I A Yang

Summary

Country: Australia

Publications

  1. doi request reprint Systematic review of multidisciplinary teams in the management of lung cancer
    M Coory
    School of Population Health, The University of Queensland, Public Health Building, Mayne Medical School, Herston Road, Brisbane 4006, Australia
    Lung Cancer 60:14-21. 2008
  2. ncbi request reprint Inhaled corticosteroids for stable chronic obstructive pulmonary disease
    I A Yang
    Prince Charles Hospital and University of Queensland, Department of Thoracic Medicine and School of Medicine, Rode Rd, Chermside, Brisbane, Queensland, Australia, 4032
    Cochrane Database Syst Rev . 2007
  3. pmc MicroRNA-34c is associated with emphysema severity and modulates SERPINE1 expression
    Santiyagu M Savarimuthu Francis
    Department of Thoracic Medicine, The Prince Charles Hospital, Brisbane, Qld 4032, Australia
    BMC Genomics 15:88. 2014
  4. pmc Genetic influences on right ventricular systolic pressure (RVSP) in chronic obstructive pulmonary disease (COPD)
    Janet G Shaw
    Department of Thoracic Medicine, The Prince Charles Hospital, Rode Rd, Chermside, Brisbane, Qld 4032, Australia
    BMC Pulm Med 12:25. 2012
  5. doi request reprint Inhaled corticosteroids for stable chronic obstructive pulmonary disease
    Ian A Yang
    Department of ThoracicMedicine, The Prince CharlesHospital, Brisbane, Australia
    Cochrane Database Syst Rev . 2012
  6. pmc Expression profiling identifies genes involved in emphysema severity
    Santiyagu M Savarimuthu Francis
    Department of Thoracic Medicine, The Prince Charles Hospital, Brisbane, Australia
    Respir Res 10:81. 2009
  7. ncbi request reprint Beta2-adrenoceptor polymorphisms and obstructive airway diseases: important issues of study design
    Ian A Yang
    Department of Thoracic Medicine, The Prince Charles Hospital, and School of Medicine, The University of Queensland, Brisbane, Queensland, Australia
    Clin Exp Pharmacol Physiol 34:1029-36. 2007
  8. ncbi request reprint Gene-environmental interaction in asthma
    Ian A Yang
    Department of Thoracic Medicine, The Prince Charles Hospital, Brisbane, Australia
    Curr Opin Allergy Clin Immunol 7:75-82. 2007
  9. doi request reprint Genetic susceptibility to the respiratory effects of air pollution
    I A Yang
    Department of Thoracic Medicine, The Prince Charles Hospital, Rode Road, Chermside, Brisbane QLD 4032, Australia
    Thorax 63:555-63. 2008
  10. ncbi request reprint The role of Toll-like receptors and related receptors of the innate immune system in asthma
    Ian A Yang
    Department of Thoracic Medicine, The Prince Charles Hospital, Brisbane, Queensland, Australia
    Curr Opin Allergy Clin Immunol 6:23-8. 2006

Collaborators

Detail Information

Publications38

  1. doi request reprint Systematic review of multidisciplinary teams in the management of lung cancer
    M Coory
    School of Population Health, The University of Queensland, Public Health Building, Mayne Medical School, Herston Road, Brisbane 4006, Australia
    Lung Cancer 60:14-21. 2008
    ..We conducted a systematic review to evaluate and critically appraise the effectiveness of multidisciplinary teams for lung cancer...
  2. ncbi request reprint Inhaled corticosteroids for stable chronic obstructive pulmonary disease
    I A Yang
    Prince Charles Hospital and University of Queensland, Department of Thoracic Medicine and School of Medicine, Rode Rd, Chermside, Brisbane, Queensland, Australia, 4032
    Cochrane Database Syst Rev . 2007
    ..Major international guidelines recommend selective use of ICS. Recently published meta-analyses have reported conflicting findings on the effects of inhaled steroid therapy in COPD...
  3. pmc MicroRNA-34c is associated with emphysema severity and modulates SERPINE1 expression
    Santiyagu M Savarimuthu Francis
    Department of Thoracic Medicine, The Prince Charles Hospital, Brisbane, Qld 4032, Australia
    BMC Genomics 15:88. 2014
    ..01) and mRNA (OperonV2.0) microarrays. Cells of lung origin (BEAS-2B and HFL1) were profiled using mRNA microarrays (Illumina HumanHT-12 V3) after in vitro manipulation...
  4. pmc Genetic influences on right ventricular systolic pressure (RVSP) in chronic obstructive pulmonary disease (COPD)
    Janet G Shaw
    Department of Thoracic Medicine, The Prince Charles Hospital, Rode Rd, Chermside, Brisbane, Qld 4032, Australia
    BMC Pulm Med 12:25. 2012
    ..In patients with COPD, we genotyped 7 SNPs in 6 candidate PH genes (NOS3, ACE, EDN1, PTGIS, SLC6A4, VEGFA). We tested for association with right ventricular systolic pressure (RVSP), spirometry and gas transfer, and hypoxemia...
  5. doi request reprint Inhaled corticosteroids for stable chronic obstructive pulmonary disease
    Ian A Yang
    Department of ThoracicMedicine, The Prince CharlesHospital, Brisbane, Australia
    Cochrane Database Syst Rev . 2012
    ..Major international guidelines recommend selective use of ICS. Recently published meta-analyses have reported conflicting findings on the effects of inhaled steroid therapy in COPD...
  6. pmc Expression profiling identifies genes involved in emphysema severity
    Santiyagu M Savarimuthu Francis
    Department of Thoracic Medicine, The Prince Charles Hospital, Brisbane, Australia
    Respir Res 10:81. 2009
    ..Gene expression profiling of lung from emphysema patients identified seven candidate genes associated with emphysema severity including COL6A3, SERPINF1, ZNHIT6, NEDD4, CDKN2A, NRN1 and GSTM3...
  7. ncbi request reprint Beta2-adrenoceptor polymorphisms and obstructive airway diseases: important issues of study design
    Ian A Yang
    Department of Thoracic Medicine, The Prince Charles Hospital, and School of Medicine, The University of Queensland, Brisbane, Queensland, Australia
    Clin Exp Pharmacol Physiol 34:1029-36. 2007
    ..Enhancing these study design factors will provide high-quality evidence regarding the biological and clinical importance of beta(2)-adrenoceptor pharmacogenomics in asthma and COPD...
  8. ncbi request reprint Gene-environmental interaction in asthma
    Ian A Yang
    Department of Thoracic Medicine, The Prince Charles Hospital, Brisbane, Australia
    Curr Opin Allergy Clin Immunol 7:75-82. 2007
    ..Asthma is likely to result from the effects of environmental stimuli in genetically susceptible individuals. This review summarizes recent studies of gene-environmental interaction in the pathogenesis of asthma, focusing on study designs...
  9. doi request reprint Genetic susceptibility to the respiratory effects of air pollution
    I A Yang
    Department of Thoracic Medicine, The Prince Charles Hospital, Rode Road, Chermside, Brisbane QLD 4032, Australia
    Thorax 63:555-63. 2008
    ....
  10. ncbi request reprint The role of Toll-like receptors and related receptors of the innate immune system in asthma
    Ian A Yang
    Department of Thoracic Medicine, The Prince Charles Hospital, Brisbane, Queensland, Australia
    Curr Opin Allergy Clin Immunol 6:23-8. 2006
    ..This review summarizes recent studies of the role of innate immunity receptors, including Toll-like receptors and CD14, in the pathogenesis of asthma...
  11. doi request reprint Genetic susceptibility to the respiratory effects of air pollution
    I A Yang
    School of Medicine, The University of Queensland, The Prince Charles Hospital, Brisbane, Australia
    Postgrad Med J 85:428-36. 2009
    ....
  12. ncbi request reprint Association of tumor necrosis factor-alpha polymorphisms and ozone-induced change in lung function
    Ian A Yang
    Asthma Genetics Laboratory, Human Genetics Division, University of Southampton, United Kingdom
    Am J Respir Crit Care Med 171:171-6. 2005
    ..The results of this study support TNF as a genetic factor for susceptibility to ozone-induced changes in lung function in humans, and has potential implications for stratifying health risks of air pollution...
  13. ncbi request reprint Toll-like receptor 4 polymorphism and severity of atopy in asthmatics
    I A Yang
    Asthma Genetics Laboratory, Division of Human Genetics and Infection, University of Southampton, Southampton, UK
    Genes Immun 5:41-5. 2004
    ..05). This study confirms the previously observed lack of association of TLR4 polymorphisms with asthma. In contrast, the findings suggest that genetically determined hyporesponsiveness to endotoxin may increase atopy severity...
  14. ncbi request reprint Genetic association studies of interleukin-13 receptor alpha1 subunit gene polymorphisms in asthma and atopy
    A K Konstantinidis
    Divisions of Human Genetics, School of Medicine, University of Southampton, Southampton, UK
    Eur Respir J 30:40-7. 2007
    ....
  15. doi request reprint Genetic association study of CYP1A1 polymorphisms identifies risk haplotypes in nonsmall cell lung cancer
    C M Wright
    Dept of Thoracic Medicine, Room 2, Level 1 Clinical Sciences Building, The Prince Charles Hospital, Chermside, QLD, Australia
    Eur Respir J 35:152-9. 2010
    ..The present study has identified risk haplotypes for CYP1A1 in NSCLC and confirmed that CYP1A1 polymorphisms are a minor risk factor for NSCLC...
  16. ncbi request reprint Cytokine gene polymorphisms in idiopathic pulmonary fibrosis
    R L Riha
    Department of Thoracic Medicine, The Prince Charles Hospital, Brisbane, Queensland, Australia
    Intern Med J 34:126-9. 2004
    ..Further research is needed to assess the utility of cytokine gene polymorphisms as markers of disease -susceptibility...
  17. doi request reprint A survey of lung cancer in rural and remote Aboriginal and Torres Strait Islander communities in Queensland: health views that impact on early diagnosis and treatment
    B J Page
    Central Integrated Regional Cancer Service, Queensland Health, Brisbane, Queensland, Australia
    Intern Med J 46:171-6. 2016
    ..If Indigenous Australians are made more aware of lung cancer through better access to health services and programmes, lung cancer outcomes might improve...
  18. doi request reprint Screening for activating EGFR mutations in surgically resected nonsmall cell lung cancer
    K B Sriram
    UQ Thoracic Research Centre, School of Medicine, The University of Queensland, Australia
    Eur Respir J 38:903-10. 2011
    ..017). ME-PCR and HRM have similar accuracy in detecting EGFR mutations but the prognostic implications of the mutations in resected NSCLC warrants further study...
  19. doi request reprint Common pathogenic mechanisms and pathways in the development of COPD and lung cancer
    Ian A Yang
    The Prince Charles Hospital, Department of Thoracic Medicine, Thoracic Research Laboratory, Brisbane, Australia
    Expert Opin Ther Targets 15:439-56. 2011
    ....
  20. ncbi request reprint Variability in the rate of prescription and cost of domiciliary oxygen therapy in Australia
    John G Serginson
    Thoracic Program, Department of Thoracic Medicine, The Prince Charles Hospital, and School of Medicine, University of Queensland, Brisbane, QLD, Australia
    Med J Aust 191:549-53. 2009
    ..To determine the rate of prescription of and government expenditure for domiciliary oxygen therapy (DOT) in Australia, and to identify interstate differences in rates, costs and service provision...
  21. ncbi request reprint Epigenomic targets for the treatment of respiratory disease
    Rayleen V Bowman
    The Prince Charles Hospital, Department of Thoracic Medicine, Brisbane, Australia
    Expert Opin Ther Targets 13:625-40. 2009
    ..A number of processes lead to epigenetic and epigenomic modifications...
  22. ncbi request reprint Cellular localization of interleukin 13 receptor alpha2 in human primary bronchial epithelial cells and fibroblasts
    A K Konstantinidis
    Division of Infection, Inflammation and Repair, School of Medicine, University of Southampton, Southampton, UK
    J Investig Allergol Clin Immunol 18:174-80. 2008
    ..Another IL-13 binding chain, IL-13Ralpha2, binds IL-13 with high affinity but has no known signaling capability and is thought to serve as a decoy receptor providing tight regulation of IL-13 responses...
  23. doi request reprint Exploratory study of the 'weekend effect' for acute medical admissions to public hospitals in Queensland, Australia
    M S Clarke
    School of Medicine, The University of Queensland, Brisbane, Queensland, Australia
    Intern Med J 40:777-83. 2010
    ....
  24. ncbi request reprint Polymorphisms in Toll-like receptor 4 and the systemic inflammatory response syndrome
    N J A Child
    Human Genetics Division and Infection, Inflammation and Repair Division, School of Medicine, University of Southampton, Southampton, UK
    Biochem Soc Trans 31:652-3. 2003
    ..A trend was found between the minor allele and mortality in SIRS (odds ratio of 4.3; P =0.076), suggesting a role for TLR4 signalling in the severity of SIRS...
  25. doi request reprint Queensland Lung Cancer Screening Study: rationale, design and methods
    H M Marshall
    Department of Thoracic Medicine, The Prince Charles Hospital, Brisbane, Queensland, Australia
    Intern Med J 43:174-82. 2013
    ..The feasibility of screening in Australia is unknown. This paper describes the rationale, design and methods of the Queensland Lung Cancer Screening Study...
  26. ncbi request reprint Cochrane systematic reviews of treatments for lung cancer
    K M Fong
    Department of Thoracic Medicine, The Prince Charles Hospital, Brisbane, Australia
    Respir Med 99:1071-8. 2005
    ..The integration of expert clinical experience, patient preference and high-quality evidence, including Cochrane systematic reviews, can only help improve outcomes from this highly lethal condition...
  27. ncbi request reprint Mannose-binding lectin gene polymorphism predicts hospital admissions for COPD infections
    I A Yang
    Division of Thoracic Medicine, The Prince Charles Hospital, and Department of Medicine, University of Queensland, Brisbane, Australia
    Genes Immun 4:269-74. 2003
    ..MBL2 genotype should be explored prospectively as a prognostic marker for infection risk in COPD...
  28. ncbi request reprint Gene expression of lung squamous cell carcinoma reflects mode of lymph node involvement
    J E Larsen
    Dept of Thoracic Medicine, The Prince Charles Hospital, Brisbane, Australia
    Eur Respir J 30:21-5. 2007
    ..This is relevant for prognosis prediction and also for clinical management, particularly in selecting those patients most likely to benefit from adjuvant chemotherapy...
  29. ncbi request reprint Epigenetics of lung cancer
    Rayleen V Bowman
    The University of Queensland, Queensland, Australia
    Respirology 11:355-65. 2006
    ..These diseases include cancer, and lung cancer in particular has been increasingly studied for the potential biological role of epigenetic changes with the promise of better and novel diagnostic and therapeutic tools...
  30. doi request reprint Genetics of allergic disease
    John W Holloway
    Division of Infection, Inflammation and Immunity, School of Medicine, University of Southampton, Southampton, United Kingdom
    J Allergy Clin Immunol 125:S81-94. 2010
    ....
  31. doi request reprint Interpatient variability in rates of asthma progression: can genetics provide an answer?
    John W Holloway
    Division of Infection, Inflammation and Repair, School of Medicine, University of Southampton, Southampton, United Kingdom
    J Allergy Clin Immunol 121:573-9. 2008
    ....
  32. doi request reprint ADAM28: a potential oncogene involved in asbestos-related lung adenocarcinomas
    Casey M Wright
    School of Medicine, The University of Queensland, QLD, Australia
    Genes Chromosomes Cancer 49:688-98. 2010
    ....
  33. ncbi request reprint Variation in the toll-like receptor 4 gene and susceptibility to myocardial infarction
    John W Holloway
    Human Genetics Division, School of Medicine, University of Southampton, Southampton, UK
    Pharmacogenet Genomics 15:15-21. 2005
    ....
  34. ncbi request reprint Arg389Gly-beta1-adrenergic receptors determine improvement in left ventricular systolic function in nonischemic cardiomyopathy patients with heart failure after chronic treatment with carvedilol
    Lu Chen
    Department of Medicine, The University of Queensland, Brisbane, Queensland, Australia
    Pharmacogenet Genomics 17:941-9. 2007
    ..We aimed to determine whether these polymorphisms contribute to variability in response to carvedilol in patients with chronic heart failure...
  35. ncbi request reprint Association of asthma with a functional promoter polymorphism in the IL16 gene
    Kristin M Burkart
    Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    J Allergy Clin Immunol 117:86-91. 2006
    ..A T-->C single nucleotide polymorphism (SNP) at the -295 position in the promoter region of the IL16 gene has been described...
  36. ncbi request reprint Mucociliary clearance in patients with chronic asthma: effects of beta agonists
    Evangelia Daviskas
    Department of Respiratory Medicine, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia
    Respirology 10:426-35. 2005
    ..We investigated baseline MCC and the acute effect of terbutaline in chronic asthmatics with sputum production while on long-term treatment with salmeterol in combination with inhaled corticosteroids (ICS)...
  37. ncbi request reprint Beta2-Adrenergic receptor polymorphism and asthma: true or false?
    John W Holloway
    Division of Infection, Inflammation and Repair, University of Southhampton, UK
    J Allergy Clin Immunol 115:960-2. 2005
  38. ncbi request reprint TLR4 Asp299Gly polymorphism is not associated with coronary artery stenosis
    Ian A Yang
    Human Genetics Division Mailpoint 808, University of Southampton School of Medicine, Tremona Road, Southampton SO16 6YD, UK
    Atherosclerosis 170:187-90. 2003
    ..We analyzed this polymorphism in relation to susceptibility to and severity of coronary artery disease...