Michael J Ausserlechner

Summary

Affiliation: University of Innsbruck
Country: Austria

Publications

  1. ncbi G1 arrest by p16INK4A uncouples growth from cell cycle progression in leukemia cells with deregulated cyclin E and c-Myc expression
    M J Ausserlechner
    Molecular Biology Research Laboratory, Department of Pediatrics, Medical University Innsbruck, A 6020 Innsbruck, Austria
    Leukemia 19:1051-7. 2005
  2. ncbi A retroviral expression system based on tetracycline-regulated tricistronic transactivator/repressor vectors for functional analyses of antiproliferative and toxic genes
    Michael J Ausserlechner
    Molecular Biology Research Laboratory, Pediatric Department, Medical University Innsbruck, Innrain 66, A 6020 Innsbruck, Austria
    Mol Cancer Ther 5:1927-34. 2006
  3. pmc p16INK4A sensitizes human leukemia cells to FAS- and glucocorticoid-induced apoptosis via induction of BBC3/Puma and repression of MCL1 and BCL2
    Petra Obexer
    Tyrolean Cancer Research Institute, Department of Pediatrics IV, Medical University Innsbruck, Innsbruck 6020, Austria
    J Biol Chem 284:30933-40. 2009
  4. pmc Therapy-resistant acute lymphoblastic leukemia (ALL) cells inactivate FOXO3 to escape apoptosis induction by TRAIL and Noxa
    Michael J Ausserlechner
    Department of Pediatrics I, Medical University Innsbruck, Austria
    Oncotarget 4:995-1007. 2013
  5. doi Nuclear FOXO3 predicts adverse clinical outcome and promotes tumor angiogenesis in neuroblastoma
    Judith Hagenbuchner
    Departments of Pediatrics II, Medical University Innsbruck, Innsbruck, Austria
    Oncotarget . 2016
  6. pmc C10ORF10/DEPP, a transcriptional target of FOXO3, regulates ROS-sensitivity in human neuroblastoma
    Stefan Salcher
    Department of Pediatrics I, Medical University Innsbruck, Anichstra├če 35, 6020 Innsbruck, Austria
    Mol Cancer 13:224. 2014
  7. pmc A novel Mcl1 variant inhibits apoptosis via increased Bim sequestration
    Judith Hagenbuchner
    Department of Pediatrics II, Medical University Innsbruck, Austria
    Oncotarget 4:1241-52. 2013
  8. ncbi p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa
    Andreas Villunger
    Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Science 302:1036-8. 2003
  9. ncbi Functional analysis of the mutated Epstein-Barr virus oncoprotein LMP1(69del): implications for a new role of naturally occurring LMP1 variants
    Clara Larcher
    Institute of Hygiene and Social Medicine, University of Innsbruck, Austria
    Haematologica 88:1324-35. 2003
  10. ncbi The cell cycle inhibitor p16(INK4A) sensitizes lymphoblastic leukemia cells to apoptosis by physiologic glucocorticoid levels
    M J Ausserlechner
    Institute for General and Experimental Pathology, Division of Molecular Pathophysiology, University of Innsbruck Medical School and the Tyrolean Cancer Research Institute, A 6020 Innsbruck, Austria
    J Biol Chem 276:10984-9. 2001

Collaborators

Detail Information

Publications19

  1. ncbi G1 arrest by p16INK4A uncouples growth from cell cycle progression in leukemia cells with deregulated cyclin E and c-Myc expression
    M J Ausserlechner
    Molecular Biology Research Laboratory, Department of Pediatrics, Medical University Innsbruck, A 6020 Innsbruck, Austria
    Leukemia 19:1051-7. 2005
    ....
  2. ncbi A retroviral expression system based on tetracycline-regulated tricistronic transactivator/repressor vectors for functional analyses of antiproliferative and toxic genes
    Michael J Ausserlechner
    Molecular Biology Research Laboratory, Pediatric Department, Medical University Innsbruck, Innrain 66, A 6020 Innsbruck, Austria
    Mol Cancer Ther 5:1927-34. 2006
    ..This proves that this expression system allows concentration-dependent analysis of gene function and implicates p27(Kip1) as a critical regulator of both proliferation and apoptosis in SH-EP neuroblastoma cells...
  3. pmc p16INK4A sensitizes human leukemia cells to FAS- and glucocorticoid-induced apoptosis via induction of BBC3/Puma and repression of MCL1 and BCL2
    Petra Obexer
    Tyrolean Cancer Research Institute, Department of Pediatrics IV, Medical University Innsbruck, Innsbruck 6020, Austria
    J Biol Chem 284:30933-40. 2009
    ....
  4. pmc Therapy-resistant acute lymphoblastic leukemia (ALL) cells inactivate FOXO3 to escape apoptosis induction by TRAIL and Noxa
    Michael J Ausserlechner
    Department of Pediatrics I, Medical University Innsbruck, Austria
    Oncotarget 4:995-1007. 2013
    ..This suggests that if p16INK4A is deleted during leukemia development, FOXO3 levels elevate and FOXO3 has to be inactivated by deregulation of the PI3K-PKB pathway to prevent FOXO3-induced cell death. ..
  5. doi Nuclear FOXO3 predicts adverse clinical outcome and promotes tumor angiogenesis in neuroblastoma
    Judith Hagenbuchner
    Departments of Pediatrics II, Medical University Innsbruck, Innsbruck, Austria
    Oncotarget . 2016
    ..The combined data suggest that, depending on the mode and intensity of activation, cellular FOXO3 acts as a homeostasis regulator promoting tumor growth at hypoxic conditions and tumor angiogenesis in high-stage neuroblastoma...
  6. pmc C10ORF10/DEPP, a transcriptional target of FOXO3, regulates ROS-sensitivity in human neuroblastoma
    Stefan Salcher
    Department of Pediatrics I, Medical University Innsbruck, Anichstra├če 35, 6020 Innsbruck, Austria
    Mol Cancer 13:224. 2014
    ..As a physiological function of C10orf10/DEPP has not been described so far we analyzed its effects on cellular ROS detoxification and death sensitization in human neuroblastoma cells...
  7. pmc A novel Mcl1 variant inhibits apoptosis via increased Bim sequestration
    Judith Hagenbuchner
    Department of Pediatrics II, Medical University Innsbruck, Austria
    Oncotarget 4:1241-52. 2013
    ..This suggests that this novel Mcl1L variant efficiently protects tumor cells against extrinsic death signalling and therefore may provide a survival advantage for highly aggressive tumors. ..
  8. ncbi p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa
    Andreas Villunger
    Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Science 302:1036-8. 2003
    ..Hence, Puma and Noxa are critical mediators of the apoptotic responses induced by p53 and other agents...
  9. ncbi Functional analysis of the mutated Epstein-Barr virus oncoprotein LMP1(69del): implications for a new role of naturally occurring LMP1 variants
    Clara Larcher
    Institute of Hygiene and Social Medicine, University of Innsbruck, Austria
    Haematologica 88:1324-35. 2003
    ..Here we describe functional properties of a rare 69-bp LMP1 deletion mutant (LMP1(69del)) isolated from a patient with polyclonal B-cell lymphocytosis...
  10. ncbi The cell cycle inhibitor p16(INK4A) sensitizes lymphoblastic leukemia cells to apoptosis by physiologic glucocorticoid levels
    M J Ausserlechner
    Institute for General and Experimental Pathology, Division of Molecular Pathophysiology, University of Innsbruck Medical School and the Tyrolean Cancer Research Institute, A 6020 Innsbruck, Austria
    J Biol Chem 276:10984-9. 2001
    ....
  11. ncbi FKHRL1-mediated expression of Noxa and Bim induces apoptosis via the mitochondria in neuroblastoma cells
    P Obexer
    Tyrolean Cancer Research Institute, Innsbruck, Austria
    Cell Death Differ 14:534-47. 2007
    ..We conclude that Noxa and Bim establish a connection between FKHRL1 and mitochondria, and that both BH3-only proteins are critically involved in FKHRL1-induced apoptosis in neuroblastoma...
  12. ncbi Cyclin D3 and c-MYC control glucocorticoid-induced cell cycle arrest but not apoptosis in lymphoblastic leukemia cells
    M J Ausserlechner
    Institute of Pathophysiology, Division of Molecular Pathophysiology, University of Innsbruck, Medical School, A 6020 Innsbruck, Austria
    Cell Death Differ 11:165-74. 2004
    ..The combined data suggest that repression of both, c-myc and cyclin D3, is necessary to arrest human leukemia cells in the G1 phase of the cell division cycle, but that neither one is required for GC-induced apoptosis...
  13. ncbi Resistance to glucocorticoid-induced apoptosis in lymphoblastic leukemia
    R Kofler
    Tyrolean Cancer Research Institute at the University of Innsbruck, Austria
    J Endocrinol 178:19-27. 2003
    ..Herein, we review reports and hypotheses regarding 'upstream' and 'downstream' mechanisms for GC resistance in lymphoblastic leukemia and present an in vitro GC resistance model that might allow identification of resistance mechanisms...
  14. pmc The anti-apoptotic protein BCL2L1/Bcl-xL is neutralized by pro-apoptotic PMAIP1/Noxa in neuroblastoma, thereby determining bortezomib sensitivity independent of prosurvival MCL1 expression
    Judith Hagenbuchner
    Department of Pediatrics IV, Biocenter, Medical University Innsbruck, Tyrolean Cancer Research Institute, 6020 Innsbruck, Austria
    J Biol Chem 285:6904-12. 2010
    ....
  15. doi Targeting transcription factors by small compounds--Current strategies and future implications
    Judith Hagenbuchner
    Department of Pediatrics II, Medical University Innsbruck, Innrain 66, A 6020 Innsbruck, Austria
    Biochem Pharmacol 107:1-13. 2016
    ....
  16. pmc Mitochondrial survivin - an Achilles' heel in cancer chemoresistance
    Michael J Ausserlechner
    Department of Pediatrics I, Medical University Innsbruck, Innsbruck, Austria
    Mol Cell Oncol 3:e1076589. 2016
    ....
  17. doi Premature aging of the immune system in children with juvenile idiopathic arthritis
    Martina Prelog
    Department of Pediatrics, Medical University Innsbruck, Innsbruck, Austria
    Arthritis Rheum 58:2153-62. 2008
    ..We undertook this study to determine whether patients with JIA demonstrate premature immunosenescence...
  18. ncbi Oxindole alkaloids from Uncaria tomentosa induce apoptosis in proliferating, G0/G1-arrested and bcl-2-expressing acute lymphoblastic leukaemia cells
    Nicole Bacher
    Department of Internal Medicine, Medical University of Innsbruck, Innsbruck, Austria
    Br J Haematol 132:615-22. 2006
    ..Our results show the strong apoptotic effects of pteropodine and uncarine F on acute leukaemic lymphoblasts and recommend the alkaloids for further studies in xenograft models...
  19. doi Isotype-specific inhibitors of the glycolytic key regulator pyruvate kinase subtype M2 moderately decelerate tumor cell proliferation
    Gilles A Spoden
    Cell Metabolism and Differentiation Research Group, Institute for Biomedical Aging Research of the Austrian Academy of Sciences, Innsbruck, Austria
    Int J Cancer 123:312-21. 2008
    ..In the present study, we developed the first specific inhibitors of the pyruvate kinase isoenzyme type M2 and present evidence that these inhibitors moderately decelerate tumor cell proliferation...