Dontscho Kerjaschki

Summary

Affiliation: Medical University of Vienna
Country: Austria

Publications

  1. pmc The crucial role of macrophages in lymphangiogenesis
    Dontscho Kerjaschki
    Department of Pathology, Medical University Vienna, Vienna, Austria
    J Clin Invest 115:2316-9. 2005
  2. ncbi request reprint Lymphatic neoangiogenesis in renal transplants: a driving force of chronic rejection?
    Dontscho Kerjaschki
    Department of Pathology, Medical University of Vienna, Vienna, Austria
    J Nephrol 19:403-6. 2006
  3. pmc 2015 Homer W. Smith Award: The Podocyte from Periphery to Center Stage
    Dontscho Kerjaschki
    Clinical Department of Pathology, Medical University of Vienna, Vienna, Austria
    J Am Soc Nephrol 27:3266-3270. 2016
  4. pmc Lipoxygenase mediates invasion of intrametastatic lymphatic vessels and propagates lymph node metastasis of human mammary carcinoma xenografts in mouse
    Dontscho Kerjaschki
    Clinical Institute of Pathology, Medical University of Vienna, Vienna, Austria
    J Clin Invest 121:2000-12. 2011
  5. ncbi request reprint How to control lymphangiogenesis: a novel role for rapamycin
    D Kerjaschki
    Department of Pathology, Medical University of Vienna Allgemeines Krankenhaus, Vienna, Austria
    Kidney Int 71:717-9. 2007
  6. ncbi request reprint Lymphatic endothelial progenitor cells contribute to de novo lymphangiogenesis in human renal transplants
    Dontscho Kerjaschki
    Department of Pathology, Medical University of Vienna Allgemeines Krankenhaus Währinger Gürtel 18 20, A 1090 Vienna, Austria
    Nat Med 12:230-4. 2006
  7. pmc Lymphatic precollectors contain a novel, specialized subpopulation of podoplanin low, CCL27-expressing lymphatic endothelial cells
    Nikolaus Wick
    Department of Pathology, Vienna Medical University, Vienna, Austria
    Am J Pathol 173:1202-9. 2008
  8. ncbi request reprint Laser capture microdissection of epithelial cancers guided by antibodies against fibroblast activation protein and endosialin
    Christian Rupp
    Institute of Clinical Pathology, Medical University of Vienna, Vienna, Austria
    Diagn Mol Pathol 15:35-42. 2006
  9. pmc Modeling colon adenocarcinomas in vitro a 3D co-culture system induces cancer-relevant pathways upon tumor cell and stromal fibroblast interaction
    Helmut Dolznig
    Institute of Pathology, Medical University of Vienna, Vienna, Austria
    Am J Pathol 179:487-501. 2011
  10. ncbi request reprint Mouse endosialin, a C-type lectin-like cell surface receptor: expression during embryonic development and induction in experimental cancer neoangiogenesis
    Christian Rupp
    Institute of Clinical Pathology, Medical University of Vienna, Waehringer Guertel 18 20, 1090 Vienna, Austria
    Cancer Immun 6:10. 2006

Detail Information

Publications58

  1. pmc The crucial role of macrophages in lymphangiogenesis
    Dontscho Kerjaschki
    Department of Pathology, Medical University Vienna, Vienna, Austria
    J Clin Invest 115:2316-9. 2005
    ..Thus, macrophages support lymphangiogenesis in 2 different ways, either by transdifferentiating and directly incorporating into the endothelial layer or by stimulating division of preexistent local lymphatic endothelial cells...
  2. ncbi request reprint Lymphatic neoangiogenesis in renal transplants: a driving force of chronic rejection?
    Dontscho Kerjaschki
    Department of Pathology, Medical University of Vienna, Vienna, Austria
    J Nephrol 19:403-6. 2006
    ..However, the newly formed lymphatic vessels presumably also organize the perivascular lymphocytes into immunologically active follicular structures which are involved in the survival of the transplant...
  3. pmc 2015 Homer W. Smith Award: The Podocyte from Periphery to Center Stage
    Dontscho Kerjaschki
    Clinical Department of Pathology, Medical University of Vienna, Vienna, Austria
    J Am Soc Nephrol 27:3266-3270. 2016
    ..This review emphasizes the importance of continuous reality checks of experimental results obtained in vitro or with genetically modified animals with human disease...
  4. pmc Lipoxygenase mediates invasion of intrametastatic lymphatic vessels and propagates lymph node metastasis of human mammary carcinoma xenografts in mouse
    Dontscho Kerjaschki
    Clinical Institute of Pathology, Medical University of Vienna, Vienna, Austria
    J Clin Invest 121:2000-12. 2011
    ..These results provide evidence that lipoxygenase serves as a mediator of tumor cell invasion into lymphatic vessels and formation of lymph node metastasis in ductal mammary carcinomas...
  5. ncbi request reprint How to control lymphangiogenesis: a novel role for rapamycin
    D Kerjaschki
    Department of Pathology, Medical University of Vienna Allgemeines Krankenhaus, Vienna, Austria
    Kidney Int 71:717-9. 2007
    ..In this issue Huber et al. demonstrate that rapamycin acts as an efficient inhibitor of lymphangiogenesis...
  6. ncbi request reprint Lymphatic endothelial progenitor cells contribute to de novo lymphangiogenesis in human renal transplants
    Dontscho Kerjaschki
    Department of Pathology, Medical University of Vienna Allgemeines Krankenhaus Währinger Gürtel 18 20, A 1090 Vienna, Austria
    Nat Med 12:230-4. 2006
    ....
  7. pmc Lymphatic precollectors contain a novel, specialized subpopulation of podoplanin low, CCL27-expressing lymphatic endothelial cells
    Nikolaus Wick
    Department of Pathology, Vienna Medical University, Vienna, Austria
    Am J Pathol 173:1202-9. 2008
    ....
  8. ncbi request reprint Laser capture microdissection of epithelial cancers guided by antibodies against fibroblast activation protein and endosialin
    Christian Rupp
    Institute of Clinical Pathology, Medical University of Vienna, Vienna, Austria
    Diagn Mol Pathol 15:35-42. 2006
    ..Using these procedures, RNA from distinct tumor compartments can be isolated, analyzed, amplified, and used for transcription profiling...
  9. pmc Modeling colon adenocarcinomas in vitro a 3D co-culture system induces cancer-relevant pathways upon tumor cell and stromal fibroblast interaction
    Helmut Dolznig
    Institute of Pathology, Medical University of Vienna, Vienna, Austria
    Am J Pathol 179:487-501. 2011
    ....
  10. ncbi request reprint Mouse endosialin, a C-type lectin-like cell surface receptor: expression during embryonic development and induction in experimental cancer neoangiogenesis
    Christian Rupp
    Institute of Clinical Pathology, Medical University of Vienna, Waehringer Guertel 18 20, 1090 Vienna, Austria
    Cancer Immun 6:10. 2006
    ..In future studies, the search for intrinsic or extrinsic signals contributing to endosialin induction in cancer stroma will be of interest...
  11. doi request reprint Thymic medullar conduits-associated podoplanin promotes natural regulatory T cells
    Elke Fuertbauer
    Molecular Immunology Unit, Institute for Hygiene and Applied Immunology, Centre for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Lazarettgasse 19, 1090 Vienna, Austria
    Immunol Lett 154:31-41. 2013
    ..The animals do not remain devoid of nTreg but generate them delayed within the first month resulting in Th2-biased hypergammaglobulinemia but not in the death-causing autoimmune phenotype of Foxp3-deficient Scurfy mice. ..
  12. ncbi request reprint Transcriptomal comparison of human dermal lymphatic endothelial cells ex vivo and in vitro
    Nikolaus Wick
    Clinical Institute for Pathology, General Hospital and Medical University of Vienna, Vienna, Austria
    Physiol Genomics 28:179-92. 2007
    ..Direct ex vivo analysis of the lymphatic endothelial cell transcriptome is helpful for the understanding of the physiology of the lymphatic vascular system and of the pathogenesis of its diseases...
  13. pmc Enhanced lymph vessel density, remodeling, and inflammation are reflected by gene expression signatures in dermal lymphatic endothelial cells in type 2 diabetes
    Monika Haemmerle
    Clinical Institute of Pathology, Medical University of Vienna, Vienna, Austria
    Diabetes 62:2509-29. 2013
    ..In addition, we provide evidence for paracrine cross-talk fostering macrophage recruitment to LECs as one pathophysiological process that might contribute to aberrant lymphangiogenesis and persistent inflammation in the skin. ..
  14. doi request reprint Novel function for blood platelets and podoplanin in developmental separation of blood and lymphatic circulation
    Pavel Uhrin
    Department of Vascular Biology and Thrombosis Research, Center for Biomolecular Medicine and Pharmacology, Medical University of Vienna, Vienna, Austria
    Blood 115:3997-4005. 2010
    ..Therefore, interaction of endothelial podoplanin of the developing lymph sac with circulating platelets from the cardinal vein is critical for separating the lymphatic from the blood vascular system...
  15. ncbi request reprint Lymphatic neoangiogenesis in human kidney transplants is associated with immunologically active lymphocytic infiltrates
    Dontscho Kerjaschki
    Department of Pathology, Medical University of Vienna, Allgemeines Krankenhaus, Vienna, Austria
    J Am Soc Nephrol 15:603-12. 2004
    ....
  16. pmc Selection of scFv Antibody Fragments Binding to Human Blood versus Lymphatic Endothelial Surface Antigens by Direct Cell Phage Display
    Thomas Keller
    Clinical Institute of Pathology, Medical University of Vienna, Vienna, Austria
    PLoS ONE 10:e0127169. 2015
    ....
  17. pmc Alterations in fatty acid utilization and an impaired antioxidant defense mechanism are early events in podocyte injury: a proteomic analysis
    Corina Mayrhofer
    Clinical Institute of Pathology, Medical University of Vienna, Waehringer Gurtel 18 20, A 1090 Vienna, Austria
    Am J Pathol 174:1191-202. 2009
    ..Taken together, these results indicate that a disrupted fatty acid metabolism in concert with an impaired antioxidant defense mechanism in podocytes may play a role in the early stages of PA-induced lesions in podocytes...
  18. pmc Sp1/Sp3 and DNA-methylation contribute to basal transcriptional activation of human podoplanin in MG63 versus Saos-2 osteoblastic cells
    Brigitte Hantusch
    Institute of Clinical Pathology, Medical University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    BMC Mol Biol 8:20. 2007
    ..Here, we characterized the molecular mechanism controlling basal PDPN transcription in human osteoblast-like MG63 versus Saos-2 cells...
  19. ncbi request reprint Podocyte flattening and disorder of glomerular basement membrane are associated with splitting of dystroglycan-matrix interaction
    Kenichiro Kojima
    Institute of Pathology, Medical University of Vienna Allgemeines Krankenhaus, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    J Am Soc Nephrol 15:2079-89. 2004
    ..This links functional damage of the dystroglycan complex with structural changes in the GBM...
  20. ncbi request reprint Lymphatic microvessels in the rat remnant kidney model of renal fibrosis: aminopeptidase p and podoplanin are discriminatory markers for endothelial cells of blood and lymphatic vessels
    Katsuyuki Matsui
    Institute of Clinical Pathology, University of Vienna, Allgemeines Krankenhaus, Vienna, Austria
    J Am Soc Nephrol 14:1981-9. 2003
    ..As lymphatic endothelial cells secrete chemokines that attract dendritic cells, it is possible that the increase in lymphatic vascularization could enhance the immunologic surveillance of remnant kidneys...
  21. pmc Type I interferons promote fatal immunopathology by regulating inflammatory monocytes and neutrophils during Candida infections
    Olivia Majer
    Medical University Vienna Max F Perutz Laboratories, Christian Doppler Laboratory for Infection Biology, Campus Vienna Biocenter, Vienna, Austria
    PLoS Pathog 8:e1002811. 2012
    ..Moreover, our data demonstrate a therapeutic relevance of PPAR-γ agonists for microbial infectious diseases where inflammatory myeloid cells may contribute to fatal tissue damage...
  22. pmc Putting the brakes on mammary tumorigenesis: loss of STAT1 predisposes to intraepithelial neoplasias
    Christine Schneckenleithner
    Institute of Pharmacology and Toxicology, University of Veterinary Medicine, Vienna, Austria
    Oncotarget 2:1043-54. 2011
    ..Furthermore, they define the loss of STAT1 as a predisposing event via enhanced MIN formation...
  23. pmc Tumor-associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesis
    Sebastian F Schoppmann
    Department of Pathology, University of Vienna Allgemeines Krankenhaus, Austria
    Am J Pathol 161:947-56. 2002
    ..In conclusion VEGF-C-expressing TAMs play a novel role in peritumoral lymphangiogenesis and subsequent dissemination in human cancer...
  24. ncbi request reprint A previously unknown dermal blood vessel phenotype in skin inflammation
    Marion Groger
    Division of General Dermatology, Department of Dermatology, Medical University of Vienna, Vienna, Austria
    J Invest Dermatol 127:2893-900. 2007
    ..These findings signify that expression of "lymphatic proteins" on BEC corresponds to cell activation...
  25. pmc Molecular mimicry in pauci-immune focal necrotizing glomerulonephritis
    Renate Kain
    Department of Pathology, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Wien, Austria
    Nat Med 14:1088-96. 2008
    ..Thus, FimH-triggered autoimmunity to LAMP-2 provides a previously undescribed clinically relevant molecular mechanism for the development of pauci-immune FNGN...
  26. ncbi request reprint DIGE compatible labelling of surface proteins on vital cells in vitro and in vivo
    Corina Mayrhofer
    Department of Clinical Pathology, Medical University of Vienna, Vienna, Austria
    Proteomics 6:579-85. 2006
    ..It allows detection of fluorophore-tagged cell surface proteins and visualisation of the accessible proteome within a single 2-D gel, simplifying subsequent UV MALDI-MS analysis...
  27. ncbi request reprint Capillary deposition of complement split product C4d in renal allografts is associated with basement membrane injury in peritubular and glomerular capillaries: a contribution of humoral immunity to chronic allograft rejection
    Heinz Regele
    Clinical Institute of Pathology, University of Vienna, Vienna, Austria
    J Am Soc Nephrol 13:2371-80. 2002
    ....
  28. ncbi request reprint Characterization of cancer stroma markers: in silico analysis of an mRNA expression database for fibroblast activation protein and endosialin
    Helmut Dolznig
    Institute of Clinical Pathology, Medical University of Vienna, Waehringer Guertel 18 20, 1090 Vienna, Austria
    Cancer Immun 5:10. 2005
    ..Constructing databases from microdissected cancer tissues may be an essential step for tumor stroma-targeted therapies...
  29. doi request reprint Focal segmental glomerulosclerosis is induced by microRNA-193a and its downregulation of WT1
    Christoph A Gebeshuber
    Clinical Institute of Pathology, Medical University of Vienna, Vienna, Austria
    Nat Med 19:481-7. 2013
    ..Thus, upregulation of miR-193a provides a new pathogenic mechanism for FSGS and is a potential therapeutic target...
  30. ncbi request reprint Nonuniform hybridization: a potential source of error in oligonucleotide-chip experiments with low amounts of starting material
    Nikolaus Wick
    Clinical Institute for Pathology, Medical University of Vienna, Vienna, Austria
    Diagn Mol Pathol 13:151-9. 2004
    ..We show that optimized normalization prevented exclusion of angiopoietin-2, a lymphatic endothelial marker, from the lymphovascular transcriptome...
  31. ncbi request reprint Pathomechanisms and molecular basis of membranous glomerulopathy
    Dontscho Kerjaschki
    Department of Pathology, Medical University of Vienna, Allgemeines Krankenhaus, A 1090 Wien, Austria
    Lancet 364:1194-6. 2004
  32. ncbi request reprint Is podocyte shape controlled by the dystroglycan complex?
    Kenichiro Kojima
    Department of Clinical Pathology, University of Vienna, Vienna, Austria
    Nephrol Dial Transplant 17:23-4. 2002
    ....
  33. ncbi request reprint Everolimus inhibits glomerular endothelial cell proliferation and VEGF, but not long-term recovery in experimental thrombotic microangiopathy
    Katja Keller
    Division of Nephrology, Universitat Erlangen Nurnberg, Loschgestrasse 8, 91054 Erlangen, Germany
    Nephrol Dial Transplant 21:2724-35. 2006
    ..The effects of an everolimus therapy were investigated in a model of renal thrombotic microangiopathy (TMA) with specific endothelial cell (EC) injury in the rat in vivo as well as in glomerular ECs in vitro...
  34. ncbi request reprint Lymphatic spread of ductal pancreatic adenocarcinoma is independent of lymphangiogenesis
    Bence Sipos
    Department of Pathology, University of Kiel, Germany
    J Pathol 207:301-12. 2005
    ..The weak expression of lymphangiogenic cytokines in neoplastic cells and lymphatic vessel proliferation in peritumoural regions and chronic pancreatitis indicate that inflammation may be the reason for the low rate of lymphangiogenesis...
  35. ncbi request reprint Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasis
    Tatiana V Petrova
    Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki and Helsinki University Central Hospital, University of Helsinki, Haartmaninkatu 8, P O B 63, 00014 Helsinki, Finland
    Nat Med 10:974-81. 2004
    ..Our results indicate that an abnormal interaction between the lymphatic endothelial cells and pericytes, as well as valve defects, underlie the pathogenesis of LD...
  36. ncbi request reprint Early lymph vessel development from embryonic stem cells
    Johan Kreuger
    Department of Genetics and Pathology, Uppsala University, Sweden
    Arterioscler Thromb Vasc Biol 26:1073-8. 2006
    ..The purpose of this study was to establish a model system for lymph vessel development based on directed differentiation of murine embryonic stem cells...
  37. ncbi request reprint Tumor invasion in the absence of epithelial-mesenchymal transition: podoplanin-mediated remodeling of the actin cytoskeleton
    Andreas Wicki
    Institute of Biochemistry and Genetics, Department of Clinical Biological Sciences, Center of Biomedicine, University of Basel, 4058 Basel, Switzerland
    Cancer Cell 9:261-72. 2006
    ..In conclusion, podoplanin induces an alternative pathway of tumor cell invasion in the absence of epithelial-mesenchymal transition (EMT)...
  38. pmc Expression of lymphangiogenic factors and evidence of intratumoral lymphangiogenesis in pancreatic endocrine tumors
    Bence Sipos
    Department of Pathology, University of Kiel, Michaelisstr 11, 24105 Kiel, Germany
    Am J Pathol 165:1187-97. 2004
    ..PET is the first human tumor entity in which VEGF-C-related intratumoral lymphangiogenesis has been demonstrated...
  39. ncbi request reprint Lymphangiogenesis in the bone-implant interface of orthopedic implants: importance and consequence
    Gavin Jell
    Department of Materials, Imperial College London, South Kensington Campus, Exhibition Road, London, United Kingdom
    J Biomed Mater Res A 77:119-27. 2006
    ..This paper highlights the importance of lymphatic vessels in the maintenance of local and distal inflammatory responses to prosthetic wear particles...
  40. pmc Vascular endothelial growth factor-C, a potential paracrine regulator of glomerular permeability, increases glomerular endothelial cell monolayer integrity and intracellular calcium
    Rebecca R Foster
    Academic Renal Unit, Southmead Hospital, Bristol, UK
    Am J Pathol 173:938-48. 2008
    ..These observations suggest that podocytes direct GEnC behavior through both VEGF-C and VEGF-A...
  41. pmc Selective loss of podoplanin protein expression accompanies proteinuria and precedes alterations in podocyte morphology in a spontaneous proteinuric rat model
    Klaas Koop
    Department of Pathology, Leiden University Medical Center, Building 1, L1 Q, PO Box 9600, 2300 RC Leiden, The Netherlands
    Am J Pathol 173:315-26. 2008
    ..Our study suggests that decreased expression of podoplanin plays a role in the decrease of glomerular permselectivity...
  42. pmc Extrarenal effects on the pathogenesis and relapse of idiopathic nephrotic syndrome in Buffalo/Mna rats
    Ludmilla Le Berre
    Institut National de la Sante et de la Recherche Medicale INSERM, Immunointervention dans les Allo et Xenotransplantations, Nantes, France
    J Clin Invest 109:491-8. 2002
    ....
  43. ncbi request reprint In vivo identification of the mitogen-activated protein kinase cascade as a central pathogenic pathway in experimental mesangioproliferative glomerulonephritis
    Dirk Bokemeyer
    Medical Policlinic, Division of Nephrology, University of Bonn, Bonn, Germany
    J Am Soc Nephrol 13:1473-80. 2002
    ..These observations point to ERK as a putative intracellular mediator of the proliferative response in GN and suggest that pharmacologic treatments that interfere with the activation of ERK may be of potential therapeutic interest...
  44. pmc Radiogenic lymphangiogenesis in the skin
    Susanne Jackowski
    Department of Dermatology, University of Heidelberg, Heidelberg, Germany
    Am J Pathol 171:338-48. 2007
    ..Thus, our results indicate that vascular endothelial growth factor-C expression by invading macrophages could be a pathogenetic route of induction of radiogenic lymphangiogenesis...
  45. ncbi request reprint Podocalyxin in human haematopoietic cells
    Laura Kerosuo
    Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Finland
    Br J Haematol 124:809-18. 2004
    ..Almost all of the K562 cells expressed PCLP protein. Surprisingly, PCLP protein was not detected in any mature blood cells. These results suggest that human PCLP may be a valuable marker for a subset of haematopoietic stem cells...
  46. ncbi request reprint Unexplained nephrotic-range proteinuria in a 38-year-old man: a case of "no change disease"
    Kendra S Good
    Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Am J Kidney Dis 43:933-8. 2004
  47. ncbi request reprint Human podocytes express angiopoietin 1, a potential regulator of glomerular vascular endothelial growth factor
    Simon C Satchell
    Academic Renal Unit, University of Bristol, Southmead Hospital, Bristol, United Kingdom
    J Am Soc Nephrol 13:544-50. 2002
    ....
  48. ncbi request reprint R-roscovitine (CYC202) alleviates renal cell proliferation in nephritis without aggravating podocyte injury
    Maja Milovanceva-Popovska
    Division of Nephrology, University of Aachen, Aachen, Germany
    Kidney Int 67:1362-70. 2005
    ..Since podocytes express CDK2 in nephritis and since loss of podocytes contributes to glomerulosclerosis, the rationale of the present study was to test whether CDK2 inhibition is safe in instances of podocyte injury...
  49. ncbi request reprint Role of CXCR3 in cellular but not humoral renal allograft rejection
    Stephan Segerer
    Medizinische Poliklinik, Klinikum Innenstadt, University of Munich, Munich, Germany
    Transpl Int 18:676-80. 2005
    ..CXCR3-positive cells infiltrate renal allografts during cellular rejection, whereas C4d deposition is not associated with the recruitment of these cells...
  50. ncbi request reprint The human glomerular podocyte is a novel target for insulin action
    Richard J M Coward
    Academic and Children s Renal Unit, University of Bristol, Southmead Hospital, Bristol, UK BS10 5NB
    Diabetes 54:3095-102. 2005
    ..Insulin responsiveness in this key structural component of the glomerular filtration barrier may have central relevance for understanding of diabetic nephropathy and for the association of albuminuria with states of insulin resistance...
  51. pmc The sialomucin CD34 is a marker of lymphatic endothelial cells in human tumors
    Ulrike Fiedler
    Department of Vascular Biology and Angiogenesis Research, Tumor Biology Center, Breisacher Strasse 117, D 79106 Freiburg, Germany
    Am J Pathol 168:1045-53. 2006
    ..The data warrant further exploration of CD34 in tumor-associated LECs as a prognostic tumor marker...
  52. pmc Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor
    Tatiana V Petrova
    Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Haartman Institute and Helsinki University Central Hospital, Helsinki, Finland
    EMBO J 21:4593-9. 2002
    ..Furthermore, the data provide insights into the phenotypic diversity of endothelial cells and into the possibility of transcriptional reprogramming of differentiated endothelial cells...
  53. ncbi request reprint Derivation of nephrogenic adenomas from renal tubular cells in kidney-transplant recipients
    Peter R Mazal
    Department of Clinical Pathology and Center of Excellence in Clinical and Experimental Oncology, University of Vienna General Hospital, Austria
    N Engl J Med 347:653-9. 2002
    ..Nephrogenic adenomas are benign, tumor-like lesions within the urothelial mucosa of the urinary tract that are not uncommon in renal-transplant recipients. We investigated the origin of nephrogenic adenomas in renal-transplant recipients...
  54. pmc The contribution of B cells to renal interstitial inflammation
    Florian Heller
    Medizinische Poliklinik Innenstadt, University of Munich, Germany
    Am J Pathol 170:457-68. 2007
    ..CXCR5-positive B cells might be recruited via the chemokine CXCL13 and seem to contribute to the formation of intrarenal lymphoid follicle-like structures. These might represent an intrarenal immune system...
  55. ncbi request reprint Adenoviral VEGF-C overexpression induces blood vessel enlargement, tortuosity, and leakiness but no sprouting angiogenesis in the skin or mucous membranes
    Anne Saaristo
    Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum, University of Helsinki and Helsinki University Central Hospital, 00014 Helsinki, Finland
    FASEB J 16:1041-9. 2002
    ..These results show that virally produced VEGF-C induces blood vessel changes, including vascular leak, but its angiogenic potency is much reduced compared with VEGF in normal skin...
  56. ncbi request reprint Mesenchymal stem cells prevent progressive experimental renal failure but maldifferentiate into glomerular adipocytes
    Uta Kunter
    Division of Nephrology, University Hospital RWTH Aachen, Pauwelsstrasse 30, D 52057 Aachen, Germany
    J Am Soc Nephrol 18:1754-64. 2007
    ..These data suggest that MSC treatment can be a valuable therapeutic approach only if adipogenic maldifferentiation is prevented...
  57. ncbi request reprint Selective binding and presentation of CCL5 by discrete tissue microenvironments during renal inflammation
    Stephan Segerer
    Medizinische Poliklinik Innenstadt, University of Munich, Pettenkoferstrasse 8a, 80336 Munich, Germany
    J Am Soc Nephrol 18:1835-44. 2007
    ..Both clusters of basic residues in CCL5 are necessary for sufficient binding of CCL5 to tissue sections...
  58. ncbi request reprint When renal allografts turn DARC
    Stephan Segerer
    Medizinische Poliklinik, Klinikum Innenstadt der Universitat, Pettenkoferstrasse 8a, 80336 Munich, Germany
    Transplantation 75:1030-4. 2003
    ..Because DARC is expressed at the site of C4d deposition and might be involved in inflammatory cell recruitment, the authors evaluated the expression of DARC in different forms of human renal allograft rejection...