nanoparticles bearing Gd-DTPA chelates: an exploration of magnetic resonance molecular imaging (MRMI)
    Irena Paschkunova-Martic
    Institute of Inorganic Chemistry, University of Vienna, Wahringerstrasse 42, 1090 Vienna, Austria
    Histochem Cell Biol 123:283-301. 2005
    ..The data suggest that 100-nm nanoparticles generate adequate contrast for MRMI and cause least disruption to endothelial cell surfaces...
  65. ncbi request reprint Tumour-inhibiting platinum complexes--state of the art and future perspectives
    M A Jakupec
    Institute of Inorganic Chemistry, University of Vienna, Wahringer Strasse 42, 1090, Vienna, Austria
    Rev Physiol Biochem Pharmacol 146:1-54. 2003
    ..The development of oral platinum drugs and drug targeting strategies using liposomes, polymers or low-molecular-weight carriers in order to improve the therapeutic index of platinum chemotherapy are also covered...
  66. ncbi request reprint Capillary electrophoretic study of carboplatin and analogues with nucleoside monophosphates, di- and trinucleotides
    A Kung
    Institute of Inorganic Chemistry, University of Vienna, Austria
    J Inorg Biochem 83:181-6. 2001
    ..A preference for GMP- and AMP-coordination was found. The ability of separating all four common nucleotides and their major platinum adducts in a single run demonstrates the suitability of CE for this kind of investigations...
  67. ncbi request reprint HPIC-UV-ICP-SFMS study of the interaction of cisplatin with guanosine monophosphate
    S Hann
    Institute of Chemistry, University of Agricultural Sciences, Vienna, Austria
    Fresenius J Anal Chem 370:581-6. 2001
    ..The P/Pt signal ratio of 2/1 obtained corresponds to the molar ratio in the bis adduct cis-[Pt(NH3)2(GMP)2]2-...
  68. ncbi request reprint (Aminoethanol)dichloroplatinum(II) complexes: influence of the hydroxyethyl moiety on 5'-GMP and DNA binding, intramolecular stability, the partition coefficient and anticancer activity
    Marc S Robillard
    Leiden Institute of Chemistry, Leiden University, PO Box 9502, 2300 RA Leiden, The Netherlands
    J Inorg Biochem 88:254-9. 2002
    ..No correlation between lipophilicity and anticancer activity was detected. Furthermore, the lipophilicity and anticancer activity could not be directly correlated to 5'-GMP or DNA binding activity...
  69. ncbi request reprint Analysis of platinum adducts with DNA nucleotides and nucleosides by capillary electrophoresis coupled to ESI-MS: indications of guanosine 5'-monophosphate O6-N7 chelation
    Ulrich Warnke
    Institute of Pharmacy, Department of Clinical Pharmacy, Freie Universitat Berlin, Germany
    Chembiochem 5:1543-9. 2004
    ..Additionally, offline MS experiments with 2'-deoxyguanosine (dG) and stabilization of the controversially discussed O(6)-N7 chelate by oxidation with hydrogen peroxide support the assumption of the existence of O(6)-N7 chelation...
  70. ncbi request reprint DNA interactions of pH-sensitive, antitumor bis(aminoalcohol)dichloroplatinum(II) complexes
    Stefanie Zorbas-Seifried
    Max Planck Institute of Biochemistry, Am Klopferspitz 18, D 82152 Martinsried, Germany
    Biochemistry 45:14817-25. 2006
    ..0. The results of this study may stimulate and contribute to further improvement of these novel, specific cytotoxic drugs that are anticipated to exert their full power in the tumor while being reasonably inactive in normal tissue...
  71. doi request reprint Resistance against novel anticancer metal compounds: differences and similarities
    Petra Heffeter
    Institute of Cancer Research, Department of Medicine I, Medical University Vienna, Austria
    Drug Resist Updat 11:1-16. 2008
    ....
  72. ncbi request reprint Signal separation and determination of the enantiomeric purity of primary amines with (-)-myrtenal--a 13C NMR study
    Francois Dufrasne
    Laboratoire de Chimie Pharmaceutique Organique, Institut de Pharmacie, Universite Libre de Bruxelles, CP 205 5, Campus Plaine, B 1050 Brussels, Belgium
    Spectrochim Acta A Mol Biomol Spectrosc 65:869-73. 2006
    ....