Burkert Pieske

Summary

Affiliation: Medical University of Graz
Country: Austria

Publications

  1. pmc Effect of eplerenone on parathyroid hormone levels in patients with primary hyperparathyroidism: a randomized, double-blind, placebo-controlled trial
    Andreas Tomaschitz
    Department of Cardiology, Medical University of Graz, Auenbruggerplatz 15, Graz, 8036, Austria
    BMC Endocr Disord 12:19. 2012
  2. doi request reprint Impact of diabetes and hypertension on the heart
    Burkert Pieske
    Department of Cardiology, Medical University of Graz, Graz, Austria
    Curr Opin Cardiol 23:340-9. 2008
  3. pmc The slow force response to stretch in atrial and ventricular myocardium from human heart: functional relevance and subcellular mechanisms
    Jens Kockskamper
    Department of Cardiology, Medical University of Graz, Auenbruggerplatz 15, Graz, Austria
    Prog Biophys Mol Biol 97:250-67. 2008
  4. pmc Angiotensin II and myosin light-chain phosphorylation contribute to the stretch-induced slow force response in human atrial myocardium
    Jens Kockskamper
    Division of Cardiology, Medical University of Graz, Auenbruggerplatz 15, A 8036 Graz, Austria
    Cardiovasc Res 79:642-51. 2008
  5. doi request reprint Na+-dependent SR Ca2+ overload induces arrhythmogenic events in mouse cardiomyocytes with a human CPVT mutation
    Simon Sedej
    Division of Cardiology, Medical University of Graz, Auenbruggerplatz 15, Graz A 8036, Austria
    Cardiovasc Res 87:50-9. 2010
  6. doi request reprint Direct pro-arrhythmogenic effects of angiotensin II can be suppressed by AT1 receptor blockade in human atrial myocardium
    Dirk von Lewinski
    Department of Cardiology, Medical University Graz, Graz, Austria
    Eur J Heart Fail 10:1172-6. 2008
  7. doi request reprint Reduced stretch-induced force response in failing human myocardium caused by impaired Na(+)-contraction coupling
    Dirk von Lewinski
    Department of Cardiology, Medical University Graz, Graz, Austria
    Circ Heart Fail 2:47-55. 2009
  8. ncbi request reprint Endothelin-1 enhances nuclear Ca2+ transients in atrial myocytes through Ins(1,4,5)P3-dependent Ca2+ release from perinuclear Ca2+ stores
    Jens Kockskamper
    Department of Cardiology and Pneumology, University Medicine Gottingen, Germany
    J Cell Sci 121:186-95. 2008
  9. ncbi request reprint Frequency-dependence of the slow force response
    Dirk von Lewinski
    Department of Cardiology, Medical University Graz, Austria
    Front Biosci 13:7202-9. 2008
  10. doi request reprint Glucose-transporter-mediated positive inotropic effects in human myocardium of diabetic and nondiabetic patients
    Dirk von Lewinski
    Department of Cardiology, Medical University Graz, Graz, Austria
    Metabolism 59:1020-8. 2010

Collaborators

  • Jens Kockskamper
  • Dirk von Lewinski
  • L S Maier
  • Thomas Eschenhagen
  • G Hasenfuss
  • Harald Kogler
  • Paul M L Janssen
  • O Zeitz
  • Michael Grimm
  • D M Bers
  • Gerrit Isenberg
  • Jan D Schmitto
  • Godfrey Smith
  • H Drexler
  • Claus Luers
  • Wolfgang Schillinger
  • Andreas Tomaschitz
  • Simon Sedej
  • Albrecht Schmidt
  • Stefanie Walther
  • Frank R Heinzel
  • Olga V Nakipova
  • Gero Tenderich
  • Egbert Bisping
  • Kurt Reifenberg
  • Rolf Wachter
  • Li Zhen Yang
  • Andreas Elgner
  • Heiner Post
  • Nils Teucher
  • Hans Peter Hermann
  • Stefan Wagner
  • Beate Fiedler
  • Clemens Mittmann
  • Andreas Meinitzer
  • Katharina Kienreich
  • Karin Amrein
  • Elisabeth Kraigher-Krainer
  • Stefan Pilz
  • Eberhard Ritz
  • Nicolas Verheyen
  • Jörg H Horina
  • Caterina Colantonio
  • Astrid Fahrleitner-Pammer
  • Jan Groborz
  • Carlo Napolitano
  • Paulina Wakula
  • Phillip Gronau
  • F Anthony Lai
  • Silvia G Priori
  • Nataliya Dybkova
  • Marc A Vos
  • Nadezhda A Chumaeva
  • Lutz Binder
  • Gerd Rechtsteiner
  • Christoph Herrmann-Lingen
  • Andrey I Anufriev
  • Sarah Kettlewell
  • Christoph Becker
  • Samuel Sossalla
  • Burkhard Stumme
  • Jürgen Löhler
  • Friedrich A Schöndube
  • Michael Torzewski
  • Hans Anton Lehr
  • Gisela Steige
  • Sibylle Kleta
  • Giuliano Ramadori
  • Nico Janicke
  • Nadezhda M Zakharova
  • Leonid S Kosarskii
  • Carola Werner
  • Dirk Raddatz
  • Andrea Pautz
  • Ines Küpper
  • Ken Ichi Yamamura
  • Elena Wiese
  • Kerstin Griebel
  • Sebastian Bruns
  • Sibylle Ott
  • Petra Nusser
  • Philip Wenzel
  • Aleksey Averin
  • Dirk Wetzel
  • Paul Barckhausen
  • Harald Schwörer
  • Hartmut Kleinert
  • Thomas Munzel
  • Tobias Warger
  • Dirk von Lewinski

Detail Information

Publications36

  1. pmc Effect of eplerenone on parathyroid hormone levels in patients with primary hyperparathyroidism: a randomized, double-blind, placebo-controlled trial
    Andreas Tomaschitz
    Department of Cardiology, Medical University of Graz, Auenbruggerplatz 15, Graz, 8036, Austria
    BMC Endocr Disord 12:19. 2012
    ..abstract:..
  2. doi request reprint Impact of diabetes and hypertension on the heart
    Burkert Pieske
    Department of Cardiology, Medical University of Graz, Graz, Austria
    Curr Opin Cardiol 23:340-9. 2008
    ....
  3. pmc The slow force response to stretch in atrial and ventricular myocardium from human heart: functional relevance and subcellular mechanisms
    Jens Kockskamper
    Department of Cardiology, Medical University of Graz, Auenbruggerplatz 15, Graz, Austria
    Prog Biophys Mol Biol 97:250-67. 2008
    ..Increased myofilament Ca2+ sensitivity through MLCK-induced phosphorylation of MLC2 is a novel mechanism contributing to the SFR in both atrium and ventricle...
  4. pmc Angiotensin II and myosin light-chain phosphorylation contribute to the stretch-induced slow force response in human atrial myocardium
    Jens Kockskamper
    Division of Cardiology, Medical University of Graz, Auenbruggerplatz 15, A 8036 Graz, Austria
    Cardiovasc Res 79:642-51. 2008
    ..The functional effects of stretch on human atrium, however, are poorly understood. Thus, we characterized the stretch-induced force response in human atrium and evaluated the underlying cellular mechanisms...
  5. doi request reprint Na+-dependent SR Ca2+ overload induces arrhythmogenic events in mouse cardiomyocytes with a human CPVT mutation
    Simon Sedej
    Division of Cardiology, Medical University of Graz, Auenbruggerplatz 15, Graz A 8036, Austria
    Cardiovasc Res 87:50-9. 2010
    ..However, whether elevated SR Ca(2+) content--in the absence of protein kinase A activation--affects RyR2 function and arrhythmogenesis in CPVT remains elusive...
  6. doi request reprint Direct pro-arrhythmogenic effects of angiotensin II can be suppressed by AT1 receptor blockade in human atrial myocardium
    Dirk von Lewinski
    Department of Cardiology, Medical University Graz, Graz, Austria
    Eur J Heart Fail 10:1172-6. 2008
    ..Since mechanisms of this protective effect of RAS-blockade are poorly understood, we directly tested proarrhythmic effects of angiotensin II (Ang II) in human atrial myocardium...
  7. doi request reprint Reduced stretch-induced force response in failing human myocardium caused by impaired Na(+)-contraction coupling
    Dirk von Lewinski
    Department of Cardiology, Medical University Graz, Graz, Austria
    Circ Heart Fail 2:47-55. 2009
    ..This study aimed to characterize functional differences in the stretch response between failing and nonfailing human myocardium...
  8. ncbi request reprint Endothelin-1 enhances nuclear Ca2+ transients in atrial myocytes through Ins(1,4,5)P3-dependent Ca2+ release from perinuclear Ca2+ stores
    Jens Kockskamper
    Department of Cardiology and Pneumology, University Medicine Gottingen, Germany
    J Cell Sci 121:186-95. 2008
    ..This effect is mediated by the coupling of endothelin receptor A to PLC-Ins(1,4,5)P3 signalling and might contribute to excitation-transcription coupling...
  9. ncbi request reprint Frequency-dependence of the slow force response
    Dirk von Lewinski
    Department of Cardiology, Medical University Graz, Austria
    Front Biosci 13:7202-9. 2008
    ..Subcellular mechanisms underlying the SFR are not fundamentally affected by stimulation rate. The SFR may have more pronounced physiological effects at lower heart rates...
  10. doi request reprint Glucose-transporter-mediated positive inotropic effects in human myocardium of diabetic and nondiabetic patients
    Dirk von Lewinski
    Department of Cardiology, Medical University Graz, Graz, Austria
    Metabolism 59:1020-8. 2010
    ..Differences in functional effects or messenger RNA expression of glucose transporters were not detectable between patients with and without diabetes...
  11. ncbi request reprint Negative inotropy of the gastric proton pump inhibitor pantoprazole in myocardium from humans and rabbits: evaluation of mechanisms
    Wolfgang Schillinger
    Herzzentrum, Kardiologie und Pneumologie, Georg August Universitaet Goettingen, Robert Koch Strasse 40, 37099 Goettingen, Germany
    Circulation 116:57-66. 2007
    ..Proton pump inhibitors are used extensively for acid-related gastrointestinal diseases. Their effect on cardiac contractility has not been assessed directly...
  12. ncbi request reprint Stretch-dependent slow force response in isolated rabbit myocardium is Na+ dependent
    Dirk von Lewinski
    Department of Cardiology and Pneumology, Georg August University, Robert Koch Str 40, 37075, Gottingen, Germany
    Cardiovasc Res 57:1052-61. 2003
    ..Stretch induces functional and trophic effects in mammalian myocardium via various signal transduction pathways. We tested stretch signal transduction on immediate and slow force response (SFR) in rabbit myocardium...
  13. ncbi request reprint Sarcoplasmic reticulum Ca2+ load in human heart failure
    Burkert Pieske
    Labor für Molekulare Kardiologie und Herzmuskelphysiologie, Abteilung Kardiologie und Angiologie, Georg August Universitat Gottingen, Robert Koch Str 40, 37085 Göttingen, Germany
    Basic Res Cardiol 97:I63-71. 2002
    ..Reduced SR Ca2+ release is due to diminished SR Ca2+ content directly related to a depressed expression of SERCA2a protein. Enhancing SERCA function or expression may improve SR Ca2+ handling in failing human myocardium...
  14. ncbi request reprint Calcium cycling in congestive heart failure
    Gerd Hasenfuss
    Department of Cardiology and Pneumology, University of Gottingen, Robert Koch Strasse 40, 37075 Gottingen, Germany
    J Mol Cell Cardiol 34:951-69. 2002
  15. ncbi request reprint The seasonal peculiarities of force-frequency relationships in active ground squirrel Spermophilus undulatus ventricle
    Olga V Nakipova
    Institute of Cell Biophysics, Russian Academy of Sciences, Institutskaya Street 3, 142290 Pushchino Moscow region, Russia
    Cryobiology 55:173-81. 2007
    ..Also, how myocardium during the hibernation period copes functionally with acute decreases in temperature was investigated...
  16. ncbi request reprint Atrial myocardium is the predominant inotropic target of adrenomedullin in the human heart
    Egbert Bisping
    Department of Cardiology, University of Gottingen, Gottingen, Germany
    Am J Physiol Heart Circ Physiol 293:H3001-7. 2007
    ..The inotropic effects are related to increased cAMP levels and stimulation of PKA. In heart failure, the responsiveness to ADM is reduced in atria and ventricles...
  17. pmc Interferon-gamma induces chronic active myocarditis and cardiomyopathy in transgenic mice
    Kurt Reifenberg
    Central Laboratory Animal Facility, Johannes Gutenberg University, Mainz, Germany
    Am J Pathol 171:463-72. 2007
    ..Myotoxic IFN-gamma effects could not be detected in smooth or striated muscle tissue, suggesting cardiomyocellular specificity of the toxic IFN-gamma effect. The precise mechanism of IFN-gamma cardiotoxicity remains to be elucidated...
  18. ncbi request reprint Impact of diabetes on left ventricular diastolic function in patients with arterial hypertension
    Rolf Wachter
    Department of Cardiology and Pneumology, University of Gottingen, Robert Koch Str 40, 37075 Gottingen, Germany
    Eur J Heart Fail 9:469-76. 2007
    ..To analyse the effect of diabetes (DM) on diastolic function in hypertensive patients...
  19. ncbi request reprint Phosphorylation of the cardiac ryanodine receptor by Ca2+/calmodulin-dependent protein kinase II: the dominating twin of protein kinase A?
    Jens Kockskamper
    Circ Res 99:333-5. 2006
  20. ncbi request reprint Arginase: a modulator of myocardial function
    Heiner Post
    Am J Physiol Heart Circ Physiol 290:H1747-8. 2006
  21. ncbi request reprint Urocortin II enhances contractility in rabbit ventricular myocytes via CRF(2) receptor-mediated stimulation of protein kinase A
    Li Zhen Yang
    Department of Molecular Neuroendocrinology, Max Planck Institute for Experimental Medicine, Hermann Rein Strasse 3, D 37075 Gottingen, Germany
    Cardiovasc Res 69:402-11. 2006
    ..Direct effects of UcnII on adult cardiomyocytes have not been evaluated before. Our aim was to characterize functional effects of UcnII on cardiomyocytes and to elucidate the underlying signaling pathway(s) and cellular mechanisms...
  22. ncbi request reprint The role of SR Ca(2+)-content in blunted inotropic responsiveness of failing human myocardium
    Lars S Maier
    Abteilung Kardiologie und Pneumologie, Zentrum Innere Medizin, Georg August Universitat Gottingen, Gottingen, Germany
    J Mol Cell Cardiol 34:455-67. 2002
    ..In contrast, the maintained inotropic response to pyruvate despite reduced SR Ca(2+)-loading points to additional subcellular effects such as enhanced myofilament Ca(2+)-responsiveness...
  23. ncbi request reprint Rate dependence of [Na+]i and contractility in nonfailing and failing human myocardium
    Burkert Pieske
    Abteilung Kardiologie und Pneumologie, Georg August Universitat Gottingen, Germany
    Circulation 106:447-53. 2002
    ..Because Ca2+ and Na+ homeostasis are intimately linked through the Na+/Ca2+ exchanger, we compared the regulation of [Na+]i in nonfailing (NF) and failing human myocardium...
  24. ncbi request reprint Expression of ten RGS proteins in human myocardium: functional characterization of an upregulation of RGS4 in heart failure
    Clemens Mittmann
    Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Abteilung für Pharmakologie, Universitatsklinikum Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Cardiovasc Res 55:778-86. 2002
    ..We investigated the expression of RGS proteins in the human heart and whether they take part in the pathophysiological changes of heart failure...
  25. pmc Inhibition of calcineurin-NFAT hypertrophy signaling by cGMP-dependent protein kinase type I in cardiac myocytes
    Beate Fiedler
    Department of Cardiology and Angiology, Hannover Medical School, 30625 Hannover, Germany
    Proc Natl Acad Sci U S A 99:11363-8. 2002
    ..Inhibition of calcineurin-NFAT signaling by PKG I provides a framework for understanding how NO inhibits cardiac myocyte hypertrophy...
  26. ncbi request reprint Alternans goes subcellular: a "disease" of the ryanodine receptor?
    Burkert Pieske
    Circ Res 91:553-5. 2002
  27. ncbi request reprint Insulin-like growth factor-1 exerts Ca2+-dependent positive inotropic effects in failing human myocardium
    Dirk von Lewinski
    Abteilung Kardiologie und Pneumologie, Georg August Universitat Gottingen, Germany
    Circ Res 92:169-76. 2003
    ..The increased [Ca2+]i with IGF-1 originates from both enhanced L-type Ca2+ currents and enhanced Na+-H+ exchange-dependent reverse-mode Na+-Ca2+ exchange. These nongenomic functional effects of IGF-1 may be of clinical relevance...
  28. ncbi request reprint Sodium and the heart: a hidden key factor in cardiac regulation
    Burkert Pieske
    Cardiovasc Res 57:871-2. 2003
  29. ncbi request reprint [Na+]i handling in the failing human heart
    Burkert Pieske
    Abt Kardiologie und Pneumologie, Zentrum Innere Medizin, Klinik der Georg August Universität, Robert Koch Strasse 40, 37075, Gottingen, Germany
    Cardiovasc Res 57:874-86. 2003
    ....
  30. ncbi request reprint Na(+)-Ca(2+) exchanger overexpression predisposes to reactive oxygen species-induced injury
    Stefan Wagner
    Department of Cardiology and Pneumology, , Robert Koch Str 40, , Germany
    Cardiovasc Res 60:404-12. 2003
    ..It was shown that failing cardiac myocytes are more susceptible to ROS-induced damage, possibly due to increased expression of the sarcolemmal Na-Ca exchanger (NCX)...
  31. ncbi request reprint Improved systolic and diastolic myocardial function with intracoronary pyruvate in patients with congestive heart failure
    Hans Peter Hermann
    Abteilung Kardiologie und Pneumologie, Georg August Universitat Gottingen, Robert Koch Str 40, Göttingen D 37075, Germany
    Eur J Heart Fail 6:213-8. 2004
    ..Pyruvate increases myocardial performance in isolated myocardium and improves hemodynamics in patients with congestive heart failure...
  32. ncbi request reprint Functional relevance of the stretch-dependent slow force response in failing human myocardium
    Dirk von Lewinski
    Department of Cardiology and Pneumology, Georg August University, Gottingen, Germany
    Circ Res 94:1392-8. 2004
    ..The data demonstrate the existence of a functionally relevant, SR-Ca2+-dependent SFR in failing human myocardium, which partly depends on NHE1 and reverse-mode NCX activation...
  33. ncbi request reprint Insulin causes [Ca2+]i-dependent and [Ca2+]i-independent positive inotropic effects in failing human myocardium
    Dirk von Lewinski
    Abteilung Kardiologie und Pneumologie, Georg August Universitat Gottingen, Gottingen, Germany
    Circulation 111:2588-95. 2005
    ..We examined inotropic responses and signal transduction mechanisms of insulin in human myocardium...
  34. ncbi request reprint Increased SR Ca2+ cycling contributes to improved contractile performance in SERCA2a-overexpressing transgenic rats
    Lars S Maier
    Abt Kardiologie and Pneumologie Herzzentrum, Georg August Universitat Gottingen, Germany
    Cardiovasc Res 67:636-46. 2005
    ..We reported that SERCA2a-overexpression in transgenic rat hearts (TG) results in improved contractility. However, it was not clear whether TG have improved contractility due to frequency-dependent improved SR Ca2+ handling...
  35. ncbi request reprint Stretch-dependent modulation of [Na+]i, [Ca2+]i, and pHi in rabbit myocardium--a mechanism for the slow force response
    Claus Luers
    Department of Cardiology and Pneumology, University of Goettingen, Robert Koch Strasse 40, 37075 Goettingen, Germany
    Cardiovasc Res 68:454-63. 2005
    ..We tested whether stretch-dependent stimulation of Na(+)/H(+) exchange (NHE1) and consecutive changes in pH(i) and/or [Na(+)](i) may underlie the SFR...
  36. ncbi request reprint Influence of pyruvate on contractile performance and Ca(2+) cycling in isolated failing human myocardium
    Gerd Hasenfuss
    Abteilung Kardiologie und Pneumologie, Zentrum Innere Medizin, Georg August Universitat Gottingen, Germany
    Circulation 105:194-9. 2002
    ..We assessed the influence of pyruvate on systolic and diastolic myocardial function and its subcellular mode of action in isolated myocardium from end-stage failing human hearts...