Rainer Mittermayr

Summary

Affiliation: Ludwig Boltzmann Institute for Experimental and Clinical Traumatology
Country: Austria

Publications

  1. ncbi request reprint Skin graft fixation by slow clotting fibrin sealant applied as a thin layer
    Rainer Mittermayr
    Research Center of the AUVA, Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Donaueschingenstrasse 13, 1200 Vienna, Austria
    Burns 32:305-11. 2006
  2. doi request reprint Sustained (rh)VEGF(165) release from a sprayed fibrin biomatrix induces angiogenesis, up-regulation of endogenous VEGF-R2, and reduces ischemic flap necrosis
    Rainer Mittermayr
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria
    Wound Repair Regen 16:542-50. 2008
  3. ncbi request reprint Light therapy by blue LED improves wound healing in an excision model in rats
    Natalia Adamskaya
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, AUVA Research Center, Austrian Cluster for Tissue Regeneration, Donaueschingenstrasse 13, A 1200 Vienna, Austria
    Injury 42:917-21. 2011
  4. doi request reprint Extracorporeal shock wave therapy (ESWT) minimizes ischemic tissue necrosis irrespective of application time and promotes tissue revascularization by stimulating angiogenesis
    Rainer Mittermayr
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria
    Ann Surg 253:1024-32. 2011
  5. doi request reprint Extracorporeal shockwave therapy (ESWT) ameliorates healing of tibial fracture non-union unresponsive to conventional therapy
    Nicolas Haffner
    Orthopaedic Hospital Gersthof, Vienna, Austria
    Injury 47:1506-13. 2016
  6. doi request reprint Extracorporeal shock wave therapy (ESWT) for wound healing: technology, mechanisms, and clinical efficacy
    Rainer Mittermayr
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Austrian Cluster for Tissue Regeneration, Vienna, Austria
    Wound Repair Regen 20:456-65. 2012
  7. doi request reprint Fibrin biomatrix-conjugated platelet-derived growth factor AB accelerates wound healing in severe thermal injury
    Rainer Mittermayr
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Austrian Cluster for Tissue Regeneration, Vienna, Austria
    J Tissue Eng Regen Med 10:E275-85. 2016
  8. ncbi request reprint Fibrin-embedded administration of VEGF plasmid enhances skin flap survival
    Wolfgang Michlits
    Laboratory for Cardiovascular Research, Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria
    Wound Repair Regen 15:360-7. 2007
  9. doi request reprint VEGF released from a fibrin biomatrix increases VEGFR-2 expression and improves early outcome after ischaemia-reperfusion injury
    Martina Moritz
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, AUVA Research Centre, Austrian Cluster for Tissue Regeneration, Vienna, Austria
    J Tissue Eng Regen Med . 2016
  10. doi request reprint Controlled release of fibrin matrix-conjugated platelet derived growth factor improves ischemic tissue regeneration by functional angiogenesis
    Rainer Mittermayr
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology Austrian Cluster for Tissue Regeneration, AUVA Research Center, Vienna, Austria AUVA Trauma Center Meidling, Vienna, Austria Electronic address
    Acta Biomater 29:11-20. 2016

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Skin graft fixation by slow clotting fibrin sealant applied as a thin layer
    Rainer Mittermayr
    Research Center of the AUVA, Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Donaueschingenstrasse 13, 1200 Vienna, Austria
    Burns 32:305-11. 2006
    ..9% (IQR 93.2-98%) in the suture group. The results indicate, that the usage of a sprayed thin FS layer (0.05 ml/cm2) in a slow clotting rate (4-5 IUthrombin/ml) is an appropriate fixation method in split thickness skin transplantation...
  2. doi request reprint Sustained (rh)VEGF(165) release from a sprayed fibrin biomatrix induces angiogenesis, up-regulation of endogenous VEGF-R2, and reduces ischemic flap necrosis
    Rainer Mittermayr
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria
    Wound Repair Regen 16:542-50. 2008
    ..This work demonstrates the clinical ability of sprayed FS to locally deliver growth factors to ischemic tissue of patients...
  3. ncbi request reprint Light therapy by blue LED improves wound healing in an excision model in rats
    Natalia Adamskaya
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, AUVA Research Center, Austrian Cluster for Tissue Regeneration, Donaueschingenstrasse 13, A 1200 Vienna, Austria
    Injury 42:917-21. 2011
    ..Here, we compared the effects of blue and red low level light by light-emitting diodes (LEDs) on in vivo wound healing in an excision wound model in rats...
  4. doi request reprint Extracorporeal shock wave therapy (ESWT) minimizes ischemic tissue necrosis irrespective of application time and promotes tissue revascularization by stimulating angiogenesis
    Rainer Mittermayr
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria
    Ann Surg 253:1024-32. 2011
    ..To assess the time-dependent treatment effects of extracorporeal shock wave therapy (ESWT) in a standard rodent ischemic epigastric flap model...
  5. doi request reprint Extracorporeal shockwave therapy (ESWT) ameliorates healing of tibial fracture non-union unresponsive to conventional therapy
    Nicolas Haffner
    Orthopaedic Hospital Gersthof, Vienna, Austria
    Injury 47:1506-13. 2016
    ..The procedure is well tolerated, time-saving, lacking side effects, with potential to significantly decrease health care costs. Thus, in our view, ESWT should be considered the treatment of first choice in established tibial non-unions. ..
  6. doi request reprint Extracorporeal shock wave therapy (ESWT) for wound healing: technology, mechanisms, and clinical efficacy
    Rainer Mittermayr
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Austrian Cluster for Tissue Regeneration, Vienna, Austria
    Wound Repair Regen 20:456-65. 2012
    ..Recent research advances are discussed emphasizing the role of extracorporeal shock wave therapy in soft tissue wound healing...
  7. doi request reprint Fibrin biomatrix-conjugated platelet-derived growth factor AB accelerates wound healing in severe thermal injury
    Rainer Mittermayr
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Austrian Cluster for Tissue Regeneration, Vienna, Austria
    J Tissue Eng Regen Med 10:E275-85. 2016
    ..Copyright © 2013 John Wiley & Sons, Ltd. ..
  8. ncbi request reprint Fibrin-embedded administration of VEGF plasmid enhances skin flap survival
    Wolfgang Michlits
    Laboratory for Cardiovascular Research, Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria
    Wound Repair Regen 15:360-7. 2007
    ..The suggested therapeutic approach is easily applicable and inexpensive in preparation. Thus, this protocol may also enhance wound healing in posttrauma skin lacerations or in skin grafts...
  9. doi request reprint VEGF released from a fibrin biomatrix increases VEGFR-2 expression and improves early outcome after ischaemia-reperfusion injury
    Martina Moritz
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, AUVA Research Centre, Austrian Cluster for Tissue Regeneration, Vienna, Austria
    J Tissue Eng Regen Med . 2016
    ..These results showed that VEGF released from fibrin had a positive effect on early I-R outcome in a mouse model, possibly via VEGFR-2. Copyright © 2016 John Wiley & Sons, Ltd...
  10. doi request reprint Controlled release of fibrin matrix-conjugated platelet derived growth factor improves ischemic tissue regeneration by functional angiogenesis
    Rainer Mittermayr
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology Austrian Cluster for Tissue Regeneration, AUVA Research Center, Vienna, Austria AUVA Trauma Center Meidling, Vienna, Austria Electronic address
    Acta Biomater 29:11-20. 2016
    ..The sealing properties of the fibrin matrix in conjunction with the prolonged growth factor stimulus enabled by the TG-hook binding technology may present an innovative and suitable tool in tissue regeneration...
  11. doi request reprint Thrombin as important factor for cutaneous wound healing: comparison of fibrin biomatrices in vitro and in a rat excisional wound healing model
    Alfred Gugerell
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Austrian Cluster for Tissue Regeneration, Vienna, Austria Division of Plastic and Reconstructive Surgery, Department of Surgery, Medical University of Vienna, Vienna, Austria
    Wound Repair Regen 22:740-8. 2014
    ..Hence, we conclude that the composition of fibrin biomatrices influences keratinocytes and therefore has an impact on wound healing...
  12. doi request reprint Low level light therapy by LED of different wavelength induces angiogenesis and improves ischemic wound healing
    Peter Dungel
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, AUVA Research Center, Austrian Cluster for Tissue Regeneration, Vienna, Austria
    Lasers Surg Med 46:773-80. 2014
    ..Therefore, the aim of this study was to evaluate and compare the therapeutic value of blue or red light emitting diodes (LEDs) on wound healing in an ischemia disturbed rodent flap model...
  13. ncbi request reprint Adverse effects associated with the use of porcine cross-linked collagen implants in an experimental model of incisional hernia repair
    Alexander H Petter-Puchner
    Ludwig Boltzmann Institute for Traumatology, Vienna, Austria
    J Surg Res 145:105-10. 2008
    ..Porcine cross-linked collagen (PermaCol, PCL; TSL, Aldershot, United Kingdom) has been proposed as permanent biomaterial in incisional hernia repair. We evaluated the biocompatibility of PCL in an established animal model...
  14. doi request reprint Extracorporeal shockwave therapy (ESWT) - First choice treatment of fracture non-unions?
    Wolfgang Schaden
    AUVA Trauma Center Meidling, Vienna, Austria Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, AUVA Research Center, Austrian Cluster for Tissue Regeneration, Vienna, Austria
    Int J Surg 24:179-83. 2015
    ....
  15. doi request reprint In vitro extracorporeal shock wave treatment enhances stemness and preserves multipotency of rat and human adipose-derived stem cells
    Christina Maria Anna Pia Schuh
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, AUVA Research Center, Vienna, Austria Austrian Cluster for Tissue Regeneration, Vienna, Austria University of Applied Sciences Technikum Wien Department of Biochemical Engineering, Vienna, Austria Electronic address
    Cytotherapy 16:1666-78. 2014
    ..However, its applicability for the clinic is still difficult due to intra- and inter-donor heterogeneity and limited life span in vitro, influencing differentiation capacity as a consequence to decreased multipotency...
  16. ncbi request reprint Assessment of bone union/nonunion in an experimental model using microcomputed technology
    Robert Schmidhammer
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology and Research Center for Traumatology, Austrian Workers Compensation Board, Vienna, Austria
    J Trauma 61:199-205. 2006
    ..Our study had two goals: to develop a reproducible nonunion model and to determine the efficacy of microCT for the assessment of bone healing in this model...
  17. ncbi request reprint Light therapy by blue LED improves wound healing in an excision model in rats
    Natalia Adamskaya
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, AUVA Research Center, Austrian Cluster for Tissue Regeneration, Donaueschingenstrasse 13, A 1200 Vienna, Austria
    Injury 41:1038-42. 2010
    ..Here, we compared the effects of blue and red low level light by light-emitting diodes (LEDs) on in vivo wound healing in an excision wound model in rats...
  18. pmc Shock wave treatment enhances cell proliferation and improves wound healing by ATP release-coupled extracellular signal-regulated kinase (ERK) activation
    Anna M Weihs
    From the Department of Biochemical Engineering, University of Applied Sciences Technikum Wien, 1200 Vienna, Austria, The Austrian Cluster for Tissue Regeneration, Vienna, Austria
    J Biol Chem 289:27090-104. 2014
    ..In conclusion, our findings shed further light on the molecular mechanisms by which shock wave treatment exerts its beneficial effects. These findings could help to improve the clinical use of shock wave treatment for wound healing. ..
  19. pmc Blue laser light increases perfusion of a skin flap via release of nitric oxide from hemoglobin
    Rainer Mittermayr
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology in the AUVA Research Center, Vienna, Austria
    Mol Med 13:22-9. 2007
    ..This study demonstrates that blue laser irradiation improves local tissue perfusion in a controlled manner stimulating NO release from NO-Hb complexes...
  20. ncbi request reprint Protective effect of a novel NO-donor on ischemia/reperfusion injury in a rat epigastric flap model
    Rainer Mittermayr
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria
    Wound Repair Regen 11:3-10. 2003
    ..These findings support the role of nitric oxide as an important mediator in the protection against skin flap ischemia/reperfusion injury...
  21. doi request reprint Illumination with blue light reactivates respiratory activity of mitochondria inhibited by nitric oxide, but not by glycerol trinitrate
    Peter Dungel
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology in the Research Center of AUVA, Donaueschingenstr 23, A 1200 Vienna, Austria
    Arch Biochem Biophys 471:109-15. 2008
    ..The inhibition of mitochondrial respiration by GTN is not sensitive to visible light, suggesting an inhibition mechanism other that NO mediation...