G Brandacher

Summary

Affiliation: University of Innsbruck
Country: Austria

Publications

  1. ncbi Prognostic value of indoleamine 2,3-dioxygenase expression in colorectal cancer: effect on tumor-infiltrating T cells
    Gerald Brandacher
    Department of General and Transplant Surgery, Innsbruck Medical University, Austria
    Clin Cancer Res 12:1144-51. 2006
  2. ncbi Non-invasive monitoring of kidney allograft rejection through IDO metabolism evaluation
    G Brandacher
    Department of General and Transplant Surgery, Innsbruck Medical University, Innsbruck, Austria
    Kidney Int 71:60-7. 2007
  3. doi The Innsbruck hand transplant program: update at 8 years after the first transplant
    G Brandacher
    Center of Operative Medicine, Department of Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, Innsbruck, Austria
    Transplant Proc 41:491-4. 2009
  4. pmc Donor pretreatment with tetrahydrobiopterin saves pancreatic isografts from ischemia reperfusion injury in a mouse model
    M Maglione
    Department of Visceral, Transplant and Thoracic Surgery, Center of Operative Medicine, Center of Operative Medicine, Innsbruck Medical University, Austria
    Am J Transplant 10:2231-40. 2010
  5. ncbi First forearm transplantation: outcome at 3 years
    S Schneeberger
    Department of General and Transplant Surgery, Innsbruck Medical University, Innsbruck, Austria
    Am J Transplant 7:1753-62. 2007
  6. ncbi The 4-amino analogue of tetrahydrobiopterin efficiently prolongs murine cardiac-allograft survival
    G Brandacher
    Department of Transplant Surgery, University Hospital Innsbruck, Innsbruck, Austria
    J Heart Lung Transplant 20:747-9. 2001
  7. doi Indoleamine 2,3-dioxygenase and foxp3 expression in skin rejection of human hand allografts
    T Hautz
    Center of Operative Medicine, Department of Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, Innsbruck, Austria
    Transplant Proc 41:509-12. 2009
  8. doi Alemtuzumab: key for minimization of maintenance immunosuppression in reconstructive transplantation?
    S Schneeberger
    Center of Operative Medicine, Department of Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, Innsbruck, Austria
    Transplant Proc 41:499-502. 2009
  9. doi Immunologic aspects and rejection in solid organ versus reconstructive transplantation
    T Hautz
    Center for Operative Medicine, Department of Visceral, Transplant, and Thoracic Surgery, Innsbruck Medical University, Innsbruck, Austria
    Transplant Proc 42:3347-53. 2010
  10. doi The effect of secretory leukocyte protease inhibitor (SLPI) on ischemia/reperfusion injury in cardiac transplantation
    S Schneeberger
    D Swarovski Research Laboratory, Department of General and Transplant Surgery, Innsbruck Medical University, Innsbruck, Austria
    Am J Transplant 8:773-82. 2008

Collaborators

Detail Information

Publications36

  1. ncbi Prognostic value of indoleamine 2,3-dioxygenase expression in colorectal cancer: effect on tumor-infiltrating T cells
    Gerald Brandacher
    Department of General and Transplant Surgery, Innsbruck Medical University, Austria
    Clin Cancer Res 12:1144-51. 2006
    ..In this study, we examined the contribution of the immunomodulatory enzyme indoleamine 2,3-dioxygenase (IDO) on this phenomenon...
  2. ncbi Non-invasive monitoring of kidney allograft rejection through IDO metabolism evaluation
    G Brandacher
    Department of General and Transplant Surgery, Innsbruck Medical University, Innsbruck, Austria
    Kidney Int 71:60-7. 2007
    ..Acute rejection is associated with simultaneously increased serum and urinary kyn/trp in patients after kidney transplantation. Thus, IDO activity might offer a novel non-invasive means of immunomonitoring of renal allografts...
  3. doi The Innsbruck hand transplant program: update at 8 years after the first transplant
    G Brandacher
    Center of Operative Medicine, Department of Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, Innsbruck, Austria
    Transplant Proc 41:491-4. 2009
    ..Despite immunologic challenging postoperative courses, patients are now free of rejection with moderate levels of IS and good functional results. No signs indicating chronic rejection have been encountered...
  4. pmc Donor pretreatment with tetrahydrobiopterin saves pancreatic isografts from ischemia reperfusion injury in a mouse model
    M Maglione
    Department of Visceral, Transplant and Thoracic Surgery, Center of Operative Medicine, Center of Operative Medicine, Innsbruck Medical University, Austria
    Am J Transplant 10:2231-40. 2010
    ..002) and improved survival and endocrine function (p = 0.0002 each). H4B donor pretreatment abrogates ischemia-induced parenchymal damage and represents a promising strategy to prevent IRI following pancreas transplantation...
  5. ncbi First forearm transplantation: outcome at 3 years
    S Schneeberger
    Department of General and Transplant Surgery, Innsbruck Medical University, Innsbruck, Austria
    Am J Transplant 7:1753-62. 2007
    ..Although discrimination of hot and cold recovered, overall sensitivity remains poor. The patient is satisfied with the outcome. Bilateral forearm transplantation represents a novel therapeutic option after loss of forearms...
  6. ncbi The 4-amino analogue of tetrahydrobiopterin efficiently prolongs murine cardiac-allograft survival
    G Brandacher
    Department of Transplant Surgery, University Hospital Innsbruck, Innsbruck, Austria
    J Heart Lung Transplant 20:747-9. 2001
    ....
  7. doi Indoleamine 2,3-dioxygenase and foxp3 expression in skin rejection of human hand allografts
    T Hautz
    Center of Operative Medicine, Department of Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, Innsbruck, Austria
    Transplant Proc 41:509-12. 2009
    ..Characteristics of the cellular infiltrate indicate tolerogenic properties of a proportion of the cells and therefore a tendency toward self-limitation of the alloimmune response during skin rejection after hand transplantation...
  8. doi Alemtuzumab: key for minimization of maintenance immunosuppression in reconstructive transplantation?
    S Schneeberger
    Center of Operative Medicine, Department of Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, Innsbruck, Austria
    Transplant Proc 41:499-502. 2009
    ....
  9. doi Immunologic aspects and rejection in solid organ versus reconstructive transplantation
    T Hautz
    Center for Operative Medicine, Department of Visceral, Transplant, and Thoracic Surgery, Innsbruck Medical University, Innsbruck, Austria
    Transplant Proc 42:3347-53. 2010
    ..We herein portray the evolution of this novel type of transplant with particular reference to immunologic aspects, particularly differences between reconstructive and solid organ transplantation...
  10. doi The effect of secretory leukocyte protease inhibitor (SLPI) on ischemia/reperfusion injury in cardiac transplantation
    S Schneeberger
    D Swarovski Research Laboratory, Department of General and Transplant Surgery, Innsbruck Medical University, Innsbruck, Austria
    Am J Transplant 8:773-82. 2008
    ..SLPI plays a crucial role in early myocardial performance and postischemic inflammation after cardiac transplantation. A dual inhibitory effect on protease and TGF-beta expression might be the underlying mechanism...
  11. ncbi Excellent results with calcineurin inhibitor-free initial immunosuppression in old recipients of old kidneys
    C Bösmüller
    Department of General and Transplant Surgery, Innsbruck Medical University, Innsbruck, Austria
    Transplant Proc 37:881-3. 2005
    ..4%, 94.7%, and 1.5 mg/dL at 1 and 92.1%, 92.1%, and 1.7 mg/dL at 2 years, respectively. Thus, excellent results can be achieved in old recipients of old donor kidneys with CI-free initial immunosuppression...
  12. doi [Immunosuppression in hand transplantation: state of the art and future perspectives]
    Robert Sucher
    Medizinische Universität Insbruck, Abteilung für Allgemein, Transplantations und Thoraxchirurgie, Innsbruck, Austria
    Handchir Mikrochir Plast Chir 41:217-23. 2009
    ..We herein review the current knowledge on acute rejection in reconstructive transplantation and discuss findings in the light of novel immunosuppressive and immunomodulatory strategies...
  13. ncbi Tetrahydrobiopterin attenuates microvascular reperfusion injury following murine pancreas transplantation
    M Maglione
    Department of General and Transplant Surgery, D Swarovski Research Laboratory, Austria
    Am J Transplant 6:1551-9. 2006
    ..01). BH4 treatment significantly reduces post-ischemic deterioration of microcirculation as well as histologic damage and might be a promising novel strategy in attenuating IRI following pancreas transplantation...
  14. doi Molecular markers and targeted therapy of skin rejection in composite tissue allotransplantation
    T Hautz
    Department of Visceral, Transplant and Thoracic Surgery, Center for Operative Medicine, Innsbruck Medical University, Innsbruck, Austria
    Am J Transplant 10:1200-9. 2010
    ..Blocking E- and P-selectin in the skin holds potential to significantly prolong limb allograft survival...
  15. ncbi Status 5 years after bilateral hand transplantation
    S Schneeberger
    Department of General and Transplant Surgery, Innsbruck Medical Univeristy, Anichstrasse 35, Innsbruck, Austria
    Am J Transplant 6:834-41. 2006
    ..Motor and sensory function improved profoundly between years 1 and 5 after hand transplantation. No signs whatsoever of chronic rejection have been observed...
  16. ncbi Enhanced degradation of tryptophan in patients on hemodialysis
    P Koenig
    Department of Internal Medicine, Innsbruck Medical University, Austria
    Clin Nephrol 74:465-70. 2010
    ..The often chronic inflammation and immune activation status in dialysis patients may accelerate tryptophan degradation, which could influence patients' psychological performance...
  17. doi How reconstructive transplantation is different from organ transplantation--and how it is not
    T Hautz
    Center for Operative Medicine, Department of Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, Innsbruck, Austria
    Transplant Proc 43:3504-11. 2011
    ....
  18. ncbi A double-hand transplant can be worth the effort!
    Raimund Margreiter
    Department of Surgery, Innsbruck University Hospital, Austria
    Transplantation 74:85-90. 2002
    ..We here report on our experience with a double-hand transplant performed more than 18 months ago...
  19. ncbi Cross reactivity of three T cell attracting murine chemokines stimulating the CXC chemokine receptor CXCR3 and their induction in cultured cells and during allograft rejection
    M Meyer
    Institute of Medical Chemistry and Biochemistry, University of Innsbruck, Innsbruck, Austria
    Eur J Immunol 31:2521-7. 2001
    ..Chemokine mRNA levels exceeded those of CXCR3 and IFN-gamma which were induced with similar kinetics by several orders of magnitude...
  20. ncbi Percutaneous portal vein embolisation in preparation for extended hepatic resection of primary nonresectable liver tumours
    R Ladurner
    Department of General and Transplant Surgery, Innsbruck University Hospital, Anichstrasse 35, A 6020 Innsbruck, Austria
    Dig Liver Dis 35:716-21. 2003
    ..Radical resection, however, often requires the removal of a large amount of liver parenchyma, resulting in a marked reduction of functional liver tissue with the risk of liver failure...
  21. ncbi Chronic immune activation underlies morbid obesity: is IDO a key player?
    G Brandacher
    Department of General and Transplant Surgery, D Swarovski Research Laboratory, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
    Curr Drug Metab 8:289-95. 2007
    ..We here review the potential pathogenic links between chronic immune activation and decreased IDO mediated tryptophan and serotonin levels in morbid obesity...
  22. ncbi 14-3-3sigma expression is an independent prognostic parameter for poor survival in colorectal carcinoma patients
    Alexander Perathoner
    Tyrolean Cancer Research Institute, Innsbruck, Austria
    Clin Cancer Res 11:3274-9. 2005
    ..In this study, we examined the expression of 14-3-3sigma and evaluated its clinical significance in colorectal carcinoma...
  23. ncbi Induction of indoleamine 2,3-dioxygenase in vascular smooth muscle cells by interferon-gamma contributes to medial immunoprivilege
    Madison C Cuffy
    Interdepartmental Program in Vascular Biology and Transplantation, Department of Surgery, Yale University School of Medicine, New Haven, CT 06510, USA
    J Immunol 179:5246-54. 2007
    ....
  24. ncbi Antitumoral activity of interferon-gamma involved in impaired immune function in cancer patients
    Gerald Brandacher
    Department of General and Transplant Surgery, Tyrolean Cancer Research Institute, Innsbruck Medical University, Fritz Pregl Strasse 3, A 6020 Innsbruck, Austria
    Curr Drug Metab 7:599-612. 2006
    ....
  25. ncbi Implications of IFN-gamma-mediated tryptophan catabolism on solid organ transplantation
    Gerald Brandacher
    Department of General and Transplant Surgery, D Swarovski Research Laboratory, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
    Curr Drug Metab 8:273-82. 2007
    ..Here we review the current literature on IDO in the context of transplantation and outline its potential implication as a target for tolerance induction...
  26. ncbi Bariatric surgery cannot prevent tryptophan depletion due to chronic immune activation in morbidly obese patients
    Gerald Brandacher
    Department of General and Transplant Surgery, Ludwig Boltzmann Institute for AIDS Research, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
    Obes Surg 16:541-8. 2006
    ..Bariatric surgery significantly diminishes immune mediators by substantial weight reduction. We examined IDO-mediated tryptophan-catabolism in morbidly obese patients compared to lean individuals...
  27. ncbi Gene expression profiling of prolonged cold ischemia and reperfusion in murine heart transplants
    Albert Amberger
    D Swarovski Research Laboratory, Department of Transplant Surgery, University Hospital Innsbruck, Austria
    Transplantation 74:1441-9. 2002
    ..Efficient strategies to prevent I/R injury, however, require a better understanding of its mechanisms. Using cDNA microarrays, we investigated gene expression profiles of murine cardiac isografts...
  28. ncbi Lessons to be learned from a complicated case of rhino-cerebral mucormycosis in a renal allograft recipient
    Ruth Ladurner
    Department of Transplant Surgery, Innsbruck University Hospital, Anichstrasse 35, 6020 Innsbruck, Austria
    Transpl Int 16:885-9. 2003
    ..This case stresses the importance of early diagnosis that can only be made from tissue biopsies and allows appropriate timely treatment...
  29. ncbi Estradiol enhances murine cardiac allograft rejection under cyclosporin and can be antagonized by the antiestrogen tamoxifen
    Yiping Zou
    Department of Hepatobiliary Surgery, Beijing 309 Hospital, Peoples Republic of China
    Transplantation 74:354-7. 2002
    ..However, the exact mechanisms of gender-specific differences in alloreactivity are not completely understood...
  30. ncbi Steroid- and ATG-resistant rejection after double forearm transplantation responds to Campath-1H
    Stefan Schneeberger
    Department of General and Transplant Surgery, Innsbruck Univerity Hospital, Austria
    Am J Transplant 4:1372-4. 2004
    ..Hence, Campath-1H treatment might be a novel and powerful therapeutic option for multiresistant allograft rejection...
  31. doi Clinical relevance of indoleamine 2,3-dioxygenase for alloimmunity and transplantation
    Gerald Brandacher
    Department of General and Transplant Surgery, D Swarovski Research Laboratory, Innsbruck Medical University, Austria
    Curr Opin Organ Transplant 13:10-5. 2008
    ..In addition, IDO-mediated tryptophan catabolism occurring in dendritic cells is an emerging potent mechanism of peripheral tolerance...
  32. ncbi Tetrahydro-4-aminobiopterin attenuates dendritic cell-induced T cell priming independently from inducible nitric oxide synthase
    Guntram Thoeni
    Biocenter, Division of Biological Chemistry, Department of Dermatology and Venerology, Innsbruck Medical University, Innsbruck, Austria
    J Immunol 174:7584-91. 2005
    ..These findings characterize attenuation of T cell stimulatory capacity of murine bone marrow-derived dendritic cells as an immunosuppressive mechanism of tetrahydro-4-aminobiopterin that is not related to its iNOS-inhibiting properties...
  33. ncbi Cytomegalovirus-related complications in human hand transplantation
    Stefan Schneeberger
    Department of General and Transplant Surgery, Innsbruck Medical University, Innsbruck, Austria
    Transplantation 80:441-7. 2005
    ..Up to date, 24 hands/thumbs have been transplanted in 18 patients. We herein report on cytomegalovirus (CMV) infection, disease, and the adopted treatment...
  34. ncbi A novel technique for heterotopic vascularized pancreas transplantation in mice to assess ischemia reperfusion injury and graft pancreatitis
    Manuel Maglione
    Department of General and Transplant Surgery, D Swarovski Research Laboratory, Innsbruck Medical University, Innsbruck, Austria
    Surgery 141:682-9. 2007
    ..We therefore designed a surgical model for cervical heterotopic pancreas transplantation using a cuff technique...
  35. ncbi Laparoscopically implanted gastric pacemaker after kidney-pancreas transplantation: treatment of morbid obesity and diabetic gastroparesis
    Hugo Bonatti
    Department of General and Transplant Surgery, Medical University Innsbruck, Austria
    Obes Surg 17:100-3. 2007
    ....
  36. ncbi Hemolytic uremic syndrome following Campath-1H induction
    Hugo Bonatti
    Department of General and Transplant Surgery, Medical University of Innsbruck, Innsbruck, Austria
    Transpl Int 20:386-9. 2007
    ..However, graft function could not be restored...