Andreas Villunger

Summary

Affiliation: Innsbruck Medical University
Country: Austria

Publications

  1. pmc BH3-only protein Bmf mediates apoptosis upon inhibition of CAP-dependent protein synthesis
    F Grespi
    Innsbruck Medical University, Biocenter, Austria
    Cell Death Differ 17:1672-83. 2010
  2. pmc Minor cell-death defects but reduced tumor latency in mice lacking the BH3-only proteins Bad and Bmf
    F Baumgartner
    Division of Developmental Immunology, Biocenter, Innsbruck Medical University, Innsbruck, Austria
    Oncogene 32:621-30. 2013
  3. pmc Death of p53-defective cells triggered by forced mitotic entry in the presence of DNA damage is not uniquely dependent on Caspase-2 or the PIDDosome
    C Manzl
    Division of Developmental Immunology, Biocenter, Innsbruck Medical University, Innsbruck, Austria
    Cell Death Dis 4:e942. 2013
  4. pmc Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction
    Miriam Erlacher
    Division of Developmental Immunology, Biocenter, Innsbruck Medical University, A 6020 Innsbruck, Austria
    J Exp Med 203:2939-51. 2006
  5. pmc Generation and evaluation of an IPTG-regulated version of Vav-gene promoter for mouse transgenesis
    Francesca Grespi
    Division of Developmental Immunology, Medical University Innsbruck, Innsbruck, Austria
    PLoS ONE 6:e18051. 2011
  6. pmc Loss of the BH3-only protein Bmf impairs B cell homeostasis and accelerates gamma irradiation-induced thymic lymphoma development
    Verena Labi
    Division of Developmental Immunology, Biocenter, Innsbruck Medical University, 6020 Innsbruck, Austria
    J Exp Med 205:641-55. 2008
  7. pmc Bcl-2-regulated cell death signalling in the prevention of autoimmunity
    D Tischner
    Division of Developmental Immunology, Biocenter, Medical University Innsbruck, Innsbruck, Austria
    Cell Death Dis 1:e48. 2010
  8. pmc Caspase-2 activation in the absence of PIDDosome formation
    Claudia Manzl
    Division of Developmental Immunology, Biocenter, Innsbruck Medical University, A 6020 Innsbruck, Austria
    J Cell Biol 185:291-303. 2009
  9. pmc Possible pitfalls investigating cell death responses in genetically engineered mouse models and derived cell lines
    Claudia Manzl
    Division of Developmental Immunology, Biocenter, Medical University of Innsbruck, Innsbruck, Austria
    Methods 61:130-7. 2013
  10. pmc A1/Bfl-1 in leukocyte development and cell death
    Eleonora Ottina
    Division of Developmental Immunology, Biocenter, Innsbruck Medical University, Innsbruck, Austria
    Exp Cell Res 318:1291-303. 2012

Collaborators

Detail Information

Publications32

  1. pmc BH3-only protein Bmf mediates apoptosis upon inhibition of CAP-dependent protein synthesis
    F Grespi
    Innsbruck Medical University, Biocenter, Austria
    Cell Death Differ 17:1672-83. 2010
    ..Knock down or deletion of Bmf reduces apoptosis under some of these conditions, demonstrating that Bmf can act as a sentinel for stress-impaired CAP-dependent protein translation machinery...
  2. pmc Minor cell-death defects but reduced tumor latency in mice lacking the BH3-only proteins Bad and Bmf
    F Baumgartner
    Division of Developmental Immunology, Biocenter, Innsbruck Medical University, Innsbruck, Austria
    Oncogene 32:621-30. 2013
    ..Together our study suggests that Bad and Bmf co-regulate lymphocyte homeostasis and limit spontaneous transformation by mechanisms that may not exclusively be linked to the induction of lymphocyte apoptosis...
  3. pmc Death of p53-defective cells triggered by forced mitotic entry in the presence of DNA damage is not uniquely dependent on Caspase-2 or the PIDDosome
    C Manzl
    Division of Developmental Immunology, Biocenter, Innsbruck Medical University, Innsbruck, Austria
    Cell Death Dis 4:e942. 2013
    ....
  4. pmc Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction
    Miriam Erlacher
    Division of Developmental Immunology, Biocenter, Innsbruck Medical University, A 6020 Innsbruck, Austria
    J Exp Med 203:2939-51. 2006
    ..Their combined loss promotes spontaneous tumorigenesis, causing the malignancies observed in Bcl-2 transgenic mice, but does not exacerbate the autoimmunity observed in the absence of Bim...
  5. pmc Generation and evaluation of an IPTG-regulated version of Vav-gene promoter for mouse transgenesis
    Francesca Grespi
    Division of Developmental Immunology, Medical University Innsbruck, Innsbruck, Austria
    PLoS ONE 6:e18051. 2011
    ..g. for the activation of oncogenes or transgenes that act in a dominant-negative manner...
  6. pmc Loss of the BH3-only protein Bmf impairs B cell homeostasis and accelerates gamma irradiation-induced thymic lymphoma development
    Verena Labi
    Division of Developmental Immunology, Biocenter, Innsbruck Medical University, 6020 Innsbruck, Austria
    J Exp Med 205:641-55. 2008
    ..Finally, Bmf-deficiency accelerated the development of gamma irradiation-induced thymic lymphomas. Our results demonstrate that Bmf plays a critical role in apoptosis signaling and can function as a tumor suppressor...
  7. pmc Bcl-2-regulated cell death signalling in the prevention of autoimmunity
    D Tischner
    Division of Developmental Immunology, Biocenter, Medical University Innsbruck, Innsbruck, Austria
    Cell Death Dis 1:e48. 2010
    ..This review focuses on the role of Bcl-2 family proteins implicated in the development of autoimmune disorders and their potential as targets for therapeutic intervention...
  8. pmc Caspase-2 activation in the absence of PIDDosome formation
    Claudia Manzl
    Division of Developmental Immunology, Biocenter, Innsbruck Medical University, A 6020 Innsbruck, Austria
    J Cell Biol 185:291-303. 2009
    ....
  9. pmc Possible pitfalls investigating cell death responses in genetically engineered mouse models and derived cell lines
    Claudia Manzl
    Division of Developmental Immunology, Biocenter, Medical University of Innsbruck, Innsbruck, Austria
    Methods 61:130-7. 2013
    ..Furthermore, we show as an example that C57BL/6 mice are more susceptible to γ-irradiation induced cell death after whole body irradiation in vivo and subsequent T cell lymphomagenesis...
  10. pmc A1/Bfl-1 in leukocyte development and cell death
    Eleonora Ottina
    Division of Developmental Immunology, Biocenter, Innsbruck Medical University, Innsbruck, Austria
    Exp Cell Res 318:1291-303. 2012
    ..In this review, we aim to summarize current knowledge on A1 biology, focusing on its role in the immune system and compare it to that of other pro-survival Bcl-2 proteins...
  11. pmc Defective cell death signalling along the Bcl-2 regulated apoptosis pathway compromises Treg cell development and limits their functionality in mice
    Denise Tischner
    Biocenter, Division of Developmental Immunology, Innsbruck Medical University, A 6020 Innsbruck, Austria
    J Autoimmun 38:59-69. 2012
    ..Remarkably, apoptosis resistant Treg cells showed reduced suppressive capacity in a model of T cell-driven colitis, posing a caveat for the use of such long-lived cells in possible therapeutic settings...
  12. pmc Suppression of B-cell lymphomagenesis by the BH3-only proteins Bmf and Bad
    Anna Frenzel
    Division of Developmental Immunology, Biocenter, Innsbruck Medical University, Innsbruck, Austria
    Blood 115:995-1005. 2010
    ..Loss of Bmf reduced the pressure to inactivate p53, whereas Bad deficiency did not, identifying Bmf as a novel component of the p53-independent tumor suppressor pathway triggered by c-Myc...
  13. pmc BH3-only proteins Puma and Bim are rate-limiting for gamma-radiation- and glucocorticoid-induced apoptosis of lymphoid cells in vivo
    Miriam Erlacher
    Division of Experimental Pathophysiology and Immunology, Biocenter, Innsbruck Medical University, A 6020 Innsbruck, Austria
    Blood 106:4131-8. 2005
    ..Our results thus establish that Puma and Bim are key initiators of gamma-radiation- and glucocorticoid-induced apoptosis in lymphoid cells in vivo...
  14. pmc Apoptosis of leukocytes triggered by acute DNA damage promotes lymphoma formation
    Verena Labi
    Division of Developmental Immunology, Biocenter, Innsbruck Medical University, Innsbruck 6020, Austria
    Genes Dev 24:1602-7. 2010
    ....
  15. pmc Deregulated cell death and lymphocyte homeostasis cause premature lethality in mice lacking the BH3-only proteins Bim and Bmf
    Verena Labi
    Division of Developmental Immunology, Biocenter, Medical University Innsbruck, Innsbruck, Austria
    Blood 123:2652-62. 2014
    ..Thus, our results demonstrate that Bim and Bmf act in concert to prevent autoimmunity and malignant disease, strengthening the rational for the development of BH3-only protein mimicking therapeutics for the treatment of such disorders...
  16. ncbi request reprint Impact of cellular lifespan on the T cell receptor repertoire
    Abdelbasset Hamrouni
    Division of Developmental Immunology, Biocenter, Innsbruck Medical University, Innsbruck, Austria
    Eur J Immunol 37:1978-85. 2007
    ..However, the changes that we observed were less pronounced than those found in lck-bcl-x(L) transgenic mice, pointing towards qualitative differences between Bcl-2- and Bcl-x(L)-mediated cell death inhibition during T cell development...
  17. pmc PIDDosome-independent tumor suppression by Caspase-2
    C Manzl
    Division of Developmental Immunology, Biocenter, Medical University Innsbruck, Austria
    Cell Death Differ 19:1722-32. 2012
    ....
  18. doi request reprint Necrosis-like death can engage multiple pro-apoptotic Bcl-2 protein family members
    Denise Tischner
    Division of Developmental Immunology, Biocenter, Medical University Innsbruck, 6020 Innsbruck, Austria
    Apoptosis 17:1197-209. 2012
    ..Further, necroptosis may depend on mitochondrial changes engaging proteins considered critical for MOMP during apoptosis that ultimately contribute to caspase-independent necrotic cell death...
  19. pmc Targeting antiapoptotic A1/Bfl-1 by in vivo RNAi reveals multiple roles in leukocyte development in mice
    Eleonora Ottina
    Division of Developmental Immunology, Biocenter, Innsbruck Medical University, Innrain 80 82, Innsbruck, Austria
    Blood 119:6032-42. 2012
    ..These models highlight the critical role of A1 in leukocyte development and homeostasis, constituting valuable tools for investigating presumed roles of this Bcl-2 family member in immunity, tumorigenesis, and drug resistance...
  20. pmc Haematopoietic stem cell survival and transplantation efficacy is limited by the BH3-only proteins Bim and Bmf
    Verena Labi
    Division of Developmental Immunology, Biocenter, Innsbruck Medical University, Innsbruck, Austria
    EMBO Mol Med 5:122-36. 2013
    ....
  21. doi request reprint Shaping the T-cell repertoire: a matter of life and death
    G Jan Wiegers
    Division of Developmental Immunology, Biocenter, Medical University Innsbruck, Innsbruck, Austria
    Immunol Cell Biol 89:33-9. 2011
    ..This review aims to highlight the role of Bcl-2-regulated cell death for clonal T-cell selection...
  22. pmc Bcl2 family proteins in carcinogenesis and the treatment of cancer
    Anna Frenzel
    Biocenter Division of Developmental Immunology, Innsbruck Medical University, Innsbruck, Austria
    Apoptosis 14:584-96. 2009
    ..This review aims to give an overview on the most recent findings on the role of the Bcl2 family in tumour development in model systems of cancer, to relate these findings with observations made in human pathologies and drug-action...
  23. doi request reprint Infiltrating CD11b+CD11c+ cells have the potential to mediate inducible nitric oxide synthase-dependent cell death in mammary carcinomas of HER-2/neu transgenic mice
    Nirmala Parajuli
    Division of Medical Biochemistry, Biocenter, Innsbruck Medical University, Innsbruck, Austria
    Int J Cancer 126:896-908. 2010
    ....
  24. pmc The anti-apoptotic protein BCL2L1/Bcl-xL is neutralized by pro-apoptotic PMAIP1/Noxa in neuroblastoma, thereby determining bortezomib sensitivity independent of prosurvival MCL1 expression
    Judith Hagenbuchner
    Department of Pediatrics IV, Biocenter, Medical University Innsbruck, Tyrolean Cancer Research Institute, 6020 Innsbruck, Austria
    J Biol Chem 285:6904-12. 2010
    ....
  25. pmc Upregulation of miR-24 is associated with a decreased DNA damage response upon etoposide treatment in highly differentiated CD8(+) T cells sensitizing them to apoptotic cell death
    Stefan Brunner
    Immunology Division, Institute for Biomedical Aging Research, Austrian Academy of Sciences, Innsbruck, Austria
    Aging Cell 11:579-87. 2012
    ..Interleukin (IL)-15 could prevent etoposide-mediated apoptosis of CD8(+) CD28(-) T cells, suggesting a role for IL-15 in the survival and the age-dependent accumulation of CD8(+) CD28(-) T cells in humans...
  26. ncbi request reprint The nuclear orphan receptor NR2F6 suppresses lymphocyte activation and T helper 17-dependent autoimmunity
    Natascha Hermann-Kleiter
    Department for Medical Genetics, Molecular and Clinical Pharmacology, Medical University Innsbruck, 6020 Innsbruck, Austria
    Immunity 29:205-16. 2008
    ..Our study establishes NR2F6 as a transcriptional repressor of IL-17 expression in Th17-differentiated CD4(+) T cells in vitro and in vivo...
  27. pmc p14-MP1-MEK1 signaling regulates endosomal traffic and cellular proliferation during tissue homeostasis
    David Teis
    Division of Cell Biology, Innsbruck Medical University, A 6020 Innsbruck, Austria
    J Cell Biol 175:861-8. 2006
    ....
  28. ncbi request reprint The Bcl-2 protein family and its role in the development of neoplastic disease
    Dietmar Heiser
    Institute of Pathophysiology, University of Innsbruck Medical School, Fritz Pregl Str 3, A 6020 Innsbruck, Austria
    Exp Gerontol 39:1125-35. 2004
    ....
  29. ncbi request reprint Apoptosis and necroptosis are induced in rainbow trout cell lines exposed to cadmium
    Gerhard Krumschnabel
    Division of Developmental Immunology, Biocenter, Medical University Innsbruck, Fritz Preglstr 3, Innsbruck, Austria
    Aquat Toxicol 99:73-85. 2010
    ....
  30. ncbi request reprint PUMA-mediated tumor suppression: A tale of two stories
    Verena Labi
    Biocenter, Innsbruck Medical University, Austria
    Cell Cycle 9:4269-75. 2010
    ....
  31. doi request reprint Lapatinib and doxorubicin enhance the Stat1-dependent antitumor immune response
    Lára Hannesdóttir
    Division of Medical Biochemistry, Biocenter, Innsbruck Medical University, Innsbruck, Austria
    Eur J Immunol 43:2718-29. 2013
    ..Taken together, the results point to an important contribution toward enhancing T-cell and IFN-γ-based immunity by lapatinib as well as doxorubicin and emphasize the role of Stat1 in building an effective antitumor immune response...