P Fratzl

Summary

Affiliation: University of Vienna
Country: Austria

Publications

  1. ncbi request reprint Bone mineralization as studied by small-angle x-ray scattering
    P Fratzl
    Materials Physics Institute, University of Vienna, Austria
    Connect Tissue Res 34:247-54. 1996
  2. ncbi request reprint Bone mineralization density distribution in health and disease
    P Roschger
    4th Medical Department, Hanusch Hospital, Heinrich Collin Street 30, A 1140, Vienna, Austria
    Bone 42:456-66. 2008
  3. ncbi request reprint Two different correlations between nanoindentation modulus and mineral content in the bone-cartilage interface
    H S Gupta
    Department of Biomaterials, Max Planck Institute of Colloids and Interfaces, Germany
    J Struct Biol 149:138-48. 2005
  4. ncbi request reprint Combined treatment with PTH (1-34) and OPG increases bone volume and uniformity of mineralization in aged ovariectomized rats
    A Valenta
    Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, 4th Medical Department, Hanusch Hospital Heinrich Collin Str 30 A 1140 Vienna, Austria
    Bone 37:87-95. 2005
  5. ncbi request reprint Constant mineralization density distribution in cancellous human bone
    P Roschger
    Ludwig Boltzmann Institute of Osteology, 4th Medical Department, Hanusch Hospital and UKH Meidling, Vienna, Austria
    Bone 32:316-23. 2003
  6. ncbi request reprint Structural development of the mineralized tissue in the human L4 vertebral body
    P Roschger
    Ludwig Boltzmann Institute of Osteology, 4th Medical Department, Hanusch Hospital and UKH-Meidling, Vienna, Austria
    J Struct Biol 136:126-36. 2001
  7. ncbi request reprint Age- and genotype-dependence of bone material properties in the osteogenesis imperfecta murine model (oim)
    B Grabner
    Ludwig Boltzmann Institute of Osteology, Fourth Medical Department, Hanusch Hospital and UKH Meidling, Vienna, Austria
    Bone 29:453-7. 2001
  8. ncbi request reprint Alendronate increases degree and uniformity of mineralization in cancellous bone and decreases the porosity in cortical bone of osteoporotic women
    P Roschger
    Ludwig Boltzmann Institute of Osteology, Fourth Medical Department, Hanusch Krankenhaus and Unfallkrankenhaus Meidling, Vienna, Austria
    Bone 29:185-91. 2001
  9. ncbi request reprint The bone mineralization density distribution as a fingerprint of the mineralization process
    D Ruffoni
    Max Planck Institute of Colloids and Interfaces, Department of Biomaterials, 14424 Potsdam, Germany
    Bone 40:1308-19. 2007
  10. ncbi request reprint Normal mineralization and nanostructure of sclerotic bone in mice overexpressing Fra-1
    P Roschger
    Ludwig Boltzmann Institute of Osteology and Fourth Med Department, Hanusch Hospital and UKH Meidling, Vienna, Austria
    Bone 34:776-82. 2004

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Bone mineralization as studied by small-angle x-ray scattering
    P Fratzl
    Materials Physics Institute, University of Vienna, Austria
    Connect Tissue Res 34:247-54. 1996
    ..The SAXS results also suggest the existence of needle-shaped mineral crystals in mouse or rat bone and more plate-shaped crystals in other tissues like adult human bone or mineralized turkey leg tendon...
  2. ncbi request reprint Bone mineralization density distribution in health and disease
    P Roschger
    4th Medical Department, Hanusch Hospital, Heinrich Collin Street 30, A 1140, Vienna, Austria
    Bone 42:456-66. 2008
    ....
  3. ncbi request reprint Two different correlations between nanoindentation modulus and mineral content in the bone-cartilage interface
    H S Gupta
    Department of Biomaterials, Max Planck Institute of Colloids and Interfaces, Germany
    J Struct Biol 149:138-48. 2005
    ..2D material property maps of the ZCC were generated from the mechanical-mineral correlation, showing that bands of high and low stiffness were found between the bone and tidemark, and between the ZCC and the unmineralized cartilage...
  4. ncbi request reprint Combined treatment with PTH (1-34) and OPG increases bone volume and uniformity of mineralization in aged ovariectomized rats
    A Valenta
    Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, 4th Medical Department, Hanusch Hospital Heinrich Collin Str 30 A 1140 Vienna, Austria
    Bone 37:87-95. 2005
    ....
  5. ncbi request reprint Constant mineralization density distribution in cancellous human bone
    P Roschger
    Ludwig Boltzmann Institute of Osteology, 4th Medical Department, Hanusch Hospital and UKH Meidling, Vienna, Austria
    Bone 32:316-23. 2003
    ..Because we find the BMDD to be essentially constant in healthy adult humans, qBEI provides a sensitive means to detect even small changes in mineralization due to bone disease or therapeutic intervention...
  6. ncbi request reprint Structural development of the mineralized tissue in the human L4 vertebral body
    P Roschger
    Ludwig Boltzmann Institute of Osteology, 4th Medical Department, Hanusch Hospital and UKH-Meidling, Vienna, Austria
    J Struct Biol 136:126-36. 2001
    ..CaMaxFreq and mean particle thickness increase rapidly during the first years and reach saturation. Remarkably, when these parameters are plotted versus logarithm of age, they appear linear...
  7. ncbi request reprint Age- and genotype-dependence of bone material properties in the osteogenesis imperfecta murine model (oim)
    B Grabner
    Ludwig Boltzmann Institute of Osteology, Fourth Medical Department, Hanusch Hospital and UKH Meidling, Vienna, Austria
    Bone 29:453-7. 2001
    ..A second model for possible collagen-mineral association in oim material would consist of two families of mineral crystals, one being smaller and the other being much larger than the crystals found in normal mouse long bones...
  8. ncbi request reprint Alendronate increases degree and uniformity of mineralization in cancellous bone and decreases the porosity in cortical bone of osteoporotic women
    P Roschger
    Ludwig Boltzmann Institute of Osteology, Fourth Medical Department, Hanusch Krankenhaus and Unfallkrankenhaus Meidling, Vienna, Austria
    Bone 29:185-91. 2001
    ..It also decreases the porosity of the corticalis. Together these effects may contribute to the observed reduction in fractures...
  9. ncbi request reprint The bone mineralization density distribution as a fingerprint of the mineralization process
    D Ruffoni
    Max Planck Institute of Colloids and Interfaces, Department of Biomaterials, 14424 Potsdam, Germany
    Bone 40:1308-19. 2007
    ..This is of important clinical interest because it helps to find therapeutic approaches directly targeting the primary etiological defects to correct the patients' BMDD towards normal BMDD...
  10. ncbi request reprint Normal mineralization and nanostructure of sclerotic bone in mice overexpressing Fra-1
    P Roschger
    Ludwig Boltzmann Institute of Osteology and Fourth Med Department, Hanusch Hospital and UKH Meidling, Vienna, Austria
    Bone 34:776-82. 2004
    ..The bone nanostructure did not show abnormalities in Fra-1 transgenic or Fos-/-. These results provide a rationale for the development of therapeutic applications involving Fra-1-induced bone formation...
  11. ncbi request reprint Lead accumulation in tidemark of articular cartilage
    N Zoeger
    Vienna University of Technology, Atominstitut, Stadionallee 2, 1020 Vienna, Austria
    Osteoarthritis Cartilage 14:906-13. 2006
    ..Determination of the spatial distribution of the toxic element lead (Pb) and other trace elements in normal articular cartilage and subchondral bone from adult humans with no history of work-related exposure to Pb...
  12. ncbi request reprint Association of COLIA1 Sp1 alleles with defective bone nodule formation in vitro and abnormal bone mineralization in vivo
    T L Stewart
    Department of Medicine and Therapeutics, University of Aberdeen Medical School, Aberdeen, AB25 2ZD, UK
    Calcif Tissue Int 77:113-8. 2005
    ..This suggests that the increased bone fragility in carriers of the COLIA1 Sp1 allele may result in part from defects in bone mineralization...
  13. ncbi request reprint Bone osteonal tissues by Raman spectral mapping: orientation-composition
    M Kazanci
    Max Planck Institute of Colloids and Interfaces, Department of Biomaterials, 14424 Potsdam, Germany
    J Struct Biol 156:489-96. 2006
    ..Moreover, the results of the present study demonstrate the versatility of the analytical technique, and provide insights into the organization of bone tissue at the ultrastructural level...
  14. ncbi request reprint Synchrotron diffraction study of deformation mechanisms in mineralized tendon
    H S Gupta
    Max Planck Institute of Colloids and Interfaces, Department of Biomaterials, 14424 Potsdam, Germany
    Phys Rev Lett 93:158101. 2004
    ..Scanning electron microscopy measurements lead us to conclude that the inhomogeneous mineralization in mineralized tendon is at the origin of the high fracture strain...
  15. ncbi request reprint Targeted overexpression of vitamin D receptor in osteoblasts increases calcium concentration without affecting structural properties of bone mineral crystals
    B M Misof
    Ludwig Boltzmann Institute of Osteology, 4th Med Dept, Hanusch Hospital and UKH Meidling, Vienna, Austria
    Calcif Tissue Int 73:251-7. 2003
    ....
  16. ncbi request reprint Mineralized microstructure of calcified avian tendons: a scanning small angle X-ray scattering study
    H S Gupta
    Ludwig Boltzmann Institute of Osteology, 4th Med Dept, Hanusch Hospital, Vienna, Austria
    Calcif Tissue Int 72:567-76. 2003
    ....
  17. ncbi request reprint Characteristics of mineral particles in the human bone/cartilage interface
    I Zizak
    Erich Schmid Institute of Materials Science and Metal Physics Institute, Austrian Academy of Sciences and University of Leoben, Jahnstr 12, A 8700, Leoben, Austria
    J Struct Biol 141:208-17. 2003
    ..The tight bonding of mineralized cartilage to bone suggests a mechanical role for the interface of the two elastically different tissues, bone and cartilage...
  18. ncbi request reprint Orientation of mineral crystallites and mineral density during skeletal development in mice deficient in tissue nonspecific alkaline phosphatase
    W Tesch
    Ludwig Boltzmann Institute of Osteology 4th Medical Department, Hanusch Hospital and UKH Meidling, Vienna, Austria
    J Bone Miner Res 18:117-25. 2003
    ....
  19. ncbi request reprint Graded microstructure and mechanical properties of human crown dentin
    W Tesch
    Ludwig Boltzmann Institute of Osteology, 4th Medical Department, Hanusch Hospital, Vienna, Austria
    Calcif Tissue Int 69:147-57. 2001
    ..Hence, the observed variations of mechanical and structural properties in an area between 0 and 1.5 mm below the DEJ define crown dentin as a gradient material optimized for its mechanical function...
  20. ncbi request reprint p53 influences mice skeletal development
    K Ohyama
    Department of Biochemistry, School of Dental Medicine, University of Pennsylvania, Philadelphia 19104, USA
    J Craniofac Genet Dev Biol 17:161-71. 1997
    ..On this basis, we predict that after birth, in mice that survive, differences in bone length would become minimal, and at maturity, the length of the long bones of (+/+) and (-/-) mice would be similar...
  21. pmc Bone mineralization in an osteogenesis imperfecta mouse model studied by small-angle x-ray scattering
    P Fratzl
    Ludwig Boltzmann Institute for Osteology, 4th Medical Department, Hanusch Hospital, Vienna, Austria
    J Clin Invest 97:396-402. 1996
    ..94, P < 0.001) between the two parameters. The presence of smaller crystals with more variable alignment in corticalis of oim/oim mice may contribute to the brittleness of their bone, similar to that of human osteogenesis imperfecta...