Cynthia Shannon Weickert

Summary

Affiliation: University of New South Wales
Country: Australia

Publications

  1. ncbi request reprint Human dysbindin (DTNBP1) gene expression in normal brain and in schizophrenic prefrontal cortex and midbrain
    Cynthia Shannon Weickert
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    Arch Gen Psychiatry 61:544-55. 2004
  2. pmc Reduced DTNBP1 (dysbindin-1) mRNA in the hippocampal formation of schizophrenia patients
    Cynthia Shannon Weickert
    MiNDS Unit of the Clinical Brain Disorders Branch, IRP, NIMH, NIH, Bethesda, MD 20892, USA
    Schizophr Res 98:105-10. 2008
  3. pmc Elevated neuregulin-1 and ErbB4 protein in the prefrontal cortex of schizophrenic patients
    Victor Z Chong
    MiNDS Unit, CBDB, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bldg 10, Bethesda, MD 20892, USA
    Schizophr Res 100:270-80. 2008
  4. ncbi request reprint A conserved mRNA expression profile of SREB2 (GPR85) in adult human, monkey, and rat forebrain
    Mitsuyuki Matsumoto
    Clinical Brain Disorders Branch, NIMH, NIH, Bethesda, MD 20892, USA
    Brain Res Mol Brain Res 138:58-69. 2005
  5. ncbi request reprint Expression of DISC1 binding partners is reduced in schizophrenia and associated with DISC1 SNPs
    Barbara K Lipska
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Hum Mol Genet 15:1245-58. 2006
  6. pmc Variants in the estrogen receptor alpha gene and its mRNA contribute to risk for schizophrenia
    Cynthia Shannon Weickert
    MiNDS Unit, Section on Neuropathology, GCAP, NIMH, NIH, Bethesda, MD 20892, USA
    Hum Mol Genet 17:2293-309. 2008
  7. ncbi request reprint Age-related differences in glucocorticoid receptor mRNA levels in the human brain
    William R Perlman
    MiNDS Unit, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, U S Department of Health and Human Services, Bethesda, MD 20892 1385, USA
    Neurobiol Aging 28:447-58. 2007
  8. ncbi request reprint Critical factors in gene expression in postmortem human brain: Focus on studies in schizophrenia
    Barbara K Lipska
    Clinical Brain Disorders Branch, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1385, USA
    Biol Psychiatry 60:650-8. 2006
  9. ncbi request reprint Glutamate carboxypeptidase II gene expression in the human frontal and temporal lobe in schizophrenia
    Subroto Ghose
    Clinical Brain Disorders Branch, IRP, NIMH, NIH, Bethesda, MD 20892, USA
    Neuropsychopharmacology 29:117-25. 2004
  10. ncbi request reprint Discordant changes in cortical TrkC mRNA and protein during the human lifespan
    Senda Beltaifa
    Clinical Brain Disorders Branch, IRP, NIMH, NIH, Bethesda, MD 20892, USA
    Eur J Neurosci 21:2433-44. 2005

Detail Information

Publications24

  1. ncbi request reprint Human dysbindin (DTNBP1) gene expression in normal brain and in schizophrenic prefrontal cortex and midbrain
    Cynthia Shannon Weickert
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    Arch Gen Psychiatry 61:544-55. 2004
    ..3) encodes a neuronal protein that binds to beta-dystrobrevin and may be part of the dystrophin protein complex. Little is known about dysbindin expression in normal or schizophrenic brain...
  2. pmc Reduced DTNBP1 (dysbindin-1) mRNA in the hippocampal formation of schizophrenia patients
    Cynthia Shannon Weickert
    MiNDS Unit of the Clinical Brain Disorders Branch, IRP, NIMH, NIH, Bethesda, MD 20892, USA
    Schizophr Res 98:105-10. 2008
    ..Our results indicate that previously reported dysbindin-1 protein reductions may be due in part to decreased dysbindin-1 mRNA and that reduced dysbindin-1 may contribute to hippocampal formation synaptic pathology in schizophrenia...
  3. pmc Elevated neuregulin-1 and ErbB4 protein in the prefrontal cortex of schizophrenic patients
    Victor Z Chong
    MiNDS Unit, CBDB, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bldg 10, Bethesda, MD 20892, USA
    Schizophr Res 100:270-80. 2008
    ..We hypothesize that ErbB4 proteolytic processing may also be altered in schizophrenia, yielding altered ratios of functionally distinct forms of ErbB4...
  4. ncbi request reprint A conserved mRNA expression profile of SREB2 (GPR85) in adult human, monkey, and rat forebrain
    Mitsuyuki Matsumoto
    Clinical Brain Disorders Branch, NIMH, NIH, Bethesda, MD 20892, USA
    Brain Res Mol Brain Res 138:58-69. 2005
    ..Together, these data suggest a possible link between SREB family and neural plasticity, which may explain its extremely high conservation throughout vertebrate evolution...
  5. ncbi request reprint Expression of DISC1 binding partners is reduced in schizophrenia and associated with DISC1 SNPs
    Barbara K Lipska
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Hum Mol Genet 15:1245-58. 2006
    ..Although, many other DISC1 binding partners still need to be investigated, these data implicate genetically linked abnormalities in the DISC1 molecular pathway in the pathophysiology of schizophrenia...
  6. pmc Variants in the estrogen receptor alpha gene and its mRNA contribute to risk for schizophrenia
    Cynthia Shannon Weickert
    MiNDS Unit, Section on Neuropathology, GCAP, NIMH, NIH, Bethesda, MD 20892, USA
    Hum Mol Genet 17:2293-309. 2008
    ..Thus, the variation in the ESR1 gene is associated with schizophrenia and the mechanism of this association may involve alternative gene regulation and transcript processing...
  7. ncbi request reprint Age-related differences in glucocorticoid receptor mRNA levels in the human brain
    William R Perlman
    MiNDS Unit, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, U S Department of Health and Human Services, Bethesda, MD 20892 1385, USA
    Neurobiol Aging 28:447-58. 2007
    ..Increased GR mRNA in prefrontal cortex during adolescence and adulthood suggests that human GR-mediated forebrain regulation of cognition and the neuroendocrine stress response may be more salient during late maturation and at maturity...
  8. ncbi request reprint Critical factors in gene expression in postmortem human brain: Focus on studies in schizophrenia
    Barbara K Lipska
    Clinical Brain Disorders Branch, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1385, USA
    Biol Psychiatry 60:650-8. 2006
    ..They are, however, confounded by pre- and postmortem factors. The purpose of this study was to identify sources of variation that will enable a better design of gene expression studies and higher reliability of gene expression data...
  9. ncbi request reprint Glutamate carboxypeptidase II gene expression in the human frontal and temporal lobe in schizophrenia
    Subroto Ghose
    Clinical Brain Disorders Branch, IRP, NIMH, NIH, Bethesda, MD 20892, USA
    Neuropsychopharmacology 29:117-25. 2004
    ..Our findings support the notion that the hydrolysis of NAAG is disrupted in schizophrenia and that specific anatomical regions may show discrete abnormalities in GCP II synthesis...
  10. ncbi request reprint Discordant changes in cortical TrkC mRNA and protein during the human lifespan
    Senda Beltaifa
    Clinical Brain Disorders Branch, IRP, NIMH, NIH, Bethesda, MD 20892, USA
    Eur J Neurosci 21:2433-44. 2005
    ..Our results suggest that truncated trkC is prevalent in the human PFC and that neurons and glia may be responsive to NT-3 in the PFC throughout life...
  11. pmc Postmortem investigations of the pathophysiology of schizophrenia: the role of susceptibility genes
    William R Perlman
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, U S Department of Health and Human Services, Bethesda, MD 20892 1384, USA
    J Psychiatry Neurosci 29:287-93. 2004
    ....
  12. ncbi request reprint Effects of chronic haloperidol and clozapine treatment on neurogenesis in the adult rat hippocampus
    Nader D Halim
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, NIH, Bethesda, MD 20892 1385, USA
    Neuropsychopharmacology 29:1063-9. 2004
    ..These preliminary findings suggest that clozapine may influence the number of cells which divide, but antipsychotics do not promote the survival of the newly generated neurons at 3 weeks after a BrdU injection...
  13. doi request reprint Specific developmental reductions in subventricular zone ErbB1 and ErbB4 mRNA in the human brain
    Victor Z Chong
    MiNDS Unit, CBDB, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    Int J Dev Neurosci 26:791-803. 2008
    ..The restriction of robust SVZ ErbB4 expression to neonate and infant age groups may indicate that SVZ-derived ErbB4-dependent postnatal neuronal development is most extensive within a narrow time frame early after birth...
  14. ncbi request reprint Reduced glucocorticoid and estrogen receptor alpha messenger ribonucleic acid levels in the amygdala of patients with major mental illness
    William R Perlman
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, U S Department of Health and Human Services, Bethesda, Maryland, USA
    Biol Psychiatry 56:844-52. 2004
    ..We also hypothesized that estrogen receptor alpha (ERalpha) mRNA expression might be altered in the amygdala, on the basis of observed gender differences in mental illness...
  15. pmc Gonadectomy negatively impacts social behavior of adolescent male primates
    A Brent Richards
    MiNDS Unit, NIMH, Bethesda, MD, USA
    Horm Behav 56:140-8. 2009
    ..Our work suggests that intact gonads, which are needed to produce adolescent increases in circulating testosterone, impact social behavior during adolescences in primates...
  16. ncbi request reprint Gene expression in dopamine and GABA systems in an animal model of schizophrenia: effects of antipsychotic drugs
    Barbara K Lipska
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, NIH, Bldg 10, Rm 4N306, Bethesda, MD 20892 1385, USA
    Eur J Neurosci 18:391-402. 2003
    ....
  17. ncbi request reprint Widespread expression of ErbB2, ErbB3 and ErbB4 in non-human primate brain
    Mia Thompson
    MiNDS Unit Clinical Brain Disorders Branch, IRP NIMH NIH, NIH, Mail Stop 1385, Building 10 Room 4D18, Bethesda, MD 20892, USA
    Brain Res 1139:95-109. 2007
    ..The ubiquitous expression of ErbB receptors indicates that many cell populations throughout the brain of juvenile and adult primates have the potential to respond to NRG-1 in a variety of ways...
  18. ncbi request reprint Catechol O-methyltransferase (COMT) mRNA expression in the dorsolateral prefrontal cortex of patients with schizophrenia
    Mitsuyuki Matsumoto
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, USA
    Neuropsychopharmacology 28:1521-30. 2003
    ..The disease-related laminar difference of COMT expression may be involved in dysregulation of dopamine signaling circuits in the DLPFC of patients with schizophrenia...
  19. pmc Neuregulin 1 transcripts are differentially expressed in schizophrenia and regulated by 5' SNPs associated with the disease
    Amanda J Law
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, United Kingdom
    Proc Natl Acad Sci U S A 103:6747-52. 2006
    ..These data implicate variation in isoform expression as a molecular mechanism for the genetic association of NRG1 with schizophrenia...
  20. ncbi request reprint Reduced spinophilin but not microtubule-associated protein 2 expression in the hippocampal formation in schizophrenia and mood disorders: molecular evidence for a pathology of dendritic spines
    Amanda J Law
    University Department of Psychiatry, Neurosciences Building, Warneford Hospital, Oxford OX3 7JX, UK
    Am J Psychiatry 161:1848-55. 2004
    ..There is reasonable neuropathological evidence for a presynaptic pathology but few studies of the postsynaptic component. This study tested the hypothesis that hippocampal dendritic pathology is also present in schizophrenia...
  21. ncbi request reprint Alteration in estrogen receptor alpha mRNA levels in frontal cortex and hippocampus of patients with major mental illness
    William R Perlman
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, U S Department of Health and Human Services, MD 20892 1385, USA
    Biol Psychiatry 58:812-24. 2005
    ..We hypothesized that gender-specific alterations in DLPFC and hippocampus estrogen receptor alpha (ERalpha) mRNA levels may exist in MMI patients...
  22. ncbi request reprint Disease-associated intronic variants in the ErbB4 gene are related to altered ErbB4 splice-variant expression in the brain in schizophrenia
    Amanda J Law
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK
    Hum Mol Genet 16:129-41. 2007
    ....
  23. ncbi request reprint Changes in NMDA receptor subunit mRNAs and cyclophilin mRNA during development of the human hippocampus
    Amanda J Law
    Department of Psychiatry, University of Oxford, OX3 7JX, United Kingdom
    Ann N Y Acad Sci 1003:426-30. 2003
  24. ncbi request reprint Expression of NMDA receptor NR1, NR2A and NR2B subunit mRNAs during development of the human hippocampal formation
    Amanda J Law
    Department of Psychiatry, University of Oxford, Neurosciences Building, Warneford Hospital, Oxford OX3 7JX, UK
    Eur J Neurosci 18:1197-205. 2003
    ..Changes in subunit composition may thus contribute to maturational differences in human hippocampal N-methyl-d-aspartate receptor function, and to their role in the pathophysiology of schizophrenia and other neurodevelopmental disorders...