Renate Kain

Summary

Affiliation: Medical University of Vienna
Country: Austria

Publications

  1. ncbi Histopathology
    Renate Kain
    Clinical Institute of Pathology, Medical University of Vienna, Währinger Gürtel 18 20 5P, Vienna, 1090, Austria
    Methods Mol Biol 1508:185-193. 2017
  2. doi What is the evidence for antibodies to LAMP-2 in the pathogenesis of ANCA associated small vessel vasculitis?
    Renate Kain
    Clinical Institute of Pathology, Medical University of Vienna, Vienna, Austria
    Curr Opin Rheumatol 25:26-34. 2013
  3. pmc High prevalence of autoantibodies to hLAMP-2 in anti-neutrophil cytoplasmic antibody-associated vasculitis
    Renate Kain
    Clinical Institute of Pathology, Medical University of Vienna, Vienna, Austria
    J Am Soc Nephrol 23:556-66. 2012
  4. pmc Anti-hLAMP2-antibodies and dual positivity for anti-GBM and MPO-ANCA in a patient with relapsing pulmonary-renal syndrome
    Christoph Etter
    Division of Nephrology, University Hospital Zurich, Zurich, Switzerland
    BMC Nephrol 12:26. 2011
  5. pmc Molecular mimicry in pauci-immune focal necrotizing glomerulonephritis
    Renate Kain
    Department of Pathology, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Wien, Austria
    Nat Med 14:1088-96. 2008
  6. doi Pathogenesis of small vessel vasculitis associated with autoantibodies to neutrophil cytoplasmic antigens: new insights from animal models
    Renate Kain
    Institute of Clinical Pathology, Medical University of Vienna, Wahringer Gurtel, Vienna, Austria
    Curr Opin Rheumatol 22:15-20. 2010
  7. ncbi Histological and clinical predictors of early and late renal outcome in ANCA-associated vasculitis
    Irmgard Neumann
    Department of Nephrology, Wilhelminenspital, Vienna, Austria
    Nephrol Dial Transplant 20:96-104. 2005
  8. pmc Autoantibodies to hLAMP-2 in ANCA-negative pauci-immune focal necrotizing GN
    Andrea Peschel
    Clinical Institute of Pathology, Medical University of Vienna, Austria and
    J Am Soc Nephrol 25:455-63. 2014
  9. pmc Long-term outcome of anti-glomerular basement membrane antibody disease treated with immunoadsorption
    Peter Biesenbach
    Internal Medicine III Clinical Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria
    PLoS ONE 9:e103568. 2014
  10. pmc LAMP-2 is required for incorporating syntaxin-17 into autophagosomes and for their fusion with lysosomes
    Virginie Hubert
    Clinical Institute of Pathology, Medical University of Vienna, Vienna 1090, Austria
    Biol Open 5:1516-1529. 2016

Collaborators

Detail Information

Publications18

  1. ncbi Histopathology
    Renate Kain
    Clinical Institute of Pathology, Medical University of Vienna, Währinger Gürtel 18 20 5P, Vienna, 1090, Austria
    Methods Mol Biol 1508:185-193. 2017
    ..Gomori methenamine silver (GMS) and Periodic acid-Schiff (PAS) or their modifications are the most commonly used for tissue sections and in cytology specimens...
  2. doi What is the evidence for antibodies to LAMP-2 in the pathogenesis of ANCA associated small vessel vasculitis?
    Renate Kain
    Clinical Institute of Pathology, Medical University of Vienna, Vienna, Austria
    Curr Opin Rheumatol 25:26-34. 2013
    ..It addresses recent controversies over prevalence of anti-hLAMP-2 antibodies as well as their potential for diagnosis and monitoring disease activity...
  3. pmc High prevalence of autoantibodies to hLAMP-2 in anti-neutrophil cytoplasmic antibody-associated vasculitis
    Renate Kain
    Clinical Institute of Pathology, Medical University of Vienna, Vienna, Austria
    J Am Soc Nephrol 23:556-66. 2012
    ..Large-scale prospective studies are now needed to determine whether they are pathogenic or merely an epiphenomenon...
  4. pmc Anti-hLAMP2-antibodies and dual positivity for anti-GBM and MPO-ANCA in a patient with relapsing pulmonary-renal syndrome
    Christoph Etter
    Division of Nephrology, University Hospital Zurich, Zurich, Switzerland
    BMC Nephrol 12:26. 2011
    ..Whilst anti-GBM disease is considered a non-relapsing condition, the long-term course of double-positive patients is less predictable...
  5. pmc Molecular mimicry in pauci-immune focal necrotizing glomerulonephritis
    Renate Kain
    Department of Pathology, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Wien, Austria
    Nat Med 14:1088-96. 2008
    ..Thus, FimH-triggered autoimmunity to LAMP-2 provides a previously undescribed clinically relevant molecular mechanism for the development of pauci-immune FNGN...
  6. doi Pathogenesis of small vessel vasculitis associated with autoantibodies to neutrophil cytoplasmic antigens: new insights from animal models
    Renate Kain
    Institute of Clinical Pathology, Medical University of Vienna, Wahringer Gurtel, Vienna, Austria
    Curr Opin Rheumatol 22:15-20. 2010
    ..In-vitro experiments have provided invaluable insight into the molecular mechanisms of antibody action and their subcellular effects; however, they may not reflect the in-vivo situation that can only be assessed in animal models...
  7. ncbi Histological and clinical predictors of early and late renal outcome in ANCA-associated vasculitis
    Irmgard Neumann
    Department of Nephrology, Wilhelminenspital, Vienna, Austria
    Nephrol Dial Transplant 20:96-104. 2005
    ..Renal involvement remains a major determinant in antineutrophil cytoplasmic autoantibody-associated small vessel vasculitis (AASV). While some patients may develop persistent renal damage, others have a favourable outcome...
  8. pmc Autoantibodies to hLAMP-2 in ANCA-negative pauci-immune focal necrotizing GN
    Andrea Peschel
    Clinical Institute of Pathology, Medical University of Vienna, Austria and
    J Am Soc Nephrol 25:455-63. 2014
    ..In conclusion, in patients with ANCA-negative piFNGN, we have identified autoantibodies to hLAMP-2 that bind native glomerular but not neutrophil hLAMP-2, suggesting a role in pathogenesis...
  9. pmc Long-term outcome of anti-glomerular basement membrane antibody disease treated with immunoadsorption
    Peter Biesenbach
    Internal Medicine III Clinical Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria
    PLoS ONE 9:e103568. 2014
    ..Immunoadsorption (IAS) is superior to PE regarding efficiency of antibody-removal and safety. Apart from anecdotal data, there is no systemic analysis of the long-term effects of IAS on anti-GBM-disease and antibody kinetics...
  10. pmc LAMP-2 is required for incorporating syntaxin-17 into autophagosomes and for their fusion with lysosomes
    Virginie Hubert
    Clinical Institute of Pathology, Medical University of Vienna, Vienna 1090, Austria
    Biol Open 5:1516-1529. 2016
    ..The results have clear implications for situations associated with a reduction of LAMP-2 expression...
  11. doi Hereditary amyloidosis caused by R554L fibrinogen Aα-chain mutation in a Spanish family and review of the literature
    Michael Haidinger
    Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Vienna, Austria
    Amyloid 20:72-9. 2013
    ..Here, we describe the clinical course of AFib amyloidosis associated with the rare R554L mutation, and the significance of extrarenal amyloid deposits and their possible influence on cardiovascular morbidity...
  12. doi Effects of angiotensin-converting-enzyme inhibitor therapy on the regulation of the plasma and cardiac tissue renin-angiotensin system in heart transplant patients
    Johannes J Kovarik
    Department of Internal Medicine III, Clinical Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria
    J Heart Lung Transplant . 2016
    ..Particularly, the effects of ACEis on plasma and cardiac metabolites of the "classical" and "alternative" renin-angiotensin system (RAS) in HTx patients are unknown...
  13. pmc The Phenotypic Characterization of the Human Renal Mononuclear Phagocytes Reveal a Co-Ordinated Response to Injury
    Dario A Leone
    Clinical Institute of Pathology, Medical University of Vienna, Vienna, Austria
    PLoS ONE 11:e0151674. 2016
    ....
  14. pmc B-cell deficiency and severe autoimmunity caused by deficiency of protein kinase C δ
    Elisabeth Salzer
    CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria
    Blood 121:3112-6. 2013
    ..Our study uncovers human PRKCD deficiency as a novel cause of common variable immunodeficiency-like B-cell deficiency with severe autoimmunity...
  15. doi Gross proteinuria and subacute renal failure after coronary angiography - a case report of cholesterol crystal embolization
    Peter Biesenbach
    Internal Medicine III Clinical Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria
    Wien Klin Wochenschr 122:251-4. 2010
    ..Identification of high-risk patients is of utmost importance as efficient therapeutic strategies do not exist...
  16. pmc Cooperation of ETV6/RUNX1 and BCL2 enhances immunoglobulin production and accelerates glomerulonephritis in transgenic mice
    Eva Bauer
    Ludwig Boltzmann Institute for Cancer Research, Vienna, Austria
    Oncotarget 7:12191-205. 2016
    ..Thus, our study reveals a previously unrecognized synergism between ETV6/RUNX1 and BCL2 impacting on malignant disease and autoimmunity. ..
  17. doi Focal segmental glomerulosclerosis is induced by microRNA-193a and its downregulation of WT1
    Christoph A Gebeshuber
    Clinical Institute of Pathology, Medical University of Vienna, Vienna, Austria
    Nat Med 19:481-7. 2013
    ..Thus, upregulation of miR-193a provides a new pathogenic mechanism for FSGS and is a potential therapeutic target...
  18. ncbi Glomerular immune deposits are associated with increased proteinuria in patients with ANCA-associated crescentic nephritis
    Irmgard Neumann
    Department of Nephrology, Wilhelminenspital, Vienna, Austria
    Nephrol Dial Transplant 18:524-31. 2003
    ..In some patients, however, significant amounts of immune deposits may be detected. Therefore, we evaluated the clinical significance of these immune deposits in anti-neutrophil cytoplasmic autoantibody (ANCA)-associated pauci-immune CGN...