Walter H Horl

Summary

Affiliation: Medical University of Vienna
Country: Austria

Publications

  1. doi Comparing the efficacy of intravenous iron and oral iron in nondialysis patients with chronic kidney disease
    Walter H Horl
    Department of Medicine III, Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria
    Nat Clin Pract Nephrol 4:530-1. 2008
  2. pmc Nonsteroidal Anti-Inflammatory Drugs and the Kidney
    Walter H Horl
    Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Pharmaceuticals (Basel) 3:2291-2321. 2010
  3. doi Tumor lysis syndrome: risk factors and treatment
    Walter H Horl
    Klinische Abteilung für Nephrologie und Dialyse, Medizinische Klinik III, Medizinische Universität Wien, Wien, Osterreich
    Wien Klin Wochenschr 117:7-17. 2005
  4. pmc Immune dysfunction in uremia—an update
    Gerald Cohen
    Abteilung für Nephrologie und Dialyse, Univ Klinik für Innere Medizin III, Wahringer Gurtel 18 20, Wien A 1090, Austria
    Toxins (Basel) 4:962-90. 2012
  5. doi Anaemia management and mortality risk in chronic kidney disease
    Walter H Horl
    Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Vienna, Austria
    Nat Rev Nephrol 9:291-301. 2013
  6. doi Differentiating factors between erythropoiesis-stimulating agents: an update to selection for anaemia of chronic kidney disease
    Walter H Horl
    Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Drugs 73:117-30. 2013
  7. pmc VITA-D: cholecalciferol substitution in vitamin D deficient kidney transplant recipients: a randomized, placebo-controlled study to evaluate the post-transplant outcome
    Ursula Thiem
    Department of Internal Medicine III, Division of Nephrology and Dialysis, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Trials 10:36. 2009
  8. ncbi Optimal treatment of renal anaemia (OPTA): improving the efficacy and efficiency of renal anaemia therapy in haemodialysis patients receiving intravenous epoetin
    Walter H Horl
    Klinische Abteilung für Nephrologie und Dialyse, Universitätsklinik für Innere Medizin III, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Nephrol Dial Transplant 20:iii25-32. 2005
  9. ncbi [Tumor lysis syndrome: risk factors and treatment]
    Walter H Horl
    Klinische Abteilung für Nephrologie und Dialyse, Medizinische Klinik III, Medizinische Universität Wien, Wien, Osterreich
    Wien Klin Wochenschr 117:7-17. 2005
  10. ncbi Anaemia and the heart
    W H Horl
    Department of Medicine, University of Vienna, Austria
    Eur J Clin Invest 35:20-5. 2005

Detail Information

Publications175 found, 100 shown here

  1. doi Comparing the efficacy of intravenous iron and oral iron in nondialysis patients with chronic kidney disease
    Walter H Horl
    Department of Medicine III, Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria
    Nat Clin Pract Nephrol 4:530-1. 2008
    ..Ferumoxytol was well tolerated. The superiority of ferumoxytol over other intravenous iron preparations, however, needs to be investigated, and optimal serum ferritin levels for the nondialysis CKD population need to be defined...
  2. pmc Nonsteroidal Anti-Inflammatory Drugs and the Kidney
    Walter H Horl
    Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Pharmaceuticals (Basel) 3:2291-2321. 2010
    ....
  3. doi Tumor lysis syndrome: risk factors and treatment
    Walter H Horl
    Klinische Abteilung für Nephrologie und Dialyse, Medizinische Klinik III, Medizinische Universität Wien, Wien, Osterreich
    Wien Klin Wochenschr 117:7-17. 2005
    ..Hyperphosphate-induced acute renal failure due to intrarenal calcium phosphate precipitation may, however, occur even during rasburicase therapy...
  4. pmc Immune dysfunction in uremia—an update
    Gerald Cohen
    Abteilung für Nephrologie und Dialyse, Univ Klinik für Innere Medizin III, Wahringer Gurtel 18 20, Wien A 1090, Austria
    Toxins (Basel) 4:962-90. 2012
    ..This review summarizes the interrelated parameters interfering with the immune response in uremia, with a special focus on the non-specific immune response and the role of uremic toxins...
  5. doi Anaemia management and mortality risk in chronic kidney disease
    Walter H Horl
    Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Vienna, Austria
    Nat Rev Nephrol 9:291-301. 2013
    ....
  6. doi Differentiating factors between erythropoiesis-stimulating agents: an update to selection for anaemia of chronic kidney disease
    Walter H Horl
    Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Drugs 73:117-30. 2013
    ..Phase III clinical trials with peginesatide, a pegylated synthetic peptide-based ESA without any homology to erythropoietin raised safety concerns in non-dialysis CKD patients but not in dialysis patients...
  7. pmc VITA-D: cholecalciferol substitution in vitamin D deficient kidney transplant recipients: a randomized, placebo-controlled study to evaluate the post-transplant outcome
    Ursula Thiem
    Department of Internal Medicine III, Division of Nephrology and Dialysis, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Trials 10:36. 2009
    ..As such, vitamin D is thought to exert beneficial effects within the transplant setting, especially in kidney transplant recipients, considering the high prevalence of vitamin D deficiency in kidney transplant recipients...
  8. ncbi Optimal treatment of renal anaemia (OPTA): improving the efficacy and efficiency of renal anaemia therapy in haemodialysis patients receiving intravenous epoetin
    Walter H Horl
    Klinische Abteilung für Nephrologie und Dialyse, Universitätsklinik für Innere Medizin III, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Nephrol Dial Transplant 20:iii25-32. 2005
    ..The Optimal Treatment of Renal Anaemia (OPTA) initiative aims to help both physicians and nurses improve renal anaemia management by "translating" the standards set in published guidelines into practical clinical advice...
  9. ncbi [Tumor lysis syndrome: risk factors and treatment]
    Walter H Horl
    Klinische Abteilung für Nephrologie und Dialyse, Medizinische Klinik III, Medizinische Universität Wien, Wien, Osterreich
    Wien Klin Wochenschr 117:7-17. 2005
    ..hyperphosphate-induced acute renal failure due to intrarenal calcium phosphate precipitation may, however, occur even during rasburicase therapy..
  10. ncbi Anaemia and the heart
    W H Horl
    Department of Medicine, University of Vienna, Austria
    Eur J Clin Invest 35:20-5. 2005
    ..Pleiotropic effects of recombinant human erythropoietin include reduction of myocardial and cerebral infarct size without an increase in haematocrit, neovascularization as well as mobilization of endothelial progenitor cells...
  11. doi Natriuretic peptides in acute and chronic kidney disease and during renal replacement therapy
    Walter H Horl
    Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Austria
    J Investig Med 53:366-70. 2005
    ..Since proANP31-67 peptide does not cause hypotension, this vessel dilator may protect the kidney during acute renal failure by intrarenal vasodilation and stimulation of endogenous prostaglandin E2 synthesis...
  12. ncbi [Anemia and its treatment in peritoneal dialysis patients]
    Walter H Horl
    Klinische Abteilung für Nephrologie und Dialyse, Medizinische Universitatsklinik III, Medizinische Universität Wien, Wien, Austria
    Wien Klin Wochenschr 117:69-72. 2005
    ..Factors that may negatively influence anemia in PD patients are inflammation, infection, antihypertensive therapy with ACE inhibitors or angiotensin II blockers and neutralizing antibodies against rhuEPO or darbepoetin-alpha...
  13. ncbi [Sequelae of hypertenson: kidney disease]
    W H Horl
    Klinische Abteilung für Nephrologie und Dialyse, Medizinische Universität Wien, Wien
    Internist (Berl) 47:226, 228-32. 2006
    ....
  14. ncbi [Thrombocytopathy and blood complications in uremia]
    Walter H Horl
    Klinische Abteilung für Nephrologie und Dialyse, Medizinische Universitatsklinik III, Medizinische Universität Wien, Austria
    Wien Klin Wochenschr 118:134-50. 2006
    ..Substitution of heparin by hirudin, danaparoid or regional citrate anticoagulation should be decided based on each single case...
  15. pmc Iron therapy for renal anemia: how much needed, how much harmful?
    Walter H Horl
    Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Pediatr Nephrol 22:480-9. 2007
    ..The integration of ESA and intravenous iron therapy into anemia management allowed attainment of target hemoglobin values in the majority of pediatric and adult CKD and ESRD patients...
  16. ncbi Clinical aspects of iron use in the anemia of kidney disease
    Walter H Horl
    Division of Nephrology and Dialysis, Department of Medicine III, Währinger Gürtel 18 20 A 1090 Vienna, Austria
    J Am Soc Nephrol 18:382-93. 2007
  17. doi [Contrast induced nephropathy]
    Walter H Horl
    Klinische Abteilung für Nephrologie und Dialyse, Medizinische Universitatsklinik III, Medizinische Universität Wien, Austria
    Wien Klin Wochenschr 121:15-32. 2009
    ....
  18. doi Hypertension in end-stage renal disease: different measures and their prognostic significance
    Walter H Horl
    Division of Nephrology and Dialysis, Department of Medicine III, University of Vienna, Vienna, Austria
    Nephrol Dial Transplant 25:3161-6. 2010
    ....
  19. doi [Urinary tract infections]
    W H Horl
    Klinische Abteilung für Nephrologie und Dialyse, Medizinische Universitatsklinik III, Wien, Osterreich
    Internist (Berl) 52:1026, 1028-31. 2011
    ..Treatment of community acquired urosepsis includes cephalosporins of the third generation, piperacillin/tazobactam or ciprofloxacin. For nosocomial urosepsis the combination with an aminoglycoside or a carbapenem is recommended...
  20. ncbi Risk factors for capillary C4d deposition in kidney allografts: evaluation of a large study cohort
    Matthias Lorenz
    Department of Internal Medicine III, University of Vienna, Vienna, Austria
    Transplantation 78:447-52. 2004
    ..The impact of pre- and posttransplant variables including particular immunosuppressive regimens on the frequency of C4d deposition has not yet been systematically investigated in a large multivariate analysis...
  21. ncbi Inhibition of human dendritic cell maturation and function by the novel immunosuppressant FK778
    Maximilian Zeyda
    Clinical Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
    Transplantation 80:1105-11. 2005
    ....
  22. ncbi Alemtuzumab (Campath-1H) induction therapy and dendritic cells: Impact on peripheral dendritic cell repertoire in renal allograft recipients
    Bernhard M Kirsch
    Department of Medicine III, Clinical Division of Nephrology and Dialysis, Medical University of Vienna, Austria
    Transpl Immunol 16:254-7. 2006
    ..Further studies are warranted to further elucidate the functional significance of these finding in the setting of allogeneic organ transplantation...
  23. doi Calcineurin inhibitor-based immunosuppressive therapy, donor age, and long-term outcome after kidney transplantation
    Georg Heinze
    Section of Clinical Biometrics, Core Unit for Medical Statistics and Informatics, Medical University Vienna, Vienna, Austria
    Transplantation 87:1821-9. 2009
    ..It is unclear whether the choice of maintenance immunosuppression modulates the negative effect of advanced donor age on outcome after renal transplantation...
  24. doi Glucose control is associated with patient survival in diabetic patients after renal transplantation
    Franz Wiesbauer
    Department of Cardiology, Medical University of Vienna, Vienna, Austria
    Transplantation 89:612-9. 2010
    ..However, in diabetic renal-allograft recipients, the effect of different treatment strategies on outcomes is undetermined...
  25. doi Independent or synergistic relationship of proteinuria and glomerular filtration rate on patient and renal survival in patients with glomerulonephritis?
    Dominik G Haider
    Division of Nephrology and Dialysis, Department of Internal Medicine III, General Hospital Medical University of Vienna, Waehringer Guertel 18 20, 1090, Vienna, Austria
    J Nephrol 27:643-51. 2014
    ..We therefore tested the predictive power of the combination of GFR with proteinuria in patients with different histologically-diagnosed types of glomerulonephritis (GN)...
  26. ncbi Intravenous iron increases labile serum iron but does not impair forearm blood flow reactivity in dialysis patients
    Georg Schaller
    Department of Clinical Pharmacology, Medical University Vienna, Vienna, Austria
    Kidney Int 68:2814-22. 2005
    ..We therefore examined the effect of a single high dose of intravenous iron on endothelial function and biochemical markers of iron homeostasis...
  27. doi Solid phase detection of C4d-fixing HLA antibodies to predict rejection in high immunological risk kidney transplant recipients
    Gregor Bartel
    Department of Medicine III, Medical University Vienna, Vienna, Austria
    Transpl Int 26:121-30. 2013
    ..C4d]DSA detected 6 months post-transplantation were not related to clinical outcomes. Our data suggest that pretransplant SAB-based detection of complement-fixing DSA may be a valuable tool for risk stratification...
  28. pmc Fluid overload in hemodialysis patients: a cross-sectional study to determine its association with cardiac biomarkers and nutritional status
    Marlies Antlanger
    Department of Internal Medicine III Clinical Division of Nephrology and Dialysis, Medical University of Vienna, Wahringer Gurtel 18 20, 1090, Vienna Austria
    BMC Nephrol 14:266. 2013
    ..In addition, we aimed to confirm whether volume status correlates with nutritional status...
  29. ncbi Efficacy of a low-dose intravenous iron sucrose regimen in peritoneal dialysis patients
    Elisabeth Dittrich
    Department of Medicine III, University of Vienna, Austria
    Perit Dial Int 22:60-6. 2002
    ..Therefore, we investigated the effectiveness of a low-dose i.v. iron regimen in peritoneal dialysis (PD) patients...
  30. ncbi A case of severe C4d-positive kidney allograft dysfunction in the absence of histomorphologic features of rejection
    Antje Habicht
    Department of Internal Medicine III, University of Vienna, Vienna, Austria
    Wien Klin Wochenschr 114:945-8. 2002
    ..This case reinforces the high diagnostic value of C4d staining. In severe graft dysfunction humoral immune mechanisms should be considered, even when histopathologic features of humoral rejection are completely absent...
  31. ncbi Disruption of the interaction of T cells with antigen-presenting cells by the active leflunomide metabolite teriflunomide: involvement of impaired integrin activation and immunologic synapse formation
    Maximilian Zeyda
    Medical University of Vienna, Vienna, Austria
    Arthritis Rheum 52:2730-9. 2005
    ..In this study, we evaluated the impact of the active leflunomide metabolite teriflunomide on T cell integrin activation, evolution of the IS, and antigen-specific formation of stable T cell/APC conjugates...
  32. ncbi Long-term patient and graft survival in the eurotransplant senior program: a single-center experience
    Veronika Fabrizii
    Division of Nephrology and Dialysis, Department of Internal Medicine III, Medical University of Vienna, Austria
    Transplantation 80:582-9. 2005
    ..The Eurotransplant Senior Program (ESP) was launched in 1999, targeted to increase the supply of donor kidneys to the elderly. This program requires local allocation of kidneys from cadaveric donors >>65 years to recipients >>65 years...
  33. pmc A randomized, placebo-controlled, double-blind, prospective trial to evaluate the effect of vildagliptin in new-onset diabetes mellitus after kidney transplantation
    Michael Haidinger
    Clinical Division of Nephrology and Dialysis, Department of Internal Medicine III, Medical University of Vienna, Austria
    Trials 11:91. 2010
    ..This study will evaluate the safety and efficacy of vildagliptin monotherapy in renal transplant recipients with recently diagnosed NODAT...
  34. ncbi Effect of radio contrast media on residual renal function in peritoneal dialysis patients--a prospective study
    Elisabeth Dittrich
    Division of Nephrology and Dialysis, Department of Medicine III, Medical University Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Nephrol Dial Transplant 21:1334-9. 2006
    ..Systemic administration of radio contrast media (CM) may increase the risk of acute renal failure in patients with impaired renal function not on dialysis. There are few data on the influence of CM administration in dialysis patients...
  35. ncbi Rescue therapy with tacrolimus and mycophenolate mofetil does not prevent deterioration of graft function in C4d-positive chronic allograft nephropathy
    Christoph Schwarz
    Department of Medicine III, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Wien Klin Wochenschr 118:397-404. 2006
    ..For chronic humoral rejection, the efficacy of rescue therapy with tacrolimus and mycophenolate mofetil has been suggested...
  36. doi A versatile role of mammalian target of rapamycin in human dendritic cell function and differentiation
    Michael Haidinger
    Clinical Division of Nephrology and Dialysis, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
    J Immunol 185:3919-31. 2010
    ....
  37. doi Sirolimus in renal transplant recipients with tuberous sclerosis complex: clinical effectiveness and implications for innate immunity
    Michael Haidinger
    Clinical Division of Nephrology and Dialysis, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
    Transpl Int 23:777-85. 2010
    ..Larger studies are warranted to further examine the relationship between clinical parameters and the molecular response to mTOR-inhibition in TSC patients after renal transplantation...
  38. ncbi Vitamin C plasma level and response to erythropoietin in patients on maintenance haemodialysis
    Robert Deicher
    Universitätsklinik für Innere Medizin III, Klinische Abteilung für Nephrologie und Dialyse, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Nephrol Dial Transplant 19:2319-24. 2004
    ..This study was performed to analyse the relation between vitamin C plasma concentration and response to rHuEpo...
  39. pmc Mortality in renal transplant recipients given erythropoietins to increase haemoglobin concentration: cohort study
    Georg Heinze
    Core Unit of Medical Statistics and Informatics, Medical University of Vienna, 1090 Vienna, Austria
    BMJ 339:b4018. 2009
    ..To determine the optimal range of increase in haemoglobin concentration with treatment with erythropoietins that is safe and is not associated with mortality...
  40. ncbi Hyporesponsiveness in alloreactive T-cells by NF-kappaB inhibitor-treated dendritic cells: resistance to calcineurin inhibition
    Marcus D Saemann
    Institute of Immunology, University of Vienna Medical School, Borschkegasse 8a, A 1090 Vienna, Austria
    Am J Transplant 4:1448-58. 2004
    ..These data may have important implications for the design of clinical regimens for the establishment of antidonor hyporeactivity in organ transplantation using in vitro-modulated DC...
  41. pmc Glucose metabolism after renal transplantation
    Manfred Hecking
    Department of Nephrology, Medical University of Vienna, Vienna, Austria
    Diabetes Care 36:2763-71. 2013
    ..We determined prevalence, risk factors, phenotype, and pathophysiological mechanism of new-onset diabetes after transplantation (NODAT) to generate strategies for optimal pharmacological management of hyperglycemia in NODAT patients...
  42. ncbi The effect of ACE inhibitor and angiotensin II blocker therapy on early posttransplant kidney graft function
    Matthias Lorenz
    Department of Internal Medicine III, Division of Nephrology and Dialysis, University Hospital Vienna, Vienna, Austria
    Am J Kidney Dis 43:1065-70. 2004
    ..It is unknown whether continuation of angiotensin-converting enzyme (ACE) inhibitor or angiotensin II (ATII) blocker therapy after kidney transplantation has an influence on early kidney graft function...
  43. ncbi Potential risk for infection and atherosclerosis due to iron therapy
    Gürkan Sengoelge
    Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Vienna, Austria
    J Ren Nutr 15:105-10. 2005
    ..Potential long-term complications of intravenous iron therapy in end-stage renal disease patients include atherosclerosis and infection, particularly in patients with iron overload...
  44. ncbi Effects of 12 months of recombinant growth hormone therapy on parameters of bone metabolism and bone mineral density in patients on chronic hemodialysis
    Harald Kotzmann
    Division of Endocrinology and Metabolism, Department of Medicine III, Ludwig Boltzmann Institute for Experimental Endocrinology, University of Vienna, Vienna, Austria
    J Nephrol 17:87-94. 2004
    ....
  45. doi Inhibition of mTOR blocks the anti-inflammatory effects of glucocorticoids in myeloid immune cells
    Thomas Weichhart
    Department of Internal Medicine III, Division of Nephrology and Dialysis, Medical University Vienna, Vienna, Austria
    Blood 117:4273-83. 2011
    ....
  46. ncbi Prevention of CD40-triggered dendritic cell maturation and induction of T-cell hyporeactivity by targeting of Janus kinase 3
    Marcus D Saemann
    Institute of Immunology, University of Vienna, Vienna, Austria
    Am J Transplant 3:1341-9. 2003
    ..This property of JAK3 inhibitors therefore represents a further level of interference, which together with the well-established suppression of cgamma signaling could be responsible for their clinical efficacy...
  47. ncbi Riboflavin is a determinant of total homocysteine plasma concentrations in end-stage renal disease patients
    Sonja Skoupy
    Division of Nephrology and Dialysis, Department of Medicine III, University of Vienna, Vienna, Austria
    J Am Soc Nephrol 13:1331-7. 2002
    ..This finding may have implications for tHcy lowering therapy in individuals with end-stage renal disease...
  48. pmc Blood volume-monitored regulation of ultrafiltration in fluid-overloaded hemodialysis patients: study protocol for a randomized controlled trial
    Manfred Hecking
    Department of Internal Medicine III, Nephrology and Dialysis, Medical University of Vienna, Wahringer Gurtel 18 20, Vienna 1090, Austria
    Trials 13:79. 2012
    ....
  49. doi Clinical evaluation of two novel biointact PTH(1-84) assays in hemodialysis patients
    Manfred Hecking
    Medical University of Vienna, Department of Medicine III, Division of Nephrology and Dialysis, Austria
    Clin Biochem 45:1645-51. 2012
    ..Here, we aimed at assessing the technical and clinical performance of two novel automated biointact PTH(1-84) assays, from Roche Diagnostics (Ro) and DiaSorin (DS), in hemodialysis patients...
  50. pmc Early basal insulin therapy decreases new-onset diabetes after renal transplantation
    Manfred Hecking
    Department of Nephrology, Medical University of Vienna, Vienna, Austria
    J Am Soc Nephrol 23:739-49. 2012
    ..In conclusion, this study suggests regimens that include basal insulin significantly reduce the odds for NODAT after renal transplantation, presumably via insulin-mediated protection of β cells...
  51. ncbi Endothelial progenitor cells in kidney transplant recipients
    Sabine Steiner
    Division of Angiology, Department of Medicine II, Medical University Vienna, Vienna, Austria
    Transplantation 81:599-606. 2006
    ..Lower concentrations of endothelial progenitor cells (EPCs) may be associated with increased cardiovascular risk. EPC counts and their correlates have not yet been studied in kidney transplant recipients (KTR)...
  52. pmc p38α senses environmental stress to control innate immune responses via mechanistic target of rapamycin
    Karl Katholnig
    Clinical Division of Nephrology and Dialysis, Department of Internal Medicine III, Medical University of Vienna, 1090 Vienna, Austria
    J Immunol 190:1519-27. 2013
    ..Our data link p38α to mTOR signaling in myeloid immune cells that is decisive for tuning the immune response in dependence on the environmental milieu...
  53. doi Modified solid-phase alloantibody detection for improved crossmatch prediction
    Markus Wahrmann
    Division of Nephrology and Dialysis, Department of Medicine III, Medical University Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Hum Immunol 74:32-40. 2013
    ..Overall, B-cell-CDXM prediction was less precise, but could be enhanced by adjusting CDCXM thresholds to higher levels. Our data suggest particular efficiency of solid-phase complement detection as a tool for virtual crossmatching...
  54. ncbi Donor heme oxygenase-1 genotype is associated with renal allograft function
    Markus Exner
    Department of Medical and Chemical Laboratory Diagnostics, University of Vienna, Vienna, Austria
    Transplantation 77:538-42. 2004
    ..In the present study we investigated the impact of the promoter polymorphism of kidney allograft donors on clinical outcomes after transplantation...
  55. ncbi Protocol biopsies after kidney transplantation
    Georg A Böhmig
    Division of Nephrology and Dialysis, Department of Internal Medicine III, University of Vienna, Vienna, Austria
    Transpl Int 18:131-9. 2005
    ..In this review, potential benefits and risks associated with kidney allograft biopsy in stable renal transplant recipients are discussed...
  56. ncbi Antithymocyte globulin impairs T-cell/antigen-presenting cell interaction: disruption of immunological synapse and conjugate formation
    Michael Haidinger
    Clinical Division of Nephrology and Dialysis, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
    Transplantation 84:117-21. 2007
    ..In conclusion, ATG impairs T-cell/APC conjugate formation, a mechanism that may help to understand the functional inactivation of peripheral blood T-cells that have escaped cellular depletion after ATG treatment...
  57. doi The uraemic retention solute para-hydroxy-hippuric acid attenuates apoptosis of polymorphonuclear leukocytes from healthy subjects but not from haemodialysis patients
    Gerald Cohen
    Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Austria
    Nephrol Dial Transplant 23:2512-9. 2008
    ....
  58. doi Cinacalcet increases calcium excretion in hypercalcemic hyperparathyroidism after kidney transplantation
    Kyra A Borchhardt
    Department of Medicine III, Division of Nephrology and Dialysis, Medical University Vienna, Vienna, Austria
    Transplantation 86:919-24. 2008
    ..The mechanism of action is not fully understood. We hypothesized that cinacalcet increases renal elimination of calcium, thereby improving hypercalcemia in kidney transplant recipients...
  59. doi Cinacalcet effect on polymorphonuclear leucocytes of kidney transplant patients
    Gerald Cohen
    Division of Nephrology and Dialysis, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
    Eur J Clin Invest 43:476-82. 2013
    ..We investigated essential functions of PMNLs of kidney transplant recipients with and without hypercalcaemia and with and without cinacalcet therapy...
  60. doi Hereditary amyloidosis caused by R554L fibrinogen Aα-chain mutation in a Spanish family and review of the literature
    Michael Haidinger
    Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Vienna, Austria
    Amyloid 20:72-9. 2013
    ..Here, we describe the clinical course of AFib amyloidosis associated with the rare R554L mutation, and the significance of extrarenal amyloid deposits and their possible influence on cardiovascular morbidity...
  61. ncbi Immunoadsorption and plasma exchange in pregnancy
    Elisabeth Dittrich
    Department of Medicine III, Division of Nephrology and Dialysis, University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    Kidney Blood Press Res 25:232-9. 2002
    ..Immunoadsorption is established for removal of pathogenic proteins lipoproteins or autoantibodies, but this procedure has only rarely been used in pregnancy...
  62. ncbi Anaemia as a risk factor for the progression of chronic kidney disease
    Robert Deicher
    Department of Medicine III, Division of Nephrology and Dialysis, University Hospital of Vienna, Austria
    Curr Opin Nephrol Hypertens 12:139-43. 2003
    ..This review addresses the question of why and how anaemia could possibly enhance the progression of chronic kidney disease, and summarizes relevant clinical trials...
  63. ncbi TGF-beta1 impairs homocysteine metabolism in human renal cells: possible implications for transplantation
    Gürkan Sengoelge
    Department of Internal Medicine III, Division of Nephrology and Dialysis, University of Vienna, Wahringer Gurtel 18 20, 1090, Vienna, Austria
    Transpl Int 16:843-8. 2003
    ..We demonstrated that the release of Hcy from huRPTECs is enhanced by TGF-beta1, but that TGF-beta1 plasma levels in renal graft recipients show no independent relationship with hyperhomocysteinemia...
  64. ncbi A need for an individualized approach to end-stage renal disease patients
    Walter H Horl
    Universitätsklinik für Innere Medizin III, Wien, Austria
    Nephrol Dial Transplant 17:17-21. 2002
    ..As early intervention has an impact on patient outcome and the progression of risk factors, this approach may also be appropriate for patients who are not yet receiving RRT...
  65. ncbi Rapamycin-associated post-transplantation glomerulonephritis and its remission after reintroduction of calcineurin-inhibitor therapy
    Elisabeth Dittrich
    Department of Medicine III, Division of Nephrology and Dialysis, University of Vienna, 1090 Vienna, Austria
    Transpl Int 17:215-20. 2004
    ..We conclude that in the case of rapamycin-associated post-transplantation glomerulonephritis an attempt should be made to replace rapamycin by a calcineurin inhibitor...
  66. ncbi Dose-dependent effect of parenteral iron therapy on bleomycin-detectable iron in immune apheresis patients
    Gürkan Sengoelge
    Department of Medicine III, Division of Nephrology and Dialysis, University of Vienna, Vienna, Austria
    Kidney Int 66:295-302. 2004
    ..This makes erythropoietin and iron substitution necessary in most patients. However, intravenous iron therapy may result in an increase of potentially toxic nontransferrin-bound iron...
  67. ncbi Bacterial metabolite interference with maturation of human monocyte-derived dendritic cells
    Marcus D Saemann
    Institute of Immunology, University of Vienna, Austria
    J Leukoc Biol 71:238-46. 2002
    ....
  68. ncbi Prospective multicenter study of HX575 (biosimilar epoetin-α) in patients with chronic kidney disease applying a target hemoglobin of 10--12 g/dl
    Walter H Horl
    Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria
    Clin Nephrol 78:24-32. 2012
    ..3 g/dl following the conversion from a broad spectrum of pre-study ESA treatments with stable overall mean i.v. HX575 doses. The proportion of patients within the Hb target range increased from 57.5% at baseline to 66.8% at study end...
  69. ncbi Ferrous sulfate does not affect mycophenolic acid pharmacokinetics in kidney transplant patients
    Matthias Lorenz
    Department of Medicine III, Division of Nephrology and Dialysis, and Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, Vienna, Austria
    Am J Kidney Dis 43:1098-103. 2004
    ..Oral administration of ferrous-sulfate was reported to decrease intestinal absorption of mycophenolate mofetil (MMF) in healthy Japanese individuals by 90%...
  70. ncbi Iron overload in kidney transplants: prospective analysis of biochemical and genetic markers
    Matthias Lorenz
    Division of Nephrology and Dialysis, Department of Medicine III, Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University Vienna, Vienna, Austria
    Kidney Int 67:691-7. 2005
    ..The prevalence of iron overload and the influence of mutations in the HFE and TRF2 gene on biochemical markers of iron overload among renal transplant patients is unknown...
  71. ncbi Impairment of T cell interactions with antigen-presenting cells by immunosuppressive drugs reveals involvement of calcineurin and NF-kappaB in immunological synapse formation
    Maximilian Zeyda
    Department of Internal Medicine III, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    J Leukoc Biol 81:319-27. 2007
    ..Furthermore, these data imply novel functions of calcineurin and NF-kappaB for successful IS maturation...
  72. doi Prognosis in patients with congestive heart failure and subacute renal failure treated with hemodialysis
    Gregor Lindner
    Department of Medicine III, Division of Nephrology, Vienna, Austria
    Wien Klin Wochenschr 121:391-7. 2009
    ..Little, however, is known about prognostic indices and outcome in patients with CHF who (sub-)acutely progress to dialysis dependency...
  73. ncbi Atherosclerosis and uremic retention solutes
    Walter H Horl
    Division of Nephrology, Department of Medicine III, Medical University of Vienna, Vienna, Austria
    Kidney Int 66:1719-31. 2004
  74. ncbi High-dose parenteral iron sucrose depresses neutrophil intracellular killing capacity
    Robert Deicher
    Universitätsklinik für Innere Medizin III, Klinische Abteilung für Nephrologie und Dialyse, Allgemeines Krankenhaus der Stadt Wien, Vienna, Austria
    Kidney Int 64:728-36. 2003
    ..However, concern exists about possible detrimental effects of parenteral iron on cellular host defense and iron-mediated increments of oxidative stress...
  75. ncbi Low total vitamin C plasma level is a risk factor for cardiovascular morbidity and mortality in hemodialysis patients
    Robert Deicher
    Department of Medicine III, Division of Nephrology and Dialysis, Medical University of Vienna, Austria
    J Am Soc Nephrol 16:1811-8. 2005
    ..Future studies should address the potential protective effect of an adequate vitamin C supplementation...
  76. ncbi Determinants of the complement-fixing ability of recipient presensitization against HLA antigens
    Gregor Bartel
    Department of Medicine III, Medical University of Vienna, Vienna, Austria
    Transplantation 83:727-33. 2007
    ..The aim of this study was to evaluate variables that determine the complement-fixing capability of human leukocyte antigen (HLA) sensitization...
  77. ncbi No associations between prolactin concentrations and response to erythropoiesis-stimulating agents in hemodialysis patients
    Markus Riegersperger
    Division of Nephrology and Dialysis, Department of Medicine III, Medical University Vienna, Vienna, Austria
    Am J Nephrol 27:390-6. 2007
    ..The effect of serum prolactin levels on the response to erythropoiesis-stimulating agents (ESA) in patients on chronic hemodialysis is unknown...
  78. ncbi Analysis of liver function in renal transplant recipients undergoing C2-monitoring for cyclosporine
    Manfred Hecking
    Department of Internal Medicine III, Clinical Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria
    Transpl Int 21:223-33. 2008
    ..Collectively, our data emphasize the need for increased awareness toward individual predispositions for CsA-sensitivity...
  79. doi The TSC-mTOR signaling pathway regulates the innate inflammatory response
    Thomas Weichhart
    Department of Internal Medicine III, Clinical Division of Nephrology and Dialysis, Medical University Vienna, Vienna, Austria
    Immunity 29:565-77. 2008
    ..These data identify the TSC2-mTOR pathway as a key regulator of innate immune homeostasis with broad clinical implications for infectious and autoimmune diseases, vaccination, cancer, and transplantation...
  80. doi Sodium setpoint and sodium gradient: influence on plasma sodium change and weight gain
    Manfred Hecking
    Department of Medicine III, Medical University of Vienna, Austria
    Am J Nephrol 33:39-48. 2011
    ..We determined the relationship between setpoint, gradient and pre- to postdialysis PNa change (delta PNa), and studied associations with dialysis-related variables...
  81. doi The uraemic toxin phenylacetic acid contributes to inflammation by priming polymorphonuclear leucocytes
    Gerald Cohen
    Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Austria
    Nephrol Dial Transplant 28:421-9. 2013
    ..One uraemic toxin is phenylacetic acid (PAA). We therefore investigated whether PAA contributes to the deranged immune response in uraemia by modulating PMNL activities...
  82. doi Lisinopril pharmacokinetics and erythropoietin requirement in haemodialysis patients
    Wolfgang Winnicki
    Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Vienna, Austria
    Eur J Clin Invest 42:1087-93. 2012
    ..However, it is unknown whether or not plasma levels or area under the curve (AUC) of ACE-I are associated with responsiveness to ESA therapy...
  83. pmc Serum amyloid A in uremic HDL promotes inflammation
    Thomas Weichhart
    Department of Internal Medicine III, Division of Nephrology and Dialysis, Medical University of Vienna, Austria
    J Am Soc Nephrol 23:934-47. 2012
    ..These data suggest a potential link between the high levels of inflammation and cardiovascular mortality in uremia...
  84. pmc The active metabolite of leflunomide, A77 1726, interferes with dendritic cell function
    Bernhard M Kirsch
    Department of Internal Medicine III Clinical Division of Nephrology, Medical University of Vienna, Vienna, Austria
    Arthritis Res Ther 7:R694-703. 2005
    ..These data indicate that interference with several aspects of DC function could significantly contribute to the beneficial effects of leflunomide in inflammatory diseases, including RA...
  85. ncbi Peri-operative immunoadsorption in sensitized renal transplant recipients
    Martin Haas
    Division of Nephrology and Dialysis, Department of Internal Medicine III, University of Vienna, Austria
    Nephrol Dial Transplant 17:1503-8. 2002
    ..In these patients, prophylactic peri-operative antibody depletion by immunoadsorption (IA) could prevent humoral graft injury and thus, in combination with anti-cellular rejection therapy, improve graft survival...
  86. ncbi Non-erythropoietin-based anaemia management in chronic kidney disease
    Walter H Horl
    Department of Medicine III, University of Vienna, Vienna, Austria
    Nephrol Dial Transplant 17:35-8. 2002
    ..Correction of anaemia with rHuEPO may slow progression of CKD by reducing oxidative stress. These and other factors need to be considered for the optimal treatment of patients with anaemia of CKD...
  87. ncbi Predialysis Survey on Anemia Management: patient referral
    Walter H Horl
    Klinische Abteilung für Nephrologie und Dialyse, Universitätsklinik für Innere Medizin III, Wien, Austria
    Am J Kidney Dis 41:49-61. 2003
    ..In this presentation, we focus on demographic data and patient referral practices of patients who enter kidney centers...
  88. ncbi Vitamin C in chronic kidney disease and hemodialysis patients
    Robert Deicher
    Universitätsklinik für Innere Medizin III, Klinische Abteilung für Nephrologie und Dialyse, Wien, Osterreich
    Kidney Blood Press Res 26:100-6. 2003
    ..Ascorbate's role in modifying arterial blood pressure remains unclear, but anemic patients with functional iron deficiency might benefit from short-term, moderately dosed ascorbate supplements...
  89. ncbi Pre-transplant predictors of cerebrovascular events after kidney transplantation
    Susanne Aull-Watschinger
    Universitätsklinik für Innere Medizin III, Medizinische Universität Wien, Wahringer Gurtel 18 20, A 1090 Wien, Austria
    Nephrol Dial Transplant 23:1429-35. 2008
    ..We evaluated cerebrovascular events (CVE) after kidney transplantation (KTx) and sought to identify pre-transplant predictors of transient ischaemic attacks (TIA) and strokes post-transplantation...
  90. doi The versatility of HDL: a crucial anti-inflammatory regulator
    Marcus D Saemann
    Department of Internal Medicine III, Division of Nephrology and Dialysis, Medical University Vienna, Wahringer Gurtel, Vienna, Austria
    Eur J Clin Invest 40:1131-43. 2010
    ..However, the current evidence that raising HDL per se will reduce atherosclerosis and thereby cardiovascular events still remains controversial...
  91. ncbi Resistin inhibits essential functions of polymorphonuclear leukocytes
    Gerald Cohen
    Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Vienna, Austria
    J Immunol 181:3761-8. 2008
    ....
  92. ncbi Adjunctive therapy in anaemia management
    Walter H Horl
    Division of Nephrology and Dialysis, Department of Medicine III, University of Vienna, Vienna, Austria
    Nephrol Dial Transplant 17:56-9. 2002
    ..v. L-carnitine therapy results in an increase in haematocrit and a significant decrease in rHuEPO requirement in HD patients. As yet, there is no general recommendation for L-carnitine supplementation for ESRD patients with renal anaemia...
  93. ncbi One-year growth hormone therapy improves granulocyte function without major effects on nutritional and anthropometric parameters in malnourished hemodialysis patients
    Harald Kotzmann
    Division of Endocrinology and Metabolism, Department of Medicine III, University of Vienna, Austria
    Nephron Clin Pract 93:C75-82. 2003
    ..In short-term trials anabolic effects of rhGH therapy have been demonstrated in patients on chronic hemodialysis...
  94. ncbi [Treatment of renal anemia with darbepoetin alfa: results of an Austrian multicenter study]
    Walter H Horl
    Klinische Abteilung für Nephrologie und Dialyse, Universitätsklinik für Innere Medizin III, Wien
    Wien Klin Wochenschr 114:967-71. 2002
    ..These data confirm that unit dosing with darbepoetin alfa at increased dosing intervals and reduced dose effectively and safely maintains Hb levels in haemodialysis patients...
  95. ncbi Impairment of transendothelial leukocyte migration by iron complexes
    Gürkan Sengoelge
    Department of Medicine III, Division of Nephrology and Dialysis, University of Vienna, Vienna, Austria
    J Am Soc Nephrol 14:2639-44. 2003
    ..001), and of the preincubation of PMN with iron (P < 0.000001) on PMN diapedesis. It is concluded that iron sucrose and iron gluconate cause a significant inhibition of transendothelial migration of PMN...
  96. ncbi Reversibility of 'secondary hypercalcitoninemia' after kidney transplantation
    Kyra A Borchhardt
    Department of Medicine III, Division of Nephrology and Dialysis, Medical University Vienna, Austria
    Am J Transplant 5:1757-63. 2005
    ..After transplantation, CT correlated with serum creatinine. Therefore, the increase of CT concentration in patients with impaired kidney function presumably reflects 'secondary hypercalcitoninemia' due to C-cell hyperactivity...
  97. doi Pure red cell aplasia induced by erythropoiesis-stimulating agents
    Carol Pollock
    Department of Medicine, Royal North Shore Hospital, University of Sydney, Department of Medicine, Pacific Highway, Street Leonards, NSW, 2065, Australia
    Clin J Am Soc Nephrol 3:193-9. 2008
    ..Continued study of epoetin-induced pure red cell aplasia is needed to help nephrologists prevent or manage future cases and will have implications for the use of other protein-based therapeutic agents...
  98. pmc Statin use is associated with prolonged survival of renal transplant recipients
    Franz Wiesbauer
    Department of Cardiology, Medical University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    J Am Soc Nephrol 19:2211-8. 2008
    ..Although these results are encouraging, a definitive causal relationship can be determined only from randomized clinical trials...
  99. doi Gross proteinuria and subacute renal failure after coronary angiography - a case report of cholesterol crystal embolization
    Peter Biesenbach
    Internal Medicine III Clinical Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria
    Wien Klin Wochenschr 122:251-4. 2010
    ..Identification of high-risk patients is of utmost importance as efficient therapeutic strategies do not exist...
  100. ncbi Role of humoral immune reactions as target for antirejection therapy in recipients of a spousal-donor kidney graft
    G A Böhmig
    Department of Internal Medicine III, Institute of Clinical Pathology, Institute of Immunology, University of Vienna, Austria
    Am J Kidney Dis 35:667-73. 2000
    ..Thus, in this particular setting, a detailed immunologic and histopathologic work-up regarding antibody-mediated allograft dysfunction is warranted because immunoadsorption may be a highly effective treatment modality...
  101. ncbi Iron overload and cardiovascular complications in dialysis patients
    Josef Kletzmayr
    Division of Nephrology and Dialysis, Department of Medicine, University of Vienna, Austria
    Nephrol Dial Transplant 17:25-9. 2002
    ..Prospective studies are needed to clarify the influence of iron stores and iron therapy on overall and cardiovascular morbidity and mortality in ESRD patients...