Martin Pichler

Summary

Country: Austria

Publications

  1. doi request reprint Loss of the putative tumor suppressor protein spinophilin is associated with poor prognosis in head and neck cancer
    Alena Maria Aigelsreiter
    Department of Neurosurgery, Klinikum Klagenfurt, Klagenfurt, Austria Electronic address
    Hum Pathol 45:683-90. 2014
  2. pmc High plasma fibrinogen level represents an independent negative prognostic factor regarding cancer-specific, metastasis-free, as well as overall survival in a European cohort of non-metastatic renal cell carcinoma patients
    M Pichler
    Division of Oncology, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 25, Graz A 8036, Austria
    Br J Cancer 109:1123-9. 2013
  3. doi request reprint Predictive ability of the 2002 and 2010 versions of the Tumour-Node-Metastasis classification system regarding metastasis-free, cancer-specific and overall survival in a European renal cell carcinoma single-centre series
    Martin Pichler
    Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria
    BJU Int 111:E191-5. 2013
  4. pmc Validation of the pre-treatment neutrophil-lymphocyte ratio as a prognostic factor in a large European cohort of renal cell carcinoma patients
    M Pichler
    Division of Oncology, Department of Internal Medicine, Medical University of Graz MUG, Graz, Austria
    Br J Cancer 108:901-7. 2013
  5. doi request reprint Presence and extent of histological tumour necrosis is an adverse prognostic factor in papillary type 1 but not in papillary type 2 renal cell carcinoma
    Martin Pichler
    Division of Oncology, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 25, Graz, Austria
    Histopathology 62:219-28. 2013
  6. pmc Hedgehog signaling pathway in ovarian cancer
    Joanna Szkandera
    Division of Clinical Oncology, Department of Medicine, Medical University of Graz, 8036 Graz, Austria
    Int J Mol Sci 14:1179-96. 2013
  7. doi request reprint Trends of stage, grade, histology and tumour necrosis in renal cell carcinoma in a European centre surgical series from 1984 to 2010
    Martin Pichler
    Division of Oncology, Department of Internal Medicine, Medical University of Graz MUG, Graz, Austria
    J Clin Pathol 65:721-4. 2012
  8. pmc Down-regulation of KRAS-interacting miRNA-143 predicts poor prognosis but not response to EGFR-targeted agents in colorectal cancer
    M Pichler
    Division of Oncology, Department of Internal Medicine, Medical University of Graz MUG, Auenbruggerplatz 15, Graz, Austria
    Br J Cancer 106:1826-32. 2012
  9. doi request reprint Cardiac fibrosis in human transplanted hearts is mainly driven by cells of intracardiac origin
    Martin Pichler
    Division of Oncology, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, Graz, Austria
    J Am Coll Cardiol 59:1008-16. 2012
  10. doi request reprint miR-181a is associated with poor clinical outcome in patients with colorectal cancer treated with EGFR inhibitor
    Martin Pichler
    Division of Oncology, Department of Internal Medicine, Medical University of Graz MUG, Graz, Austria
    J Clin Pathol 67:198-203. 2014

Detail Information

Publications86

  1. doi request reprint Loss of the putative tumor suppressor protein spinophilin is associated with poor prognosis in head and neck cancer
    Alena Maria Aigelsreiter
    Department of Neurosurgery, Klinikum Klagenfurt, Klagenfurt, Austria Electronic address
    Hum Pathol 45:683-90. 2014
    ..Based on our results, spinophilin might play a previously unrecognized role in the pathogenesis of HNSCC. ..
  2. pmc High plasma fibrinogen level represents an independent negative prognostic factor regarding cancer-specific, metastasis-free, as well as overall survival in a European cohort of non-metastatic renal cell carcinoma patients
    M Pichler
    Division of Oncology, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 25, Graz A 8036, Austria
    Br J Cancer 109:1123-9. 2013
    ..A relatively small-scale study has indicated that plasma fibrinogen levels may serve as a prognostic factor for predicting clinical outcomes in non-metastatic renal cell carcinoma (RCC) patients...
  3. doi request reprint Predictive ability of the 2002 and 2010 versions of the Tumour-Node-Metastasis classification system regarding metastasis-free, cancer-specific and overall survival in a European renal cell carcinoma single-centre series
    Martin Pichler
    Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria
    BJU Int 111:E191-5. 2013
    ..To compare the predictive ability of the Tumour-Node-Metastasis (TNM) classification systems for renal cell carcinoma (RCC) using three different endpoints: metastasis-free (MFS); overall (OS); and cancer-specific survival (CSS)...
  4. pmc Validation of the pre-treatment neutrophil-lymphocyte ratio as a prognostic factor in a large European cohort of renal cell carcinoma patients
    M Pichler
    Division of Oncology, Department of Internal Medicine, Medical University of Graz MUG, Graz, Austria
    Br J Cancer 108:901-7. 2013
    ..Therefore, the aim of our study was the validation of the prognostic significance of NLR in a large cohort of RCC patients...
  5. doi request reprint Presence and extent of histological tumour necrosis is an adverse prognostic factor in papillary type 1 but not in papillary type 2 renal cell carcinoma
    Martin Pichler
    Division of Oncology, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 25, Graz, Austria
    Histopathology 62:219-28. 2013
    ..Thus, the aim of this study was to evaluate the prognostic impact of these pathological features on the clinical outcome in papillary subtypes...
  6. pmc Hedgehog signaling pathway in ovarian cancer
    Joanna Szkandera
    Division of Clinical Oncology, Department of Medicine, Medical University of Graz, 8036 Graz, Austria
    Int J Mol Sci 14:1179-96. 2013
    ....
  7. doi request reprint Trends of stage, grade, histology and tumour necrosis in renal cell carcinoma in a European centre surgical series from 1984 to 2010
    Martin Pichler
    Division of Oncology, Department of Internal Medicine, Medical University of Graz MUG, Graz, Austria
    J Clin Pathol 65:721-4. 2012
    ..To analyse renal cell carcinoma (RCC) stage, grade, histology and necrosis migration in a large European centre series over the last 27 years...
  8. pmc Down-regulation of KRAS-interacting miRNA-143 predicts poor prognosis but not response to EGFR-targeted agents in colorectal cancer
    M Pichler
    Division of Oncology, Department of Internal Medicine, Medical University of Graz MUG, Auenbruggerplatz 15, Graz, Austria
    Br J Cancer 106:1826-32. 2012
    ..However, the prognostic significance of miRNA-143 expression and the ability to predict patient response to epidermal growth factor receptor (EGFR)-targeted agents have not yet been explored...
  9. doi request reprint Cardiac fibrosis in human transplanted hearts is mainly driven by cells of intracardiac origin
    Martin Pichler
    Division of Oncology, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, Graz, Austria
    J Am Coll Cardiol 59:1008-16. 2012
    ..The aim of our study was to determine the origin of collagen in the progression of myocardial fibrosis in human adult transplanted hearts...
  10. doi request reprint miR-181a is associated with poor clinical outcome in patients with colorectal cancer treated with EGFR inhibitor
    Martin Pichler
    Division of Oncology, Department of Internal Medicine, Medical University of Graz MUG, Graz, Austria
    J Clin Pathol 67:198-203. 2014
    ..However, the role of miR-181a expression in CRC and its ability to predict survival and response to agents targeting the epidermal growth factor receptor (EGFR) have not been explored yet...
  11. pmc External validation of the derived neutrophil to lymphocyte ratio as a prognostic marker on a large cohort of pancreatic cancer patients
    Joanna Szkandera
    Division of Clinical Oncology, Department of Medicine, Medical University of Graz, Graz, Austria
    PLoS ONE 8:e78225. 2013
    ..The derived neutrophil to lymphocyte ratio (dNLR), which represents an easily determinable potential prognostic marker in daily practise and clinical trials, has never been externally validated in pancreatic cancer (PC) patients...
  12. ncbi request reprint Preoperative neutrophil-to-lymphocyte ratio predicts clinical outcome in patients with stage II and III colon cancer
    Gudrun Absenger
    Priv Doz, Assoc Prof Division of Clinical Oncology, Research Unit Genetic Epidemiology and Pharmacogenetics, Department of Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria
    Anticancer Res 33:4591-4. 2013
    ..We evaluated the effect of NLR on time-to-recurrence (TTR) and overall survival (OS) in selected patients...
  13. doi request reprint A common and functional gene variant in the vascular endothelial growth factor a predicts clinical outcome in early-stage breast cancer
    Gudrun Absenger
    Division of Clinical Oncology, Department of Internal Medicine, Medical University Graz, Graz, Austria
    Mol Carcinog 52:E96-102. 2013
    ..379; 95% CI 0.841-6.728; P = 0.068). This study provides evidence that the functional VEGF-A rs3025039 C > T polymorphism influences recurrence-free survival in early-stage breast cancer...
  14. pmc Platelet-to-lymphocyte ratio: a novel marker for critical limb ischemia in peripheral arterial occlusive disease patients
    Thomas Gary
    Division of Vascular Medicine, Department of Internal Medicine, Medical University Graz, Graz, Austria
    PLoS ONE 8:e67688. 2013
    ..As platelets play a key role in atherosclerosis and atherothrombosis, we investigated PLR and its association with critical limb ischemia (CLI) and other vascular endpoints in peripheral arterial occlusive disease (PAOD) patients...
  15. doi request reprint Comparison of the 2002 and 2010 TNM classification systems regarding outcome prediction in clear cell and papillary renal cell carcinoma
    Martin Pichler
    Division of Oncology, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 25, Graz, Austria
    Histopathology 62:237-46. 2013
    ..Therefore, the aim of our study was to compare the predictive ability of the 2002 and 2010 versions of the TNM classification system for clear cell and papillary RCC...
  16. doi request reprint Prognostic value of the Leibovich prognosis score supplemented by vascular invasion for clear cell renal cell carcinoma
    Martin Pichler
    Division of Oncology, Department of Internal Medicine, Medical University of Graz MUG, Graz, Austria
    J Urol 187:834-9. 2012
    ..We assessed whether supplementing the Leibovich prognosis score with vascular invasion would improve prognostic value to predict metastatic disease in patients with nonmetastatic clear cell renal cell carcinoma...
  17. pmc Establishment of tumor-specific copy number alterations from plasma DNA of patients with cancer
    Ellen Heitzer
    Institute of Human Genetics, Medical University of Graz, Harrachgasse 21 8, A 8010 Graz, Austria
    Int J Cancer 133:346-56. 2013
    ..This is the first description of such a biphasic distribution in a surprisingly high proportion of cancer patients which may have important implications for tumor diagnosis and monitoring...
  18. doi request reprint Histologic tumor necrosis is an independent prognostic indicator for clear cell and papillary renal cell carcinoma
    Martin Pichler
    Department of Urology, Medical University of Graz, Auenbruggerplatz 5 6, Graz, Austria
    Am J Clin Pathol 137:283-9. 2012
    ..Thus, histologic TN might be a reliable prognostic indicator and should, therefore, routinely be examined during pathologic analysis of RCC specimens...
  19. pmc Current Insights into Long Non-Coding RNAs in Renal Cell Carcinoma
    Maximilian Seles
    Department of Urology, Medical University of Graz, A 8036 Graz, Austria
    Int J Mol Sci 17:573. 2016
    ..Recently, several lncRNAs were described in RCC. This review emphasises the rising importance of lncRNAs in RCC. Moreover, it provides an outlook on their therapeutic potential in the future. ..
  20. doi request reprint The lymphocyte/monocyte ratio predicts poor clinical outcome and improves the predictive accuracy in patients with soft tissue sarcomas
    Joanna Szkandera
    Division of Clinical Oncology Department of Medicine, Medical University of Graz, Graz, Austria
    Int J Cancer 135:362-70. 2014
    ..This easily determinable biomarker might be helpful in improved individual risk assessment. ..
  21. doi request reprint Tumour-associated macrophages might represent a favourable prognostic indicator in patients with papillary renal cell carcinoma
    Georg C Hutterer
    Department of Urology, Medical University of Graz, Graz, Austria
    Histopathology 63:309-15. 2013
    ..Tumour-associated macrophages (TAM) have been reported to be regulators of progression in various human cancers. We evaluated the prognostic relevance of TAM in a large series of patients with papillary renal cell carcinoma (PRCC)...
  22. doi request reprint Clinico-pathological characteristics and clinical outcome of different histological types of pancreatic cancer in a large Middle European series
    Michael Stotz
    Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria
    J Clin Pathol 66:753-7. 2013
    ..The aim of this study was to evaluate the prognostic impact of different histological subtypes on cancer-specific survival (CSS) in a large single-centre Middle European cohort...
  23. doi request reprint The clinical significance of fibrinogen plasma levels in patients with diffuse large B cell lymphoma
    Katharina T Troppan
    Division of Hematology, Department of Internal Medicine, Medical University of Graz MUG, Graz, Austria
    J Clin Pathol 69:326-30. 2016
    ....
  24. doi request reprint The elevated pre-operative plasma fibrinogen level is an independent negative prognostic factor for cancer-specific, disease-free and overall survival in soft-tissue sarcoma patients
    Joanna Szkandera
    Division of Clinical Oncology, Department of Medicine, Medical University of Graz, Graz, Australia Research Unit Genetic Epidemiology and Pharmacogenetics, Division of Clinical Oncology, Department of Medicine, Medical University of Graz, Graz, Australia
    J Surg Oncol 109:139-44. 2014
    ..The aim of the present study was to evaluate the prognostic relevance of pre-operative fibrinogen levels on clinical outcome in a large cohort of STS patients...
  25. doi request reprint Association of common gene variants in vitamin D modulating genes and colon cancer recurrence
    Joanna Szkandera
    Division of Clinical Oncology, Department of Medicine, Medical University of Graz, Graz, Austria
    J Cancer Res Clin Oncol 139:1457-64. 2013
    ....
  26. doi request reprint External validation of the Leibovich prognosis score for nonmetastatic clear cell renal cell carcinoma at a single European center applying routine pathology
    Martin Pichler
    Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria
    J Urol 186:1773-7. 2011
    ..However, this scoring system has never been externally validated. We externally validated its prognostic accuracy using routine pathology reports...
  27. pmc Low spinophilin expression enhances aggressive biological behavior of breast cancer
    Daniela Schwarzenbacher
    Division of Oncology, Department of Internal Medicine, Medical University of Graz, Austria
    Oncotarget 6:11191-202. 2015
    ..05). Finally, we identified several differentially expressed genes in spinophilin-silenced cells. According to our data, low levels of spinophilin are associated with aggressive behavior of breast cancer. ..
  28. pmc Blood-Based Biomarkers Are Associated with Disease Recurrence and Survival in Gastrointestinal Stroma Tumor Patients after Surgical Resection
    Michael Stotz
    Division of Clinical Oncology, Department of Medicine, Medical University of Graz, Graz, Austria
    PLoS ONE 11:e0159448. 2016
    ..Here, we quantify the prognostic impact of blood-based biomarkers on recurrence risk and long-term survival in a large cohort of gastrointestinal stroma tumor (GIST) patients after curative surgery...
  29. ncbi request reprint Validation of the Preoperative Platelet-to-Lymphocyte Ratio as a Prognostic Factor in a European Cohort of Patients with Upper Tract Urothelial Carcinoma
    Orietta Dalpiaz
    Department of Urology, Medical University of Graz, Graz, Austria
    Urol Int . 2016
    ..This study is aimed at investigating the potential prognostic impact of the preoperatively assessed platelet-to-lymphocyte ratio (PLR) in a European cohort of patients with non-metastatic upper tract urothelial carcinoma (UTUC)...
  30. doi request reprint The significance of pretreatment anemia in the era of R-IPI and NCCN-IPI prognostic risk assessment tools: a dual-center study in diffuse large B-cell lymphoma patients
    Katharina T Troppan
    Division of Hematology, Medical University of Graz MUG, Graz, Austria
    Eur J Haematol 95:538-44. 2015
    ..Anemia is frequently identified at the time of diagnosis in patients with diffuse large B-cell lymphoma (DLBCL); however, studies addressing the prognostic significance of this important clinical parameter are lacking...
  31. doi request reprint MiR-96-5p influences cellular growth and is associated with poor survival in colorectal cancer patients
    Anna Lena Ress
    Division of Oncology, Department of Internal Medicine, Medical University of Graz MUG, Graz, Austria
    Mol Carcinog 54:1442-50. 2015
    ..In conclusion, our data suggest that miR-96-5p influences cellular growth of CRC cells and low expression of miR-96-5p seems to be associated with poor clinical outcome in CRC patients...
  32. doi request reprint Preoperative serum-gamma-glutamyltransferase (GGT) does not represent an independent prognostic factor in a European cohort of patients with non-metastatic renal cell carcinoma
    Orietta Dalpiaz
    Department of Urology, Medical University of Graz, Graz, Austria
    J Clin Pathol 68:547-51. 2015
    ..Thus, we decided to investigate the potential prognostic impact of the preoperatively assessed serum-GGT in a European cohort of patients with non-metastatic renal cell carcinoma (RCC)...
  33. doi request reprint The derived neutrophil/lymphocyte ratio predicts poor clinical outcome in soft tissue sarcoma patients
    Joanna Szkandera
    Division of Clinical Oncology, Department of Medicine, Medical University of Graz, Graz, Austria Research Unit Genetic Epidemiology and Pharmacogenetics, Division of Clinical Oncology, Department of Medicine, Medical University of Graz, Graz, Austria Electronic address
    Am J Surg 210:111-6. 2015
    ..The aim of this study was to investigate the prognostic impact of the pre-operative-derived neutrophil/lymphocyte ratio (dNLR) in a large cohort of soft tissue sarcoma (STS) patients after curative surgical resection...
  34. doi request reprint Validation of pretreatment neutrophil-lymphocyte ratio as a prognostic factor in a European cohort of patients with upper tract urothelial carcinoma
    Orietta Dalpiaz
    Department of Urology, Medical University of Graz, Graz, Austria
    BJU Int 114:334-9. 2014
    ..To investigate the potential prognostic significance of the neutrophil-lymphocyte ratio (NLR) in a large European cohort of patients with upper urinary tract urothelial cell carcinoma (UUT-UCC)...
  35. doi request reprint The elevated preoperative platelet to lymphocyte ratio predicts decreased time to recurrence in colon cancer patients
    Joanna Szkandera
    Division of Clinical Oncology, Department of Medicine, Medical University of Graz, Graz, Austria Research Unit Genetic Epidemiology and Pharmacogenetics, Division of Clinical Oncology, Department of Medicine, Medical University of Graz, Graz, Austria
    Am J Surg 208:210-4. 2014
    ....
  36. doi request reprint Validation of the preoperative plasma fibrinogen level as a prognostic factor in a European cohort of patients with localized upper tract urothelial carcinoma
    Martin Pichler
    Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria
    J Urol 191:920-5. 2014
    ..We validated the prognostic impact of this potential biomarker in a European cohort of patients with localized upper tract urothelial carcinoma...
  37. pmc Changes in colorectal carcinoma genomes under anti-EGFR therapy identified by whole-genome plasma DNA sequencing
    Sumitra Mohan
    Institute of Human Genetics, Medical University of Graz, Graz, Austria
    PLoS Genet 10:e1004271. 2014
    ..Thus, plasma-Seq enables the identification of novel mutant clones and may therefore facilitate early adjustments of therapies that may delay or prevent disease progression...
  38. doi request reprint Renal cell carcinoma stage migration in a single European centre over 25 years: effects on 5- and 10-year metastasis-free survival
    Martin Pichler
    Division of Oncology, Department of Internal Medicine, Medical University of Graz MUG, Auenbruggerplatz 25, 8036 Graz, Austria
    Int Urol Nephrol 44:997-1004. 2012
    ..To assess renal cell carcinoma (RCC) stage migration in a large European academic centre series over 25 years and its possible impact on patients' metastasis-free survival...
  39. pmc NCCN-IPI score-independent prognostic potential of pretreatment uric acid levels for clinical outcome of diffuse large B-cell lymphoma patients
    Katharina T Prochazka
    Division of Hematology, Department of Internal Medicine, Medical University of Graz MUG, Graz 8036, Austria
    Br J Cancer 115:1264-1272. 2016
    ..The aim of this study was to comprehensively evaluate the prognostic significance of pretreatment plasma uric acid levels in patients with newly diagnosed DLBCL...
  40. doi request reprint The association of an elevated plasma fibrinogen level with cancer-specific and overall survival in prostate cancer patients
    Eva Maria Thurner
    Department of Therapeutic Radiology and Oncology, Comprehensive Cancer Center Graz, Medical University of Graz, Auenbruggerplatz 32, 8036, Graz, Austria
    World J Urol 33:1467-73. 2015
    ..The present study was performed to analyse the prognostic impact of an elevated fibrinogen level in prostate cancer patients...
  41. doi request reprint Association of the Derived Neutrophil-Lymphocyte Ratio With Critical Limb Ischemia
    Klara Belaj
    Division of Angiology, Department of Internal Medicine, Medical University Graz, Graz, Austria
    Angiology 67:350-4. 2016
    ..001). A high dNLR is associated with an increased rate of CLI in patients with PAD. This might be a useful parameter to highlight patients at increased risk of CLI. ..
  42. ncbi request reprint Preoperative Leucocytosis, Thrombocytosis and Anemia as Potential Prognostic Factors in Non-metastatic Renal Cell Carcinoma
    Georg C Hutterer
    Department of Urology, Medical University of Graz, Graz, Austria
    Anticancer Res 35:3463-9. 2015
    ..To validate the potential prognostic significance of preoperatively assessed inflammatory parameters leucocytosis, thrombocytosis and anemia in patients with non-metastatic renal cell carcinoma (RCC)...
  43. doi request reprint Combination of tumour markers CEA and CA19-9 improves the prognostic prediction in patients with pancreatic cancer
    Daniel Reitz
    Division of Clinical Oncology, Department of Medicine, Medical University of Graz, Graz, Austria
    J Clin Pathol 68:427-33. 2015
    ..In this work, the main focus is on mathematical combinations of these two tumour markers in order to validate an improvement of prognostic test results in terms of sensitivity and specificity...
  44. pmc Spinophilin expression determines cellular growth, cancer stemness and 5-flourouracil resistance in colorectal cancer
    Anna Lena Ress
    Division of Oncology, Department of Internal Medicine, Medical University of Graz, Austria These authors contributed equally to this work
    Oncotarget 5:8492-502. 2014
    ..001). In conclusion, gain of aggressive biological properties of CRC cells including cellular growth, cancer stem cell features and 5-flourouracil resistance partly explains the role of spinophilin in CRC. ..
  45. doi request reprint Pretreatment lymphocyte-monocyte ratio as a potential prognostic factor in a cohort of patients with upper tract urothelial carcinoma
    Georg C Hutterer
    Department of Urology, Medical University of Graz, Graz, Austria
    J Clin Pathol 68:351-5. 2015
    ..The LMR as an indicator of systemic inflammatory response has been shown to represent a potential prognostic factor in various types of human cancers. Up to date, the prognostic significance of the LMR in UTUC has not been evaluated...
  46. pmc Evaluation of uric acid as a prognostic blood-based marker in a large cohort of pancreatic cancer patients
    Michael Stotz
    Division of Clinical Oncology, Department of Medicine, Medical University of Graz, Graz, Austria Research Unit Genetic Epidemiology and Pharmacogenetics, Division of Clinical Oncology, Department of Medicine, Medical University of Graz, Graz, Austria
    PLoS ONE 9:e104730. 2014
    ..In the present study we investigated the prognostic relevance of the uric acid (UA) level in blood plasma at the time of diagnosis for overall survival (OS) in a large cohort of patients with PC...
  47. pmc Pre-treatment anemia is a poor prognostic factor in soft tissue sarcoma patients
    Joanna Szkandera
    Division of Clinical Oncology, Department of Medicine, Medical University of Graz, Graz, Austria Research Unit Genetic Epidemiology and Pharmacogenetics, Division of Clinical Oncology, Department of Medicine, Medical University of Graz, Graz, Austria
    PLoS ONE 9:e107297. 2014
    ..In the present study, we aimed to explore the prognostic impact of pre-operative Hb levels on clinical outcome in a large cohort of soft tissue sarcoma (STS) patients after curative surgery...
  48. doi request reprint The elevated preoperative derived neutrophil-to-lymphocyte ratio predicts poor clinical outcome in breast cancer patients
    Sabine Krenn-Pilko
    Department of Therapeutic Radiology and Oncology, Comprehensive Cancer Center, Medical University of Graz, Auenbruggerplatz 32, 8036, Graz, Austria
    Tumour Biol 37:361-8. 2016
    ..54, 95 % CI 0.91-2.59, p = 0.106). The present study shows that the pre-treatment dNLR is an independent prognostic factor that could be useful for future individual risk assessment in breast cancer patients. ..
  49. pmc Loss of adipose triglyceride lipase is associated with human cancer and induces mouse pulmonary neoplasia
    Wael Al-Zoughbi
    Institute of Pathology, Medical University of Graz, Graz, Austria
    Oncotarget 7:33832-40. 2016
    ..We propose to evaluate loss of ATGL protein expression for the diagnosis of malignant tumors. Finally, modulation of the lipolytic pathway may represent a novel therapeutic approach in the treatment of human cancer. ..
  50. pmc The AST/ALT (De-Ritis) ratio: A novel marker for critical limb ischemia in peripheral arterial occlusive disease patients
    Peter Rief
    aDivision of Vascular Medicine bDivision of Oncology cIntensive Care Unit, Department of Internal Medicine, Medical University Graz, Graz, Austria
    Medicine (Baltimore) 95:e3843. 2016
    ..The AAR is a broadly available and cheap marker, which might be useful to highlight patients at high risk for vascular endpoints. ..
  51. pmc Critical evaluation of the potential prognostic value of the pretreatment-derived neutrophil-lymphocyte ratio under consideration of C-reactive protein levels in clear cell renal cell carcinoma
    Orietta Dalpiaz
    Department of Urology, Medical University of Graz, Auenbruggerplatz 5 6, Graz A 8036, Austria
    Br J Cancer 116:85-90. 2017
    ....
  52. ncbi request reprint Comparison of the 2002 and 2010 version of the TNM classification system regarding the prediction of metastasis-free survival in patients with renal cell carcinoma
    Georg C Hutterer
    Department of Urology, Medical University of Graz, Graz, Austria Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria Weill Cornell Medical College, New York, NY Department of Urology, Medical University Graz, Graz, Austria
    J Clin Oncol 30:448. 2012
    ..Therefore, we decided to compare the predictive ability of the 2010 vs. the 2002 version of the TNM classification system...
  53. doi request reprint Evaluation of the platelet-to-lymphocyte ratio as a prognostic indicator in a European cohort of patients with prostate cancer treated with radiotherapy
    Tanja Langsenlehner
    Department of Therapeutic Radiology and Oncology, Comprehensive Cancer Center, Medical University of Graz, Austria Electronic address
    Urol Oncol 33:201.e9-16. 2015
    ..To evaluate the prognostic value of the PLR in prostate cancer, we performed the present study...
  54. doi request reprint An elevated preoperative plasma fibrinogen level is associated with poor disease-specific and overall survival in breast cancer patients
    Sabine Krenn-Pilko
    Department of Therapeutic Radiology and Oncology, Comprehensive Cancer Center, Medical University of Graz, Austria
    Breast 24:667-72. 2015
    ..In the present study, we evaluated the prognostic significance of the preoperative plasma fibrinogen level in a large cohort of breast cancer patients...
  55. pmc Current Status of Long Non-Coding RNAs in Human Breast Cancer
    Stefanie Cerk
    Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz 8026, Austria
    Int J Mol Sci 17:. 2016
    ..lncRNAs are involved in cancer initiation, progression, and metastases. In this review, we summarize the recent literature to highlight the current status of this class of long non-coding lncRNAs in breast cancer. ..
  56. doi request reprint Validation of the neutrophil-to-lymphocyte ratio as a prognostic factor in a cohort of European prostate cancer patients
    Tanja Langsenlehner
    Department of Therapeutic Radiology and Oncology, Comprehensive Cancer Center Graz, Medical University of Graz, Auenbruggerplatz 32, 8036, Graz, Austria
    World J Urol 33:1661-7. 2015
    ..In the present study, we validated the prognostic relevance of an elevated NLR in a cohort of European prostate cancer patients...
  57. pmc Elevated Blood Urea Nitrogen is Associated With Critical Limb Ischemia in Peripheral Arterial Disease Patients
    Thomas Gary
    From the Division of Angiology TG, FH, GH, PR, PE, MB Division of Oncology MP and Division of Nephrology GS, Department of Internal Medicine, Medical University Graz, Graz, Austria
    Medicine (Baltimore) 94:e948. 2015
    ..The BUN is an easily determinable, broadly available, and inexpensive marker that could be used to identify patients at high risk for vascular endpoints...
  58. doi request reprint Common gene variants in RAD51, XRCC2 and XPD are not associated with clinical outcome in soft-tissue sarcoma patients
    Joanna Szkandera
    Division of Clinical Oncology, Research Unit Genetic Epidemiology and Pharmacogenetics, Department of Medicine, Medical University of Graz, Graz, Austria
    Cancer Epidemiol 37:1003-9. 2013
    ..In this study we investigated the association between these polymorphisms and time to recurrence (TTR) and overall survival (OS) in soft-tissue sarcoma (STS) patients after curative surgery...
  59. doi request reprint Low preoperative lymphocyte-monocyte ratio (LMR) represents a potentially poor prognostic factor in nonmetastatic clear cell renal cell carcinoma
    Georg C Hutterer
    Department of Urology, Medical University of Graz, Graz, Austria Electronic address
    Urol Oncol 32:1041-8. 2014
    ..However, findings about LMR׳s prognostic significance in RCC have not been reported yet...
  60. pmc Can Multistate Modeling of Local Recurrence, Distant Metastasis, and Death Improve the Prediction of Outcome in Patients With Soft Tissue Sarcomas?
    Florian Posch
    Clinical Division of Medical Oncology, Department of Medicine, Comprehensive Cancer Center Graz, Medical University of Graz, Auenbruggerplatz 15, 8036, Graz, Austria
    Clin Orthop Relat Res . 2017
    ..To our knowledge, no study of this kind has been performed before in patients with soft tissue sarcoma...
  61. doi request reprint The Preoperative AST/ALT (De Ritis) Ratio Represents a Poor Prognostic Factor in a Cohort of Patients with Nonmetastatic Renal Cell Carcinoma
    Angelika Bezan
    Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria
    J Urol 194:30-5. 2015
    ..We evaluated the prognostic value of the preoperatively assessed AST/ALT (De Ritis) ratio on clinically meaningful end points in a large European cohort of patients with nonmetastatic renal cell carcinoma...
  62. doi request reprint NEMO expression in human hepatocellular carcinoma and its association with clinical outcome
    Ariane Aigelsreiter
    Institute of Pathology, Medical University of Graz, Austria
    Hum Pathol 43:1012-9. 2012
    ..Although low NEMO expression is correlated with a poor 5-year overall survival in patients with HCC, NEMO cannot be regarded as an independent prognostic marker for predicting the clinical outcome of patients suffering from HCC...
  63. doi request reprint A common gene variant in PLS3 predicts colon cancer recurrence in women
    Joanna Szkandera
    Division of Clinical Oncology, Department of Medicine, Medical University of Graz, Graz, Austria
    Tumour Biol 34:2183-8. 2013
    ..In conclusion, we identified a common gene variant in PLS3 as an independent prognostic marker in female patients with stage II and III colon cancer. Larger prospective trials are warranted to confirm these findings...
  64. ncbi request reprint Molecular Targeted Therapies in Hepatocellular Carcinoma: Past, Present and Future
    Michael Stotz
    Division of Clinical Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria
    Anticancer Res 35:5737-44. 2015
    ..We explore the current status of evidence, identify areas of pressing experimental need, and provide an outline of promising future therapeutic options. ..
  65. pmc miR-199a and miR-497 Are Associated with Better Overall Survival due to Increased Chemosensitivity in Diffuse Large B-Cell Lymphoma Patients
    Katharina Troppan
    Division of Hematology, Department of Internal Medicine, Medical University Graz, 8036 Graz, Austria
    Int J Mol Sci 16:18077-95. 2015
    ..This functional impairment may serve as a potential novel therapeutic target in future treatment of patients with DLBCL...
  66. doi request reprint The elevated C-reactive protein level is associated with poor prognosis in prostate cancer patients treated with radiotherapy
    Eva Maria Thurner
    Department of Therapeutic Radiology and Oncology, Medical University of Graz, Austria
    Eur J Cancer 51:610-9. 2015
    ..In the present study, we analysed the prognostic relevance of elevated plasma CRP levels in prostate cancer patients treated with radiotherapy...
  67. doi request reprint Nephroblastomas show low expression of microR-204 and high expression of its target, the oncogenic transcription factor MEIS1
    Karin Koller
    1 Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, 8036 Graz, Austria
    Pediatr Dev Pathol 17:169-75. 2014
    ..The statistically significantly lower expression of miR-204 in all nephroblastomas investigated might point to an involvement of miR-204 in the regulation of MEIS1 in nephroblastomas...
  68. doi request reprint The pluripotent renal stem cell regulator SIX2 is activated in renal neoplasms and influences cellular proliferation and migration
    Upeka Senanayake
    Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, 8036 Graz, Austria
    Hum Pathol 44:336-45. 2013
    ..SIX2 also appears to be a valuable marker for minimal residual blastema contributing to the prognosis of nephroblastomas...
  69. ncbi request reprint MicroRNAs in renal cell carcinoma: implications for pathogenesis, diagnosis, prognosis and therapy
    Bader Mohamad Al-Ali
    Department of Urology, Medical University of Graz, Graz, Austria
    Anticancer Res 32:3727-32. 2012
    ..The aim of this review is to provide an overview of the role of microRNAs in the pathogenesis of RCC and to discuss their potential as diagnostic, prognostic and, ultimately, therapeutic biomolecules...
  70. doi request reprint Sunitinib causes dose-dependent negative functional effects on myocardium and cardiomyocytes
    Peter P Rainer
    Division of Cardiology, Department of Internal Medicine, Medical University Graz, Austria
    BJU Int 110:1455-62. 2012
    ..To search for microRNAs as suitable biomarkers for indicating toxic cardiac effects...
  71. doi request reprint Quantitative short-tandem repeat analysis of recipient-derived cells as an additional tool for diagnosing cardiac allograft rejection
    Martin Pichler
    Department of Oncology, University Clinic of Internal Medicine, Medical University of Graz, Graz, Austria
    Transplantation 89:749-55. 2010
    ..We compared the amount of recipient-derived cells with the histopathologic grade of rejection in cardiac allografts to determine whether this method might be useful for the assessment of rejection episodes...
  72. ncbi request reprint Independent Prognostic Value of Serum Markers in Diffuse Large B-Cell Lymphoma in the Era of the NCCN-IPI
    Thomas Melchardt
    From the Department of Internal Medicine III, Cancer Research Institute, Paracelsus Medical University Salzburg, Salzburg, Austria Division of Hematology, Medical University of Graz, Graz, Austria Institute of Pathology, Paracelsus Medical University Salzburg, Salzburg, Austria and Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Duarte, Texas
    J Natl Compr Canc Netw 13:1501-8. 2015
    ....
  73. doi request reprint Successful use of sorafenib after bortezomib failure in metastatic follicular thyroid cancer - a case report
    Florian Eisner
    Division of Oncology, Department of Internal Medicine, Medical University of Graz, Austria
    Onkologie 36:368-70. 2013
    ..When DTC recurs or metastasizes to distant sites despite the use of local and radiotherapeutic treatment modalities, the currently effective treatment options are limited...
  74. pmc Tumor macroenvironment and metabolism
    Wael Al-Zoughbi
    Institute of Pathology, Medical University of Graz, Graz, Austria
    Semin Oncol 41:281-95. 2014
    ..Finally, ways to target the tumor macroenvironment that will provide new approaches for therapeutic concepts are described. ..
  75. doi request reprint Complex tumor genomes inferred from single circulating tumor cells by array-CGH and next-generation sequencing
    Ellen Heitzer
    Institute of Human Genetics, Medical University of Graz, Graz, Austria
    Cancer Res 73:2965-75. 2013
    ..This study paves the way to use CTCs as a liquid biopsy in patients with cancer, providing more effective options to monitor tumor genomes that are prone to change during progression, treatment, and relapse...
  76. pmc The role of microRNAs in breast cancer stem cells
    Daniela Schwarzenbacher
    Division of Clinical Oncology, Department of Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria
    Int J Mol Sci 14:14712-23. 2013
    ..This review highlights the recent findings and crucial role of miRNAs in the maintenance, growth and behavior of BCSCs, thus indicating the potential for novel diagnostic, prognostic and therapeutic miRNA-based strategies. ..
  77. pmc Neutrophil-to-lymphocyte ratio and its association with critical limb ischemia in PAOD patients
    Thomas Gary
    Division of Vascular Medicine, Department of Internal Medicine, Medical University Graz, Graz, Austria
    PLoS ONE 8:e56745. 2013
    ..We therefore investigated NLR and its association with CLI and other vascular endpoints in peripheral arterial occlusive disease (PAOD) patients...
  78. doi request reprint Histiocytic sarcoma - targeted therapy: novel therapeutic options? A series of 4 cases
    Konstantin Schlick
    Department of Internal Medicine, Division of Hematooncology, Paracelsus Medical University of Salzburg, Austria
    Onkologie 35:447-50. 2012
    ..Some data from single case reports have suggested efficacy for high-dose chemotherapy and autologous/allogeneic stem cell transplantation...
  79. pmc Evaluation of high-resolution melting analysis as a diagnostic tool to detect the BRAF V600E mutation in colorectal tumors
    Martin Pichler
    Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria
    J Mol Diagn 11:140-7. 2009
    ..Despite the expected decrease in sensitivity, HRM can reliably be applied in archival formalin-fixed, paraffin-embedded samples tissues...
  80. pmc Current status of long non-coding RNAs in human cancer with specific focus on colorectal cancer
    Maria Smolle
    Institute of Pathology, Medical University Graz, Auenbruggerplatz 25, A 8036 Graz, Austria
    Int J Mol Sci 15:13993-4013. 2014
    ..In this review, we provide an overview of different lncRNAs and their role in human cancers. In particular, we emphasize their importance in tumorigenesis of colorectal cancer, the third most common cancer worldwide. ..
  81. pmc MicroRNAs as novel predictive biomarkers and therapeutic targets in colorectal cancer
    Verena Stiegelbauer
    Verena Stiegelbauer, Samantha Perakis, Armin Gerger, Division of Clinical Oncology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, Austria
    World J Gastroenterol 20:11727-35. 2014
    ..This review summarizes current therapeutic approaches for treating CRC and highlights the role of miRNAs as novel predictive biomarkers and potential drug targets in CRC patients. ..
  82. pmc Quality control of RNA preservation and extraction from paraffin-embedded tissue: implications for RT-PCR and microarray analysis
    Karl Kashofer
    Institute of Pathology, Medical University of Graz, Graz, Austria
    PLoS ONE 8:e70714. 2013
    ....
  83. ncbi request reprint MicroRNAs in testicular cancer: implications for pathogenesis, diagnosis, prognosis and therapy
    Angelika Bezan
    Division of Clinical Oncology, Medical University of Graz, Comprehensive Cancer Center Graz, Graz, Austria
    Anticancer Res 34:2709-13. 2014
    ..This proportion of patients is even lower for those with seminomas or pure embryonal carcinomas as alpha-fetoprotein is predominantly related to yolk sac tumor and human chorionic gonadotropin to choriocarcinoma. ..
  84. pmc High quality assessment of DNA methylation in archival tissues from colorectal cancer patients using quantitative high-resolution melting analysis
    Marija Balic
    Division of Oncology, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036, Graz, Austria
    J Mol Diagn 11:102-8. 2009
    ..The ability to analyze archival tissues greatly facilitates further research and its clinical implementation...
  85. pmc Targeting signaling pathways in epithelial ovarian cancer
    Elisabeth Smolle
    Institute of Pathology, Medical University Graz, Auenbruggerplatz 25, A 8036 Graz, Austria
    Int J Mol Sci 14:9536-55. 2013
    ..The understanding of these molecular pathways is essential for the development of novel therapeutic strategies...
  86. ncbi request reprint Clusterin expression in elastofibroma dorsi
    Ariane Aigelsreiter
    Institute of Pathology, Medical University of Graz, Austria
    Histol Histopathol 28:597-603. 2013
    ..We evaluated the staining pattern and possible role of clusterin in elastofibroma dorsi...