B J Dickson

Summary

Affiliation: University of Vienna
Country: Austria

Publications

  1. ncbi Netrins
    Barry J Dickson
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030, Vienna, Austria
    Curr Biol 12:R154-5. 2002
  2. ncbi Regulation of commissural axon pathfinding by slit and its Robo receptors
    Barry J Dickson
    Research Institute of Molecular Pathology IMP, A 1030 Vienna, Austria
    Annu Rev Cell Dev Biol 22:651-75. 2006
  3. ncbi fruitless regulates aggression and dominance in Drosophila
    Eleftheria Vrontou
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Nat Neurosci 9:1469-71. 2006
  4. ncbi Molecular mechanisms of axon guidance
    Barry J Dickson
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Science 298:1959-64. 2002
  5. ncbi Axon guidance: growth cones make an unexpected turn
    Barry J Dickson
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Curr Biol 12:R218-20. 2002
  6. ncbi Development. Wiring the brain with insulin
    Barry J Dickson
    Institute of Molecular Biotechnology, Austrian Academy of Sciences, Vienna, Austria
    Science 300:440-1. 2003
  7. ncbi Rho GTPases in growth cone guidance
    B J Dickson
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Curr Opin Neurobiol 11:103-10. 2001
  8. ncbi Crossing the midline: roles and regulation of Robo receptors
    S Rajagopalan
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030, Vienna, Austria
    Neuron 28:767-77. 2000
  9. ncbi Short- and long-range repulsion by the Drosophila Unc5 netrin receptor
    K Keleman
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Neuron 32:605-17. 2001
  10. ncbi Trio combines with dock to regulate Pak activity during photoreceptor axon pathfinding in Drosophila
    T P Newsome
    Research Institute of Molecular Pathology, Vienna, Austria
    Cell 101:283-94. 2000

Collaborators

  • Takashi Suzuki
  • Frank Schnorrer
  • Carlos Ribeiro
  • J Berger
  • Doris Chen
  • Marko Brankatschk
  • F Eisenhaber
  • Julian Ng
  • Giorgio F Gilestro
  • ULRIKE A HEBERLEIN
  • Yimin Zou
  • Liqun Luo
  • S Zipursky
  • S Schmidt
  • Pontus Aspenstrom
  • Marco Gallio
  • Krystyna Keleman
  • Ebru Demir
  • Nilay Yapici
  • Jai Y Yu
  • Africa Couto
  • Young Joon Kim
  • Duda Kvitsiani
  • Georg Dietzl
  • K Keleman
  • Bettina Spitzweck
  • S Rajagopalan
  • T P Newsome
  • Martin Häsemeyer
  • Andrea Pauli
  • Rosemarie V Barkus
  • Sandeep Robert Datta
  • Amina Kurtovic
  • Daisuke Hattori
  • Lora B Sweeney
  • Mattias Alenius
  • Eleftheria Vrontou
  • Petra Stockinger
  • Christine E Holt
  • Annika Lundström
  • Kirsten André Senti
  • Satoko Hakeda-Suzuki
  • Ju Youn Lee
  • K Senti
  • Neil Audsley
  • Milica Markovic
  • Naoki Yamanaka
  • B Asling
  • Elwyn Isaac
  • Yong Chul Kim
  • Yoshiaki Tanaka
  • Katarina Bartalska
  • E Nicolas
  • V Vivancos
  • Dai Horiuchi
  • Christian F Lehner
  • Allan Wong
  • Vanessa Ruta
  • Oren Schuldiner
  • William M Saxton
  • Sean Luo
  • Friederike Althoff
  • Raquel A Oliveira
  • Stefan Heidmann
  • Maria Luisa Vasconcelos
  • Jorge Flores
  • Karen Balonze
  • Olga Klyachko
  • Richard Axel
  • Kim Nasmyth
  • Sebastian Krüttner
  • Kuan Chung Su
  • Takaki Komiyama
  • Erika Viragh
  • Silvia Oppel
  • Alexandre Widmer
  • Beate Gasser
  • Ya Hui Chou
  • Ho Won Kim
  • Michaela Fellner
  • Vincent Marra
  • Daniela Berdnik
  • Kaolin Kinsey
  • Susanne Scheiblauer
  • Yulia Barinova
  • Steven P Nilsen
  • Edward A Kravitz
  • Shay Rotkopf
  • László Tirián
  • Johanna Hemphälä

Detail Information

Publications49

  1. ncbi Netrins
    Barry J Dickson
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030, Vienna, Austria
    Curr Biol 12:R154-5. 2002
  2. ncbi Regulation of commissural axon pathfinding by slit and its Robo receptors
    Barry J Dickson
    Research Institute of Molecular Pathology IMP, A 1030 Vienna, Austria
    Annu Rev Cell Dev Biol 22:651-75. 2006
    ..We hope that this review encourages further efforts to tackle these questions, in the expectation that this system will continue to reveal the general principles of axon pathfinding...
  3. ncbi fruitless regulates aggression and dominance in Drosophila
    Eleftheria Vrontou
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Nat Neurosci 9:1469-71. 2006
    ..Here we show that sex-specific splicing of the fruitless gene plays a critical role in determining who and how a fly fights, and whether a dominance relationship forms...
  4. ncbi Molecular mechanisms of axon guidance
    Barry J Dickson
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Science 298:1959-64. 2002
    ..With such regulatory mechanisms in place, a relatively small number of guidance factors can be used to generate intricate patterns of neuronal wiring...
  5. ncbi Axon guidance: growth cones make an unexpected turn
    Barry J Dickson
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Curr Biol 12:R218-20. 2002
    ..Axonal growth cones can turn in response to minute concentration differences in extracellular guidance cues. Surprising new work suggests that these cues might steer the growth cone by inducing rapid local changes in protein levels...
  6. ncbi Development. Wiring the brain with insulin
    Barry J Dickson
    Institute of Molecular Biotechnology, Austrian Academy of Sciences, Vienna, Austria
    Science 300:440-1. 2003
  7. ncbi Rho GTPases in growth cone guidance
    B J Dickson
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Curr Opin Neurobiol 11:103-10. 2001
    ..The growth cone is therefore guided by signals transduced both via and independently of Rho GTPases...
  8. ncbi Crossing the midline: roles and regulation of Robo receptors
    S Rajagopalan
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030, Vienna, Austria
    Neuron 28:767-77. 2000
    ..Robo2 and Robo3 levels are also tightly regulated, most likely by a mechanism similar to but distinct from the regulation of Robo by Comm...
  9. ncbi Short- and long-range repulsion by the Drosophila Unc5 netrin receptor
    K Keleman
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Neuron 32:605-17. 2001
    ..Ectopic expression of Unc5 on CNS axons can elicit either short- or long-range repulsion from the midline. Both short- and long-range repulsion require Netrin function, but only long-range repulsion requires Frazzled...
  10. ncbi Trio combines with dock to regulate Pak activity during photoreceptor axon pathfinding in Drosophila
    T P Newsome
    Research Institute of Molecular Pathology, Vienna, Austria
    Cell 101:283-94. 2000
    ..We propose that distinct signals transduced via Trio and Dock act combinatorially to activate Pak in spatially restricted domains within the growth cone, thereby controlling the direction of axon extension...
  11. ncbi brakeless is required for lamina targeting of R1-R6 axons in the Drosophila visual system
    K Senti
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Development 127:2291-301. 2000
    ..These data demonstrate the existence of a lamina-specific targeting mechanism for R1-R6 axons in the Drosophila visual system, and provide the first entry point in the molecular characterization of this process...
  12. ncbi Selecting a longitudinal pathway: Robo receptors specify the lateral position of axons in the Drosophila CNS
    S Rajagopalan
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Cell 103:1033-45. 2000
    ..Local cues further refine the lateral position. Together, these long- and short-range guidance cues allow growth cones to select with precision a specific longitudinal pathway...
  13. ncbi Comm function in commissural axon guidance: cell-autonomous sorting of Robo in vivo
    Krystyna Keleman
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohr Gasse 3 5, A 1030 Vienna, Austria
    Nat Neurosci 8:156-63. 2005
    ..We show here, however, that ubiquitination of Comm is not required for its function in vitro or in vivo, and that Nedd4 is unlikely to function in axon guidance at the midline...
  14. ncbi Flamingo regulates R8 axon-axon and axon-target interactions in the Drosophila visual system
    Kirsten André Senti
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Curr Biol 13:828-32. 2003
    ..The latter, together with the finding that N-Cadherin has an analogous role in R7 axon-target interactions, points to a cadherin-based system for target layer specificity in the Drosophila visual system...
  15. ncbi Comm sorts robo to control axon guidance at the Drosophila midline
    Krystyna Keleman
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Cell 110:415-27. 2002
    ..Axon traffic at the CNS midline is thus controlled by the intracellular trafficking of the Robo guidance receptor, which in turn depends on the precisely regulated expression of the Comm sorting receptor...
  16. ncbi Sexual behaviour: do a few dead neurons make the difference?
    Jai Y Yu
    Institute of Molecular Pathology, A 1030 Vienna, Austria
    Curr Biol 16:R23-5. 2006
    ..Might this explain why males and females have such distinct sexual behaviours?..
  17. doi Distinct protein domains and expression patterns confer divergent axon guidance functions for Drosophila Robo receptors
    Bettina Spitzweck
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Cell 140:409-20. 2010
    ..These data demonstrate how diversification of expression and structure within a single family of guidance receptors can shape complex patterns of neuronal wiring...
  18. ncbi Neural circuitry that governs Drosophila male courtship behavior
    Petra Stockinger
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences, A 1030 Vienna, Austria
    Cell 121:795-807. 2005
    ..This circuit includes olfactory neurons required for the behavioral response to sex pheromones. Anatomical differences in this circuit that might account for the dramatic differences in male and female sexual behavior are not apparent...
  19. ncbi fruitless splicing specifies male courtship behavior in Drosophila
    Ebru Demir
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences, A 1030 Vienna, Austria
    Cell 121:785-94. 2005
    ..These females direct their courtship toward other females (or males engineered to produce female pheromones). The splicing of a single neuronal gene thus specifies essentially all aspects of a complex innate behavior...
  20. ncbi A receptor that mediates the post-mating switch in Drosophila reproductive behaviour
    Nilay Yapici
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Nature 451:33-7. 2008
    ..SPR is highly conserved across insects, opening up the prospect of new strategies to control the reproductive and host-seeking behaviours of agricultural pests and human disease vectors...
  21. ncbi Axon guidance: morphogens show the way
    Frank Schnorrer
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohr Gasse 7, A 1030, Vienna, Austria
    Curr Biol 14:R19-21. 2004
    ..Surprising new studies show that members of these same protein families also act as guidance cues for growing axons in the developing nervous system...
  22. ncbi Analysis of Drosophila photoreceptor axon guidance in eye-specific mosaics
    T P Newsome
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Development 127:851-60. 2000
    ..Rather, we suggest that PTP69D plays a permissive role, perhaps reducing the adhesion of R1-R6 and R7 growth cones to the pioneer R8 axon so that they can respond independently to their specific targeting cues...
  23. ncbi Netrins guide Drosophila commissural axons at short range
    Marko Brankatschk
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohr Gasse 3 5, A 1030 Vienna, Austria
    Nat Neurosci 9:188-94. 2006
    ..We therefore propose that netrins act in commissural axon guidance as short-range cues that promote midline crossing, not as long-range chemoattractants...
  24. ncbi The transmembrane protein Kon-tiki couples to Dgrip to mediate myotube targeting in Drosophila
    Frank Schnorrer
    Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Dev Cell 12:751-66. 2007
    ..Forced overexpression of Kon stimulates muscle motility. We propose that Kon promotes directed myotube migration and transduces a target-derived signal that initiates the formation of a stable connection...
  25. ncbi Genetic mapping with SNP markers in Drosophila
    J Berger
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7 A 1030, Vienna, Austria
    Nat Genet 29:475-81. 2001
    ..These methods should accelerate the rate of positional cloning in Drosophila...
  26. ncbi Function of the Drosophila CPEB protein Orb2 in long-term courtship memory
    Krystyna Keleman
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Nat Neurosci 10:1587-93. 2007
    ..Our data thus demonstrate that a CPEB protein is important in long-term memory and map the molecular, spatial and temporal requirements for its function in memory formation...
  27. ncbi Rac function and regulation during Drosophila development
    Satoko Hakeda-Suzuki
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Nature 416:438-42. 2002
    ..Different Rac activators thus act in different developmental processes. The specific cellular response to Rac activation may be determined more by the upstream activator than the specific Rac protein involved...
  28. doi Sex peptide receptor and neuronal TOR/S6K signaling modulate nutrient balancing in Drosophila
    Carlos Ribeiro
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Curr Biol 20:1000-5. 2010
    ..We propose that the brain uses these internal states to assign value to external sensory information from potential food sources, thereby guiding food choice and ensuring nutrient homeostasis...
  29. pmc MIPs are ancestral ligands for the sex peptide receptor
    Young Joon Kim
    Research Institute of Molecular Pathology, A 1030 Vienna, Austria
    Proc Natl Acad Sci U S A 107:6520-5. 2010
    ..We conclude that MIPs are evolutionarily conserved ligands for SPR, which are likely to mediate functions other than the regulation of female reproductive behaviors...
  30. doi Wired for sex: the neurobiology of Drosophila mating decisions
    Barry J Dickson
    Research Institute of Molecular Pathology, Doktor Bohr Gasse 7, A 1030 Vienna, Austria
    Science 322:904-9. 2008
    ..This simple and genetically tractable system provides an excellent model to explore the neurobiology of decision making...
  31. pmc Navigating intermediate targets: the nervous system midline
    Barry J Dickson
    Research Institute of Molecular Pathology, Dr Bohrgasse 7, A 1030 Vienna, Austria
    Cold Spring Harb Perspect Biol 2:a002055. 2010
    ..And for many of these axons the midline provides signals that guide them along specific lateral pathways or up and down the longitudinal axis...
  32. doi Sensory neurons in the Drosophila genital tract regulate female reproductive behavior
    Martin Häsemeyer
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Neuron 61:511-8. 2009
    ..These neurons project to regions of the central nervous system that have been implicated in the control of reproductive behaviors in Drosophila and other insects...
  33. ncbi A single class of olfactory neurons mediates behavioural responses to a Drosophila sex pheromone
    Amina Kurtovic
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Nature 446:542-6. 2007
    ..Thus, activation of a single ORN class is both necessary and sufficient to mediate behavioural responses to the Drosophila sex pheromone cVA...
  34. ncbi A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila
    Georg Dietzl
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences IMBA, Dr Bohr Gasse 3 5, A 1030 Vienna, Austria
    Nature 448:151-6. 2007
    ..Our transgenic RNAi library thus opens up the prospect of systematically analysing gene functions in any tissue and at any stage of the Drosophila lifespan...
  35. doi High-resolution, high-throughput SNP mapping in Drosophila melanogaster
    Doris Chen
    Research Institute of Molecular Pathology IMP, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Nat Methods 5:323-9. 2008
    ..3 kb, and demonstrated the utility of these tools by rapidly mapping 14 mutations that disrupt embryonic muscle patterning. These resources enable high-resolution high-throughput genetic mapping in Drosophila...
  36. ncbi Muscle building; mechanisms of myotube guidance and attachment site selection
    Frank Schnorrer
    Institute of Molecular Biotechnology IMBA, Austrian Academy of Sciences, Dr Bohr Gasse 3 5, 1030 Vienna, Austria
    Dev Cell 7:9-20. 2004
    ..Much of this knowledge comes from studies in Drosophila, where powerful methods for in vivo imaging and genetic manipulation can be used to tackle this important but largely unsolved problem in developmental biology...
  37. doi Neuroscience: hidden female talent
    Jai Y Yu
    Nature 453:41-2. 2008
  38. pmc Systematic identification of genes that regulate neuronal wiring in the Drosophila visual system
    Jürg Berger
    Max Planck Institute of Neurobiology, Martinsried, Germany
    PLoS Genet 4:e1000085. 2008
    ..This work demonstrates the feasibility of combining large-scale gene identification with large-scale mutagenesis in Drosophila, and provides a comprehensive overview of the molecular mechanisms that regulate visual system wiring...
  39. pmc Identification of an axonal kinesin-3 motor for fast anterograde vesicle transport that facilitates retrograde transport of neuropeptides
    Rosemarie V Barkus
    Department of Biology, Indiana University, Bloomington, IN 47405 3700, USA
    Mol Biol Cell 19:274-83. 2008
    ..This suggests that Unc-104, a member of an anterograde kinesin subfamily, contributes to an organelle-specific dynein-driven retrograde transport mechanism...
  40. doi The Drosophila pheromone cVA activates a sexually dimorphic neural circuit
    Sandeep Robert Datta
    Department of Biochemistry and Molecular Biophysics and Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Nature 452:473-7. 2008
    ..The observation that cVA activates a sexually dimorphic circuit in the protocerebrum suggests a mechanism by which a single pheromone can elicit different behaviours in males and in females...
  41. pmc Cell-type-specific TEV protease cleavage reveals cohesin functions in Drosophila neurons
    Andrea Pauli
    Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK
    Dev Cell 14:239-51. 2008
    ..These data demonstrate essential roles for cohesin in nondividing cells and also introduce a powerful tool by which to investigate protein function in metazoa...
  42. pmc Dscam diversity is essential for neuronal wiring and self-recognition
    Daisuke Hattori
    Department of Biological Chemistry, Howard Hughes Medical Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90049, USA
    Nature 449:223-7. 2007
    ..We conclude that Dscam diversity provides each neuron with a unique identity by which it can distinguish its own processes from those of other neurons, and that this self-recognition is essential for wiring the Drosophila brain...
  43. ncbi Shared neural circuitry for female and male sexual behaviours in Drosophila
    Duda Kvitsiani
    Curr Biol 16:R355-6. 2006
  44. ncbi Temporal target restriction of olfactory receptor neurons by Semaphorin-1a/PlexinA-mediated axon-axon interactions
    Lora B Sweeney
    Howard Hughes Medical Institute, Department of Biological Sciences and Neurosciences Program, Stanford University, Stanford, CA 94305, USA
    Neuron 53:185-200. 2007
    ..We propose that Sema-1a/PlexinA-mediated repulsion provides a mechanism by which early-arriving ORN axons constrain the target choices of late-arriving axons...
  45. pmc Vilse, a conserved Rac/Cdc42 GAP mediating Robo repulsion in tracheal cells and axons
    Annika Lundström
    Department of Developmental Biology, Wenner Gren Institute, Stockholm University, S 106 96 Stockholm, Sweden
    Genes Dev 18:2161-71. 2004
    ..These results together with genetic interaction experiments with robo, vilse, and rac mutants suggest a mechanism whereby Robo repulsion is mediated by the localized inactivation of Rac through Vilse...
  46. ncbi Rac GTPases control axon growth, guidance and branching
    Julian Ng
    Department of Biological Sciences, Stanford University, Stanford, California 94305, USA
    Nature 416:442-7. 2002
    ..These results demonstrate the central role of Rac GTPases in multiple aspects of axon development in vivo, and suggest that axon growth, guidance and branching could be controlled by differential activation of Rac signalling pathways...
  47. ncbi Molecular, anatomical, and functional organization of the Drosophila olfactory system
    Africa Couto
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohr Gasse 3 5 A 1030 Vienna, Austria
    Curr Biol 15:1535-47. 2005
    ..A comprehensive understanding of the molecular and neural mechanisms of odor detection and processing requires complete maps of odorant receptor (Or) expression and ORN connectivity, preferably at single-cell resolution...
  48. ncbi Wnts send axons up and down the spinal cord
    Barry J Dickson
    Nat Neurosci 8:1130-2. 2005
  49. pmc Sugar codes for axons?
    Christine E Holt
    Department of Anatomy, University of Cambridge, Downing Street, Cambridge, CB2 3DY, United Kingdom
    Neuron 46:169-72. 2005
    ..This raises the intriguing possibility that the complexity of neuronal wiring may in part reflect the complexity of proteoglycan modifications...