David J Speers
Affiliation: Western Australia
- Clinical applications of molecular biology for infectious diseasesDavid J Speers
Division of Clinical Microbiology and Infectious Diseases, PathWest Laboratory Medicine WA, Nedlands, WA, Australia
Clin Biochem Rev 27:39-51. 2006....
- Neisseria meningitidis porA, fetA and fHbp gene distribution in Western Australia 2000 to 2011Peter Boan
Department of Microbiology, PathWest Laboratory Medicine WA, Princess Margaret Hospital for Children, Roberts Road, Subiaco 6008, Australia
BMC Infect Dis 14:686. 2014..PorA, fetA and fHbp are three antigen encoding genes useful for meningococcal typing and FHbp is an important component of meningococcal B vaccines...
- Clinical and radiological predictors of outcome for Murray Valley encephalitisDavid J Speers
Department of Microbiology, PathWest Laboratory Medicine WA, Nedlands, Western Australia, Australia
Am J Trop Med Hyg 88:481-9. 2013..MRI scans repeated months after acute illness showed destruction of the thalamus and basal ganglia, cortex, or cerebellum. These findings may help clinicians predict the neurological outcome when evaluating patients with MVE...
- Diagnosis of malaria aided by polymerase chain reaction in two cases with low-level parasitaemiaD J Speers
Department of General Medicine, Sir Charles Gairdner Hospital, The Western Australian Centre for Pathology and Medical Research, Perth, Western Australia 6009, Australia
Intern Med J 33:613-5. 2003..Plasmodium vivax was detected by PCR prior to the light microscopy becoming positive in one case, and in the second case Plasmodium malariae was detected when light microscopy was unable to speciate the causative Plasmodium species...
- Combination assay detecting both human immunodeficiency virus (HIV) p24 antigen and anti-HIV antibodies opens a second diagnostic windowDavid Speers
Division of Clinical Microbiology and Infectious Diseases, The Western Australian Centre for Pathology and Medical Research PathCentre, Hospital Avenue, Nedlands, Western Australia 6009, Australia
J Clin Microbiol 43:5397-9. 2005..Although it is likely to be rare, this phenomenon has also been reported for other fourth-generation HIV immunoassays and has implications for the reported diagnostic windows of these assays...
- Oseltamivir-resistant pandemic (H1N1) 2009 influenza in a severely ill patient: the first Australian caseDavid J Speers
Division of Microbiology and Infectious Diseases, PathWest Laboratory Medicine WA, Perth, WA
Med J Aust 192:166-8. 2010..He subsequently died of non-respiratory complications. This is the first case of oseltamivir-resistant pandemic (H1N1) 2009 in Australia and the first report of resistance in a solid organ transplant recipient...
- The detection of oseltamivir-resistant pandemic influenza A/H1N1 2009 viruses using a real-time RT-PCR assayGlenys R Chidlow
Department of Microbiology, PathWest Laboratory Medicine WA, Nedlands, Australia
J Virol Methods 169:47-51. 2010..The sensitive rRT-PCR assays may be performed directly on patient specimens, can detect resistant virus at low levels, and therefore may provide early warning of developing resistance within individual patients or the wider population...
- Penicillin-resistant Neisseria meningitidis bacteraemia, Kimberley region, March 2010Shivanti D Abeysuriya
Department of Microbiology, PathWest Laboratory Medicine, Queen Elizabeth II Medical Centre, Nedlands, Western Australia
Commun Dis Intell Q Rep 34:342-4. 2010..meningitidis disease is of concern and emphasises the importance of ongoing surveillance for antimicrobial resistance...
- Validation of the FibroTest biochemical markers score in assessing liver fibrosis in hepatitis C patientsEnrico Rossi
Clinical Biochemistry, PathCentre, Nedlands, Western Australia, Australia
Clin Chem 49:450-4. 2003..We investigated the predictive value of the proprietary FibroTest score to accurately identify significant fibrosis in Australian hepatitis C patients...
- Duplex real-time reverse transcriptase PCR assays for rapid detection and identification of pandemic (H1N1) 2009 and seasonal influenza A/H1, A/H3, and B virusesGlenys Chidlow
Department of Microbiology, PathWest Laboratory Medicine WA, QEII Medical Centre, Nedlands, Western Australia, Australia
J Clin Microbiol 48:862-6. 2010..9% for seasonal A/H1, and 96.3% and 99.6% for A/H3. Automated sample extraction facilitated the rapid processing of samples so that the assays allowed accurate, rapid, and cost-effective screening of large numbers of clinical samples...
- Procalcitonin and C-reactive protein in severe 2009 H1N1 influenza infectionPaul Robert Ingram
Microbiology and Infectious Diseases, PathWest Laboratories, Hospital Ave, Nedlands, Perth, WA 6160, Australia
Intensive Care Med 36:528-32. 2010..To examine whether, in an adult intensive care unit (ICU), procalcitonin or C-reactive protein (CRP) levels discriminated between 2009 H1N1 influenza infection and community-acquired pneumonia of bacterial origin...
- Influenza and respiratory syncytial virus are the major respiratory viruses detected from prospective testing of pediatric and adult coronial autopsiesDavid J Speers
Department of Microbiology, PathWest Laboratory Medicine WA, Queen Elizabeth II Medical Centre, Nedlands, WA, Australia School of Medicine and Pharmacology, University of Western Australia, Crawley, WA, Australia
Influenza Other Respir Viruses 7:1113-21. 2013..To ascertain the full mortality of influenza and other respiratory viruses, the testing of community autopsy specimens is essential...
- Enterovirus D68 disease and molecular epidemiology in AustraliaAvram Levy
PathWest Laboratory Medicine WA, Perth, Australia School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia Electronic address
J Clin Virol 69:117-21. 2015..Neurological syndromes such as acute flaccid paralysis following EV-D68 infection have also been reported in a small number of cases...
- Real-time PCR assay for detection of blaZ genes in Staphylococcus aureus clinical isolatesLynette A Pereira
Department of Microbiology, PathWest Laboratory Medicine WA, Queen Elizabeth II Medical Centre, Nedlands, Western Australia, Australia
J Clin Microbiol 52:1259-61. 2014..Conventional PCR methods have demonstrated superior sensitivity and specificity to phenotypic tests. To our knowledge, this is the first description of real-time PCR detection of the blaZ gene. ..
- The viruses of Australia and the risk to touristsDavid W Smith
PathWest Laboratory Medicine WA, Queen Elizabeth II Medical Centre, Nedlands, Western Australia 6909, Australia
Travel Med Infect Dis 9:113-25. 2011..However, it is important to remember that most tourists pass through other countries in the Asia/Pacific region on their way to and from Australia and may therefore have acquired infections prior to or after leaving Australia...
- Decline in native kidney function in liver transplant recipients is not associated with BK virus infectionMuna Salama
Department of Gastroenterology Hepatology, University of Western Australia, Perth, Australia
Liver Transpl 14:1787-92. 2008..It appears that the most probable pathway for the development of BKV nephropathy requires a second hit, such as kidney inflammation, kidney ischemia, or donor-recipient human leukocyte antigen mismatch...
- Hepascore: an accurate validated predictor of liver fibrosis in chronic hepatitis C infectionLeon A Adams
Department of Gastroenterology and Hepatology, Sir Charles Gairdner Hospital, Perth, Australia
Clin Chem 51:1867-73. 2005..We sought to create an algorithm of serum markers that accurately and reliably predict liver fibrosis stage among hepatitis C patients...
- Outbreak of sporotrichosis, Western AustraliaKynan T Feeney
Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia
Emerg Infect Dis 13:1228-31. 2007..Declining infection rates have occurred after various community measures were instigated...
- Does sequencing the PKRBD of hepatitis C virus NS5A predict therapeutic response to combination therapy in an Australian population?Gerry C MacQuillan
Department of Medicine, University of Western Australia, Crawley, Western Australia, Australia
J Gastroenterol Hepatol 19:551-7. 2004..The ability of the ISDR and PKRBD sequence to predict a response to IFN-alpha and ribavirin combination therapy was investigated in an Australian population...